Fragment-based screening identifies novel targets for inhibitors of conjugative transfer of antimicrobial resistance by plasmid pKM101

Monomer-to-dimer transition of Brucella suis type IV secretion system component VirB8 induces conformational changes

(2017) Mahzad Sharifahmadian et al.   FEBS Journal

Structural Analysis and Inhibition of TraE from the pKM101 Type IV Secretion System

(2016) Bastien Casu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antibacterial drug discovery in the resistance era

(2016) Eric D. Brown et al.   NATURE

Structural Biology of Bacterial Type IV Secretion Systems

(2015) Vidya Chandran Darbari et al.   Annual Review of Biochemistry

Virulence-targeted Antibacterials: Concept, Promise, and Susceptibility to Resistance Mechanisms

(2015) Ségolène Ruer et al.   Chemical Biology & Drug Design

Structural Insight into How Bacteria Prevent Interference between Multiple Divergent Type IV Secretion Systems

(2015) Joseph J. Gillespie et al.   mBio

Development of Antivirulence Compounds: A Biochemical Review

(2014) Riccardo Zambelloni et al.   Chemical Biology & Drug Design

Recent advances in the structural and molecular biology of type IV secretion systems

(2014) Martina Trokter et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structure of a type IV secretion system

(2014) Harry H. Low et al.   NATURE

A three-stage biophysical screening cascade for fragment-based drug discovery

(2013) Ellene H Mashalidis et al.   Nature Protocols

Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery

(2013) H. L. Silvestre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of the Binding Site of Brucella VirB8 Interaction Inhibitors

(2012) Mark A. Smith et al.   CHEMISTRY & BIOLOGY

The 2.5 Å Structure of theEnterococcusConjugation Protein TraM resembles VirB8 Type IV Secretion Proteins

(2012) Nikolaus Goessweiner-Mohr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Bacterial Target Proteins for the Salicylidene Acylhydrazide Class of Virulence-blocking Compounds

(2011) Dai Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antivirulence drugs to target bacterial secretion systems

(2010) Christian Baron   CURRENT OPINION IN MICROBIOLOGY

AnIn VivoHigh-Throughput Screening Approach Targeting the Type IV Secretion System Component VirB8 Identified Inhibitors ofBrucella abortus2308 Proliferation

(2010) Athanasios Paschos et al.   INFECTION AND IMMUNITY

Structure of the outer membrane complex of a type IV secretion system

(2009) Vidya Chandran et al.   NATURE

Structure of a Type IV Secretion System Core Complex

(2009) R. Fronzes et al.   SCIENCE