Immortalized N/TERT keratinocytes as an alternative cell source in 3D human epidermal models

Epidermal equivalents of filaggrin null keratinocytes do not show impaired skin barrier function

(2017) Hanna Niehues et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Pro-inflammatory Signaling in a 3D Organotypic Skin Model after Low LET Irradiation—NF-κB, COX-2 Activation, and Impact on Cell Differentiation

(2017) Anna Acheva et al.   Frontiers in Immunology

Reprogrammed CRISPR-Cas9 targeting the conserved regions of HPV6/11 E7 genes inhibits proliferation and induces apoptosis in E7-transformed keratinocytes

(2016) Zhi-Ming Cai et al.   ASIAN JOURNAL OF ANDROLOGY

Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis

(2016) Eric L. Simpson et al.   NEW ENGLAND JOURNAL OF MEDICINE

MALDI-MSI for the analysis of a 3D tissue-engineered psoriatic skin model

(2016) Amanda Harvey et al.   PROTEOMICS

Tissue-engineered human psoriatic skin supplemented with cytokines as an in vitro model to study plaque psoriasis

(2016) Claudia Pouliot-Bérubé et al.   Regenerative Medicine

Impaired Tight Junctions in Atopic Dermatitis Skin and in a Skin-Equivalent Model Treated with Interleukin-17

(2016) Takuo Yuki et al.   PLoS One

Antibiotics in cell culture: friend or foe? Suppression of keratinocyte growth and differentiation in monolayer cultures and 3D skin models

(2015) Uffe H. Nygaard et al.   EXPERIMENTAL DERMATOLOGY

Psoriasis

(2015) Wolf-Henning Boehncke et al.   LANCET

Development of a Full-Thickness Human Skin EquivalentIn VitroModel Derived from TERT-Immortalized Keratinocytes and Fibroblasts

(2015) Christianne M.A. Reijnders et al.   TISSUE ENGINEERING PART A

Three-DimensionalIn VitroSkin and Skin Cancer Models Based on Human Fibroblast-Derived Matrix

(2015) Manuel Berning et al.   TISSUE ENGINEERING PART C-METHODS

Reduced filaggrin expression is accompanied by increasedStaphylococcus aureuscolonization of epidermal skin models

(2014) V. van Drongelen et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Low Expression of the IL-23/Th17 Pathway in Atopic Dermatitis Compared to Psoriasis

(2014) E. Guttman-Yassky et al.   JOURNAL OF IMMUNOLOGY

TNF-α and Th2 Cytokines Induce Atopic Dermatitis–Like Features on Epidermal Differentiation Proteins and Stratum Corneum Lipids in Human Skin Equivalents

(2014) Mogbekeloluwa O. Danso et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

IL-17 Induces an Expanded Range of Downstream Genes in Reconstituted Human Epidermis Model

(2014) Andrea Chiricozzi et al.   PLoS One

Mechanisms of DNA Damage Response to Targeted Irradiation in Organotypic 3D Skin Cultures

(2014) Anna Acheva et al.   PLoS One

Barrier Properties of an N/TERT-Based Human Skin Equivalent

(2014) Vincent van Drongelen et al.   TISSUE ENGINEERING PART A

Performance of the N/TERT epidermal model for skin sensitizer identification via Nrf2-Keap1-ARE pathway activation

(2014) Mariam Alloul-Ramdhani et al.   TOXICOLOGY IN VITRO

Knock-down of filaggrin does not affect lipid organization and composition in stratum corneum of reconstructed human skin equivalents

(2013) Vincent van Drongelen et al.   EXPERIMENTAL DERMATOLOGY

Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis

(2013) Ellen H. van den Bogaard et al.   JOURNAL OF CLINICAL INVESTIGATION

Crosstalk between Keratinocytes and T Cells in a 3D Microenvironment: A Model to Study Inflammatory Skin Diseases

(2013) Ellen H. van den Bogaard et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The oncogenic GLI transcription factors facilitate keratinocyte survival and transformation upon exposure to genotoxic agents

(2013) W Harrison et al.   ONCOGENE

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Functions of the aryl hydrocarbon receptor in the skin

(2013) Charlotte Esser et al.   Seminars in Immunopathology

HaCaT Keratinocytes and Primary Epidermal Keratinocytes Have Different Transcriptional Profiles of Cornified Envelope-Associated Genes to T Helper Cell Cytokines

(2012) Min-Duk Seo et al.   Biomolecules & Therapeutics

ARNT controls the expression of epidermal differentiation genes through HDAC- and EGFR-dependent pathways

(2012) E. D. Robertson et al.   JOURNAL OF CELL SCIENCE

Human Papillomavirus Type 8 E6 Oncoprotein Inhibits Transcription of the PDZ Protein Syntenin-2

(2012) D. Lazic et al.   JOURNAL OF VIROLOGY

IL-4 regulates chemokine CCL26 in keratinocytes through the Jak1, 2/Stat6 signal transduction pathway: Implication for atopic dermatitis

(2012) Lei Bao et al.   MOLECULAR IMMUNOLOGY

Rho Kinase Inhibitor Y-27632 Prolongs the Life Span of Adult Human Keratinocytes, Enhances Skin Equivalent Development, and Facilitates Lentiviral Transduction

(2012) Ellen H. van den Bogaard et al.   TISSUE ENGINEERING PART A

Type 2 Helper T-Cell Cytokines Induce Morphologic and Molecular Characteristics of Atopic Dermatitis in Human Skin Equivalent

(2011) Marijke Kamsteeg et al.   AMERICAN JOURNAL OF PATHOLOGY

Hornerin is a component of the epidermal cornified cell envelopes

(2011) Julie Henry et al.   FASEB JOURNAL

Research in practice: IL-22 and IL-20: significance for epithelial homeostasis and psoriasis pathogenesis

(2011) Robert Sabat et al.   JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT

Intragenic Copy Number Variation within Filaggrin Contributes to the Risk of Atopic Dermatitis with a Dose-Dependent Effect

(2011) Sara J. Brown et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Filaggrin Mutations Associated with Skin and Allergic Diseases

(2011) Alan D. Irvine et al.   NEW ENGLAND JOURNAL OF MEDICINE

Differentiation of Effector CD4 T Cell Populations

(2010) Jinfang Zhu et al.   Annual Review of Immunology

Elevated tumour necrosis factor-alpha (TNF-α) biological activity in psoriatic skin lesions

(2010) P. ETTEHADI et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Human keratinocytes are efficiently immortalized by a Rho kinase inhibitor

(2010) Sandra Chapman et al.   JOURNAL OF CLINICAL INVESTIGATION

Knockdown of Filaggrin Impairs Diffusion Barrier Function and Increases UV Sensitivity in a Human Skin Model

(2010) Michael Mildner et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Skin Barrier Function in Healthy Subjects and Patients with Atopic Dermatitis in Relation to Filaggrin Loss-of-Function Mutations

(2010) Ivone Jakasa et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Proteomic Profiling of Human Keratinocytes Undergoing UVB-Induced Alternative Differentiation Reveals TRIpartite Motif Protein 29 as a Survival Factor

(2010) Véronique Bertrand-Vallery et al.   PLoS One

Eczema Genetics: Current State of Knowledge and Future Goals

(2009) Sara J. Brown et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The Role of Leukocytes, Keratinocytes, and Allergen-Specific IgE in the Development of Atopic Dermatitis

(2009) Thomas Werfel   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Epithelial Cells Derived from Human Embryonic Stem Cells Display P16INK4ASenescence, Hypermotility, and Differentiation Properties Shared by Many P63+Somatic Cell Types

(2009) Sally Dabelsteen et al.   STEM CELLS

Development and Validation of Human Psoriatic Skin Equivalents

(2008) Geuranne Tjabringa et al.   AMERICAN JOURNAL OF PATHOLOGY

Loricrin and involucrin expression is down-regulated by Th2 cytokines through STAT-6

(2008) Byung Eui Kim et al.   CLINICAL IMMUNOLOGY