Article
Biochemistry & Molecular Biology
Doaa Ibrahim, Ahmed H. Arisha, Safaa Khater, Wafaa M. Gad, Zeinab Hassan, Sally H. Abou-Khadra, Dalia Ibrahim Mohamed, Tamer Ahmed Ismail, Sara A. Gad, Salwa A. M. Eid, Reham A. Abd El-Wahab, Asmaa T. Y. Kishawy
Summary: This study investigated the effects of reformulated omega-3-NPs on Nile tilapia's performance, flesh antioxidant stability, immunity, and disease resistance. The results showed that supplementation of omega-3-NPs improved fish performance, increased the deposition of omega-3-PUFAs in fish flesh, and reduced oxidative markers in fish flesh. Additionally, omega-3-NPs enhanced fish immunity and improved disease resistance against Aeromonas hydrophila.
Article
Cell Biology
Arindam Bhattacharjee, Adel Urmosi, Andras Jipa, Levente Kovacs, Peter Deak, Aron Szabo, Gabor Juhasz
Summary: Using a Drosophila model, researchers show that disrupting ubiquitinated protein autophagy and forming polyubiquitinated aggregates has little effect on overall autophagy, proteasome activity, and fly healthspan. However, they find that the accumulation of ref(2)P/SQSTM1 activates the antioxidant pathway, resulting in increased tolerance to oxidative stress in mutant flies.
Article
Nutrition & Dietetics
Dan-Dan Shi, Yu-Jing Fang, Yi-Ling Jiang, Ting Dong, Zhuo-Lin Zhang, Ting Ma, Ruo-Lin Zhou, Qing-Jian Ou, Cai-Xia Zhang
Summary: This case-control study found that higher levels of serum alpha-linolenic acid (ALA), docosapentaenoic acid (DPA), docosahexaenoic acid (DHA), long-chain n-3 PUFA, and total n-3 PUFA were inversely associated with the risk of colorectal cancer in the Chinese population.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Yasuaki Tatsumi, Ayako Kato, Naoko Niimi, Hideji Yako, Tatsuhito Himeno, Masaki Kondo, Shin Tsunekawa, Yoshiro Kato, Hideki Kamiya, Jiro Nakamura, Koji Higai, Kazunori Sango, Koichi Kato
Summary: This study reveals the potential application value of docosahexaenoic acid (DHA) in diabetic neuropathy. The experimental results suggest that DHA can inhibit oxidative stress-induced cell death, attenuate excessive autophagy, and has the potential to protect Schwann cells from oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Zhuo-Lin Zhang, Suzanne C. Ho, Dan-Dan Shi, Xiao-Xia Zhan, Qi-Xin Wu, Lei Xu, Cai-Xia Zhang
Summary: This study examined the association between erythrocyte membrane n-3 PUFA and breast cancer risk among Chinese women using a large sample size. The results showed a non-linear inverse association between erythrocyte membrane α-linolenic acid, docosapentaenoic acid (DPA), total n-3 PUFA and breast cancer risk. Additionally, erythrocyte membrane EPA and DHA were linearly and inversely associated with breast cancer risk.
BRITISH JOURNAL OF NUTRITION
(2023)
Review
Chemistry, Medicinal
Marine Remize, Yves Brunel, Joana L. Silva, Jean-Yves Berthon, Edith Filaire
Summary: n-3 polyunsaturated fatty acids, especially EPA and DHA, are essential for human health and mainly come from marine sources. However, due to overfishing and global warming, their supply is becoming scarce. Microalgae are considered a sustainable source of these healthy molecules.
Article
Chemistry, Medicinal
Maria Grazia Morgese, Stefania Schiavone, Maria Bove, Anna Laura Colia, Stefania Dimonte, Paolo Tucci, Luigia Trabace
Summary: The study investigated the protective role of lifelong exposure to n-3 PUFA-enriched or n-6/n-3 balanced diets in a rat model of A beta-induced toxicity. Both diets were found to reduce ROS production and oxidative stress, while affecting neurotransmitter levels.
Article
Nutrition & Dietetics
Christine Bobin-Dubigeon, Hassan Nazih, Mikael Croyal, Jean-Marie Bard
Summary: According to the findings from clinical and laboratory data, researchers discovered a correlation between EPA and DHA carried by non-HDL lipoproteins and breast cancer severity, suggesting a potential protective effect on the proliferation of breast cancer in HR- tumors.
Article
Biochemistry & Molecular Biology
Antonietta Notaro, Marianna Lauricella, Diana Di Liberto, Sonia Emanuele, Michela Giuliano, Alessandro Attanzio, Luisa Tesoriere, Daniela Carlisi, Mario Allegra, Anna De Blasio, Giuseppe Calvaruso, Antonella D'Anneo
Summary: Methyl gallate (MG), a gallotannin found in plants, showed potential as an anti-tumor phytomolecule for colon cancer treatment. It reduced the viability of HCT116 colon cancer cells but had no effect on differentiated Caco-2 cells. MG induced early ROS generation and ER stress, leading to autophagy and apoptotic cell death. The increase in p53 played a crucial role in the mechanism, which was tightly linked to oxidative injury.
Article
Environmental Sciences
Leonardo Bruni, Yara Husein, Giulia Secci, Francesca Tulli, Giuliana Parisi
Summary: By analyzing the nutritional composition of rainbow trout skin and studying the effects of different diets, it was found that the skin can be a promising source of n-3 LCPUFA. Reusing the skin of farmed fish can help reduce food industry by-products, address the shortfall of n-3 LCPUFA, and potentially lead to the development of functional foods and supplements.
WASTE AND BIOMASS VALORIZATION
(2021)
Article
Nutrition & Dietetics
Haifeng Zhang, Yinshuang Yao, Xiaoyan Zhong, Fang Meng, Kari Hemminki, Junlan Qiu, Xiaochen Shu
Summary: This study used genetic data from large-scale populations in Europe and Asia to evaluate the causal effect of plasma docosahexaenoic acid (DHA) levels on ovarian cancer (OC) risk. The results showed a causal association between higher plasma DHA levels and lower risk of OC, especially endometrioid ovarian cancer (EOC), in the European population. Similar results were found in the Asian replication set. These findings provide important genetic evidence for prevention strategies and interventions targeting DHA intake and OC.
CLINICAL NUTRITION
(2023)
Article
Fisheries
Bjarne Hatlen, Thomas Larsson, Tone-Kari Ostbye, Odd Helge Romarheim, Laura Martinez Rubio, Bente Ruyter
Summary: New research suggests that high n-3 VLC-PUFA canola oil can be an effective and safe source of docosahexaenoic acid (DHA) and other n-3 PUFA for sustainable salmon farming. Including high n-3 canola oil in the diet of Atlantic salmon improves fillet pigmentation and reduces fillet melanin spots without compromising fish growth.
Review
Food Science & Technology
Xiang Ren, Yanjun Liu, Chao Fan, Hao Hong, Wenzhong Wu, Wei Zhang, Yanwen Wang
Summary: Microalgae have the potential to address the shortages of food and nutrition as a sustainable biofactory. They can produce high-value bioactive compounds, including n-3 polyunsaturated fatty acids (PUFA), which have various health benefits. However, the supply of n-3 PUFA is facing challenges due to global warming and overfishing. Cultivating microalgae to meet the market demand and provide unique fatty acids for specific populations is an important area of research.
Article
Cell Biology
Kun Gao, Qing Shi, Yajuan Liu, Chenji Wang
Summary: This study reveals a negative regulatory role of SPOP in autophagy and NFE2L2 pathway activation. The study found that SPOP induces non-degradative ubiquitination of SQSTM1, thereby suppressing autophagy and NFE2L2 pathway activation. The PCa-associated SPOP mutants lose the capacity to ubiquitinate SQSTM1 and instead enhance autophagy and the antioxidant response in a dominant-negative manner.
Article
Health Care Sciences & Services
Karina Gonzalez-Becerra, Elisa Barron-Cabrera, Jose F. Munoz-Valle, Nathaly Torres-Castillo, Juan J. Rivera-Valdes, Roberto Rodriguez-Echevarria, Erika Martinez-Lopez
Summary: The study aimed to analyze the effects of n-3 PUFA supplementation on fatty acid profile, biochemical markers, and inflammatory markers in subjects with obesity. The results showed that both the supplementation and placebo groups increased PUFA intake and DHA in red blood cells, but the placebo group had reductions in IL-8 and MCP-1 levels. Regression analysis revealed that increased DHA levels were associated with decreased IL-8 levels in both groups, suggesting the beneficial anti-inflammatory effects of dietary DHA and n-3 supplementation.
Article
Geriatrics & Gerontology
Kristine Pettersen, Sonja Andersen, Anna van der Veen, Unni Nonstad, Shinji Hatakeyama, Christian Lambert, Estelle Lach-Trifilieff, Siver Moestue, Jana Kim, Bjorn Henning Gronberg, Alain Schilb, Carsten Jacobi, Geir Bjorkoy
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2020)
Article
Automation & Control Systems
Martin Syre Wiig, Kristin Ytterstad Pettersen, Thomas Robekk Krogstad
IEEE TRANSACTIONS ON CONTROL SYSTEMS TECHNOLOGY
(2020)
Article
Automation & Control Systems
Ida-Louise G. Borlaug, Kristin Y. Pettersen, Jan Tommy Gravdahl
Article
Automation & Control Systems
Ida-Louise G. Borlaug, Kristin Y. Pettersen, Jan Tommy Gravdahl
Summary: This article introduces a generalized super-twisting algorithm for trajectory tracking of an articulated intervention autonomous underwater vehicle (AIAUV). It also proposes the use of a higher-order sliding mode observer for velocity estimation and demonstrates the stability of control laws. The applicability of the proposed control methods is validated through comprehensive simulation and experimental results.
IEEE TRANSACTIONS ON CONTROL SYSTEMS TECHNOLOGY
(2021)
Article
Nutrition & Dietetics
Trude R. Balstad, Cinzia Brunelli, Caroline H. Pettersen, Svanhild A. Schonberg, Frank Skorpen, Marie Fallon, Stein Kaasa, Asta Bye, Barry J. A. Laird, Guro B. Stene, Tora S. Solheim
Summary: In cancer cachexia, body weight remains a critical clinical outcome measure, while body composition and physical function measures are important but require large sample sizes to detect treatment group differences.
FRONTIERS IN NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Helle Samdal, Lene C. Olsen, Knut S. Gron, Elin S. Royset, Therese S. Hoiem, Ingunn Nervik, Pal Saetrom, Arne Wibe, Svanhild A. Schonberg, Caroline H. H. Pettersen
Summary: A PDX model for colorectal cancer was successfully established in CIEA NOG mice, demonstrating retention of key histological characteristics of patients' tumors. The study further explored the delivery of liquid diets enriched with fish oil to mice, showing successful consumption by the mice and potential for future exploration of different cancer treatment regimes.
Article
Robotics
Marius Thoresen, Niels Hygum Nielsen, Kim Mathiassen, Kristin Y. Pettersen
Summary: A new path planning method for UGVs on terrain is developed based on the Hybrid A* algorithm, optimizing both traversability and distance. The method is demonstrated using simulated traversability maps and real-time experiments in real terrain, showing the benefits of terrain traversability optimization using the proposed path planning method.
IEEE ROBOTICS AND AUTOMATION LETTERS
(2021)
Article
Cell Biology
Sima Zolfaghari, Ole Jorgen Kaasboll, M. Shakil Ahmed, Fabian A. Line, Else Marie Hagelin, Vivi T. Monsen, Havard Attramadal
Summary: CCN5 primarily exists in endothelial cells, fibroblasts, and macrophages in differentiating scar tissue in the heart, and its transcription is inversely regulated by beta(2)-adrenergic agonists and TNF-alpha. It antagonizes the profibrotic actions of CCN2 and inhibits myocardial collagen deposition and fibrosis in chronic pressure overload of the heart.
JOURNAL OF CELL COMMUNICATION AND SIGNALING
(2022)
Article
Chemistry, Medicinal
Christian Bjerknes, Bomi Framroze, Crawford Currie, Caroline Hild Hakvag Pettersen, Karol Axcrona, Erland Hermansen
Summary: The study found that a bioactive peptide-rich salmon protein hydrolysate can enhance the anti-proliferative effect of bicalutamide on prostate cancer cells, potentially through modulating iron homeostasis mechanisms.
Article
Biochemistry & Molecular Biology
Sima Zolfaghari, Ole Jorgen Kaasboll, Vivi T. Monsen, Bojana Sredic, Else Marie V. Hagelin, Havard Attramadal
Summary: Cellular Communication Network (CCN) proteins play important roles in cellular responses associated with organ development and tissue homeostasis. CCN5, a divergent member of the CCN family, releases the TSP1 homology domain as its bioactive signaling entity, and inhibits key signaling pathways stimulated by CCN2. Moreover, the CCN5 TSP1 domain also inhibits cell migration and scratch wound closure induced by CCN1/2.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Automation & Control Systems
Erlend A. Basso, Henrik M. Schmidt-Didlaukies, Kristin Y. Pettersen
Summary: This letter addresses the problem of global asymptotic position and heading tracking for multirotors, and proposes a hybrid adaptive feedback control law. The theory achieves global asymptotic tracking by minimizing parameter estimates and constructing a novel rotation matrix.
IEEE CONTROL SYSTEMS LETTERS
(2022)
Article
Cell Biology
Apsana Lamsal, Sonja Benedikte Andersen, Ida Johansson, Marina Vietri, Ansooya Avinash Bokil, Natalie Jayne Kurganovs, Felicia Rylander, Geir Bjorkoy, Kristine Pettersen, Miriam S. S. Giambelluca
Summary: Solid tumors rely on suppressed local immune reactions in the tumor microenvironment, and the formation of immunosuppressive tumor microenvironments is still not fully understood. This study found that the type I interferon response is dampened in tumors with metastatic ability, and decreased expression of IFN-I-related genes predicts poor prognosis in breast cancer patients.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Automation & Control Systems
Erlend A. A. Basso, Henrik M. M. Schmidt-Didlaukies, Kristin Y. Y. Pettersen, Asgeir J. J. Sorensen
Summary: This article presents an adaptive hybrid feedback control law for global asymptotic tracking of a hybrid reference system for marine vehicles in the presence of parametric modeling errors. The proposed control law consists of a parameterized loop and a speed assignment to decouple the geometry of the path from the motion along the path. It includes a proportional-derivative action, an adaptive feedforward term, and a hysteretic switching mechanism to determine jumps.
IEEE TRANSACTIONS ON AUTOMATIC CONTROL
(2023)
Review
Cell Biology
Vivi Talstad Monsen, Havard Attramadal
Summary: CCN proteins are important in development, tissue injury repair, and cancer metastasis. Their molecular mechanisms of action are still poorly understood, but recent research has shown that they are signaling proteins that can be controlled to release bioactive peptides. The crystal structure of CCN3 domains and predictions from the AlphaFold tool provide new insights into CCN functions. Understanding the structure-function relationship of CCN proteins is crucial for developing therapeutic strategies.
JOURNAL OF CELL COMMUNICATION AND SIGNALING
(2023)
Article
Oncology
Ansooya A. Bokil, Mathieu Le Boulvais Borkja, Camilla Wolowczyk, Apsana Lamsal, Wenche S. Prestvik, Unni Nonstad, Kristine Pettersen, Sonja B. Andersen, Anna M. Bofin, Geir Bjorkoy, Sjoerd Hak, Miriam S. Giambelluca
Summary: This study identified a unique expression pattern of arginase 1 (ARG1) in myeloid cells, which is correlated with the metastatic capacity of breast cancer. The presence of ARG1-positive cells in human breast cancer biopsies is strongly associated with high-grade proliferating tumors, poor prognosis, and low survival.
CANCER CELL INTERNATIONAL
(2023)
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)