Copper-Catalyzed Innate Ethoxycarbon­yldifluoromethylation of Electron-Rich ­Arenes

Palladium-Catalyzed CF Bond FormationviaDirected CH Activation

(2014) Yan Li et al.   ADVANCED SYNTHESIS & CATALYSIS

Palladium-Catalyzed Difluoroalkylation of Aryl Boronic Acids: A New Method for the Synthesis of Aryldifluoromethylated Phosphonates and Carboxylic Acid Derivatives

(2014) Zhang Feng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Trifluoromethylation of Alkenes with Concomitant Introduction of Additional Functional Groups

(2014) Hiromichi Egami et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nickel-Catalyzed Cross-Coupling of Functionalized Difluoromethyl Bromides and Chlorides with Aryl Boronic Acids: A General Method for Difluoroalkylated Arenes

(2014) Yu-Lan Xiao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct C–H difluoromethylenephosphonation of arenes and heteroarenes with bromodifluoromethyl phosphonate via visible-light photocatalysis

(2014) Lin Wang et al.   CHEMICAL COMMUNICATIONS

Copper-catalyzed olefinic C–H difluoroacetylation of enamides

(2014) Gilles Caillot et al.   CHEMICAL COMMUNICATIONS

Addition of CF3 across unsaturated moieties: a powerful functionalization tool

(2014) Estíbaliz Merino et al.   CHEMICAL SOCIETY REVIEWS

Recent Progress in Direct Introduction of Fluorinated Groups on Alkenes and Alkynes by means of CH Bond Functionalization

(2014) Tatiana Besset et al.   CHEMISTRY-A EUROPEAN JOURNAL

Trifluoromethyl Ethers and –Thioethers as Tools for Medicinal Chemistry and Drug Discovery

(2014) Gregory Landelle et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Access to Difluoromethylated Alkynes through the Castro-Stephens Reaction

(2014) Tatiana Besset et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Direct Trifluoromethylthiolation Reactions: The “Renaissance” of an Old Concept

(2014) Fabien Toulgoat et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Indium-Promoted Diastereoselective Addition of Fluorinated Haloallylic Derivatives to Imines

(2014) Gérald Lemonnier et al.   JOURNAL OF ORGANIC CHEMISTRY

Stereoselectivity of the Honda–Reformatsky Reaction in Reactions with Ethyl Bromodifluoroacetate with α-Oxygenated Sulfinylimines

(2014) Clément Q. Fontenelle et al.   JOURNAL OF ORGANIC CHEMISTRY

Copper-Catalyzed Direct C-2 Difluoromethylation of Furans and Benzofurans: Access to C-2 CF2H Derivatives

(2014) Marie-Charlotte Belhomme et al.   JOURNAL OF ORGANIC CHEMISTRY

Pd-Catalyzed α-Arylation of α,α-Difluoroketones with Aryl Bromides and Chlorides. A Route to Difluoromethylarenes

(2014) Shaozhong Ge et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pd-Catalyzed α-Arylation of Trimethylsilyl Enolates of α,α-Difluoroacetamides

(2014) Shaozhong Ge et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic Asymmetric Synthesis of Tertiary Alkyl Fluorides: Negishi Cross-Couplings of Racemic α,α-Dihaloketones

(2014) Yufan Liang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly Selective gem-Difluoroallylation of Organoborons with Bromodifluoromethylated Alkenes Catalyzed by Palladium

(2014) Qiao-Qiao Min et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Visible Light-Mediated C–H Difluoromethylation of Electron-Rich Heteroarenes

(2014) Yi-Ming Su et al.   ORGANIC LETTERS

Visible-Light-Driven Difluoroacetamidation of Unactive Arenes and Heteroarenes by Direct C–H Functionalization at Room Temperature

(2014) Lin Wang et al.   ORGANIC LETTERS

Copper-Mediated Direct Functionalization of Unsaturated C–C Bonds with Ethyl Bromo(difluoro)acetate: A Straightforward Access to Highly Valuable Difluoromethylated Alkenes

(2014) Tatiana Besset et al.   SYNTHESIS-STUTTGART

Efficient access to fluorinated homoallylic alcohols through an indium promoted fluoroallylation reaction

(2014) Gérald Lemonnier et al.   TETRAHEDRON

Direct Trifluoromethylation of the CH Bond

(2013) Hui Liu et al.   ADVANCED SYNTHESIS & CATALYSIS

Introduction of Fluorine and Fluorine-Containing Functional Groups

(2013) Theresa Liang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent advances in transition metal-catalyzed Csp2-monofluoro-, difluoro-, perfluoromethylation and trifluoromethylthiolation

(2013) Grégory Landelle et al.   Beilstein Journal of Organic Chemistry

Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

(2013) Jiang Wang et al.   CHEMICAL REVIEWS

Direct Introduction of Ethoxycarbonyldifluoromethyl-Group to Heteroarenes with Ethyl Bromodifluoroacetate via Visible-Light Photocatalysis

(2013) Qingyu Lin et al.   CHINESE JOURNAL OF CHEMISTRY

Diethylzinc-Mediated Addition of 2,2-Dibromo-2-fluoroacetamides to Carbonyl Compounds: Synthesis of α-Bromo-α-fluoro-β-hydroxy Amides and/or (Z)-Fluorovinyl Amides

(2013) Gérald Lemonnier et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

C–H bond activation enables the rapid construction and late-stage diversification of functional molecules

(2013) Joanna Wencel-Delord et al.   Nature Chemistry

Copper-mediated oxidative difluoromethylenation of aryl boronic acids with α-silyldifluoromethylphosphonates: a new method for aryldifluorophosphonates

(2013) Xueliang Jiang et al.   NEW JOURNAL OF CHEMISTRY

Copper Catalyzed β-Difluoroacetylation of Dihydropyrans and Glycals by Means of Direct C–H Functionalization

(2013) Marie-Charlotte Belhomme et al.   ORGANIC LETTERS

Recent Advances in Transition-Metal-Catalyzed Trifluoromethylation and Related Transformations

(2013) Guosheng Liu et al.   SYNTHESIS-STUTTGART

A practical and straightforward access to fluorinated homoallylic alcohols in aqueous media

(2013) Gérald Lemonnier et al.   TETRAHEDRON LETTERS

Recent advance in transition-metal-mediated trifluoromethylation for the construction of C(sp3)–CF3 bonds

(2013) Jun Xu et al.   TETRAHEDRON LETTERS

Copper-catalyzed cross-coupling of bromozinc-difluoromethylphosphonate with iodo/bromo-aryl triazenes

(2013) Zhang Feng et al.   Organic Chemistry Frontiers

Controlling Site Selectivity in Palladium-Catalyzed C–H Bond Functionalization

(2012) Sharon R. Neufeldt et al.   ACCOUNTS OF CHEMICAL RESEARCH

Beyond Directing Groups: Transition-Metal-Catalyzed CH Activation of Simple Arenes

(2012) Nadine Kuhl et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

CH Bond Functionalization: Emerging Synthetic Tools for Natural Products and Pharmaceuticals

(2012) Junichiro Yamaguchi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct CH Functionalization of Enamides and Enecarbamates by Using Visible-Light Photoredox Catalysis

(2012) Heng Jiang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Recent Developments on the Trifluoromethylation of (Hetero)Arenes

(2012) Xiao-Feng Wu et al.   Chemistry-An Asian Journal

Palladium-Mediated Heck-Type Reactions of [(Bromodifluoromethyl)sulfonyl]benzene: Synthesis of α-Alkenyl- and α-Heteroaryl-Substituted α,α-Difluoromethyl Phenyl Sulfones

(2012) Nakin Surapanich et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Palladium catalyzed direct α-arylation of α,α-difluoroketones with aryl bromides

(2012) Chen Guo et al.   JOURNAL OF FLUORINE CHEMISTRY

Copper-Mediated Oxidative Cross-Coupling Reaction of Terminal Alkynes with α-Silyldifluoromethylphosphonates: An Efficient Method for α,α-Difluoropropargylphosphonates

(2012) Xueliang Jiang et al.   ORGANIC LETTERS

Copper Catalyzed Cross-Coupling of Iodobenzoates with Bromozinc-difluorophosphonate

(2012) Zhang Feng et al.   ORGANIC LETTERS

An Efficient Route to Difluoromethylated Pyridines

(2012) Hideki Amii et al.   SYNTHESIS-STUTTGART

Aromatic Trifluoromethylation with Metal Complexes

(2011) Olesya A. Tomashenko et al.   CHEMICAL REVIEWS

Carboxylate-Assisted Transition-Metal-Catalyzed C−H Bond Functionalizations: Mechanism and Scope

(2011) Lutz Ackermann   CHEMICAL REVIEWS

Catalysis for fluorination and trifluoromethylation

(2011) Takeru Furuya et al.   NATURE

A New Method for Aromatic Difluoromethylation: Copper-Catalyzed Cross-Coupling and Decarboxylation Sequence from Aryl Iodides

(2011) Kenichi Fujikawa et al.   ORGANIC LETTERS

Direct ethoxycarbonyldifluoromethylation of aromatic compounds using Fenton reagent

(2011) Yuhki Ohtsuka et al.   TETRAHEDRON

Functionalization of Organic Molecules by Transition-Metal-Catalyzed C(sp3)H Activation

(2010) Rodolphe Jazzar et al.   CHEMISTRY-A EUROPEAN JOURNAL

Copper-Mediated Fluoroalkylation Reactions with Iododifluoroacetamides: Controlling the Selectivity among Cross-Coupling, Intramolecular Cyclization, and Homocoupling Reactions

(2010) Jieming Zhu et al.   JOURNAL OF ORGANIC CHEMISTRY

Rhodium-Catalyzed C−C Bond Formation via Heteroatom-Directed C−H Bond Activation

(2009) Denise A. Colby et al.   CHEMICAL REVIEWS

Understanding organofluorine chemistry. An introduction to the C–F bond

(2007) David O'Hagan   CHEMICAL SOCIETY REVIEWS

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS