Cyclic nucleotide signalling in malaria parasites

New developments in anti-malarial target candidate and product profiles

(2017) Jeremy N. Burrows et al.   MALARIA JOURNAL

Parasitophorous vacuole poration precedes its rupture and rapid host erythrocyte cytoskeleton collapse inPlasmodium falciparumegress

(2017) Victoria L. Hale et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasmodium falciparum Calcium-Dependent Protein Kinase 2 Is Critical for Male Gametocyte Exflagellation but Not Essential for Asexual Proliferation

(2017) Abhisheka Bansal et al.   mBio

A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission

(2017) David A. Baker et al.   Nature Communications

Culture adaptation of malaria parasites selects for convergent loss-of-function mutants

(2017) Antoine Claessens et al.   Scientific Reports

Multiple short windows of calcium-dependent protein kinase 4 activity coordinate distinct cell cycle events during Plasmodium gametogenesis

(2017) Hanwei Fang et al.   eLife

An essential dual-function complex mediates erythrocyte invasion and channel-mediated nutrient uptake in malaria parasites

(2017) Daisuke Ito et al.   eLife

Plasmodium falciparum CRK4 directs continuous rounds of DNA replication during schizogony

(2017) Markus Ganter et al.   Nature Microbiology

Plasmodium falciparum STEVOR phosphorylation regulates host erythrocyte deformability enabling malaria parasite transmission

(2016) B. Naissant et al.   BLOOD

Evolution of developmental signalling in Dictyostelid social amoebas

(2016) Pauline Schaap   CURRENT OPINION IN GENETICS & DEVELOPMENT

PKA and Apicomplexan Parasite Diseases

(2016) M. Haidar et al.   HORMONE AND METABOLIC RESEARCH

Disrupting the Allosteric Interaction between thePlasmodium falciparumcAMP-dependent Kinase and Its Regulatory Subunit

(2016) Dene R. Littler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and functional dissection ofToxoplasma gondiiarmadillo repeats only protein

(2016) Christina Mueller et al.   JOURNAL OF CELL SCIENCE

Characterization of an A-kinase anchoring protein-like suggests an alternative way of PKA anchoring in Plasmodium falciparum

(2016) Kossiwa Bandje et al.   MALARIA JOURNAL

Invasion of hepatocytes byPlasmodiumsporozoites requires cGMP-dependent protein kinase and calcium dependent protein kinase 4

(2016) K. Govindasamy et al.   MOLECULAR MICROBIOLOGY

Vpu-Mediated Counteraction of Tetherin Is a Major Determinant of HIV-1 Interferon Resistance

(2016) Dorota Kmiec et al.   mBio

Functional profiles of orphan membrane transporters in the life cycle of the malaria parasite

(2016) Sanketha Kenthirapalan et al.   Nature Communications

Hierarchical phosphorylation of apical membrane antigen 1 is required for efficient red blood cell invasion by malaria parasites

(2016) Boris Prinz et al.   Scientific Reports

Identification of Potent Phosphodiesterase Inhibitors that Demonstrate Cyclic Nucleotide-Dependent Functions in Apicomplexan Parasites

(2015) Brittany L. Howard et al.   ACS Chemical Biology

PlasmoGEM, a database supporting a community resource for large-scale experimental genetics in malaria parasites

(2015) Frank Schwach et al.   NUCLEIC ACIDS RESEARCH

Cyclic GMP Balance Is Critical for Malaria Parasite Transmission from the Mosquito to the Mammalian Host

(2015) Viswanathan Lakshmanan et al.   mBio

Phosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion

(2015) Mahmood M. Alam et al.   Nature Communications

Crystal Structures of the Carboxyl cGMP Binding Domain of the Plasmodium falciparum cGMP-dependent Protein Kinase Reveal a Novel Capping Triad Crucial for Merozoite Egress

(2015) Jeong Joo Kim et al.   PLoS Pathogens

cAMP-Signalling Regulates Gametocyte-Infected Erythrocyte Deformability Required for Malaria Parasite Transmission

(2015) Ghania Ramdani et al.   PLoS Pathogens

Regulation ofPlasmodium falciparumDevelopment by Calcium-dependent Protein Kinase 7 (PfCDPK7)

(2014) Praveen Kumar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Advances in targeting cyclic nucleotide phosphodiesterases

(2014) Donald H. Maurice et al.   NATURE REVIEWS DRUG DISCOVERY

Plasmodium falciparum transmission stages accumulate in the human bone marrow

(2014) R. Joice et al.   Science Translational Medicine

Phosphoinositide Metabolism Links cGMP-Dependent Protein Kinase G to Essential Ca2+ Signals at Key Decision Points in the Life Cycle of Malaria Parasites

(2014) Mathieu Brochet et al.   PLOS BIOLOGY

The Central Role of cAMP in Regulating Plasmodium falciparum Merozoite Invasion of Human Erythrocytes

(2014) Amrita Dawn et al.   PLoS Pathogens

Temporal evaluation of commitment to sexual development in Plasmodium falciparum

(2013) Christopher L Peatey et al.   MALARIA JOURNAL

Malaria Parasite cGMP-dependent Protein Kinase Regulates Blood Stage Merozoite Secretory Organelle Discharge and Egress

(2013) Christine R. Collins et al.   PLoS Pathogens

A switch in infected erythrocyte deformability at the maturation and blood circulation of Plasmodium falciparum transmission stages

(2012) M. Tiburcio et al.   BLOOD

Host cell deformability is linked to transmission in the human malaria parasite Plasmodium falciparum

(2012) Mythili Aingaran et al.   CELLULAR MICROBIOLOGY

The Plasmodium falciparum Schizont Phosphoproteome Reveals Extensive Phosphatidylinositol and cAMP-Protein Kinase A Signaling

(2012) Edwin Lasonder et al.   JOURNAL OF PROTEOME RESEARCH

Exploring the Plasmodium falciparum cyclic-adenosine monophosphate (cAMP)-dependent protein kinase (PfPKA) as a therapeutic target

(2012) Nina M. Haste et al.   MICROBES AND INFECTION

Assembly of allosteric macromolecular switches: lessons from PKA

(2012) Susan S. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Characterization of Plasmodium falciparum Adenylyl Cyclase-β and Its Role in Erythrocytic Stage Parasites

(2012) Eric Salazar et al.   PLoS One

Spatiotemporal and Functional Characterisation of the Plasmodium falciparum cGMP-Dependent Protein Kinase

(2012) Christine S. Hopp et al.   PLoS One

Adaptation of the genetically tractable malaria pathogen Plasmodium knowlesi to continuous culture in human erythrocytes

(2012) R. W. Moon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dissection of Minimal Sequence Requirements for Rhoptry Membrane Targeting in the Malaria Parasite

(2012) Ana Cabrera et al.   TRAFFIC

Construction of a Plasmodium falciparum Rab-interactome identifies CK1 and PKA as Rab-effector kinases in malaria parasites

(2011) Fathia Ben Rached et al.   BIOLOGY OF THE CELL

Active site similarity between human and Plasmodium falciparum phosphodiesterases: considerations for antimalarial drug design

(2011) Brittany L. Howard et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Drug to Genome to Drug: Discovery of New Antiplasmodial Compounds

(2011) Terence B. Beghyn et al.   JOURNAL OF MEDICINAL CHEMISTRY

Drug-to-Genome-to-Drug, Step 2: Reversing Selectivity in a Series of Antiplasmodial Compounds

(2011) Terence B. Beghyn et al.   JOURNAL OF MEDICINAL CHEMISTRY

Melatonin triggers PKA activation in the rodent malaria parasite Plasmodium chabaudi

(2010) Marcos L. Gazarini et al.   JOURNAL OF PINEAL RESEARCH

cAMP-dependent protein kinase from Plasmodium falciparum: an update

(2010) NATHALIE WURTZ et al.   PARASITOLOGY

cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP Action

(2010) S. H. Francis et al.   PHARMACOLOGICAL REVIEWS

A Plant-Like Kinase in Plasmodium falciparum Regulates Parasite Egress from Erythrocytes

(2010) J. D. Dvorin et al.   SCIENCE

Distinct External Signals Trigger Sequential Release of Apical Organelles during Erythrocyte Invasion by Malaria Parasites

(2010) Shailja Singh et al.   PLoS Pathogens

Protein Kinase A Dependent Phosphorylation of Apical Membrane Antigen 1 Plays an Important Role in Erythrocyte Invasion by the Malaria Parasite

(2010) Kerstin Leykauf et al.   PLoS Pathogens

The Malaria Parasite Cyclic GMP-Dependent Protein Kinase Plays a Central Role in Blood-Stage Schizogony

(2009) Helen M. Taylor et al.   EUKARYOTIC CELL

A unique phosphatidylinositol 4-phosphate 5-kinase is activated by ADP-ribosylation factor in Plasmodium falciparum

(2009) Werner Leber et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Initiation of Plasmodium sporozoite motility by albumin is associated with induction of intracellular signalling

(2009) Chahnaz Kebaier et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Role of Plasmodium berghei cGMP-dependent Protein Kinase in Late Liver Stage Development

(2009) Adebola Falae et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Cyclic GMP Signalling Module That Regulates Gliding Motility in a Malaria Parasite

(2009) Robert W. Moon et al.   PLoS Pathogens

Cyclic nucleotide-specific phosphodiesterases of Plasmodium falciparum: PfPDEα, a non-essential cGMP-specific PDE that is an integral membrane protein

(2008) Laurent Wentzinger et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Susceptibility of Plasmodium falciparum cyclic AMP-dependent protein kinase and its mammalian homologue to the inhibitors

(2008) Atsushi Sudo et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Disruption of aPlasmodium falciparumcyclic nucleotide phosphodiesterase gene causes aberrant gametogenesis

(2008) Cathy J. Taylor et al.   MOLECULAR MICROBIOLOGY

Abscisic acid controls calcium-dependent egress and development in Toxoplasma gondii

(2008) Kisaburo Nagamune et al.   NATURE

Plasmodium falciparum Regulatory Subunit of cAMP-Dependent PKA and Anion Channel Conductance

(2008) Anaïs Merckx et al.   PLoS Pathogens

Pharmacological PKA Inhibition: All May Not Be What It Seems

(2008) A. J. Murray   Science Signaling

Gametogenesis in Malaria Parasites Is Mediated by the cGMP-Dependent Protein Kinase

(2008) Louisa McRobert et al.   PLOS BIOLOGY

Adenylyl Cyclase α and cAMP Signaling Mediate Plasmodium Sporozoite Apical Regulated Exocytosis and Hepatocyte Infection

(2008) Takeshi Ono et al.   PLoS Pathogens