Modeling the process of human tumorigenesis

Synthetic recording and in situ readout of lineage information in single cells

(2017) Kirsten L. Frieda et al.   NATURE

Detection of single cell heterogeneity in cancer

(2017) Mengjia Qian et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Stem Cells in Lung Injury and Repair

(2016) Felicia Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

Mechanisms and Consequences of Cancer Genome Instability: Lessons from Genome Sequencing Studies

(2016) June-Koo Lee et al.   Annual Review of Pathology-Mechanisms of Disease

EMT, cell plasticity and metastasis

(2016) Christine L. Chaffer et al.   CANCER AND METASTASIS REVIEWS

Instructive Role of MLL-Fusion Proteins Revealed by a Model of t(4;11) Pro-B Acute Lymphoblastic Leukemia

(2016) Shan Lin et al.   CANCER CELL

Characterization of Rare, Dormant, and Therapy-Resistant Cells in Acute Lymphoblastic Leukemia

(2016) Sarah Ebinger et al.   CANCER CELL

Twenty five years since the first prospective study by Forman et al. (1991) on Helicobacter pylori and stomach cancer risk

(2016) Freddy Sitas   Cancer Epidemiology

The fractions of cancer attributable to modifiable factors: A global review

(2016) David C. Whiteman et al.   Cancer Epidemiology

Metabolic Plasticity as a Determinant of Tumor Growth and Metastasis

(2016) Camille Lehuédé et al.   CANCER RESEARCH

A Biobank of Breast Cancer Explants with Preserved Intra-tumor Heterogeneity to Screen Anticancer Compounds

(2016) Alejandra Bruna et al.   CELL

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

The epigenetics of tumour initiation: cancer stem cells and their chromatin

(2016) Alexandra Avgustinova et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Regulation and plasticity of intestinal stem cells during homeostasis and regeneration

(2016) Joep Beumer et al.   DEVELOPMENT

Reprogramming cancer cells: overview & current progress

(2016) Kian Lam Lim et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Quantitative lineage tracing strategies to resolve multipotency in tissue-specific stem cells

(2016) Aline Wuidart et al.   GENES & DEVELOPMENT

Modeling invasive lobular breast carcinoma by CRISPR/Cas9-mediated somatic genome editing of the mammary gland

(2016) Stefano Annunziato et al.   GENES & DEVELOPMENT

Genetic lineage tracing analysis of the cell of origin of hepatotoxin-induced liver tumors in mice

(2016) Soona Shin et al.   HEPATOLOGY

Development of ZMYM2-FGFR1 driven AML in human CD34+ cells in immunocompromised mice

(2016) Mingqiang Ren et al.   INTERNATIONAL JOURNAL OF CANCER

DNMT3A R882H mutant and Tet2 inactivation cooperate in the deregulation of DNA methylation control to induce lymphoid malignancies in mice

(2016) L Scourzic et al.   LEUKEMIA

CRISPR-Barcoding for Intratumor Genetic Heterogeneity Modeling and Functional Analysis of Oncogenic Driver Mutations

(2016) Alexis Guernet et al.   MOLECULAR CELL

A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns

(2016) Faiyaz Notta et al.   NATURE

Landscape of somatic mutations in 560 breast cancer whole-genome sequences

(2016) Serena Nik-Zainal et al.   NATURE

Tissue-specific mutation accumulation in human adult stem cells during life

(2016) Francis Blokzijl et al.   NATURE

Patient-derived induced pluripotent stem cells in cancer research and precision oncology

(2016) Eirini P Papapetrou   NATURE MEDICINE

Transformation of human CD34+ hematopoietic progenitor cells with DEK-NUP214 induces AML in an immunocompromised mouse model

(2016) H Qin et al.   ONCOGENE

Generation of an induced pluripotent stem cell line from a patient with hereditary multiple endocrine neoplasia 2A (MEN2A) syndrome with RET mutation

(2016) J. Hadoux et al.   Stem Cell Research

Reprogramming bladder cancer cells for studying cancer initiation and progression

(2016) Banu Iskender et al.   TUMOR BIOLOGY

Bmi1 marks distinct castration-resistant luminal progenitor cells competent for prostate regeneration and tumour initiation

(2016) Young A. Yoo et al.   Nature Communications

Generation of a novel, multi-stage, progressive, and transplantable model of plasma cell neoplasms

(2016) Takashi Asai et al.   Scientific Reports

Low CD38 Identifies Progenitor-like Inflammation-Associated Luminal Cells that Can Initiate Human Prostate Cancer and Predict Poor Outcome

(2016) Xian Liu et al.   Cell Reports

Analysis of Normal Human Mammary Epigenomes Reveals Cell-Specific Active Enhancer States and Associated Transcription Factor Networks

(2016) Davide Pellacani et al.   Cell Reports

Frequent mutations in acetylation and ubiquitination sites suggest novel driver mechanisms of cancer

(2016) Soumil Narayan et al.   Genome Medicine

Development Refractoriness of MLL-Rearranged Human B Cell Acute Leukemias to Reprogramming into Pluripotency

(2016) Alvaro Muñoz-López et al.   Stem Cell Reports

Chromatin accessibility contributes to simultaneous mutations of cancer genes

(2016) Yi Shi et al.   Scientific Reports

Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes

(2015) D. P. Steensma et al.   BLOOD

Modeling Familial Cancer with Induced Pluripotent Stem Cells

(2015) Dung-Fang Lee et al.   CELL

Sox9 Controls Self-Renewal of Oncogene Targeted Cells and Links Tumor Initiation and Invasion

(2015) Jean-Christophe Larsimont et al.   Cell Stem Cell

Hepatitis-Associated Liver Cancer: Gaps and Opportunities to Improve Care: Table 1.

(2015) Brian McMahon et al.   JNCI-Journal of the National Cancer Institute

Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogeneity

(2015) Alexandra Van Keymeulen et al.   NATURE

Barcoding reveals complex clonal dynamics of de novo transformed human mammary cells

(2015) Long V. Nguyen et al.   NATURE

PIK3CAH1047R induces multipotency and multi-lineage mammary tumours

(2015) Shany Koren et al.   NATURE

Studying clonal dynamics in response to cancer therapy using high-complexity barcoding

(2015) Hyo-eun C Bhang et al.   NATURE MEDICINE

Intestinal-specific activatable Myb initiates colon tumorigenesis in mice

(2015) J Malaterre et al.   ONCOGENE

Single cell-derived clonal analysis of human glioblastoma links functional and genomic heterogeneity

(2015) Mona Meyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases

(2015) Fleur Weeber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High burden and pervasive positive selection of somatic mutations in normal human skin

(2015) I. Martincorena et al.   SCIENCE

Hepatitis-Associated Liver Cancer: Gaps and Opportunities to Improve Care: Table 1.

(2015) Brian McMahon et al.   JNCI-Journal of the National Cancer Institute

Tracing Dynamics and Clonal Heterogeneity of Cbx7-Induced Leukemic Stem Cells by Cellular Barcoding

(2015) Karin Klauke et al.   Stem Cell Reports

Using the MCF10A/MCF10CA1a Breast Cancer Progression Cell Line Model to Investigate the Effect of Active, Mutant Forms of EGFR in Breast Cancer Development and Treatment Using Gefitinib

(2015) Darrell C. Bessette et al.   PLoS One

Inducible loss of one Apc allele in Lrig1-expressing progenitor cells results in multiple distal colonic tumors with features of familial adenomatous polyposis

(2014) Anne E. Powell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Modeling de novo leukemogenesis from human cord blood with MN1 and NUP98HOXD13

(2014) S. Imren et al.   BLOOD

MLL3 Is a Haploinsufficient 7q Tumor Suppressor in Acute Myeloid Leukemia

(2014) Chong Chen et al.   CANCER CELL

Quiescent Sox2+ Cells Drive Hierarchical Growth and Relapse in Sonic Hedgehog Subgroup Medulloblastoma

(2014) Robert J. Vanner et al.   CANCER CELL

Premature Termination of Reprogramming In Vivo Leads to Cancer Development through Altered Epigenetic Regulation

(2014) Kotaro Ohnishi et al.   CELL

Clonal Tracking of Rhesus Macaque Hematopoiesis Highlights a Distinct Lineage Origin for Natural Killer Cells

(2014) Chuanfeng Wu et al.   Cell Stem Cell

Identification of cellular and genetic drivers of breast cancer heterogeneity in genetically engineered mouse tumour models

(2014) Lorenzo Melchor et al.   JOURNAL OF PATHOLOGY

Dominant-negative Ikaros cooperates with BCR-ABL1 to induce human acute myeloid leukemia in xenografts

(2014) A P A Theocharides et al.   LEUKEMIA

Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia

(2014) Liran I. Shlush et al.   NATURE

SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma

(2014) Soufiane Boumahdi et al.   NATURE

Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution

(2014) Peter Eirew et al.   NATURE

CRISPR-mediated direct mutation of cancer genes in the mouse liver

(2014) Wen Xue et al.   NATURE

Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing

(2014) Dirk Heckl et al.   NATURE BIOTECHNOLOGY

The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis

(2014) Sandra S. McAllister et al.   NATURE CELL BIOLOGY

Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission

(2014) M. R. Corces-Zimmerman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PGC-1β promotes enterocyte lifespan and tumorigenesis in the intestine

(2014) Elena Bellafante et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

Concise Review: Cancer Cells Escape from Oncogene Addiction: Understanding the Mechanisms Behind Treatment Failure for More Effective Targeting

(2014) Francesca Pellicano et al.   STEM CELLS

DNA barcoding reveals diverse growth kinetics of human breast tumour subclones in serially passaged xenografts

(2014) Long V. Nguyen et al.   Nature Communications

Engineering human tumour-associated chromosomal translocations with the RNA-guided CRISPR–Cas9 system

(2014) R. Torres et al.   Nature Communications

Breast Cancer Stem Cells Transition between Epithelial and Mesenchymal States Reflective of their Normal Counterparts

(2014) Suling Liu et al.   Stem Cell Reports

Hemoglobin disorders: a look to the future

(2013) D. G. Nathan   BLOOD

Heterogeneity of young and aged murine hematopoietic stem cells revealed by quantitative clonal analysis using cellular barcoding

(2013) E. Verovskaya et al.   BLOOD

Analysis of the clonal growth and differentiation dynamics of primitive barcoded human cord blood cells in NSG mice

(2013) A. M. S. Cheung et al.   BLOOD

Patient-derived induced pluripotent stem cells recapitulate hematopoietic abnormalities of juvenile myelomonocytic leukemia

(2013) S. Gandre-Babbe et al.   BLOOD

Generation of Prostate Tumor-Initiating Cells Is Associated with Elevation of Reactive Oxygen Species and IL-6/STAT3 Signaling

(2013) Y. Qu et al.   CANCER RESEARCH

Distinct evolutionary trajectories of primary high-grade serous ovarian cancers revealed through spatial mutational profiling

(2013) Ali Bashashati et al.   JOURNAL OF PATHOLOGY

Diverse and heritable lineage imprinting of early haematopoietic progenitors

(2013) Shalin H. Naik et al.   NATURE

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Tracing the cellular origin of cancer

(2013) Cédric Blanpain   NATURE CELL BIOLOGY

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

Entering the era of single-cell transcriptomics in biology and medicine

(2013) Rickard Sandberg   NATURE METHODS

The Implications of Clonal Genome Evolution for Cancer Medicine

(2013) Samuel Aparicio et al.   NEW ENGLAND JOURNAL OF MEDICINE

An iPSC Line from Human Pancreatic Ductal Adenocarcinoma Undergoes Early to Invasive Stages of Pancreatic Cancer Progression

(2013) Jungsun Kim et al.   Cell Reports

Developmental Changes in the in Vitro Activated Regenerative Activity of Primitive Mammary Epithelial Cells

(2013) Maisam Makarem et al.   PLOS BIOLOGY

Three-dimensional cultures modeling premalignant progression of human breast epithelial cells: role of cysteine cathepsins

(2012) Stefanie R. Mullins et al.   BIOLOGICAL CHEMISTRY

Generation of induced pluripotent stem cells from primary chronic myelogenous leukemia patient samples

(2012) K. Kumano et al.   BLOOD

RANK Induces Epithelial-Mesenchymal Transition and Stemness in Human Mammary Epithelial Cells and Promotes Tumorigenesis and Metastasis

(2012) M. Palafox et al.   CANCER RESEARCH

Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties

(2012) Sarah Schwitalla et al.   CELL

Genetically Modified Mouse Models for Biomarker Discovery and Preclinical Drug Testing

(2012) R. Kucherlapati   CLINICAL CANCER RESEARCH

Counting stem cells: methodological constraints

(2012) Leonid V Bystrykh et al.   NATURE METHODS

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

(2012) Marco Gerlinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rapid generation of human B-cell lymphomas via combined expression of Myc and Bcl2 and their use as a preclinical model for biological therapies

(2012) I Leskov et al.   ONCOGENE

Truncated p110 ERBB2 induces mammary epithelial cell migration, invasion and orthotopic xenograft formation and is associated with loss of phosphorylated STAT5

(2012) T M Ward et al.   ONCOGENE

Nicastrin regulates breast cancer stem cell properties and tumor growth in vitro and in vivo

(2012) Y. Lombardo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Persistence of leukemia stem cells in chronic myelogenous leukemia patients in prolonged remission with imatinib treatment

(2011) S. Chu et al.   BLOOD

Luminal Expression of PIK3CA Mutant H1047R in the Mammary Gland Induces Heterogeneous Tumors

(2011) D. S. Meyer et al.   CANCER RESEARCH

Cancer Invasion and the Microenvironment: Plasticity and Reciprocity

(2011) Peter Friedl et al.   CELL

Genetic Interactions in Cancer Progression and Treatment

(2011) Alan Ashworth et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Genetic Predisposition Directs Breast Cancer Phenotype by Dictating Progenitor Cell Fate

(2011) Theresa A. Proia et al.   Cell Stem Cell

Evolution of human BCR–ABL1 lymphoblastic leukaemia-initiating cells

(2011) Faiyaz Notta et al.   NATURE

Stem cell gene expression programs influence clinical outcome in human leukemia

(2011) Kolja Eppert et al.   NATURE MEDICINE

New model systems provide insights into Myc-induced transformation

(2011) A R Wasylishen et al.   ONCOGENE

Defining the cellular precursors to human breast cancer

(2011) P. J. Keller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation of iPSCs from cultured human malignant cells

(2010) J. E. Carette et al.   BLOOD

Identification and characterization of cancer stem cells in ovarian yolk sac tumors

(2010) Shiro Suzuki et al.   CANCER SCIENCE

A Temporarily Distinct Subpopulation of Slow-Cycling Melanoma Cells Is Required for Continuous Tumor Growth

(2010) Alexander Roesch et al.   CELL

Biological and Molecular Heterogeneity of Breast Cancers Correlates with Their Cancer Stem Cell Content

(2010) Salvatore Pece et al.   CELL

Human acute myelogenous leukemia stem cells are rare and heterogeneous when assayed in NOD/SCID/IL2Rγc-deficient mice

(2010) Jean-Emmanuel Sarry et al.   JOURNAL OF CLINICAL INVESTIGATION

Genomic instability — an evolving hallmark of cancer

(2010) Simona Negrini et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

CD24+ cells from hierarchically organized ovarian cancer are enriched in cancer stem cells

(2010) M-Q Gao et al.   ONCOGENE

Identification of a Cell of Origin for Human Prostate Cancer

(2010) A. S. Goldstein et al.   SCIENCE

Aberrant Epigenetic Silencing of Tumor Suppressor Genes Is Reversed by Direct Reprogramming

(2010) Shulamit Ron-Bigger et al.   STEM CELLS

Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders

(2009) Z. Ye et al.   BLOOD

Characterization and functional analysis of a slow cycling stem cell-like subpopulation in pancreas adenocarcinoma

(2009) Jennifer L. Dembinski et al.   CLINICAL & EXPERIMENTAL METASTASIS

Inferring tumor progression from genomic heterogeneity

(2009) N. Navin et al.   GENOME RESEARCH

Microenvironment Determines Lineage Fate in a Human Model of MLL-AF9 Leukemia

(2008) Junping Wei et al.   CANCER CELL

Identification of cells initiating human melanomas

(2008) Tobias Schatton et al.   NATURE

Efficient tumour formation by single human melanoma cells

(2008) Elsa Quintana et al.   NATURE

Stromal gene expression predicts clinical outcome in breast cancer

(2008) Greg Finak et al.   NATURE MEDICINE