A three-stage biophysical screening cascade for fragment-based drug discovery

Learning from our mistakes: The ‘unknown knowns’ in fragment screening

(2013) Ben J. Davis et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Using a Fragment-Based Approach To Target Protein-Protein Interactions

(2013) Duncan E. Scott et al.   CHEMBIOCHEM

High-Throughput Interrogation of Ligand Binding Mode Using a Fluorescence-Based Assay

(2012) Paweł Śledź et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Application of Fragment Screening and Merging to the Discovery of Inhibitors of theMycobacterium tuberculosisCytochrome P450 CYP121

(2012) Sean A. Hudson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Using Ligand-Mapping Simulations to Design a Ligand Selectively Targeting a Cryptic Surface Pocket of Polo-Like Kinase 1

(2012) Yaw Sing Tan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fragment-Based Approaches in Drug Discovery and Chemical Biology

(2012) Duncan E. Scott et al.   BIOCHEMISTRY

Natural-product-derived fragments for fragment-based ligand discovery

(2012) Björn Over et al.   Nature Chemistry

Fragment-based lead discovery grows up

(2012) Monya Baker   NATURE REVIEWS DRUG DISCOVERY

Presenting your structures: theCCP4mgmolecular-graphics software

(2011) S. McNicholas et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

From Crystal Packing to Molecular Recognition: Prediction and Discovery of a Binding Site on the Surface of Polo-Like Kinase 1

(2011) Paweł Śledź et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

STD-NMR: application to transient interactions between biomolecules—a quantitative approach

(2011) Jesus Angulo et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Route to three-dimensional fragments using diversity-oriented synthesis

(2011) A. W. Hung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Fragment-Based Approach to Identifying Ligands for Riboswitches

(2010) Liuhong Chen et al.   ACS Chemical Biology

Calorimetry as a tool for understanding biomolecular interactions and an aid to drug design

(2010) John E. Ladbury   BIOCHEMICAL SOCIETY TRANSACTIONS

Optimization of the Interligand Overhauser Effect for Fragment Linking: Application to Inhibitor Discovery againstMycobacterium tuberculosisPantothenate Synthetase

(2010) Pawel Sledz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fragment Screening by Surface Plasmon Resonance

(2010) Iva Navratilova et al.   ACS Medicinal Chemistry Letters

Application of Fragment Growing and Fragment Linking to the Discovery of Inhibitors ofMycobacterium tuberculosisPantothenate Synthetase

(2009) Alvin W. Hung et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

NMR methods in fragment screening: theory and a comparison with other biophysical techniques

(2009) Claudio Dalvit   DRUG DISCOVERY TODAY

From fragment to clinical candidate—a historical perspective

(2009) Gianni Chessari et al.   DRUG DISCOVERY TODAY

The rise of fragment-based drug discovery

(2009) Christopher W. Murray et al.   Nature Chemistry

Adding calorimetric data to decision making in lead discovery: a hot tip

(2009) John E. Ladbury et al.   NATURE REVIEWS DRUG DISCOVERY

Perspectives on NMR in drug discovery: a technique comes of age

(2008) Maurizio Pellecchia et al.   NATURE REVIEWS DRUG DISCOVERY