DNMT3A R882H mutant and Tet2 inactivation cooperate in the deregulation of DNA methylation control to induce lymphoid malignancies in mice

Mutational Cooperativity Linked to Combinatorial Epigenetic Gain of Function in Acute Myeloid Leukemia

(2015) Alan H. Shih et al.   CANCER CELL

Loss ofTET2in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis

(2015) Kasper D. Rasmussen et al.   GENES & DEVELOPMENT

Disregulated expression of the transcription factor ThPOK during T-cell development leads to high incidence of T-cell lymphomas

(2015) Hyung-Ok Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

INPP4B Is a PtdIns(3,4,5)P3 Phosphatase That Can Act as a Tumor Suppressor

(2015) S. Kofuji et al.   Cancer Discovery

In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes

(2015) C. Li Chew et al.   Cancer Discovery

TET proteins and the control of cytosine demethylation in cancer

(2015) Laurianne Scourzic et al.   Genome Medicine

Distinct effects of concomitant Jak2V617F expression and Tet2 loss in mice promote disease progression in myeloproliferative neoplasms

(2014) E. Chen et al.   BLOOD

Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation

(2014) A. Mayle et al.   BLOOD

Loss of TET2 has dual roles in murine myeloproliferative neoplasms: disease sustainer and disease accelerator

(2014) T. Kameda et al.   BLOOD

The R882H DNMT3A Mutation Associated with AML Dominantly Inhibits Wild-Type DNMT3A by Blocking Its Ability to Form Active Tetramers

(2014) David A. Russler-Germain et al.   CANCER CELL

Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses

(2014) Nicolas Fasnacht et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Somatic RHOA mutation in angioimmunoblastic T cell lymphoma

(2014) Mamiko Sakata-Yanagimoto et al.   NATURE GENETICS

Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas

(2014) Teresa Palomero et al.   NATURE GENETICS

TCF-1 and LEF-1 act upstream of Th-POK to promote the CD4+ T cell fate and interact with Runx3 to silence Cd4 in CD8+ T cells

(2014) Farrah C Steinke et al.   NATURE IMMUNOLOGY

Dissecting the dynamic changes of 5-hydroxymethylcytosine in T-cell development and differentiation

(2014) A. Tsagaratou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reduced TET2 function leads to T-cell lymphoma with follicular helper T-cell-like features in mice

(2014) H Muto et al.   Blood Cancer Journal

Whole-exome sequencing in adult ETP-ALL reveals a high rate of DNMT3A mutations

(2013) M. Neumann et al.   BLOOD

TCF-1 mediates repression of Notch pathway in T lineage-committed early thymocytes

(2013) S. Yu et al.   BLOOD

A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells

(2013) S. J. Kim et al.   BLOOD

The molecular profile of adult T-cell acute lymphoblastic leukemia: Mutations inRUNX1andDNMT3Aare associated with poor prognosis in T-ALL

(2013) Vera Grossmann et al.   GENES CHROMOSOMES & CANCER

Notch pathway activation targets AML-initiating cell homeostasis and differentiation

(2013) Camille Lobry et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders

(2013) Tomoya Muto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Notch Signaling Regulates Follicular Helper T Cell Differentiation

(2013) F. Auderset et al.   JOURNAL OF IMMUNOLOGY

Tumor suppressor functions of Dnmt3a and Dnmt3b in the prevention of malignant mouse lymphopoiesis

(2013) S L Peters et al.   LEUKEMIA

Gauging NOTCH1 Activation in Cancer Using Immunohistochemistry

(2013) Michael J. Kluk et al.   PLoS One

Heterozygosity for Roquinsan leads to angioimmunoblastic T-cell lymphoma-like tumors in mice

(2012) J. I. Ellyard et al.   BLOOD

In aggressive forms of mastocytosis, TET2 loss cooperates with c-KITD816V to transform mast cells

(2012) E. Soucie et al.   BLOOD

Recurrent TET2 mutations in peripheral T-cell lymphomas correlate with TFH-like features and adverse clinical parameters

(2012) F. Lemonnier et al.   BLOOD

Tales of the Unexpected: Tcf1 Functions as a Tumor Suppressor for Leukemias

(2012) Frank J.T. Staal et al.   IMMUNITY

Characterization of novel genomic alterations and therapeutic approaches using acute megakaryoblastic leukemia xenograft models

(2012) Clarisse Thiollier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TET2andDNMT3AMutations in Human T-Cell Lymphoma

(2012) Lucile Couronné et al.   NEW ENGLAND JOURNAL OF MEDICINE

Follicular Helper CD4 T Cells (TFH)

(2011) Shane Crotty   Annual Review of Immunology

TET2 Inactivation Results in Pleiotropic Hematopoietic Abnormalities in Mouse and Is a Recurrent Event during Human Lymphomagenesis

(2011) Cyril Quivoron et al.   CANCER CELL

Identification of recurring tumor-specific somatic mutations in acute myeloid leukemia by transcriptome sequencing

(2011) P A Greif et al.   LEUKEMIA

TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity

(2011) Kristine Williams et al.   NATURE

Dnmt3a is essential for hematopoietic stem cell differentiation

(2011) Grant A Challen et al.   NATURE GENETICS

Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia

(2011) Xiao-Jing Yan et al.   NATURE GENETICS

Preparation of reduced representation bisulfite sequencing libraries for genome-scale DNA methylation profiling

(2011) Hongcang Gu et al.   Nature Protocols

DNMT3AMutations in Acute Myeloid Leukemia

(2010) Timothy J. Ley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Acquired mutations in TET2 are common in myelodysplastic syndromes

(2009) Saskia M C Langemeijer et al.   NATURE GENETICS

DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction

(2009) Ann-Marie Bröske et al.   NATURE GENETICS

Mutation inTET2in Myeloid Cancers

(2009) François Delhommeau et al.   NEW ENGLAND JOURNAL OF MEDICINE

Activating mutations in human acute megakaryoblastic leukemia

(2008) S. Malinge et al.   BLOOD

Microenvironment Determines Lineage Fate in a Human Model of MLL-AF9 Leukemia

(2008) Junping Wei et al.   CANCER CELL

Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras–initiated leukemia

(2008) Mark Y. Chiang et al.   JOURNAL OF CLINICAL INVESTIGATION