Neuroproteomics approach and neurosystems biology analysis: ROCK inhibitors as promising therapeutic targets in neurodegeneration and neurotrauma

The therapeutic effects of Rho-ROCK inhibitors on CNS disorders

(2016) Takekazu Kubo   Therapeutics and Clinical Risk Management

Development of biomarkers to chart all Alzheimer’s disease stages: The royal road to cutting the therapeutic Gordian Knot

(2012) Harald Hampel et al.   Alzheimers & Dementia

ROCKII Ser1366phosphorylation reflects the activation status

(2012) Hsiang-Hao Chuang et al.   BIOCHEMICAL JOURNAL

Fasudil improves survival and promotes skeletal muscle development in a mouse model of spinal muscular atrophy

(2012) Melissa Bowerman et al.   BMC Medicine

Rho-Kinase Inhibitor, Fasudil, Prevents Neuronal Apoptosis via the Akt Activation and PTEN Inactivation in the Ischemic Penumbra of Rat Brain

(2012) Jianhua Wu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Nerve growth factor stimulation of ERK1/2 phosphorylation requires both p75NTR and α9β1 integrin and confers myoprotection towards ischemia in C2C12 skeletal muscle cell model

(2012) Keren Ettinger et al.   CELLULAR SIGNALLING

Striking crosstalk of ROCK signaling with endothelial function

(2012) Kensuke Noma et al.   Journal of Cardiology

A Rho kinase (ROCK) inhibitor, fasudil, prevents matrix metalloproteinase-9-related hemorrhagic transformation in mice treated with tissue plasminogen activator

(2012) M. Ishiguro et al.   NEUROSCIENCE

Neuroregeneration in neurodegenerative disorders

(2011) Ana M Enciu et al.   BMC Neurology

Gene pathway analysis of the mechanism by which the Rho-associated kinase inhibitor Y-27632 inhibits apoptosis in isolated thawed human embryonic stem cells

(2011) Hinako Ichikawa et al.   CRYOBIOLOGY

The development of a rat in vitro model of spinal cord injury demonstrating the additive effects of rho and ROCK inhibitors on neurite outgrowth and myelination

(2011) Stephanie D. Boomkamp et al.   GLIA

Fasudil and Ozagrel in Combination Show Neuroprotective Effects on Cerebral Infarction after Murine Middle Cerebral Artery Occlusion

(2011) A. Koumura et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Systems biology of Alzheimer's disease: How diverse molecular changes result in memory impairment in AD

(2011) Gábor Juhász et al.   NEUROCHEMISTRY INTERNATIONAL

Changes in hippocampal synapses and learning-memory abilities in a streptozotocin-treated rat model and intervention by using fasudil hydrochloride

(2011) Y. Hou et al.   NEUROSCIENCE

Cellular Therapy and Induced Neuronal Replacement for Huntington’s Disease

(2011) Abdellatif Benraiss et al.   Neurotherapeutics

Top-down label-free LC-MALDI analysis of the peptidome during neural progenitor cell differentiation reveals complexity in cytoskeletal protein dynamics and identifies progenitor cell markers

(2011) Daniel J. Maltman et al.   PROTEOMICS

Fasudil Mesylate Protects PC12 Cells from Oxidative Stress Injury via the Bax-Mediated Pathway

(2010) Qin Li et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Phospholipase Cδ3 Regulates RhoA/Rho Kinase Signaling and Neurite Outgrowth

(2010) Zen Kouchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rho kinase inhibitor Y-27632 facilitates recovery from experimental peripheral neuropathy induced by anti-cancer drug cisplatin

(2010) Sarah E. James et al.   NEUROTOXICOLOGY

Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules

(2010) Y. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of the Rho/ROCK pathway prevents neuronal degeneration in vitro and in vivo following methylmercury exposure

(2010) Masatake Fujimura et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease

(2009) R. Jeremy Nichols et al.   BIOCHEMICAL JOURNAL

Rho kinase inhibitor Fasudil induces neuroprotection and neurogenesis partially through astrocyte-derived G-CSF

(2009) Jing Ding et al.   BRAIN BEHAVIOR AND IMMUNITY

Rho kinase inhibition protects CA1 cells in organotypic hippocampal slices during in vitro ischemia

(2009) Lennart Gisselsson et al.   BRAIN RESEARCH

Activation of Rho Kinase Isoforms in Lung Endothelial Cells during Inflammation

(2009) P. Y. Mong et al.   JOURNAL OF IMMUNOLOGY

Temporal Analysis of Neural Differentiation Using Quantitative Proteomics†

(2009) Raghothama Chaerkady et al.   JOURNAL OF PROTEOME RESEARCH

Synergistic effects of bone marrow stromal cells and a Rho kinase (ROCK) inhibitor, Fasudil on axon regeneration in rat spinal cord injury

(2009) Yasuhiro Chiba et al.   NEUROPATHOLOGY

Cytoskeleton-associated proteins are enriched in human embryonic-stem cell-derived neuroectodermal spheres

(2009) Jung-Il Chae et al.   PROTEOMICS

Proteomic identification of differentially expressed genes in mouse neural stem cells and neurons differentiated from embryonic stem cells in vitro

(2008) Kuniko Akama et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Research in motion: the enigma of Parkinson's disease pathology spread

(2008) Patrik Brundin et al.   NATURE REVIEWS NEUROSCIENCE

Neuroproteomics and systems biology-based discovery of protein biomarkers for traumatic brain injury and clinical validation

(2008) Firas H. Kobeissy et al.   Proteomics Clinical Applications

Up-regulation of apoptosis and regeneration genes in the dorsal root ganglia during cisplatin treatment

(2007) Armin Alaedini et al.   EXPERIMENTAL NEUROLOGY