Impaired Tight Junctions in Atopic Dermatitis Skin and in a Skin-Equivalent Model Treated with Interleukin-17

An innovative three-dimensional model of normal human skin to study the proinflammatory psoriatic effects of tumor necrosis factor-alpha and interleukin-17

(2014) E. Donetti et al.   CYTOKINE

Immunology of atopic eczema: overcoming the Th1/Th2 paradigm

(2013) K. Eyerich et al.   ALLERGY

Intrinsic atopic dermatitis shows similar TH2 and higher TH17 immune activation compared with extrinsic atopic dermatitis

(2013) Mayte Suárez-Fariñas et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Tight junction dysfunction in the stratum granulosum leads to aberrant stratum corneum barrier function in claudin-1-deficient mice

(2013) Tomoko Sugawara et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Contribution of Tight Junction Proteins to Ion, Macromolecule, and Water Barrier in Keratinocytes

(2013) Nina Kirschner et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Altered stratum corneum barrier and enhanced percutaneous immune responses in filaggrin-null mice

(2012) Hiroshi Kawasaki et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A group of atopic dermatitis without IgE elevation or barrier impairment shows a high Th1 frequency: Possible immunological state of the intrinsic type

(2012) Rieko Kabashima-Kubo et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Impaired tight junctions obstruct stratum corneum formation by altering polar lipid and profilaggrin processing

(2012) Takuo Yuki et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Activation of Epidermal Toll-Like Receptor 2 Enhances Tight Junction Function: Implications for Atopic Dermatitis and Skin Barrier Repair

(2012) I-Hsin Kuo et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

IL-17 downregulates filaggrin and affects keratinocyte expression of genes associated with cellular adhesion

(2011) Danuta Gutowska-Owsiak et al.   EXPERIMENTAL DERMATOLOGY

Langerhans cell antigen capture through tight junctions confers preemptive immunity in experimental staphylococcal scalded skin syndrome

(2011) Takeshi Ouchi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Activation of TLR2 Enhances Tight Junction Barrier in Epidermal Keratinocytes

(2011) T. Yuki et al.   JOURNAL OF IMMUNOLOGY

One Remarkable Molecule: Filaggrin

(2011) Sara J. Brown et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Tight junction defects in patients with atopic dermatitis

(2010) Anna De Benedetto et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Characterization of Tight Junctions and Their Disruption by UVB in Human Epidermis and Cultured Keratinocytes

(2010) Takuo Yuki et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Alteration of Tight Junction Proteins Is an Early Event in Psoriasis

(2009) Nina Kirschner et al.   AMERICAN JOURNAL OF PATHOLOGY

Filaggrin in the frontline: role in skin barrier function and disease

(2009) A. Sandilands et al.   JOURNAL OF CELL SCIENCE

External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers

(2009) Akiharu Kubo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Molecular Basis of the Core Structure of Tight Junctions

(2009) M. Furuse   Cold Spring Harbor Perspectives in Biology

Possible Pathogenic Role of Th17 Cells for Atopic Dermatitis

(2008) Chizuko Koga et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY