Emerging Roles for Intersectin (ITSN) in Regulating Signaling and Disease Pathways

Human Intersectin 2 (ITSN2) binds to Eps8 protein and enhances its degradation

(2012) Xiaofeng Ding et al.   BMB Reports

The LMP2A protein of Epstein–Barr virus regulates phosphorylation of ITSN1 and Shb adaptors by tyrosine kinases

(2012) Oleksandr Dergai et al.   CELLULAR SIGNALLING

Wsp1 Is Downstream of Cin1 and Regulates Vesicle Transport and Actin Cytoskeleton as an Effector of Cdc42 and Rac1 in Cryptococcus neoformans

(2012) Gui Shen et al.   EUKARYOTIC CELL

Endocytic adaptor protein intersectin 1 forms a complex with microtubule stabilizer STOP in neurons

(2012) Dmytro Morderer et al.   GENE

The clathrin adaptor Dab2 recruits EH domain scaffold proteins to regulate integrin β1 endocytosis

(2012) Anjali Teckchandani et al.   MOLECULAR BIOLOGY OF THE CELL

Interactions between wild-type and mutant Ras genes in lung and skin carcinogenesis

(2012) M D To et al.   ONCOGENE

Intersectin 1 is required for neuroblastoma tumorigenesis

(2012) A Russo et al.   ONCOGENE

Intersectin (ITSN) Family of Scaffolds Function as Molecular Hubs in Protein Interaction Networks

(2012) Katy A. Wong et al.   PLoS One

A New Dimension to Ras Function: A Novel Role for Nucleotide-Free Ras in Class II Phosphatidylinositol 3-Kinase Beta (PI3KC2β) Regulation

(2012) Katy A. Wong et al.   PLoS One

DISC1: Structure, Function, and Therapeutic Potential for Major Mental Illness

(2011) Dinesh C. Soares et al.   ACS Chemical Neuroscience

Intersectin 2 nucleotide exchange factor regulates Cdc42 activity during Xenopus early development

(2011) Olga Novokhatska et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Intersectin1-s is involved in migration and invasion of human glioma cells

(2011) Yongjie Ma et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Intersectin 1 Enhances Cbl Ubiquitylation of Epidermal Growth Factor Receptor through Regulation of Sprouty2-Cbl Interaction

(2011) M. N. Okur et al.   MOLECULAR AND CELLULAR BIOLOGY

Intersectin 1 contributes to phenotypes in vivo

(2011) Michael P. Hunter et al.   NEUROREPORT

Intersectin 1 forms complexes with SGIP1 and Reps1 in clathrin-coated pits

(2010) Oleksandr Dergai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Microexon-based regulation of ITSN1 and Src SH3 domains specificity relies on introduction of charged amino acids into the interaction interface

(2010) Mykola Dergai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Reduction of intersectin1-s induced apoptosis of human glioblastoma cells

(2010) Yongjie Ma et al.   BRAIN RESEARCH

Pooled Analysis of Phosphatidylinositol 3-Kinase Pathway Variants and Risk of Prostate Cancer

(2010) S. Koutros et al.   CANCER RESEARCH

Intersectin multidomain adaptor proteins: Regulation of functional diversity

(2010) Liudmyla Tsyba et al.   GENE

A two-tiered mechanism of EGFR inhibition by RALT/MIG6 via kinase suppression and receptor degradation

(2010) Yuri Frosi et al.   JOURNAL OF CELL BIOLOGY

The Cdc42 GEF Intersectin 2 controls mitotic spindle orientation to form the lumen during epithelial morphogenesis

(2010) Alejo E. Rodriguez-Fraticelli et al.   JOURNAL OF CELL BIOLOGY

Regulation of dynamin-2 assembly-disassembly and function through the SH3A domain of intersectin-1s

(2010) Ivana Knezevic et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Pleiotropic function of intersectin homologue Cin1 in Cryptococcus neoformans

(2010) Gui Shen et al.   MOLECULAR MICROBIOLOGY

The Minimal Autoinhibited Unit of the Guanine Nucleotide Exchange Factor Intersectin

(2010) K. Farid Ahmad et al.   PLoS One

Regulation of synaptic vesicle recycling by complex formation between intersectin 1 and the clathrin adaptor complex AP2

(2010) A. Pechstein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autoinhibition of GEF activity in intersectin 1 is mediated by the short SH3-DH domain linker

(2010) Carsten Kintscher et al.   PROTEIN SCIENCE

FCHo Proteins Are Nucleators of Clathrin-Mediated Endocytosis

(2010) W. M. Henne et al.   SCIENCE

Intersectin 1 forms a complex with adaptor protein Ruk/CIN85 in vivo independently of epidermal growth factor stimulation

(2009) Oleksii Nikolaienko et al.   CELLULAR SIGNALLING

Detailed molecular and clinical characterization of three patients with 21q deletions

(2009) A Lindstrand et al.   CLINICAL GENETICS

Dividing cellular asymmetry: asymmetric cell division and its implications for stem cells and cancer

(2009) R. A. Neumuller et al.   GENES & DEVELOPMENT

Intersectin Regulates Dendritic Spine Development and Somatodendritic Endocytosis but Not Synaptic Vesicle Recycling in Hippocampal Neurons

(2009) Sébastien Thomas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Axonal Transport Defects in Neurodegenerative Diseases

(2009) G. A. Morfini et al.   JOURNAL OF NEUROSCIENCE

Constitutional RUNX1 deletion presenting as non-syndromic thrombocytopenia with myelodysplasia: 21q22 ITSN1 as a candidate gene in mental retardation

(2009) Saskia van der Crabben et al.   LEUKEMIA RESEARCH

Structural diversity and differential expression of novel human intersectin 1 isoforms

(2009) Sergii Kropyvko et al.   MOLECULAR BIOLOGY REPORTS

Oncogenic Activating Mutations Are Associated with Local Copy Gain

(2009) B. Modrek et al.   MOLECULAR CANCER RESEARCH

Alternative splicing affecting the SH3A domain controls the binding properties of intersectin 1 in neurons

(2008) Liudmyla Tsyba et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dap160/intersectin binds and activates aPKC to regulate cell polarity and cell cycle progression

(2008) C. Chabu et al.   DEVELOPMENT

DSCR1/RCAN1 regulates vesicle exocytosis and fusion pore kinetics: implications for Down syndrome and Alzheimer's disease

(2008) Damien J. Keating et al.   HUMAN MOLECULAR GENETICS

Mice deficient for the chromosome 21 ortholog Itsn1 exhibit vesicle-trafficking abnormalities

(2008) Yong Yu et al.   HUMAN MOLECULAR GENETICS

Cdc42 controls spindle orientation to position the apical surface during epithelial morphogenesis

(2008) Aron B. Jaffe et al.   JOURNAL OF CELL BIOLOGY

Kras regulatory elements and exon 4A determine mutation specificity in lung cancer

(2008) Minh D To et al.   NATURE GENETICS

Ras oncogenes: split personalities

(2008) Antoine E. Karnoub et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanisms of asymmetric cell division: flies and worms pave the way

(2008) Pierre Gönczy   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ITSN-1 Controls Vesicle Recycling at the Neuromuscular Junction and Functions in Parallel with DAB-1

(2008) Wei Wang et al.   TRAFFIC

Translational gene mapping of cognitive decline

(2006) Beth Wilmot et al.   NEUROBIOLOGY OF AGING