MECHANISMS IN ENDOCRINOLOGY: Alternative splicing: the new frontier in diabetes research

Regulation of Alternative Splicing Through Coupling with Transcription and Chromatin Structure

(2015) Shiran Naftelberg et al.   Annual Review of Biochemistry

Mechanisms and Regulation of Alternative Pre-mRNA Splicing

(2015) Yeon Lee et al.   Annual Review of Biochemistry

Functional Splicing Network Reveals Extensive Regulatory Potential of the Core Spliceosomal Machinery

(2015) Panagiotis Papasaikas et al.   MOLECULAR CELL

Alternative Splicing in the Mammalian Nervous System: Recent Insights into Mechanisms and Functional Roles

(2015) Bushra Raj et al.   NEURON

Systematic discovery of regulated and conserved alternative exons in the mammalian brain reveals NMD modulating chromatin regulators

(2015) Qinghong Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The human transcriptome across tissues and individuals

(2015) M. Mele et al.   SCIENCE

Building Robust Transcriptomes with Master Splicing Factors

(2014) Mohini Jangi et al.   CELL

Inflammation and Hyperglycemia MediateDeaf1Splicing in the Pancreatic Lymph Nodes via Distinct Pathways During Type 1 Diabetes

(2014) Linda Yip et al.   DIABETES

Type 1 diabetes in mice and men: gene expression profiling to investigate disease pathogenesis

(2014) Linda Yip et al.   IMMUNOLOGIC RESEARCH

Towards Understanding RNA-Mediated Neurological Disorders

(2014) Ranhui Duan et al.   Journal of Genetics and Genomics

Nova1 is a master regulator of alternative splicing in pancreatic beta cells

(2014) Olatz Villate et al.   NUCLEIC ACIDS RESEARCH

RNA-Seq Gene Profiling - A Systematic Empirical Comparison

(2014) Nuno A. Fonseca et al.   PLoS One

Alternative Splice Forms of CTLA-4 Induced by Antisense Mediated Splice-Switching Influences Autoimmune Diabetes Susceptibility in NOD Mice

(2014) Dan V. Mourich et al.   Nucleic Acid Therapeutics

HITS-CLIP and Integrative Modeling Define the Rbfox Splicing-Regulatory Network Linked to Brain Development and Autism

(2014) Sebastien M. Weyn-Vanhentenryck et al.   Cell Reports

A comparison of methods for differential expression analysis of RNA-seq data

(2013) Charlotte Soneson et al.   BMC BIOINFORMATICS

Progress in immune-based therapies for type 1 diabetes

(2013) M. von Herrath et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

RNA Sequencing Identifies Dysregulation of the Human Pancreatic Islet Transcriptome by the Saturated Fatty Acid Palmitate

(2013) Miriam Cnop et al.   DIABETES

Candidate genes for type 1 diabetes modulate pancreatic islet inflammation andβ-cell apoptosis

(2013) I. Santin et al.   DIABETES OBESITY & METABOLISM

Zinc-induced modulation of SRSF6 activity alters Bim splicing to promote generation of the most potent apoptotic isoform BimS

(2013) Hirokazu Hara et al.   FEBS Journal

Differential expression of alternative splice variants of CTLA4 in Kuwaiti autoimmune disease patients

(2013) Suad AlFadhli et al.   GENE

Regulation of gene expression in mammalian nervous system through alternative pre-mRNA splicing coupled with RNA quality control mechanisms

(2013) Karen Yap et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Genome-wide probing of RNA structure reveals active unfolding of mRNA structures in vivo

(2013) Silvi Rouskin et al.   NATURE

SON connects the splicing-regulatory network with pluripotency in human embryonic stem cells

(2013) Xinyi Lu et al.   NATURE CELL BIOLOGY

Systematic evaluation of spliced alignment programs for RNA-seq data

(2013) Pär G Engström et al.   NATURE METHODS

GLIS3, a Susceptibility Gene for Type 1 and Type 2 Diabetes, Modulates Pancreatic Beta Cell Apoptosis via Regulation of a Splice Variant of the BH3-Only Protein Bim

(2013) Tatiane C. Nogueira et al.   PLoS Genetics

Targeting RNA splicing for disease therapy

(2013) Mallory A. Havens et al.   Wiley Interdisciplinary Reviews-RNA

Tau alternative splicing in familial and sporadic tauopathies

(2012) Michael Niblock et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Transcriptional elongation and alternative splicing

(2012) Gwendal Dujardin et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Efficient experimental design and analysis strategies for the detection of differential expression using RNA-Sequencing

(2012) José A Robles et al.   BMC GENOMICS

Splice Modulating Therapies for Human Disease

(2012) Pietro Spitali et al.   CELL

Alternative splicing of Bim and Erk-mediated BimEL phosphorylation are dispensable for hematopoietic homeostasis in vivo

(2012) C Clybouw et al.   CELL DEATH AND DIFFERENTIATION

Alternative splicing: decoding an expansive regulatory layer

(2012) Manuel Irimia et al.   CURRENT OPINION IN CELL BIOLOGY

Identification of Novel Type 1 Diabetes Candidate Genes by Integrating Genome-Wide Association Data, Protein-Protein Interactions, and Human Pancreatic Islet Gene Expression

(2012) R. Bergholdt et al.   DIABETES

Primary and secondary prevention of Type 1 diabetes

(2012) J. S. Skyler   DIABETIC MEDICINE

Function of alternative splicing

(2012) Olga Kelemen et al.   GENE

A comprehensive comparison of RNA-Seq-based transcriptome analysis from reads to differential gene expression and cross-comparison with microarrays: a case study in Saccharomyces cerevisiae

(2012) Intawat Nookaew et al.   NUCLEIC ACIDS RESEARCH

A Comprehensive Evaluation of Alignment Algorithms in the Context of RNA-Seq

(2012) Robert Lindner et al.   PLoS One

Alternative splicing networks regulated by signaling in human T cells

(2012) N. M. Martinez et al.   RNA

The Evolutionary Landscape of Alternative Splicing in Vertebrate Species

(2012) N. L. Barbosa-Morais et al.   SCIENCE

Reduced DEAF1 function during type 1 diabetes inhibits translation in lymph node stromal cells by suppressing Eif4g3

(2012) Linda Yip et al.   Journal of Molecular Cell Biology

The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines

(2012) Décio L. Eizirik et al.   PLoS Genetics

Dysfunctional gene splicing as a potential contributor to neuropsychiatric disorders

(2011) Stephen J. Glatt et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Bayesian prediction of tissue-regulated splicing using RNA sequence and cellular context

(2011) Hui Yuan Xiong et al.   BIOINFORMATICS

Microarrays, deep sequencing and the true measure of the transcriptome

(2011) John H Malone et al.   BMC BIOLOGY

Genetics of the HLA Region in the Prediction of Type 1 Diabetes

(2011) Janelle A. Noble et al.   Current Diabetes Reports

RNA structure and the mechanisms of alternative splicing

(2011) C Joel McManus et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Peripheral and Islet Interleukin-17 Pathway Activation Characterizes Human Autoimmune Diabetes and Promotes Cytokine-Mediated  -Cell Death

(2011) S. Arif et al.   DIABETES

The Soluble CTLA-4 Splice Variant Protects From Type 1 Diabetes and Potentiates Regulatory T-Cell Function

(2011) K. D. Gerold et al.   DIABETES

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Pancreatic  -Cell Apoptosis via Regulation of the BH3-Only Protein Bim

(2011) I. Santin et al.   DIABETES

Pervasive haplotypic variation in the spliceo-transcriptome of the human major histocompatibility complex

(2011) C. Vandiedonck et al.   GENOME RESEARCH

Immune intervention for type 1 diabetes mellitus

(2011) J. S. Skyler   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Cytokines Tumor Necrosis Factor-α and Interferon-γ Induce Pancreatic β-Cell Apoptosis through STAT1-mediated Bim Protein Activation

(2011) Jenny Barthson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteins Associated with the Exon Junction Complex Also Control the Alternative Splicing of Apoptotic Regulators

(2011) L. Michelle et al.   MOLECULAR AND CELLULAR BIOLOGY

TCERG1 Regulates Alternative Splicing of the Bcl-x Gene by Modulating the Rate of RNA Polymerase II Transcription

(2011) M. Montes et al.   MOLECULAR AND CELLULAR BIOLOGY

Functional consequences of developmentally regulated alternative splicing

(2011) Auinash Kalsotra et al.   NATURE REVIEWS GENETICS

Understanding type 1 diabetes through genetics: advances and prospects

(2011) Constantin Polychronakos et al.   NATURE REVIEWS GENETICS

Next-generation transcriptome assembly

(2011) Jeffrey A. Martin et al.   NATURE REVIEWS GENETICS

Using positional distribution to identify splicing elements and predict pre-mRNA processing defects in human genes

(2011) K. H. Lim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bcl-2 proteins in diabetes: mitochondrial pathways of β-cell death and dysfunction

(2011) Esteban N. Gurzov et al.   TRENDS IN CELL BIOLOGY

An Alternative Splicing Network Links Cell-Cycle Control to Apoptosis

(2010) Michael J. Moore et al.   CELL

Mcl-1 downregulation by pro-inflammatory cytokines and palmitate is an early event contributing to β-cell apoptosis

(2010) F Allagnat et al.   CELL DEATH AND DIFFERENTIATION

How thymic antigen presenting cells sample the body's self-antigens

(2010) Jens Derbinski et al.   CURRENT OPINION IN IMMUNOLOGY

Identification of New Pancreatic Beta Cell Targets for In Vivo Imaging by a Systems Biology Approach

(2010) Thomas Bouckenooghe et al.   CURRENT PHARMACEUTICAL DESIGN

Etiology of Type 1 Diabetes

(2010) John A. Todd   IMMUNITY

Prediction and Pathogenesis in Type 1 Diabetes

(2010) Anette-G. Ziegler et al.   IMMUNITY

STAT1 Is a Master Regulator of Pancreatic β-Cell Apoptosis and Islet Inflammation

(2010) Fabrice Moore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differences in exon expression and alternatively spliced genes in blood of multiple sclerosis compared to healthy control subjects

(2010) Yingfang Tian et al.   JOURNAL OF NEUROIMMUNOLOGY

Deciphering the splicing code

(2010) Yoseph Barash et al.   NATURE

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

(2010) Josée Dupuis et al.   NATURE GENETICS

iCLIP reveals the function of hnRNP particles in splicing at individual nucleotide resolution

(2010) Julian König et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Global regulation of alternative splicing during myogenic differentiation

(2010) Christopher S. Bland et al.   NUCLEIC ACIDS RESEARCH

Alternative splicing in multiple sclerosis and other autoimmune diseases

(2010) Irina Evsyukova et al.   RNA Biology

Competing RNA secondary structures are required for mutually exclusive splicing of the Dscam exon 6 cluster

(2010) G. E. May et al.   RNA

Regulation of Alternative Splicing by Histone Modifications

(2010) R. F. Luco et al.   SCIENCE

PAR-CliP - A Method to Identify Transcriptome-wide the Binding Sites of RNA Binding Proteins

(2010) Markus Hafner et al.   Jove-Journal of Visualized Experiments

Beta cell apoptosis in diabetes

(2009) Helen E. Thomas et al.   APOPTOSIS

Regulation of Vertebrate Nervous System Alternative Splicing and Development by an SR-Related Protein

(2009) John A. Calarco et al.   CELL

The Spliceosome: Design Principles of a Dynamic RNP Machine

(2009) Markus C. Wahl et al.   CELL

Cytokines Interleukin-1  and Tumor Necrosis Factor-  Regulate Different Transcriptional and Alternative Splicing Networks in Primary  -Cells

(2009) F. Ortis et al.   DIABETES

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Interferon- -Induced Pancreatic  -Cell Apoptosis

(2009) F. Moore et al.   DIABETES

Current-generation high-throughput sequencing: deepening insights into mammalian transcriptomes

(2009) B. J. Blencowe et al.   GENES & DEVELOPMENT

Incidence trends for childhood type 1 diabetes in Europe during 1989–2003 and predicted new cases 2005–20: a multicentre prospective registration study

(2009) Christopher C Patterson et al.   LANCET

Transcription Factor Glis3, a Novel Critical Player in the Regulation of Pancreatic  -Cell Development and Insulin Gene Expression

(2009) H. S. Kang et al.   MOLECULAR AND CELLULAR BIOLOGY

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

(2009) Jeffrey C Barrett et al.   NATURE GENETICS

The role of inflammation in insulitis and β-cell loss in type 1 diabetes

(2009) Décio L. Eizirik et al.   Nature Reviews Endocrinology

RNA processing and its regulation: global insights into biological networks

(2009) Donny D. Licatalosi et al.   NATURE REVIEWS GENETICS

Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches

(2009) Mo Chen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Global analysis of alternative splicing regulation by insulin and wingless signaling in Drosophila cells

(2009) Britta Hartmann et al.   GENOME BIOLOGY

Identification of CTLA-4 isoforms produced by alternative splicing and their association with myasthenia gravis

(2008) Ming Gu et al.   CLINICAL IMMUNOLOGY

RNA-seq: An assessment of technical reproducibility and comparison with gene expression arrays

(2008) J. C. Marioni et al.   GENOME RESEARCH

Alternative isoform regulation in human tissue transcriptomes

(2008) Eric T. Wang et al.   NATURE

Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus

(2008) Sergey V Kozyrev et al.   NATURE GENETICS

Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing

(2008) Qun Pan et al.   NATURE GENETICS

Ectopic expression of peripheral-tissue antigens in the thymic epithelium: Probabilistic, monoallelic, misinitiated

(2008) J. Villasenor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA