Soluble OX40L and JAG1 Induce Selective Proliferation of Functional Regulatory T-Cells Independent of canonical TCR signaling

Thymus-Derived Regulatory T Cells Are Positively Selected on Natural Self-Antigen through Cognate Interactions of High Functional Avidity

(2016) Elisa Kieback et al.   IMMUNITY

Monoclonal regulatory T cells provide insights into T cell suppression

(2016) Céline Gubser et al.   Scientific Reports

Control of peripheral tolerance by regulatory T cell–intrinsic Notch signaling

(2015) Louis-Marie Charbonnier et al.   NATURE IMMUNOLOGY

Helios Enhances Treg Cell Function in Cooperation With FoxP3

(2015) Hiroaki Takatori et al.   Arthritis & Rheumatology

Type 1 Diabetes in NOD Mice Unaffected by Mast Cell Deficiency

(2014) Dario A. Gutierrez et al.   DIABETES

Treg Cells Expressing the Coinhibitory Molecule TIGIT Selectively Inhibit Proinflammatory Th1 and Th17 Cell Responses

(2014) Nicole Joller et al.   IMMUNITY

Activation of NF- B1 by OX40 Contributes to Antigen-Driven T Cell Expansion and Survival

(2014) J. Song et al.   JOURNAL OF IMMUNOLOGY

Epigenetic Regulation of Foxp3 Expression in Regulatory T Cells by DNA Methylation

(2014) G. Lal et al.   JOURNAL OF IMMUNOLOGY

Continuous requirement for the TCR in regulatory T cell function

(2014) Andrew G Levine et al.   NATURE IMMUNOLOGY

OX40L/Jagged1 Cosignaling by GM-CSF-Induced Bone Marrow-Derived Dendritic Cells Is Required for the Expansion of Functional Regulatory T Cells

(2013) A. Gopisetty et al.   JOURNAL OF IMMUNOLOGY

Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis

(2013) Noriko Komatsu et al.   NATURE MEDICINE

Foxp3+ Treg Expanded from Patients with Established Diabetes Reduce Helios Expression while Retaining Normal Function Compared to Healthy Individuals

(2013) Weiting Du et al.   PLoS One

Therapeutic opportunities for manipulating TReg cells in autoimmunity and cancer

(2012) Harald von Boehmer et al.   NATURE REVIEWS DRUG DISCOVERY

Regulatory T cells and Foxp3

(2011) Alexander Y. Rudensky   IMMUNOLOGICAL REVIEWS

Antigen-specific prevention of type 1 diabetes in NOD mice is ameliorated by OX40 agonist treatment

(2011) Damien Bresson et al.   JOURNAL OF AUTOIMMUNITY

GATA3 controls Foxp3+ regulatory T cell fate during inflammation in mice

(2011) Elizabeth A. Wohlfert et al.   JOURNAL OF CLINICAL INVESTIGATION

Critical role of Bcl11b in suppressor function of T regulatory cells and prevention of inflammatory bowel disease

(2011) Jeffrey VanValkenburgh et al.   JOURNAL OF EXPERIMENTAL MEDICINE

New Insights on OX40 in the Control of T Cell Immunity and Immune Tolerance In Vivo

(2011) X. Xiao et al.   JOURNAL OF IMMUNOLOGY

Notch3 and Canonical NF- B Signaling Pathways Cooperatively Regulate Foxp3 Transcription

(2011) A. Barbarulo et al.   JOURNAL OF IMMUNOLOGY

Antigen-independent signalosome of CARMA1, PKC , and TNF receptor-associated factor 2 (TRAF2) determines NF- B signaling in T cells

(2011) T. So et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autoantigens Plus Interleukin-10 Suppress Diabetes Autoimmunity

(2010) Béla Dénes et al.   Diabetes Technology & Therapeutics

A non-redundant role for OX40 in the competitive fitness of Treg in response to IL-2

(2010) Silvia Piconese et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Dendritic Cells Induce Regulatory T Cell Proliferation through Antigen-Dependent and -Independent Interactions

(2010) T. Zou et al.   JOURNAL OF IMMUNOLOGY

GM-CSF-induced, bone-marrow-derived dendritic cells can expand natural Tregs and induce adaptive Tregs by different mechanisms

(2010) Palash Bhattacharya et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Modulation of dendritic cells using granulocyte-macrophage colony-stimulating factor (GM-CSF) delays type 1 diabetes by enhancing CD4+CD25+ regulatory T cell function

(2009) Donald Cheatem et al.   CLINICAL IMMUNOLOGY

Loss of FOXP3 expression in natural human CD4+CD25+regulatory T cells upon repetitivein vitrostimulation

(2009) Petra Hoffmann et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Curing CNS autoimmune disease with myelin-reactive Foxp3+Treg

(2009) Leigh A. Stephens et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

GM-CSF-induced CD11c+CD8a--dendritic cells facilitate Foxp3+ and IL-10+ regulatory T cell expansion resulting in suppression of autoimmune thyroiditis

(2009) B. B. Ganesh et al.   INTERNATIONAL IMMUNOLOGY

Notch3 and pTα/pre-TCR sustain the in vivo function of naturally occurring regulatory T cells

(2009) Antonio F. Campese et al.   INTERNATIONAL IMMUNOLOGY

Cutting Edge: Regulatory T Cells Do Not Require Stimulation through Their TCR to Suppress

(2009) A. L. Szymczak-Workman et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: OX40 Agonists Can Drive Regulatory T Cell Expansion if the Cytokine Milieu Is Right

(2009) C. E. Ruby et al.   JOURNAL OF IMMUNOLOGY

CD39+Foxp3+ Regulatory T Cells Suppress Pathogenic Th17 Cells and Are Impaired in Multiple Sclerosis

(2009) J. M. Fletcher et al.   JOURNAL OF IMMUNOLOGY

Runx-CBFβ complexes control expression of the transcription factor Foxp3 in regulatory T cells

(2009) Dipayan Rudra et al.   NATURE IMMUNOLOGY

Jagged-1 and Notch3 Juxtacrine Loop Regulates Ovarian Tumor Growth and Adhesion

(2008) J.-H. Choi et al.   CANCER RESEARCH

Central Role of Defective Interleukin-2 Production in the Triggering of Islet Autoimmune Destruction

(2008) Qizhi Tang et al.   IMMUNITY

OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection

(2008) Silvia Piconese et al.   JOURNAL OF EXPERIMENTAL MEDICINE