Cytosolic cleaved PINK1 represses Parkin translocation to mitochondria and mitophagy

A Neo-Substrate that Amplifies Catalytic Activity of Parkinson’s-Disease-Related Kinase PINK1

(2013) Nicholas T. Hertz et al.   CELL

Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment

(2012) Andrew W Greene et al.   EMBO REPORTS

Pink1 Kinase and Its Membrane Potential (Δψ)-dependent Cleavage Product Both Localize to Outer Mitochondrial Membrane by Unique Targeting Mode

(2012) Dorothea Becker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial autophagy in cells with mtDNA mutations results from synergistic loss of transmembrane potential and mTORC1 inhibition

(2011) Robert W. Gilkerson et al.   HUMAN MOLECULAR GENETICS

Mitochondria: The Next (Neurode)Generation

(2011) Eric A. Schon et al.   NEURON

PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy

(2010) Sumihiro Kawajiri et al.   FEBS LETTERS

Effect of endogenous mutant and wild-type PINK1 on Parkin in fibroblasts from Parkinson disease patients

(2010) A. Rakovic et al.   HUMAN MOLECULAR GENETICS

PINK1 cleavage at position A103 by the mitochondrial protease PARL

(2010) Emma Deas et al.   HUMAN MOLECULAR GENETICS

A New Cytosolic Pathway from a Parkinson Disease-associated Kinase, BRPK/PINK1

(2010) Hitoshi Murata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

(2010) Seok Min Jin et al.   JOURNAL OF CELL BIOLOGY

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells

(2010) D.-F. Suen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin

(2010) E. Ziviani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Parkin stabilizes PINK1 through direct interaction

(2009) Kahori Shiba et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF- B signaling

(2009) D. Sha et al.   HUMAN MOLECULAR GENETICS

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

(2009) C. Vives-Bauza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PINK1 controls mitochondrial localization of Parkin through direct phosphorylation

(2008) Yongsung Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

The mitochondrial targeting sequence tilts the balance between mitochondrial and cytosolic dual localization

(2008) N. Regev-Rudzki et al.   JOURNAL OF CELL SCIENCE

Characterization of PINK1 processing, stability, and subcellular localization

(2008) William Lin et al.   JOURNAL OF NEUROCHEMISTRY

Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP

(2008) M. E. Haque et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The kinase domain of mitochondrial PINK1 faces the cytoplasm

(2008) C. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytoplasmic localization and proteasomal degradation of N-terminally cleaved form of PINK1

(2007) Sho Takatori et al.   NEUROSCIENCE LETTERS