MECHANISMS IN ENDOCRINOLOGY: Alternative splicing: the new frontier in diabetes research
出版年份 2015 全文链接
标题
MECHANISMS IN ENDOCRINOLOGY: Alternative splicing: the new frontier in diabetes research
作者
关键词
-
出版物
EUROPEAN JOURNAL OF ENDOCRINOLOGY
Volume 174, Issue 5, Pages R225-R238
出版商
Bioscientifica
发表日期
2016-03-11
DOI
10.1530/eje-15-0916
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Regulation of Alternative Splicing Through Coupling with Transcription and Chromatin Structure
- (2015) Shiran Naftelberg et al. Annual Review of Biochemistry
- Mechanisms and Regulation of Alternative Pre-mRNA Splicing
- (2015) Yeon Lee et al. Annual Review of Biochemistry
- Functional Splicing Network Reveals Extensive Regulatory Potential of the Core Spliceosomal Machinery
- (2015) Panagiotis Papasaikas et al. MOLECULAR CELL
- Alternative Splicing in the Mammalian Nervous System: Recent Insights into Mechanisms and Functional Roles
- (2015) Bushra Raj et al. NEURON
- Systematic discovery of regulated and conserved alternative exons in the mammalian brain reveals NMD modulating chromatin regulators
- (2015) Qinghong Yan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The human transcriptome across tissues and individuals
- (2015) M. Mele et al. SCIENCE
- Building Robust Transcriptomes with Master Splicing Factors
- (2014) Mohini Jangi et al. CELL
- Inflammation and Hyperglycemia MediateDeaf1Splicing in the Pancreatic Lymph Nodes via Distinct Pathways During Type 1 Diabetes
- (2014) Linda Yip et al. DIABETES
- Type 1 diabetes in mice and men: gene expression profiling to investigate disease pathogenesis
- (2014) Linda Yip et al. IMMUNOLOGIC RESEARCH
- Towards Understanding RNA-Mediated Neurological Disorders
- (2014) Ranhui Duan et al. Journal of Genetics and Genomics
- Nova1 is a master regulator of alternative splicing in pancreatic beta cells
- (2014) Olatz Villate et al. NUCLEIC ACIDS RESEARCH
- RNA-Seq Gene Profiling - A Systematic Empirical Comparison
- (2014) Nuno A. Fonseca et al. PLoS One
- Alternative Splice Forms of CTLA-4 Induced by Antisense Mediated Splice-Switching Influences Autoimmune Diabetes Susceptibility in NOD Mice
- (2014) Dan V. Mourich et al. Nucleic Acid Therapeutics
- HITS-CLIP and Integrative Modeling Define the Rbfox Splicing-Regulatory Network Linked to Brain Development and Autism
- (2014) Sebastien M. Weyn-Vanhentenryck et al. Cell Reports
- A comparison of methods for differential expression analysis of RNA-seq data
- (2013) Charlotte Soneson et al. BMC BIOINFORMATICS
- Progress in immune-based therapies for type 1 diabetes
- (2013) M. von Herrath et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- RNA Sequencing Identifies Dysregulation of the Human Pancreatic Islet Transcriptome by the Saturated Fatty Acid Palmitate
- (2013) Miriam Cnop et al. DIABETES
- Candidate genes for type 1 diabetes modulate pancreatic islet inflammation andβ-cell apoptosis
- (2013) I. Santin et al. DIABETES OBESITY & METABOLISM
- Zinc-induced modulation of SRSF6 activity alters Bim splicing to promote generation of the most potent apoptotic isoform BimS
- (2013) Hirokazu Hara et al. FEBS Journal
- Differential expression of alternative splice variants of CTLA4 in Kuwaiti autoimmune disease patients
- (2013) Suad AlFadhli et al. GENE
- Regulation of gene expression in mammalian nervous system through alternative pre-mRNA splicing coupled with RNA quality control mechanisms
- (2013) Karen Yap et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Genome-wide probing of RNA structure reveals active unfolding of mRNA structures in vivo
- (2013) Silvi Rouskin et al. NATURE
- SON connects the splicing-regulatory network with pluripotency in human embryonic stem cells
- (2013) Xinyi Lu et al. NATURE CELL BIOLOGY
- Systematic evaluation of spliced alignment programs for RNA-seq data
- (2013) Pär G Engström et al. NATURE METHODS
- GLIS3, a Susceptibility Gene for Type 1 and Type 2 Diabetes, Modulates Pancreatic Beta Cell Apoptosis via Regulation of a Splice Variant of the BH3-Only Protein Bim
- (2013) Tatiane C. Nogueira et al. PLoS Genetics
- Targeting RNA splicing for disease therapy
- (2013) Mallory A. Havens et al. Wiley Interdisciplinary Reviews-RNA
- Tau alternative splicing in familial and sporadic tauopathies
- (2012) Michael Niblock et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Transcriptional elongation and alternative splicing
- (2012) Gwendal Dujardin et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- Efficient experimental design and analysis strategies for the detection of differential expression using RNA-Sequencing
- (2012) José A Robles et al. BMC GENOMICS
- Splice Modulating Therapies for Human Disease
- (2012) Pietro Spitali et al. CELL
- Alternative splicing of Bim and Erk-mediated BimEL phosphorylation are dispensable for hematopoietic homeostasis in vivo
- (2012) C Clybouw et al. CELL DEATH AND DIFFERENTIATION
- Alternative splicing: decoding an expansive regulatory layer
- (2012) Manuel Irimia et al. CURRENT OPINION IN CELL BIOLOGY
- Identification of Novel Type 1 Diabetes Candidate Genes by Integrating Genome-Wide Association Data, Protein-Protein Interactions, and Human Pancreatic Islet Gene Expression
- (2012) R. Bergholdt et al. DIABETES
- Primary and secondary prevention of Type 1 diabetes
- (2012) J. S. Skyler DIABETIC MEDICINE
- Function of alternative splicing
- (2012) Olga Kelemen et al. GENE
- A comprehensive comparison of RNA-Seq-based transcriptome analysis from reads to differential gene expression and cross-comparison with microarrays: a case study in Saccharomyces cerevisiae
- (2012) Intawat Nookaew et al. NUCLEIC ACIDS RESEARCH
- A Comprehensive Evaluation of Alignment Algorithms in the Context of RNA-Seq
- (2012) Robert Lindner et al. PLoS One
- Alternative splicing networks regulated by signaling in human T cells
- (2012) N. M. Martinez et al. RNA
- The Evolutionary Landscape of Alternative Splicing in Vertebrate Species
- (2012) N. L. Barbosa-Morais et al. SCIENCE
- Reduced DEAF1 function during type 1 diabetes inhibits translation in lymph node stromal cells by suppressing Eif4g3
- (2012) Linda Yip et al. Journal of Molecular Cell Biology
- The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines
- (2012) Décio L. Eizirik et al. PLoS Genetics
- Dysfunctional gene splicing as a potential contributor to neuropsychiatric disorders
- (2011) Stephen J. Glatt et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
- Bayesian prediction of tissue-regulated splicing using RNA sequence and cellular context
- (2011) Hui Yuan Xiong et al. BIOINFORMATICS
- Microarrays, deep sequencing and the true measure of the transcriptome
- (2011) John H Malone et al. BMC BIOLOGY
- Genetics of the HLA Region in the Prediction of Type 1 Diabetes
- (2011) Janelle A. Noble et al. Current Diabetes Reports
- RNA structure and the mechanisms of alternative splicing
- (2011) C Joel McManus et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- Peripheral and Islet Interleukin-17 Pathway Activation Characterizes Human Autoimmune Diabetes and Promotes Cytokine-Mediated -Cell Death
- (2011) S. Arif et al. DIABETES
- The Soluble CTLA-4 Splice Variant Protects From Type 1 Diabetes and Potentiates Regulatory T-Cell Function
- (2011) K. D. Gerold et al. DIABETES
- PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Pancreatic -Cell Apoptosis via Regulation of the BH3-Only Protein Bim
- (2011) I. Santin et al. DIABETES
- Pervasive haplotypic variation in the spliceo-transcriptome of the human major histocompatibility complex
- (2011) C. Vandiedonck et al. GENOME RESEARCH
- Immune intervention for type 1 diabetes mellitus
- (2011) J. S. Skyler INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
- Cytokines Tumor Necrosis Factor-α and Interferon-γ Induce Pancreatic β-Cell Apoptosis through STAT1-mediated Bim Protein Activation
- (2011) Jenny Barthson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Proteins Associated with the Exon Junction Complex Also Control the Alternative Splicing of Apoptotic Regulators
- (2011) L. Michelle et al. MOLECULAR AND CELLULAR BIOLOGY
- TCERG1 Regulates Alternative Splicing of the Bcl-x Gene by Modulating the Rate of RNA Polymerase II Transcription
- (2011) M. Montes et al. MOLECULAR AND CELLULAR BIOLOGY
- Functional consequences of developmentally regulated alternative splicing
- (2011) Auinash Kalsotra et al. NATURE REVIEWS GENETICS
- Understanding type 1 diabetes through genetics: advances and prospects
- (2011) Constantin Polychronakos et al. NATURE REVIEWS GENETICS
- Next-generation transcriptome assembly
- (2011) Jeffrey A. Martin et al. NATURE REVIEWS GENETICS
- Using positional distribution to identify splicing elements and predict pre-mRNA processing defects in human genes
- (2011) K. H. Lim et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Bcl-2 proteins in diabetes: mitochondrial pathways of β-cell death and dysfunction
- (2011) Esteban N. Gurzov et al. TRENDS IN CELL BIOLOGY
- An Alternative Splicing Network Links Cell-Cycle Control to Apoptosis
- (2010) Michael J. Moore et al. CELL
- Mcl-1 downregulation by pro-inflammatory cytokines and palmitate is an early event contributing to β-cell apoptosis
- (2010) F Allagnat et al. CELL DEATH AND DIFFERENTIATION
- How thymic antigen presenting cells sample the body's self-antigens
- (2010) Jens Derbinski et al. CURRENT OPINION IN IMMUNOLOGY
- Identification of New Pancreatic Beta Cell Targets for In Vivo Imaging by a Systems Biology Approach
- (2010) Thomas Bouckenooghe et al. CURRENT PHARMACEUTICAL DESIGN
- Etiology of Type 1 Diabetes
- (2010) John A. Todd IMMUNITY
- Prediction and Pathogenesis in Type 1 Diabetes
- (2010) Anette-G. Ziegler et al. IMMUNITY
- STAT1 Is a Master Regulator of Pancreatic β-Cell Apoptosis and Islet Inflammation
- (2010) Fabrice Moore et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Differences in exon expression and alternatively spliced genes in blood of multiple sclerosis compared to healthy control subjects
- (2010) Yingfang Tian et al. JOURNAL OF NEUROIMMUNOLOGY
- Deciphering the splicing code
- (2010) Yoseph Barash et al. NATURE
- New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
- (2010) Josée Dupuis et al. NATURE GENETICS
- iCLIP reveals the function of hnRNP particles in splicing at individual nucleotide resolution
- (2010) Julian König et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Global regulation of alternative splicing during myogenic differentiation
- (2010) Christopher S. Bland et al. NUCLEIC ACIDS RESEARCH
- Alternative splicing in multiple sclerosis and other autoimmune diseases
- (2010) Irina Evsyukova et al. RNA Biology
- Competing RNA secondary structures are required for mutually exclusive splicing of the Dscam exon 6 cluster
- (2010) G. E. May et al. RNA
- Regulation of Alternative Splicing by Histone Modifications
- (2010) R. F. Luco et al. SCIENCE
- PAR-CliP - A Method to Identify Transcriptome-wide the Binding Sites of RNA Binding Proteins
- (2010) Markus Hafner et al. Jove-Journal of Visualized Experiments
- Beta cell apoptosis in diabetes
- (2009) Helen E. Thomas et al. APOPTOSIS
- Regulation of Vertebrate Nervous System Alternative Splicing and Development by an SR-Related Protein
- (2009) John A. Calarco et al. CELL
- The Spliceosome: Design Principles of a Dynamic RNP Machine
- (2009) Markus C. Wahl et al. CELL
- Cytokines Interleukin-1 and Tumor Necrosis Factor- Regulate Different Transcriptional and Alternative Splicing Networks in Primary -Cells
- (2009) F. Ortis et al. DIABETES
- PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Interferon- -Induced Pancreatic -Cell Apoptosis
- (2009) F. Moore et al. DIABETES
- Current-generation high-throughput sequencing: deepening insights into mammalian transcriptomes
- (2009) B. J. Blencowe et al. GENES & DEVELOPMENT
- Incidence trends for childhood type 1 diabetes in Europe during 1989–2003 and predicted new cases 2005–20: a multicentre prospective registration study
- (2009) Christopher C Patterson et al. LANCET
- Transcription Factor Glis3, a Novel Critical Player in the Regulation of Pancreatic -Cell Development and Insulin Gene Expression
- (2009) H. S. Kang et al. MOLECULAR AND CELLULAR BIOLOGY
- Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
- (2009) Jeffrey C Barrett et al. NATURE GENETICS
- The role of inflammation in insulitis and β-cell loss in type 1 diabetes
- (2009) Décio L. Eizirik et al. Nature Reviews Endocrinology
- RNA processing and its regulation: global insights into biological networks
- (2009) Donny D. Licatalosi et al. NATURE REVIEWS GENETICS
- Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches
- (2009) Mo Chen et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Global analysis of alternative splicing regulation by insulin and wingless signaling in Drosophila cells
- (2009) Britta Hartmann et al. GENOME BIOLOGY
- Identification of CTLA-4 isoforms produced by alternative splicing and their association with myasthenia gravis
- (2008) Ming Gu et al. CLINICAL IMMUNOLOGY
- RNA-seq: An assessment of technical reproducibility and comparison with gene expression arrays
- (2008) J. C. Marioni et al. GENOME RESEARCH
- Alternative isoform regulation in human tissue transcriptomes
- (2008) Eric T. Wang et al. NATURE
- Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus
- (2008) Sergey V Kozyrev et al. NATURE GENETICS
- Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing
- (2008) Qun Pan et al. NATURE GENETICS
- Ectopic expression of peripheral-tissue antigens in the thymic epithelium: Probabilistic, monoallelic, misinitiated
- (2008) J. Villasenor et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExplorePublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More