Mechanotransduction and Growth Factor Signalling to Engineer Cellular Microenvironments

Local Affinity Release

(2016) Vianney Delplace et al.   ACS Nano

Engineering growth factors for regenerative medicine applications

(2016) Aaron C. Mitchell et al.   Acta Biomaterialia

Stiffness-dependent cellular internalization of matrix-bound BMP-2 and its relation to Smad and non-Smad signaling

(2016) Flora Gilde et al.   Acta Biomaterialia

Sliding Hydrogels with Mobile Molecular Ligands and Crosslinks as 3D Stem Cell Niche

(2016) Xinming Tong et al.   ADVANCED MATERIALS

Substrate Stiffness Combined with Hepatocyte Growth Factor Modulates Endothelial Cell Behavior

(2016) Hao Chang et al.   BIOMACROMOLECULES

Synergistic growth factor microenvironments

(2016) Manuel Salmerón-Sánchez et al.   CHEMICAL COMMUNICATIONS

Endocytosis and trafficking of BMP receptors: Regulatory mechanisms for fine-tuning the signaling response in different cellular contexts

(2016) Marcelo Ehrlich   CYTOKINE & GROWTH FACTOR REVIEWS

Lateral Chain Length in Polyalkyl Acrylates Determines the Mobility of Fibronectin at the Cell/Material Interface

(2016) Fatma Bathawab et al.   LANGMUIR

Supramolecular Nanofibers Enhance Growth Factor Signaling by Increasing Lipid Raft Mobility

(2016) Christina J. Newcomb et al.   NANO LETTERS

Designer matrices for intestinal stem cell and organoid culture

(2016) Nikolce Gjorevski et al.   NATURE

N-cadherin adhesive interactions modulate matrix mechanosensing and fate commitment of mesenchymal stem cells

(2016) Brian D. Cosgrove et al.   NATURE MATERIALS

Directed migration of cancer cells guided by the graded texture of the underlying matrix

(2016) JinSeok Park et al.   NATURE MATERIALS

Spatially patterned matrix elasticity directs stem cell fate

(2016) Chun Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Collective cell durotaxis emerges from long-range intercellular force transmission

(2016) R. Sunyer et al.   SCIENCE

Biomimetic Extracellular Environment Based on Natural Origin Polyelectrolyte Multilayers

(2016) Joana M. Silva et al.   Small

Guiding hMSC Adhesion and Differentiation on Supported Lipid Bilayers

(2016) Gülistan Koçer et al.   Advanced Healthcare Materials

Material-driven fibronectin assembly for high-efficiency presentation of growth factors

(2016) V. Llopis-Hernandez et al.   Science Advances

Stiffening hydrogels for investigating the dynamics of hepatic stellate cell mechanotransduction during myofibroblast activation

(2016) Steven R. Caliari et al.   Scientific Reports

BMP delivery complements the guiding effect of scaffold architecture without altering bone microstructure in critical-sized long bone defects: A multiscale analysis

(2015) A. Cipitria et al.   Acta Biomaterialia

Extracellular matrix-inspired growth factor delivery systems for bone regeneration

(2015) Mikaël M. Martino et al.   ADVANCED DRUG DELIVERY REVIEWS

Biomimetic supramolecular designs for the controlled release of growth factors in bone regeneration

(2015) Helena S. Azevedo et al.   ADVANCED DRUG DELIVERY REVIEWS

Dynamic stiffening of poly(ethylene glycol)-based hydrogels to direct valvular interstitial cell phenotype in a three-dimensional environment

(2015) Kelly M. Mabry et al.   BIOMATERIALS

Nanoscale Control of Surface Immobilized BMP-2: Toward a Quantitative Assessment of BMP-Mediated Signaling Events

(2015) Elisabeth H. Schwab et al.   NANO LETTERS

Matrix elasticity of void-forming hydrogels controls transplanted-stem-cell-mediated bone formation

(2015) Nathaniel Huebsch et al.   NATURE MATERIALS

Cell-mediated fibre recruitment drives extracellular matrix mechanosensing in engineered fibrillar microenvironments

(2015) Brendon M. Baker et al.   NATURE MATERIALS

Hydrogels with tunable stress relaxation regulate stem cell fate and activity

(2015) Ovijit Chaudhuri et al.   NATURE MATERIALS

Substrate stress relaxation regulates cell spreading

(2015) Ovijit Chaudhuri et al.   Nature Communications

Engineering Nanoscale Stem Cell Niche: Direct Stem Cell Behavior at Cell-Matrix Interface

(2015) Yan Zhang et al.   Advanced Healthcare Materials

Extracellular Matrix-Inspired Growth Factor Delivery Systems for Skin Wound Healing

(2015) Priscilla S. Briquez et al.   Advances in Wound Care

The combined effects of matrix stiffness and growth factor immobilization on the bioactivity and differentiation capabilities of adipose-derived stem cells

(2014) Jessica M. Banks et al.   BIOMATERIALS

The synergetic effect of hydrogel stiffness and growth factor on osteogenic differentiation

(2014) ShihJye Tan et al.   BIOMATERIALS

Design of growth factor sequestering biomaterials

(2014) David G. Belair et al.   CHEMICAL COMMUNICATIONS

Material-based strategies to engineer fibronectin matrices for regenerative medicine

(2014) V. Llopis-Hernández et al.   INTERNATIONAL MATERIALS REVIEWS

The bone marrow niche for haematopoietic stem cells

(2014) Sean J. Morrison et al.   NATURE

Interplay of matrix stiffness and protein tethering in stem cell differentiation

(2014) Jessica H. Wen et al.   NATURE MATERIALS

Harnessing nanotopography and integrin–matrix interactions to influence stem cell fate

(2014) Matthew J. Dalby et al.   NATURE MATERIALS

Long-lasting fibrin matrices ensure stable and functional angiogenesis by highly tunable, sustained delivery of recombinant VEGF164

(2014) V. Sacchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Growth Factors Engineered for Super-Affinity to the Extracellular Matrix Enhance Tissue Healing

(2014) M. M. Martino et al.   SCIENCE

Gel Scaffolds of BMP-2-Binding Peptide Amphiphile Nanofibers for Spinal Arthrodesis

(2014) Sungsoo S. Lee et al.   Advanced Healthcare Materials

The significance of hydrated surface molecular mobility in the control of the morphology of adhering fibroblasts

(2013) Ji-Hun Seo et al.   BIOMATERIALS

Polycaprolactone scaffold and reduced rhBMP-7 dose for the regeneration of critical-sized defects in sheep tibiae

(2013) Amaia Cipitria et al.   BIOMATERIALS

Effect of BMP-2 from matrices of different stiffnesses for the modulation of stem cell fate

(2013) Omar F. Zouani et al.   BIOMATERIALS

Hydrogels with differential and patterned mechanics to study stiffness-mediated myofibroblastic differentiation of hepatic stellate cells

(2013) Murat Guvendiren et al.   Journal of the Mechanical Behavior of Biomedical Materials

Post-degradation forces kick in

(2013) Ludovic G. Vincent et al.   NATURE MATERIALS

Degradation-mediated cellular traction directs stem cell fate in covalently crosslinked three-dimensional hydrogels

(2013) Sudhir Khetan et al.   NATURE MATERIALS

Integrin-Matrix Clusters Form Podosome-like Adhesions in the Absence of Traction Forces

(2013) Cheng-han Yu et al.   Cell Reports

Polymer Chain Length Effects on Fibroblast Attachment on Nylon-3-Modified Surfaces

(2012) Runhui Liu et al.   BIOMACROMOLECULES

Spatial control of cell-mediated degradation to regulate vasculogenesis and angiogenesis in hyaluronan hydrogels

(2012) Donny Hanjaya-Putra et al.   BIOMATERIALS

The effect of molecular mobility of supramolecular polymer surfaces on fibroblast adhesion

(2012) Ji-Hun Seo et al.   BIOMATERIALS

Surface mobility regulates skeletal stem cell differentiation

(2012) Cristina González-García et al.   Integrative Biology

Porous scaffold architecture guides tissue formation

(2012) Amaia Cipitria et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Finding the weakest link – exploring integrin-mediated mechanical molecular pathways

(2012) Pere Roca-Cusachs et al.   JOURNAL OF CELL SCIENCE

Smart polymers and interfaces for dynamic cell-biomaterials interactions

(2012) Stephen Kustra et al.   MRS BULLETIN

Extracellular-matrix tethering regulates stem-cell fate

(2012) Britta Trappmann et al.   NATURE MATERIALS

Redirecting Valvular Myofibroblasts into Dormant Fibroblasts through Light-mediated Reduction in Substrate Modulus

(2012) Huan Wang et al.   PLoS One

Dynamic Microenvironments: The Fourth Dimension

(2012) M. W. Tibbitt et al.   Science Translational Medicine

A Tissue Engineering Solution for Segmental Defect Regeneration in Load-Bearing Long Bones

(2012) J. C. Reichert et al.   Science Translational Medicine

Controlled wettability, same chemistry: biological activity of plasma-polymerized coatings

(2012) Marco Cantini et al.   Soft Matter

Recombinant human bone morphogenetic protein-2: adverse events reported to the Manufacturer and User Facility Device Experience database

(2012) Emily Jane Woo   Spine Journal

Mimicking dynamic in vivo environments with stimuli-responsive materials for cell culture

(2012) Jungwook Kim et al.   TRENDS IN BIOTECHNOLOGY

Stiffening hydrogels to probe short- and long-term cellular responses to dynamic mechanics

(2012) Murat Guvendiren et al.   Nature Communications

Moving from static to dynamic complexity in hydrogel design

(2012) Jason A. Burdick et al.   Nature Communications

Geometry as a Factor for Tissue Growth: Towards Shape Optimization of Tissue Engineering Scaffolds

(2012) Cécile M. Bidan et al.   Advanced Healthcare Materials

Engineering the Regenerative Microenvironment with Biomaterials

(2012) Jeffrey J. Rice et al.   Advanced Healthcare Materials

Presentation of BMP-2 from a Soft Biopolymeric Film Unveils its Activity on Cell Adhesion and Migration

(2011) Thomas Crouzier et al.   ADVANCED MATERIALS

The use of dynamic surface chemistries to control msc isolation and function

(2011) J.M. Curran et al.   BIOMATERIALS

The effect of vascular endothelial growth factor (VEGF) presentation within fibrin matrices on endothelial cell branching

(2011) Sean M. Anderson et al.   BIOMATERIALS

Cytocompatible click-based hydrogels with dynamically tunable properties through orthogonal photoconjugation and photocleavage reactions

(2011) Cole A. DeForest et al.   Nature Chemistry

Nanoscale surfaces for the long-term maintenance of mesenchymal stem cell phenotype and multipotency

(2011) Rebecca J. McMurray et al.   NATURE MATERIALS

Early integrin binding to Arg-Gly-Asp peptide activates actin polymerization and contractile movement that stimulates outward translocation

(2011) C.-h. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering the Growth Factor Microenvironment with Fibronectin Domains to Promote Wound and Bone Tissue Healing

(2011) M. M. Martino et al.   Science Translational Medicine

Unidirectional mechanical cellular stimuli via micropost array gradients

(2011) Ryan D. Sochol et al.   Soft Matter

Fibronectins, Their Fibrillogenesis, and In Vivo Functions

(2011) J. E. Schwarzbauer et al.   Cold Spring Harbor Perspectives in Biology

Extracellular Matrix Degradation and Remodeling in Development and Disease

(2011) P. Lu et al.   Cold Spring Harbor Perspectives in Biology

Role of material-driven fibronectin fibrillogenesis in cell differentiation

(2010) Manuel Salmerón-Sánchez et al.   BIOMATERIALS

Hydrogels with time-dependent material properties enhance cardiomyocyte differentiation in vitro

(2010) Jennifer L. Young et al.   BIOMATERIALS

The 12th–14th type III repeats of fibronectin function as a highly promiscuous growth factor-binding domain

(2010) Mikaël M. Martino et al.   FASEB JOURNAL

Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells

(2010) Tom T. Chen et al.   JOURNAL OF CELL BIOLOGY

Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate

(2010) Nathaniel Huebsch et al.   NATURE MATERIALS

Geometric cues for directing the differentiation of mesenchymal stem cells

(2010) K. A. Kilian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Guided Cell Migration on Microtextured Substrates with Variable Local Density and Anisotropy

(2009) Deok-Ho Kim et al.   ADVANCED FUNCTIONAL MATERIALS

Dynamic, 3D-Pattern Formation Within Enzyme-Responsive Hydrogels

(2009) Karin S. Straley et al.   ADVANCED MATERIALS

Mechanosensitivity of fibroblast cell shape and movement to anisotropic substratum topography gradients

(2009) Deok-Ho Kim et al.   BIOMATERIALS

In situ elasticity modulation with dynamic substrates to direct cell phenotype

(2009) April M. Kloxin et al.   BIOMATERIALS

Biological Activity of the Substrate-Induced Fibronectin Network: Insight into the Third Dimension through Electrospun Fibers

(2009) Dencho Gugutkov et al.   LANGMUIR

Impact of Order and Disorder in RGD Nanopatterns on Cell Adhesion

(2009) Jinghuan Huang et al.   NANO LETTERS

A mechanosensitive transcriptional mechanism that controls angiogenesis

(2009) Akiko Mammoto et al.   NATURE

Stem cell fate dictated solely by altered nanotube dimension

(2009) S. Oh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Photodegradable Hydrogels for Dynamic Tuning of Physical and Chemical Properties

(2009) April M. Kloxin et al.   SCIENCE

The Extracellular Matrix: Not Just Pretty Fibrils

(2009) R. O. Hynes   SCIENCE

Layer-By-Layer Films as a Biomimetic Reservoir for rhBMP-2 Delivery: Controlled Differentiation of Myoblasts to Osteoblasts

(2009) Thomas Crouzier et al.   Small

Spatially controlled hydrogel mechanics to modulate stem cell interactions

(2009) Ross A. Marklein et al.   Soft Matter

Substrate-Induced Assembly of Fibronectin into Networks: Influence of Surface Chemistry and Effect on Osteoblast Adhesion

(2009) Patricia Rico et al.   TISSUE ENGINEERING PART A

Interactions between extracellular matrix and growth factors in wound healing

(2009) Gregory S. Schultz et al.   WOUND REPAIR AND REGENERATION

The effect of geometry on three-dimensional tissue growth

(2008) M. Rumpler et al.   Journal of the Royal Society Interface

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

Environmental sensing through focal adhesions

(2008) Benjamin Geiger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Emergence of Patterned Stem Cell Differentiation Within Multicellular Structures

(2008) Sami Alom Ruiz et al.   STEM CELLS

Covalently immobilized biosignal molecule materials for tissue engineering

(2007) Yoshihiro Ito   Soft Matter