The oncogenic GLI transcription factors facilitate keratinocyte survival and transformation upon exposure to genotoxic agents

Diindolylmethane-mediated Gli1 Protein Suppression Induces Anoikis in Ovarian Cancer Cellsin Vitroand Blocks Tumor Formation Abilityin Vivo

(2012) Prabodh K. Kandala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overlapping activities of TGF-β and Hedgehog signaling in cancer: Therapeutic targets for cancer treatment

(2012) Carole Y. Perrot et al.   PHARMACOLOGY & THERAPEUTICS

The Transcription Factor GLI1 Mediates TGFβ1 Driven EMT in Hepatocellular Carcinoma via a SNAI1-Dependent Mechanism

(2012) Xin Zheng et al.   PLoS One

Targeting GLI1 expression in human inflammatory breast cancer cells enhances apoptosis and attenuates migration

(2011) Z I Thomas et al.   BRITISH JOURNAL OF CANCER

Blocking Hedgehog Survival Signaling at the Level of the GLI Genes Induces DNA Damage and Extensive Cell Death in Human Colon Carcinoma Cells

(2011) T. Mazumdar et al.   CANCER RESEARCH

TGF- /SMAD/GLI2 Signaling Axis in Cancer Progression and Metastasis

(2011) D. Javelaud et al.   CANCER RESEARCH

Cancer Stem Cells in Squamous Cell Carcinoma Switch between Two Distinct Phenotypes That Are Preferentially Migratory or Proliferative

(2011) A. Biddle et al.   CANCER RESEARCH

Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations

(2011) Marina Grachtchouk et al.   JOURNAL OF CLINICAL INVESTIGATION

Expression of Sonic Hedgehog Signaling Components in Hepatocellular Carcinoma and Cyclopamine-induced Apoptosis Through Bcl-2 Downregulation In Vitro

(2010) Xi-lin Chen et al.   ARCHIVES OF MEDICAL RESEARCH

Focus on histone variant H2AX: To be or not to be

(2010) Jingsong Yuan et al.   FEBS LETTERS

ILK expression in human basal cell carcinoma correlates with epithelial-mesenchymal transition markers and tumour invasion

(2010) Sofia Papanikolaou et al.   HISTOPATHOLOGY

Epithelial–mesenchymal transition in the skin

(2010) Motonobu Nakamura et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

GLI2-Mediated Melanoma Invasion and Metastasis

(2010) Vasileia-Ismini Alexaki et al.   JNCI-Journal of the National Cancer Institute

γH2AX: a sensitive molecular marker of DNA damage and repair

(2010) L-J Mah et al.   LEUKEMIA

Upregulation of FOXM1 induces genomic instability in human epidermal keratinocytes

(2010) Muy-Teck Teh et al.   Molecular Cancer

Varying phenotypes in swine versus murine transgenic models constitutively expressing the same human Sonic hedgehog transcriptional activator, K5-HGLI2ΔN

(2010) Amy C. McCalla-Martin et al.   TRANSGENIC RESEARCH

Hedgehog signaling maintains hair follicle stem cell phenotype in young and aged human skin

(2009) Laure Rittié et al.   AGING CELL

Epidermal Growth Factor Receptor Signaling Synergizes with Hedgehog/GLI in Oncogenic Transformation via Activation of the MEK/ERK/JUN Pathway

(2009) Harald Schnidar et al.   CANCER RESEARCH

Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion

(2009) Frédéric Varnat et al.   EMBO Molecular Medicine

Cutaneous wound reepithelialization is compromised in mice lacking functional Slug (Snai2)

(2009) Laurie G. Hudson et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

GLI1 repression of ERK activity correlates with colony formation and impaired migration in human epidermal keratinocytes

(2008) Graham W. Neill et al.   CARCINOGENESIS

Sonic Hedgehog signaling impairs ionizing radiation–induced checkpoint activation and induces genomic instability

(2008) Jennifer M. Leonard et al.   JOURNAL OF CELL BIOLOGY

Superficial, Nodular, and Morpheiform Basal-Cell Carcinomas Exhibit Distinct Gene Expression Profiles

(2008) Mei Yu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Gli2 upregulates cFlip and renders basal cell carcinoma cells resistant to death ligand-mediated apoptosis

(2008) E Kump et al.   ONCOGENE