Helios Enhances Treg Cell Function in Cooperation With FoxP3

Sox5 and c-Maf cooperatively induce Th17 cell differentiation via RORγt induction as downstream targets of Stat3

(2014) Shigeru Tanaka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

New complexities in helper T cell fate determination and the implications for autoimmune diseases

(2014) Hiroaki Takatori et al.   Modern Rheumatology

Prediction of Therapeutic Responses to Tocilizumab in Patients With Rheumatoid Arthritis: Biomarkers Identified by Analysis of Gene Expression in Peripheral Blood Mononuclear Cells Using Genome-Wide DNA Microarray

(2014) Yoshie Sanayama et al.   Arthritis & Rheumatology

The Percentage of FoxP3+Helios+ Treg Cells Correlates Positively With Disease Activity in Systemic Lupus Erythematosus

(2013) Amit Golding et al.   ARTHRITIS AND RHEUMATISM

Tumor Suppressor p53 Inhibits Systemic Autoimmune Diseases by Inducing Regulatory T Cells

(2013) H. Kawashima et al.   JOURNAL OF IMMUNOLOGY

Foxp3+ Treg Expanded from Patients with Established Diabetes Reduce Helios Expression while Retaining Normal Function Compared to Healthy Individuals

(2013) Weiting Du et al.   PLoS One

AT-Rich-Interactive Domain-Containing Protein 5A Functions as a Negative Regulator of Retinoic Acid Receptor-Related Orphan Nuclear Receptor γt-Induced Th17 Cell Differentiation

(2013) Yukari Saito et al.   Arthritis & Rheumatology

Foxp3+Helios+regulatory T cells are expanded in active systemic lupus erythematosus

(2012) Tobias Alexander et al.   ANNALS OF THE RHEUMATIC DISEASES

Th17 cells are restrained by Treg cells via the inhibition of interleukin-6 in patients with rheumatoid arthritis responding to anti-tumor necrosis factor antibody therapy

(2012) Jenny L. McGovern et al.   ARTHRITIS AND RHEUMATISM

Modulation of STAT-3 in rheumatoid synovial T cells suppresses Th17 differentiation and increases the proportion of Treg cells

(2012) Ji Hyeon Ju et al.   ARTHRITIS AND RHEUMATISM

Brief Report: Inhibition of interleukin-6 function corrects Th17/Treg cell imbalance in patients with rheumatoid arthritis

(2012) Maxime Samson et al.   ARTHRITIS AND RHEUMATISM

Oligodeoxynucleotides stabilize Helios-expressing Foxp3+ human T regulatory cells during in vitro expansion

(2012) Y. C. Kim et al.   BLOOD

Plasticity of Foxp3+ T Cells Reflects Promiscuous Foxp3 Expression in Conventional T Cells but Not Reprogramming of Regulatory T Cells

(2012) Takahisa Miyao et al.   IMMUNITY

Changes of Treg-Associated Molecules on CD4+CD25+Treg Cells in Myasthenia Gravis and Effects of Immunosuppressants

(2012) Wen-Hua Xu et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Helios Induces Epigenetic Silencing of Il2 Gene Expression in Regulatory T Cells

(2012) I. Baine et al.   JOURNAL OF IMMUNOLOGY

Phenotypic and Functional Properties of Helios+ Regulatory T Cells

(2012) Daniel J. Zabransky et al.   PLoS One

Therapeutic Targeting of the Interleukin-6 Receptor

(2011) Toshio Tanaka et al.   Annual Review of Pharmacology and Toxicology

Expression of Helios in Peripherally Induced Foxp3+ Regulatory T Cells

(2011) R. A. Gottschalk et al.   JOURNAL OF IMMUNOLOGY

A Role for IL-27 in Limiting T Regulatory Cell Populations

(2011) E. D. Tait Wojno et al.   JOURNAL OF IMMUNOLOGY

The Ikaros gene family: Transcriptional regulators of hematopoiesis and immunity

(2011) Liza B. John et al.   MOLECULAR IMMUNOLOGY

Helios Expression Is a Marker of T Cell Activation and Proliferation

(2011) Tatiana Akimova et al.   PLoS One

IL-6: Regulator of Treg/Th17 balance

(2010) Akihiro Kimura et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Ikaros in immune receptor signaling, lymphocyte differentiation, and function

(2010) Matthias Merkenschlager   FEBS LETTERS

Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells

(2010) A. M. Thornton et al.   JOURNAL OF IMMUNOLOGY

A role for the transcription factor Helios in human CD4+CD25+ regulatory T cells

(2010) Derese Getnet et al.   MOLECULAR IMMUNOLOGY

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

Helios Deficiency Has Minimal Impact on T Cell Development and Function

(2009) Q. Cai et al.   JOURNAL OF IMMUNOLOGY

c-Maf activates the promoter and enhancer of the IL-21 gene, and TGF-β inhibits c-Maf-induced IL-21 production in CD4+ T cells

(2009) Yukiko Hiramatsu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Eos Mediates Foxp3-Dependent Gene Silencing in CD4+ Regulatory T Cells

(2009) F. Pan et al.   SCIENCE

Validation of the 28-joint Disease Activity Score (DAS28) and European League Against Rheumatism response criteria based on C-reactive protein against disease progression in patients with rheumatoid arthritis, and comparison with the DAS28 based on erythrocyte sedimentation rate

(2008) G Wells et al.   ANNALS OF THE RHEUMATIC DISEASES