Regulation of mTORC1 by growth factors, energy status, amino acids and mechanical stimuli at a glance

The effect of a decaffeinated green tea extract formula on fat oxidation, body composition and exercise performance

(2015) Justin D Roberts et al.   Journal of the International Society of Sports Nutrition

Extracellular Signal–Regulated Kinase–Mammalian Target of Rapamycin Signaling and Forkhead-Box Transcription Factor 3a Phosphorylation Are Involved in Testosterone’s Effect on Severe Burn Injury in a Rat Model

(2015) Li Ma et al.   SHOCK

Expanding roles for AMPK in skeletal muscle plasticity

(2015) Rémi Mounier et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Skeletal muscle atrophy and the E3 ubiquitin ligases MuRF1 and MAFbx/atrogin-1

(2014) Sue C. Bodine et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Effects of betaine on performance and body composition: a review of recent findings and potential mechanisms

(2014) Jason M. Cholewa et al.   AMINO ACIDS

Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome

(2014) Suchithra Menon et al.   CELL

Myostatin and the skeletal muscle atrophy and hypertrophy signaling pathways

(2014) J. Rodriguez et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Ursolic Acid-Induced Elevation of Serum Irisin Augments Muscle Strength During Resistance Training in Men

(2014) Hyun Seok Bang et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Disintegration of wheat aleurone structure has an impact on the bioavailability of phenolic compounds and other phytochemicals as evidenced by altered urinary metabolite profile of diet-induced obese mice

(2014) Jenna Pekkinen et al.   Nutrition & Metabolism

β-Hydroxy-β-methylbutyrate facilitates PI3K/Akt-dependent mammalian target of rapamycin and FoxO1/3a phosphorylations and alleviates tumor necrosis factor α/interferon γ–induced MuRF-1 expression in C2C12 cells

(2014) Kaoru Kimura et al.   NUTRITION RESEARCH

Growing knowledge of the mTOR signaling network

(2014) Kezhen Huang et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Regulation of mTORC1 by amino acids

(2014) Liron Bar-Peled et al.   TRENDS IN CELL BIOLOGY

The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1

(2014) Lynne Chantranupong et al.   Cell Reports

Ursolic acid stimulates mTORC1 signaling after resistance exercise in rat skeletal muscle

(2013) Riki Ogasawara et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Chronic α-hydroxyisocaproic acid treatment improves muscle recovery after immobilization-induced atrophy

(2013) Charles H. Lang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

FoxO transcription factors: their roles in the maintenance of skeletal muscle homeostasis

(2013) Anthony M. J. Sanchez et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Myostatin signaling regulates Akt activity via the regulation of miR-486 expression

(2013) Keisuke Hitachi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Role of Diacylglycerol Kinase ζ and Phosphatidic Acid in the Mechanical Activation of Mammalian Target of Rapamycin (mTOR) Signaling and Skeletal Muscle Hypertrophy

(2013) Jae-Sung You et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Eccentric contractions increase the phosphorylation of tuberous sclerosis complex-2 (TSC2) and alter the targeting of TSC2 and the mechanistic target of rapamycin to the lysosome

(2013) Brittany L. Jacobs et al.   JOURNAL OF PHYSIOLOGY-LONDON

Effects of betaine on body composition, performance, and homocysteine thiolactone

(2013) Jason M Cholewa et al.   Journal of the International Society of Sports Nutrition

International Society of Sports Nutrition Position Stand: beta-hydroxy-beta-methylbutyrate (HMB)

(2013) Jacob M Wilson et al.   Journal of the International Society of Sports Nutrition

Betaine supplement enhances skeletal muscle differentiation in murine myoblasts via IGF-1 signaling activation

(2013) Pamela Senesi et al.   Journal of Translational Medicine

Testosterone Signals through mTOR and Androgen Receptor to Induce Muscle Hypertrophy

(2013) CARLA BASUALTO-ALARCÓN et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1

(2013) Zhi-Yang Tsun et al.   MOLECULAR CELL

Signal integration by mTORC1 coordinates nutrient input with biosynthetic output

(2013) Christian C. Dibble et al.   NATURE CELL BIOLOGY

A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1

(2013) L. Bar-Peled et al.   SCIENCE

Nutrient signaling to mTOR and cell growth

(2013) Jenna L. Jewell et al.   TRENDS IN BIOCHEMICAL SCIENCES

Phosphatidic acid and lipid-sensing by mTOR

(2013) David A. Foster   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Role of PRAS40 in Akt and mTOR signaling in health and disease

(2012) Claudia Wiza et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

mTORC1 and the regulation of skeletal muscle anabolism and mass

(2012) Olasunkanmi A.J. Adegoke et al.   Applied Physiology Nutrition and Metabolism

Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1

(2012) Liron Bar-Peled et al.   CELL

Leucyl-tRNA Synthetase Is an Intracellular Leucine Sensor for the mTORC1-Signaling Pathway

(2012) Jung Min Han et al.   CELL

Betaine supplementation enhances anabolic endocrine and Akt signaling in response to acute bouts of exercise

(2012) Jenna M. Apicella et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Testosterone regulation of Akt/mTORC1/FoxO3a signaling in skeletal muscle

(2012) James P. White et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1

(2012) Christian C. Dibble et al.   MOLECULAR CELL

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks

(2011) Brian Magnuson et al.   BIOCHEMICAL JOURNAL

Akt, FoxO and regulation of apoptosis

(2011) Xinbo Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Antagonistic control of muscle cell size by AMPK and mTORC1

(2011) Rémi Mounier et al.   CELL CYCLE

mRNA Expression Signatures of Human Skeletal Muscle Atrophy Identify a Natural Compound that Increases Muscle Mass

(2011) Steven D. Kunkel et al.   Cell Metabolism

Mechanotransduction and the regulation of mTORC1 signaling in skeletal muscle

(2011) Troy A. Hornberger   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Phosphatidic Acid Activates Mammalian Target of Rapamycin Complex 1 (mTORC1) Kinase by Displacing FK506 Binding Protein 38 (FKBP38) and Exerting an Allosteric Effect

(2011) Mee-Sup Yoon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Post-translational modification of the androgen receptor

(2011) Daniel Gioeli et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

β-Hydroxy-β-methylbutyrate (HMβ) supplementation stimulates skeletal muscle hypertrophy in rats via the mTOR pathway

(2011) Gustavo D Pimentel et al.   Nutrition & Metabolism

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

Voluntary running, skeletal muscle gene expression, and signaling inversely regulated by orchidectomy and testosterone replacement

(2010) Chikwendu Ibebunjo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Testosterone-induced hypertrophy of L6 myoblasts is dependent upon Erk and mTOR

(2010) Yong Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Effects of a Novel Selective Androgen Receptor Modulator on Dexamethasone-Induced and Hypogonadism-Induced Muscle Atrophy

(2010) Amanda Jones et al.   ENDOCRINOLOGY

Testosterone modulates gene expression pathways regulating nutrient accumulation, glucose metabolism and protein turnover in mouse skeletal muscle

(2010) M. T. Haren et al.   INTERNATIONAL JOURNAL OF ANDROLOGY

GPRC6A Mediates the Non-genomic Effects of Steroids

(2010) Min Pi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Akt/protein kinase B in skeletal muscle physiology and pathology

(2010) Miaozong Wu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Examination of the efficacy of acute L-alanyl-L-glutamine ingestion during hydration stress in endurance exercise

(2010) Jay R Hoffman et al.   Journal of the International Society of Sports Nutrition

Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size

(2009) Anne Ulrike Trendelenburg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

(2009) Nahum Sonenberg et al.   CELL

The Glycogen-Binding Domain on the AMPK β Subunit Allows the Kinase to Act as a Glycogen Sensor

(2009) Andrew McBride et al.   Cell Metabolism

Effect of nandrolone decanoate administration on recovery from bupivacaine-induced muscle injury

(2009) James P. White et al.   JOURNAL OF APPLIED PHYSIOLOGY

Effects of oral creatine and resistance training on serum myostatin and GASP-1

(2009) A. Saremi et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Molecular mechanisms of mTOR-mediated translational control

(2009) Xiaoju Max Ma et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of Signaling Pathways Downstream of IGF-I/Insulin by Androgen in Skeletal Muscle of Glucocorticoid-Treated Rats

(2009) Hui-Nan Yin et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE

Androgen replacement therapy improves function in male rat muscles independently of hypertrophy and activation of the Akt/mTOR pathway

(2008) C. Hourdé et al.   Acta Physiologica

Regulation of muscle mass by growth hormone and IGF-I

(2008) C P Velloso   BRITISH JOURNAL OF PHARMACOLOGY

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE

Non-genomic actions of androgens

(2007) C.D. Foradori et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Effects of resistance exercise with and without creatine supplementation on gene expression and cell signaling in human skeletal muscle

(2007) Louise Deldicque et al.   JOURNAL OF APPLIED PHYSIOLOGY