Systematic, multiparametric analysis of Mycobacterium tuberculosis intracellular infection offers insight into coordinated virulence

Mycobacterial ESX-1 secretion system mediates host cell lysis through bacterium contact-dependent gross membrane disruptions

(2017) William H. Conrad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Cell Wall Lipid PDIM Contributes to Phagosomal Escape and Host Cell Exit of Mycobacterium tuberculosis

(2017) Jeff Quigley et al.   mBio

Phosphate starvation: a novel signal that triggers ESX-5 secretion inMycobacterium tuberculosis

(2016) Sarah R. Elliott et al.   MOLECULAR MICROBIOLOGY

Separable roles forMycobacterium tuberculosisESX-3 effectors in iron acquisition and virulence

(2016) JoAnn M. Tufariello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy

(2015) Robert O. Watson et al.   Cell Host & Microbe

Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1

(2015) Ruth Wassermann et al.   Cell Host & Microbe

Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis

(2015) Angela C. Collins et al.   Cell Host & Microbe

Mycobacteria, metals, and the macrophage

(2015) Olivier Neyrolles et al.   IMMUNOLOGICAL REVIEWS

Phylogeny to function: PE/PPE protein evolution and impact onMycobacterium tuberculosispathogenicity

(2015) S. Fishbein et al.   MOLECULAR MICROBIOLOGY

Type I IFN Induces IL-10 Production in an IL-27–Independent Manner and Blocks Responsiveness to IFN-γ for Production of IL-12 and Bacterial Killing inMycobacterium tuberculosis–Infected Macrophages

(2014) Finlay W. McNab et al.   JOURNAL OF IMMUNOLOGY

Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk

(2014) Katrin D. Mayer-Barber et al.   NATURE

Nitrogen metabolism in Mycobacterium tuberculosis physiology and virulence

(2014) Alexandre Gouzy et al.   NATURE REVIEWS MICROBIOLOGY

Identification of Host-Targeted Small Molecules That Restrict Intracellular Mycobacterium tuberculosis Growth

(2014) Sarah A. Stanley et al.   PLoS Pathogens

Take five — Type VII secretion systems of Mycobacteria

(2013) Edith N.G. Houben et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Tryptophan Biosynthesis Protects Mycobacteria from CD4 T-Cell-Mediated Killing

(2013) Yanjia J. Zhang et al.   CELL

Molybdenum cofactor: A key component ofMycobacterium tuberculosispathogenesis?

(2013) Monique Williams et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Mycobacteria manipulate macrophage recruitment through coordinated use of membrane lipids

(2013) C. J. Cambier et al.   NATURE

Virulence factors of theMycobacterium tuberculosiscomplex

(2013) Marina A. Forrellad et al.   Virulence

Genome-wide Mapping of Transcriptional Start Sites Defines an Extensive Leaderless Transcriptome in Mycobacterium tuberculosis

(2013) Teresa Cortes et al.   Cell Reports

Mycobacterium tuberculosis Type VII Secreted Effector EsxH Targets Host ESCRT to Impair Trafficking

(2013) Alka Mehra et al.   PLoS Pathogens

Mycobacterium Tuberculosis Activates the DNA-Dependent Cytosolic Surveillance Pathway within Macrophages

(2012) Paolo S. Manzanillo et al.   Cell Host & Microbe

ESX-1-mediated translocation to the cytosol controls virulence of mycobacteria

(2012) Diane Houben et al.   CELLULAR MICROBIOLOGY

EccA1, a Component of the Mycobacterium marinum ESX-1 Protein Virulence Factor Secretion Pathway, Regulates Mycolic Acid Lipid Synthesis

(2012) Shilpa A. Joshi et al.   CHEMISTRY & BIOLOGY

Composition of the type VII secretion system membrane complex

(2012) Edith N. G. Houben et al.   MOLECULAR MICROBIOLOGY

Phagosomal Rupture by Mycobacterium tuberculosis Results in Toxicity and Host Cell Death

(2012) Roxane Simeone et al.   PLoS Pathogens

A Comparative Lipidomics Platform for Chemotaxonomic Analysis of Mycobacterium tuberculosis

(2011) Emilie Layre et al.   CHEMISTRY & BIOLOGY

Spontaneous Phthiocerol Dimycocerosate-Deficient Variants of Mycobacterium tuberculosis Are Susceptible to Gamma Interferon-Mediated Immunity

(2011) Meghan A. Kirksey et al.   INFECTION AND IMMUNITY

Mycobacterium tuberculosis Triggers Host Type I IFN Signaling To Regulate IL-1  Production in Human Macrophages

(2011) A. Novikov et al.   JOURNAL OF IMMUNOLOGY

The Regulation of Sulfur Metabolism in Mycobacterium tuberculosis

(2011) Stavroula K. Hatzios et al.   PLoS Pathogens

High Content Phenotypic Cell-Based Visual Screen Identifies Mycobacterium tuberculosis Acyltrehalose-Containing Glycolipids Involved in Phagosome Remodeling

(2010) Priscille Brodin et al.   PLoS Pathogens

EspA Acts as a Critical Mediator of ESX1-Dependent Virulence in Mycobacterium tuberculosis by Affecting Bacterial Cell Wall Integrity

(2010) Alejandra Garces et al.   PLoS Pathogens

ESX/type VII secretion systems and their role in host–pathogen interaction

(2009) Roxane Simeone et al.   CURRENT OPINION IN MICROBIOLOGY

Phthiocerol Dimycocerosates of M. tuberculosis Participate in Macrophage Invasion by Inducing Changes in the Organization of Plasma Membrane Lipids

(2009) Catherine Astarie-Dequeker et al.   PLoS Pathogens

High Content Screening Identifies Decaprenyl-Phosphoribose 2′ Epimerase as a Target for Intracellular Antimycobacterial Inhibitors

(2009) Thierry Christophe et al.   PLoS Pathogens

Evidence for Pore Formation in Host Cell Membranes by ESX-1-Secreted ESAT-6 and Its Role in Mycobacterium marinum Escape from the Vacuole

(2008) J. Smith et al.   INFECTION AND IMMUNITY

Function and Structure of a Prokaryotic Formylglycine-generating Enzyme

(2008) Brian L. Carlson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Structure and Unusual Protein Chemistry of Hypoxic Response Protein 1, a Latency Antigen and Highly Expressed Member of the DosR Regulon in Mycobacterium tuberculosis

(2008) Miriam L. Sharpe et al.   JOURNAL OF MOLECULAR BIOLOGY

Mycobacterial persistence requires the utilization of host cholesterol

(2008) A. K. Pandey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA