Rho GTPases as therapeutic targets in Alzheimer’s disease

Altered Distribution of RhoA in Alzheimer's Disease and AβPP Overexpressing Mice

(2017) Gema Huesa et al.   JOURNAL OF ALZHEIMERS DISEASE

Annexin A1 restores Aβ1-42-induced blood-brain barrier disruption through the inhibition of RhoA-ROCK signaling pathway

(2016) Jong-Chan Park et al.   AGING CELL

Compromised MAPK signaling in human diseases: an update

(2015) Eun Kyung Kim et al.   ARCHIVES OF TOXICOLOGY

Altered Expression of CDC42 Signaling Pathway Components in Cortical Layer 3 Pyramidal Cells in Schizophrenia

(2015) Dibyadeep Datta et al.   BIOLOGICAL PSYCHIATRY

Modulation of Rho GTPases rescues brain mitochondrial dysfunction, cognitive deficits and aberrant synaptic plasticity in female mice modeling Rett syndrome

(2015) Bianca De Filippis et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Rho Kinase (ROCK) Inhibitors and Their Therapeutic Potential

(2015) Yangbo Feng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Reversing Synapse Loss in Alzheimer’s Disease: Rho-Guanosine Triphosphatases and Insights from Other Brain Disorders

(2015) Roger Lefort   Neurotherapeutics

Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases

(2015) Tudor I. Oprea et al.   PLoS One

Is synaptic loss a unique hallmark of Alzheimer's disease?

(2014) Stephen W. Scheff et al.   BIOCHEMICAL PHARMACOLOGY

Amyloid β peptide stimulates platelet activation through RhoA-dependent modulation of actomyosin organization

(2014) Vijay K. Sonkar et al.   FASEB JOURNAL

The Potential Role of Rho GTPases in Alzheimer's Disease Pathogenesis

(2014) Silvia Bolognin et al.   MOLECULAR NEUROBIOLOGY

Rho family GTPases: key players in neuronal development, neuronal survival, and neurodegeneration

(2014) Trisha R. Stankiewicz et al.   Frontiers in Cellular Neuroscience

Rho GTPases in neurodegeneration diseases

(2013) Jonathan DeGeer et al.   EXPERIMENTAL CELL RESEARCH

Rho GTPase signaling at the synapse: Implications for intellectual disability

(2013) Wei Ba et al.   EXPERIMENTAL CELL RESEARCH

Emerging Roles for Intersectin (ITSN) in Regulating Signaling and Disease Pathways

(2013) Michael Hunter et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Characterization of a Cdc42 Protein Inhibitor and Its Use as a Molecular Probe

(2013) Lin Hong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacologic Inhibition of ROCK2 Suppresses Amyloid-  Production in an Alzheimer's Disease Mouse Model

(2013) J. H. Herskowitz et al.   JOURNAL OF NEUROSCIENCE

CNF1 Increases Brain Energy Level, Counteracts Neuroinflammatory Markers and Rescues Cognitive Deficits in a Murine Model of Alzheimer's Disease

(2013) Stefano Loizzo et al.   PLoS One

A Rac1/Cdc42 GTPase-Specific Small Molecule Inhibitor Suppresses Growth of Primary Human Prostate Cancer Xenografts and Prolongs Survival in Mice

(2013) Karin Zins et al.   PLoS One

Small molecule targeting Cdc42–intersectin interaction disrupts Golgi organization and suppresses cell motility

(2013) Amy Friesland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase-2 is required for dendritic spine and behavioural alterations in J20 APP transgenic mice

(2013) Julio Pozueta et al.   Nature Communications

1–42 β-Amyloid peptide requires PDK1/nPKC/Rac 1 pathway to induce neuronal death

(2013) L Manterola et al.   Translational Psychiatry

Behavioral effects of Rho GTPase modulation in a model of Alzheimer's disease

(2012) Marco Musilli et al.   BEHAVIOURAL BRAIN RESEARCH

Involvement of the γ-Secretase-Mediated EphA4 Signaling Pathway in Synaptic Pathogenesis of Alzheimer's Disease

(2012) Chiyuki Matsui et al.   BRAIN PATHOLOGY

Neuroproteomics approach and neurosystems biology analysis: ROCK inhibitors as promising therapeutic targets in neurodegeneration and neurotrauma

(2012) Mohamad Raad et al.   ELECTROPHORESIS

Impaired regulation of synaptic actin cytoskeleton in Alzheimer's disease

(2011) Peter Penzes et al.   BRAIN RESEARCH REVIEWS

Dysregulation of Rho GTPases in the αPix/Arhgef6 mouse model of X-linked intellectual disability is paralleled by impaired structural and synaptic plasticity and cognitive deficits

(2011) Ger J.A. Ramakers et al.   HUMAN MOLECULAR GENETICS

Activation of Rho GTPases Triggers Structural Remodeling and Functional Plasticity in the Adult Rat Visual Cortex

(2011) C. Cerri et al.   JOURNAL OF NEUROSCIENCE

Pitavastatin decreases tau levels via the inactivation of Rho/ROCK

(2011) Tadanori Hamano et al.   NEUROBIOLOGY OF AGING

Intersectin multidomain adaptor proteins: Regulation of functional diversity

(2010) Liudmyla Tsyba et al.   GENE

Signaling Through Rho GTPase Pathway as Viable Drug Target

(2009) Qun Lu et al.   CURRENT MEDICINAL CHEMISTRY

Effect of Tarenflurbil on Cognitive Decline and Activities of Daily Living in Patients With Mild Alzheimer DiseaseA Randomized Controlled Trial

(2009) Robert C. Green   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Different Rho GTPase–dependent signaling pathways initiate sequential steps in the consolidation of long-term potentiation

(2009) Christopher S. Rex et al.   JOURNAL OF CELL BIOLOGY

Rac1 inhibition negatively regulates transcriptional activity of the amyloid precursor protein gene

(2009) Pi-Lin Wang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Targeting p38 MAPK pathway for the treatment of Alzheimer's disease

(2009) Lenka Munoz et al.   NEUROPHARMACOLOGY

Rac1 changes the substrate specificity of γ-secretase between amyloid precursor protein and Notch1

(2008) Jung Hyun Boo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS