Modulation of Ras/ERK and Phosphoinositide Signaling by Long-Chain n-3 PUFA in Breast Cancer and Their Potential Complementary Role in Combination with Targeted Drugs

Long chain n-3 polyunsaturated fatty acids increase the efficacy of docetaxel in mammary cancer cells by downregulating Akt and PKCε/δ-induced ERK pathways

(2016) Lucie Chauvin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

AKT in cancer: new molecular insights and advances in drug development

(2016) Prabhjot S. Mundi et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

NF-?B Blockers Gifted by Mother Nature: Prospectives in Cancer Cell Chemosensitization

(2016) Javadi Monisha et al.   CURRENT PHARMACEUTICAL DESIGN

The MEK5/ERK5 signalling pathway in cancer: a promising novel therapeutic target

(2016) André E.S. Simões et al.   DRUG DISCOVERY TODAY

DHA-induced stress response in human colon cancer cells – Focus on oxidative stress and autophagy

(2016) Kristine Pettersen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regulation of mTORC1 by growth factors, energy status, amino acids and mechanical stimuli at a glance

(2016) Peter Bond   Journal of the International Society of Sports Nutrition

How plausible is the use of dietary n-3 PUFA in the adjuvant therapy of cancer?

(2016) Simona Serini et al.   NUTRITION RESEARCH REVIEWS

Multi-Targeted Agents in Cancer Cell Chemosensitization: What We Learnt from Curcumin Thus Far

(2016) Devivasha Bordoloi et al.   Recent Patents on Anti-Cancer Drug Discovery

Eicosopentaneoic Acid and Other Free Fatty Acid Receptor Agonists Inhibit Lysophosphatidic Acid- and Epidermal Growth Factor-Induced Proliferation of Human Breast Cancer Cells

(2016) Mandi Hopkins et al.   Journal of Clinical Medicine

Resolvins and omega three polyunsaturated fatty acids: Clinical implications in inflammatory diseases and cancer

(2016) Kazuki Moro et al.   World Journal of Clinical Cases

Omega-3 free fatty acids inhibit tamoxifen-induced cell apoptosis

(2015) Shufan Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Recent progress on MAP kinase pathway inhibitors

(2015) David E. Uehling et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Targeting drivers of melanoma with synthetic small molecules and phytochemicals

(2015) Leah Ray Strickland et al.   CANCER LETTERS

Modulation of Breast Cancer Risk Biomarkers by High-Dose Omega-3 Fatty Acids: Phase II Pilot Study in Postmenopausal Women

(2015) C. J. Fabian et al.   Cancer Prevention Research

Modulation of Breast Cancer Risk Biomarkers by High-Dose Omega-3 Fatty Acids: Phase II Pilot Study in Premenopausal Women

(2015) C. J. Fabian et al.   Cancer Prevention Research

Long-chain n-3 PUFA against breast and prostate cancer: Which are the appropriate doses for intervention studies in animals and humans?

(2015) Elena Fasano et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

The RAF-MEK-ERK pathway: targeting ERK to overcome obstacles to effective cancer therapy

(2015) Zutao Yu et al.   Future Medicinal Chemistry

Akt inhibitors in cancer treatment: The long journey from drug discovery to clinical use (Review)

(2015) GEORGE MIHAI NITULESCU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Effect of Docosahexaenoic Acid on Cell Cycle Pathways in Breast Cell Lines With Different Transformation Degree

(2015) Tania Rescigno et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Flaxseed oil enhances the effectiveness of trastuzumab in reducing the growth of HER2-overexpressing human breast tumors (BT-474)

(2015) Julie K. Mason et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

α-linolenic acid and docosahexaenoic acid, alone and combined with trastuzumab, reduce HER2-overexpressing breast cancer cell growth but differentially regulate HER2 signaling pathways

(2015) Julie K. Mason et al.   Lipids in Health and Disease

Docosahexaenoic Acid Downregulates EGF-Induced Urokinase Plasminogen Activator and Matrix Metalloproteinase 9 Expression by Inactivating EGFR/ErbB2 Signaling in SK-BR3 Breast Cancer Cells

(2015) Chien-Chun Li et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

A potential role of PUFAs and COXIBs in cancer chemoprevention

(2015) Marianela Vara-Messler et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

MEK1/2 Inhibitors: Molecular Activity and Resistance Mechanisms

(2015) Pui-Kei Wu et al.   SEMINARS IN ONCOLOGY

Docosahexaenoic Acid Induces Cell Death in Human Non-Small Cell Lung Cancer Cells by Repressing mTOR via AMPK Activation and PI3K/Akt Inhibition

(2015) Nayeong Kim et al.   Biomed Research International

BRAF vs RAS oncogenes: Are mutations of the same pathway equal? Differential signalling and therapeutic implications

(2015) Eftychia Oikonomou et al.   Oncotarget

Syndecan-1-Dependent Suppression of PDK1/Akt/Bad Signaling by Docosahexaenoic Acid Induces Apoptosis in Prostate Cancer

(2015) Yunping Hu et al.   NEOPLASIA

AKT3 regulates ErbB2, ErbB3 and estrogen receptor α expression and contributes to endocrine therapy resistance of ErbB2+ breast tumor cells from Balb-neuT mice

(2014) Nicole Grabinski et al.   CELLULAR SIGNALLING

Picking the Point of Inhibition: A Comparative Review of PI3K/AKT/mTOR Pathway Inhibitors

(2014) R. Dienstmann et al.   MOLECULAR CANCER THERAPEUTICS

Drugging the undruggable RAS: Mission Possible?

(2014) Adrienne D. Cox et al.   NATURE REVIEWS DRUG DISCOVERY

COSMIC: exploring the world's knowledge of somatic mutations in human cancer

(2014) Simon A. Forbes et al.   NUCLEIC ACIDS RESEARCH

ω-3 Polyunsaturated fatty acids-derived lipid metabolites on angiogenesis, inflammation and cancer

(2014) Weicang Wang et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Inhibition of matrix metalloproteinase-9 expression by docosahexaenoic acid mediated by heme oxygenase 1 in 12-O-tetradecanoylphorbol-13-acetate-induced MCF-7 human breast cancer cells

(2013) Haw-Wen Chen et al.   ARCHIVES OF TOXICOLOGY

Dual inhibition of autophagy and the AKT pathway in prostate cancer

(2013) Francois Lamoureux et al.   Autophagy

Down-regulation of lipid raft-associated onco-proteins via cholesterol-dependent lipid raft internalization in docosahexaenoic acid-induced apoptosis

(2013) Eun Jeong Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Polyunsaturated fatty acids affect the localization and signaling of PIP3/AKT in prostate cancer cells

(2013) Zhennan Gu et al.   CARCINOGENESIS

Omega-3 polyunsaturated fatty acids selectively inhibit growth in neoplastic oral keratinocytes by differentially activating ERK1/2

(2013) Zacharoula Nikolakopoulou et al.   CARCINOGENESIS

Omega-3 Fatty Acid Blood Levels

(2013) H. Robert Superko et al.   CIRCULATION

Influence of omega-3 fatty acids on Tamoxifen-induced suppression of rat mammary carcinogenesis

(2013) Andrea Manni et al.   INTERNATIONAL JOURNAL OF CANCER

Inhibition of the HER2 pathway by n-3 polyunsaturated fatty acids prevents breast cancer in fat-1 transgenic mice

(2013) Zuquan Zou et al.   JOURNAL OF LIPID RESEARCH

Higher Serum EPA or DHA, and Lower ARA Compositions with Age Independent Fatty Acid Intake in Japanese Aged 40 to 79

(2013) Rei Otsuka et al.   LIPIDS

Mutational landscape and significance across 12 major cancer types

(2013) Cyriac Kandoth et al.   NATURE

Dietary Flaxseed–Trastuzumab Interactive Effects on the Growth of HER2-Overexpressing Human Breast Tumors (BT-474)

(2013) Julie K. Mason et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

mTORC1/2 targeted by n-3 polyunsaturated fatty acids in the prevention of mammary tumorigenesis and tumor progression

(2013) Z Chen et al.   ONCOGENE

Key roles for GRB2-associated-binding protein 1, phosphatidylinositol-3-kinase, cyclooxygenase 2, prostaglandin E2 and transforming growth factor alpha in linoleic acid-induced upregulation of lung and breast cancer cell growth

(2013) M. Mouradian et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Acquired Resistance and Clonal Evolution in Melanoma during BRAF Inhibitor Therapy

(2013) H. Shi et al.   Cancer Discovery

The Genetic Landscape of Clinical Resistance to RAF Inhibition in Metastatic Melanoma

(2013) E. M. Van Allen et al.   Cancer Discovery

Dietaryω-3 Polyunsaturated Fatty Acid DHA: A Potential Adjuvant in the Treatment of Cancer

(2013) Nicolò Merendino et al.   Biomed Research International

Inhibition of constitutive Akt (PKB) phosphorylation by docosahexaenoic acid in the human breast cancer cell line MDA-MB-453

(2012) Satoshi B. Sato et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Identification of a Molecular Signature Underlying Inhibition of Mammary Carcinoma Growth by Dietary N-3 Fatty Acids

(2012) W. Jiang et al.   CANCER RESEARCH

Docosahexanoic Acid Improves Chemotherapy Efficacy by Inducing CD95 Translocation to Lipid Rafts in ER− Breast Cancer Cells

(2012) Julia B. Ewaschuk et al.   LIPIDS

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

N-3 Poly-Unsaturated Fatty Acids Shift Estrogen Signaling to Inhibit Human Breast Cancer Cell Growth

(2012) WenQing Cao et al.   PLoS One

Reduction of metastasis, cell invasion, and adhesion in mouse osteosarcoma by YM529/ONO-5920-induced blockade of the Ras/MEK/ERK and Ras/PI3K/Akt pathway

(2012) Masanobu Tsubaki et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Phase II Prospective Randomized Trial of a Low-Fat Diet with Fish Oil Supplementation in Men Undergoing Radical Prostatectomy

(2011) W. J. Aronson et al.   Cancer Prevention Research

Omega-3 fatty acids induce apoptosis in human breast cancer cells and mouse mammary tissue through syndecan-1 inhibition of the MEK-Erk pathway

(2011) H. Sun et al.   CARCINOGENESIS

Dietary n-3 Polyunsaturated Fatty Acids and the Paradox of Their Health Benefits and Potential Harmful Effects

(2011) Simona Serini et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Selective action of human sera differing in fatty acids and cholesterol content on in vitro gene expression

(2011) Hylde Zirpoli et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Pathological roles of MAPK signaling pathways in human diseases

(2010) Eun Kyung Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The Impact of Fish Oil on the Chemopreventive Efficacy of Tamoxifen against Development of N-Methyl-N-Nitrosourea-Induced Rat Mammary Carcinogenesis

(2010) A. Manni et al.   Cancer Prevention Research

Akt3-Mediated Resistance to Apoptosis in B-RAF-Targeted Melanoma Cells

(2010) Y. Shao et al.   CANCER RESEARCH

Docosahexaenoic acid alters epidermal growth factor receptor-related signaling by disrupting its lipid raft association

(2010) Kristina R. Rogers et al.   CARCINOGENESIS

Effects of dietary fat modification on skeletal muscle fatty acid handling in the metabolic syndrome

(2010) A M J van Hees et al.   INTERNATIONAL JOURNAL OF OBESITY

From basic research to clinical development of MEK1/2 inhibitors for cancer therapy

(2010) Christophe Frémin et al.   Journal of Hematology & Oncology

Albumin modulates docosahexaenoic acid-induced cytotoxicity in human hepatocellular carcinoma cell lines

(2010) Syu-ichi Kanno et al.   TOXICOLOGY LETTERS

Improving outcome of chemotherapy of metastatic breast cancer by docosahexaenoic acid: a phase II trial

(2009) P Bougnoux et al.   BRITISH JOURNAL OF CANCER

Kalopanaxsaponin A inhibits PMA-induced invasion by reducing matrix metalloproteinase-9 via PI3K/Akt- and PKC -mediated signaling in MCF-7 human breast cancer cells

(2009) S. K. Park et al.   CARCINOGENESIS

Albumin as Fatty Acid Transporter

(2009) Ger J. van der Vusse   Drug Metabolism and Pharmacokinetics

mTOR signaling at a glance

(2009) M. Laplante et al.   JOURNAL OF CELL SCIENCE

Dietary flaxseed lignan or oil combined with tamoxifen treatment affects MCF-7 tumor growth through estrogen receptor- and growth factor-signaling pathways

(2009) Jasdeep Kaur Saggar et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Docosahexaenoic acid induces apoptosis in lung cancer cells by increasing MKP-1 and down-regulating p-ERK1/2 and p-p38 expression

(2008) Simona Serini et al.   APOPTOSIS

Bioactive dietary long-chain fatty acids: emerging mechanisms of action

(2008) Robert S. Chapkin et al.   BRITISH JOURNAL OF NUTRITION

Peroxisome Proliferator-Activated Receptor  -Mediated Up-regulation of Syndecan-1 by n-3 Fatty Acids Promotes Apoptosis of Human Breast Cancer Cells

(2008) H. Sun et al.   CANCER RESEARCH

Quercetin inhibition of tumor invasion via suppressing PKC /ERK/AP-1-dependent matrix metalloproteinase-9 activation in breast carcinoma cells

(2008) C.-W. Lin et al.   CARCINOGENESIS

Increased expression of Nrf2/ARE-dependent anti-oxidant proteins in tamoxifen-resistant breast cancer cells

(2008) Sang Kyum Kim et al.   FREE RADICAL BIOLOGY AND MEDICINE

Raft nanodomains contribute to Akt/PKB plasma membrane recruitment and activation

(2008) Rémi Lasserre et al.   Nature Chemical Biology