Article
Pharmacology & Pharmacy
J. Y. Fu, C. X. Jiang, M. Y. Wu, R. Y. Mei, A. F. Yang, H. P. Tao, X. J. Chen, J. Zhang, L. Huang, X. F. Zhao
Summary: Theabrownin (TB) has shown potential as an antitumor agent in glioma cells by significantly reducing cell viability and inducing cell cycle arrest through modulation of various proteins. Different mechanisms related to c-myc and P53 were proposed for cell cycle arrest in different glioma cell lines. TB could be a novel candidate drug for the treatment of gliomas based on these findings.
FRONTIERS IN PHARMACOLOGY
(2021)
Editorial Material
Biotechnology & Applied Microbiology
Xiao-Man Sun, Ying-Shuang Xu, He Huang
Summary: Thraustochytrids can accumulate high biomass and lipid content, exhibit broad substrate utilization capacity and effective metabolic pathways without genetic modification, showing great promise for future development.
TRENDS IN BIOTECHNOLOGY
(2021)
Article
Medicine, Research & Experimental
Parisa Ghaffari-Makhmalbaf, Maryam Sayyad, Katayoon Pakravan, Ehsan Razmara, Amirreza Bitaraf, Babak Bakhshinejad, Parmida Goudarzi, Hassan Yousefi, Mahmoud Pournaghshband, Fahimeh Nemati, Hossein Fahimi, Fatemeh Rohollah, Mandana Hasanzad, Mehrdad Hashemi, Seyed Hadi Mousavi, Sadegh Babashah
Summary: The research demonstrates that DHA treatment can inhibit angiogenesis of breast cancer cells by altering the exosomal miRNA contents from pro-angiogenic to anti-angiogenic properties.
Article
Agronomy
Yajing Gu, Xuan Chen, Rentao Song, Weiwei Qi
Summary: A bivector transformation system was developed, which successfully transformed two recalcitrant maize inbred lines. The system shortened the transformation cycle, eliminated interference, and ultimately obtained progenies with the target gene.
Article
Biochemistry & Molecular Biology
Ivana Predarska, Mohamad Saoud, Ibrahim Morgan, Peter Loennecke, Goran N. Kaluderovic, Evamarie Hey-Hawkins
Summary: In this study, triphenyltin(IV) derivatives of non-steroidal anti-inflammatory drugs were synthesized and evaluated for their antiproliferative effects on breast carcinoma cells. The tin(IV) complexes showed potent activity and inhibited cell proliferation possibly by downregulating nitric oxide synthase expression.
Article
Multidisciplinary Sciences
Shuchita Tiwari, Jun Yang, Christophe Morisseau, Blythe Durbin-Johnson, Bruce D. Hammock, Aldrin Gomes
Summary: The study revealed that ibuprofen disrupts not only the COX pathway, but also the CYP450 and lipoxygenase pathways in male mice, generating sex-related differences in biologically active oxylipins. Increased sEH activity after ibuprofen treatment is likely to be one of the mechanisms by which the liver reduces the higher levels of EpODEs and EpETrEs.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Bozhil Robev, Ivan Iliev, Iana Tsoneva, Albena Momchilova, Alexandrina Nesheva, Aneliya Kostadinova, Galya Staneva, Biliana Nikolova
Summary: This study investigated the effects of Iscador Qu and Iscador M on various cellular processes in breast cancer cell lines. The results showed that Iscador Qu and M did not have any phototoxic effects. The antiproliferative activity of Iscador species was dose-dependent and varied among different cell lines based on their metastatic potential.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Chao-Ming Hung, Tai-Hsin Tsai, Kuan-Ting Lee, Yi-Chiang Hsu
Summary: Our research shows that sulforaphane (SFN) has chemopreventive and potential chemotherapeutic effects on breast adenocarcinoma. Further studies are needed to understand the mechanisms behind SFN's antitumor activity. Our experiments demonstrate that SFN inhibits the growth of cancer cells and induces apoptosis, suggesting it could be used as an anticancer agent.
Article
Virology
Julio Carrera, Alice M. Trenerry, Cameron P. Simmons, Jason M. Mackenzie
Summary: The uncontrollable spread of Zika virus in the Americas during 2015-2017 and its link to microcephaly in newborns and Guillain-Barre syndrome led to a global public health emergency declaration by WHO. The ability of Zika virus to pass the placental barrier to infect the fetus is a significant factor in the clinical presentation of congenital Zika syndrome. The study observed that West Nile strain Kunjin virus replicates at a greater rate and to higher titres than Zika virus in early-term placental cell lines.
Article
Oncology
Yuzhu Wang, Junjie Li, Goncalo Dias do Vale, Jaideep Chaudhary, Arnida Anwar, Jeffrey G. G. McDonald, Tao Qin, Hongwei Zhang, Ian R. R. Corbin
Summary: Repeated hepatic arterial delivery of LDL-DHA nanoparticles effectively inhibits the growth of hepatocellular carcinoma in a rat model. The treatment leads to tumor regression and is associated with increased levels of nuclear factor-kappa B and lipid peroxidation, as well as decreased glutathione peroxidase 4. This study highlights the potential of transarterial infusions of LDL-DHA nanoparticles for the treatment of liver cancer.
FRONTIERS IN ONCOLOGY
(2022)
Review
Nutrition & Dietetics
Mahsa Jalili, Azita Hekmatdoost
Summary: Ω-3 long-chain fatty acids play a crucial role in regulating inflammation and the immune system, especially in pathogen recognition and downstream signaling pathways. They may exert anti-inflammatory effects by influencing lipid rafts, modulating cytokines, and receptors, among other pathways.
Article
Plant Sciences
Esra Kongul Safak, Gokce Seker Karatoprak, Tuncay Dirmenci, Hayri Duman, Nurgun Kucukboyaci
Summary: This study investigated the phytochemical content and cytotoxic effects of 14 Nepeta taxa collected from Turkey on breast cancer cells. Certain species of Nepeta were found to suppress the growth of breast cancer cells, and this effect was correlated with the triterpene content.
Article
Biochemistry & Molecular Biology
Katherine Ellis, Rachael Wood
Summary: The objective of this study was to compare the invasiveness of three available endometriotic cell lines to cancer cell lines and assess consistency across different invasion assays. The results showed that the endometriotic cell lines exhibited similar invasiveness to the cancer cell lines and there were no significant differences. The expression of E-Cadherin declined in the invaded EEC12Z cells, supporting the hypothesis of epithelial-to-mesenchymal transition influencing the invasiveness of peritoneal endometriosis cell line.
Article
Oncology
Jakeb S. S. M. Petersen, Sarah K. Baird
Summary: The study compared the efficacy of anthelmintic drugs mebendazole and albendazole in breast and colon cancer cell lines, revealing their selective cancer cell killing ability through classical apoptosis and cell cycle arrest involving microtubule destabilization.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Xiao Han, Zhaohui Li, Ying Wen, Zhi Chen
Summary: Enhancing oxidative stress defense pathways through overexpression of TRXR, ALDH, GPO, and ZWF enzymes promotes cell growth, lipid yield, and DHA production in Schizochytrium sp. The engineered strain OaldH-gpo-trxR achieved significantly higher values for dry cell weight, lipid yield, and DHA production compared to the wild type strain. The findings demonstrate the effectiveness of engineering oxidative stress defense pathways in promoting lipid yield and DHA production in Schizochytrium.
BIOTECHNOLOGY FOR BIOFUELS
(2021)
Article
Cell Biology
Maria Caterina De Rosa, Mariella Caputo, Hylde Zirpoli, Tania Rescigno, Roberta Tarallo, Giorgio Giurato, Alessandro Weisz, Gaetano Torino, Mario Felice Tecce
JOURNAL OF CELLULAR PHYSIOLOGY
(2015)
Review
Endocrinology & Metabolism
Maurizio Montella, Giovanni D'Arena, Anna Crispo, Mario Capunzo, Flavia Nocerino, Maria Grimaldi, Antonio Barbieri, Anna Maria D'Ursi, Mario Felice Tecce, Alfonso Amore, Massimiliano Galdiero, Gennaro Ciliberto, Aldo Giudice
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2015)
Review
Cell Biology
Aldo Giudice, Giovanni D'Arena, Anna Crispo, Mario Felice Tecce, Flavia Nocerino, Maria Grimaldi, Emanuela Rotondo, Anna Maria D'Ursi, Mario Scrima, Massimiliano Galdiero, Gennaro Ciliberto, Mario Capunzo, Gianluigi Franci, Antonio Barbieri, Sabrina Bimonte, Maurizio Montella
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2016)
Article
Cell Biology
Tania Rescigno, Anna Capasso, Mario Felice Tecce
JOURNAL OF CELLULAR PHYSIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Mariella Caputo, Maria Caterina De Rosa, Tania Rescigno, Hylde Zirpoli, Antonio Vassallo, Nunziatina De Tommasi, Gaetano Torino, Mario Felice Tecce
CELL BIOCHEMISTRY AND FUNCTION
(2014)
Article
Biology
Mariella Caputo, Hylde Zirpoli, Maria Caterina De Rosa, Tania Rescigno, Francesco Chiadini, Antonio Scaglione, Claudia Stellato, Giorgio Giurato, Alessandro Weisz, Mario Felice Tecce, Bruno Bisceglia
ELECTROMAGNETIC BIOLOGY AND MEDICINE
(2014)
Article
Biochemistry & Molecular Biology
Hylde Zirpoli, Mariella Caputo, Antonio Carraturo, Gaetano Torino, Alessia Fazio, Mohamed Attya, Luca Rastrelli, Mario Felice Tecce
JOURNAL OF CELLULAR BIOCHEMISTRY
(2012)
Article
Cell Biology
Mariella Caputo, Hylde Zirpoli, Gaetano Torino, Mario Felice Tecce
JOURNAL OF CELLULAR PHYSIOLOGY
(2011)
Article
Multidisciplinary Sciences
Antonio Buonerba, Rosita Lapenta, Anna Donniacuo, Magda Licasale, Elena Vezzoli, Stefano Milione, Carmine Capacchione, Mario Felice Tecce, Andrea Falqui, Roberto Piacentini, Claudio Grassi, Alfonso Grassi
SCIENTIFIC REPORTS
(2020)
Article
Chemistry, Medicinal
Veronica Di Sarno, Gianluigi Lauro, Simona Musella, Tania Ciaglia, Vincenzo Vestuto, Marina Sala, Maria Carmina Scala, Gerardina Smaldone, Francesca Di Matteo, Sara Novi, Mario Felice Tecce, Ornella Moltedo, Giuseppe Bifulco, Pietro Campiglia, Isabel M. Gomez-Monterrey, Robert Snoeck, Graciela Andrei, Carmine Ostacolo, Alessia Bertamino
Summary: The COVID-19 pandemic caused by the SARS-CoV-2 pathogen has resulted in a major health-socio-economic disaster. Despite efforts in vaccine development, there is still a need for effective anti-SARS-CoV-2 therapeutics. This study describes the design of compounds as main protease inhibitors and identifies two compounds as inhibitors of SARS-CoV-2 replication, potentially offering new therapeutic options.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Daniela Carbone, Vincenzo Vestuto, Maria Rosalia Ferraro, Tania Ciaglia, Camilla Pecoraro, Eduardo Sommella, Stella Cascioferro, Emanuela Salviati, Sara Novi, Mario Felice Tecce, Giuseppina Amodio, Nunzio Iraci, Girolamo Cirrincione, Pietro Campiglia, Patrizia Diana, Alessia Bertamino, Barbara Parrino, Carmine Ostacolo
Summary: In this study, metabolomics was used to identify a new selective inhibitor of glutaminase-1 (GLS-1) with remarkable antitumor potency against different aggressive tumor cell lines. Molecular modeling provided new insights into drug-target interaction, offering clues for rational hit-to-lead development.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Simone Di Micco, Veronica Di Sarno, Martina Rossi, Vincenzo Vestuto, Takumi Konno, Sara Novi, Mario Felice Tecce, Valeria Napolitano, Tania Ciaglia, Andrea Vitale, Isabel Maria Gomez-Monterrey, Giuseppe Bifulco, Alessia Bertamino, Carmine Ostacolo, Paolo Blasi, Alessio Fasano, Pietro Campiglia, Simona Musella
Summary: Different mechanisms contribute to cancer multidrug resistance, including increased drug efflux, enhanced cellular repair mechanisms, and alterations of drug metabolism or targets. ABCG2, a transporter protein, promotes drug efflux and causes chemotherapeutic resistance in malignant cells. Through a multidisciplinary approach, a new selective inhibitor (8) of ABCG2 has been identified, which effectively improves the cytotoxicity of mitoxantrone in hepatocellular carcinoma and transfected breast cancer cell lines. This inhibitor also demonstrates its efficacy in reversing multidrug resistance with the overexpression of the ABCG2 pump.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Sara Novi, Vincenzo Vestuto, Pietro Campiglia, Nicola Tecce, Alessia Bertamino, Mario Felice Tecce
Summary: Alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) are major causes of chronic liver disease worldwide. Both conditions lead to liver damage, inflammation, and a vicious cycle of ongoing damage and progression. Anti-angiogenic therapy has shown potential in treating these liver disorders and preventing their exacerbation. This review focuses on the role of natural anti-angiogenic compounds in steatohepatitis and their therapeutic benefits in diet-induced liver inflammation.
Review
Gastroenterology & Hepatology
Aldo Giudice, Anna Crispo, Galdiero Massimiliano, Giovanni D'Arena, Mario Felice Tecce, Maria Grimaldi, Alfonso Amore, Emanuela Esposito, Maurizio Montella
JOURNAL OF GASTROINTESTINAL AND LIVER DISEASES
(2014)