Article
Multidisciplinary Sciences
Eva Shrestha, Jonathan B. Coulter, William Guzman, Busra Ozbek, Megan M. Hess, Luke Mummert, Sarah E. Ernst, Janielle P. Maynard, Alan K. Meeker, Christopher M. Heaphy, Michael C. Haffner, Angelo M. De Marzo, Karen S. Sfanos
Summary: The study suggests that bacterial infections may initiate driver gene alterations in prostate cancer, with infection-induced ERG+ fusions being an early alteration in the carcinogenic process, potentially originating from proliferative inflammatory atrophy as a precursor.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Jack Freeland, Preston D. Crowell, Jenna M. Giafaglione, Paul C. Boutros, Andrew S. Goldstein
Summary: The prostate continues to grow in volume while many other organs experience a loss of tissue mass and decline in regenerative capacity during aging. Research indicates that prostate luminal progenitor cells expand with age, and age-related changes to the microenvironment may influence prostate epithelial cells and the risk of transformation. Addressing questions regarding models of aging and regulators of prostate aging is crucial for understanding mechanisms that promote age-related prostatic disease.
Article
Multidisciplinary Sciences
Sindhuja Devanapally, Pravrutha Raman, Mary Chey, Samual Allgood, Farida Ettefa, Maigane Diop, Yixin Lin, Yongyi E. Cho, Antony M. Jose
Summary: Stable epigenetic changes are relatively rare. The authors report that mating induces stable silencing of a single-copy transgene in C. elegans. Components of small RNA silencing are required for this stable silencing.
NATURE COMMUNICATIONS
(2021)
Review
Chemistry, Multidisciplinary
Filip T. Szczypinski, Steven Bennett, Kim E. Jelfs
Summary: The discovery of materials is crucial for new technologies, but it is slow. Computational screening helps identify promising candidates, but there are challenges in realizing them in the lab.
Article
Cell Biology
Jenna M. Giafaglione, Preston D. Crowell, Amelie M. L. Delcourt, Takao Hashimoto, Sung Min Ha, Aishwarya Atmakuri, Nicholas M. Nunley, Rachel M. A. Dang, Mao Tian, Johnny A. Diaz, Elisavet Tika, Marie C. Payne, Deborah L. Burkhart, Dapei Li, Nora M. Navone, Eva Corey, Peter S. Nelson, Neil Y. C. Lin, Cedric Blanpain, Leigh Ellis, Paul C. Boutros, Andrew S. Goldstein
Summary: This study reveals the differences in metabolism and nutrient utilization between basal and luminal cells in prostate epithelium, as well as the increased pyruvate oxidation during basal-to-luminal differentiation. The researchers identify the mitochondrial pyruvate carrier and lactate accumulation as crucial regulators of prostate epithelial lineage identity.
NATURE CELL BIOLOGY
(2023)
Article
Oncology
Manon Baures, Emilia Puig Lombardi, Delphine Di Martino, Wail Zeitouni, Emeline Pacreau, Leila Dos Santos, Charles Dariane, Florence Boutillon, Jacques-Emmanuel Guidotti, Vincent Goffin
Summary: The study identified LSCmed cells as matching human prostate Club/Hillock cells, regulated by EGFR/ERBB4, IGF-1 and MET pathways, and exhibiting drug resistance. These cells are considered a relevant preclinical model for investigating the cellular and molecular mechanisms driving CRPC.
Article
Oncology
Xiaoyu Wang, Kristina M. Jordahl, Chenghao Zhu, Julie Livingstone, Suhn K. Rhie, Jonathan L. Wright, William M. Grady, Paul C. Boutros, Janet L. Stanford, James Y. Dai
Summary: This study identified a DNA methylation subtype that was associated with worse prostate cancer prognosis after radical prostatectomy. The subtype was found to be associated with an increased hazard of recurrence and mortality in three separate patient populations.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Medicine, General & Internal
Pradipta Ghosh, Saptarshi Sinha, Gajanan D. Katkar, Daniella Vo, Sahar Taheri, Dharanidhar Dang, Soumita Das, Debashis Sahoo
Summary: Through machine learning algorithms on human macrophages, researchers have identified a continuum of polarization states and proposed a 338-gene signature for these states. This signature accurately identified macrophage polarization states in both physiological and pathological contexts, and showed superiority in predicting disease outcomes. These findings provide a predictive framework for the development of macrophage-targeted precision diagnostics and therapeutics.
Article
Oncology
Pin Wu, Lufeng Zhao, Yongyuan Chen, Zhongwei Xin, Mingjie Lin, Zhixing Hao, Xiaoke Chen, Di Chen, Dang Wu, Ying Chai
Summary: The study revealed a correlation between CD38 expression and survival and immune infiltration levels in non-small cell lung cancer (NSCLC), with CD38+ CD8+ T cells in tumors showing higher expression levels of cytotoxic molecules, cytokines, and PD-1 compared to CD38- CD8+ T cells. Additionally, the PD-1+ subset of CD38+ CD8+ T cells exhibited higher levels of activated markers than PD-1+ CD38- CD8+ T cells, and reactivated CD38+ CD8+ T cells in vitro expressed higher levels of CD103, IFN-gamma, TNF-alpha, and perforin compared to CD38- CD8+ T cells. Finally, it was observed that CD38+ CD8+ T cells isolated from tumors could be reinvigorated by anti-PD-1 in vitro, suggesting a potential role for PD-1 blockade in enhancing anti-tumor potency and reversing exhausted phenotype in NSCLC.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Oncology
Barbara Spitzer, Kayleigh D. Rutherford, Gunes Gundem, Erin M. McGovern, Nathan E. Millard, Juan E. Arango Ossa, Irene Y. Cheung, Teng Gao, Max F. Levine, Yanming Zhang, Juan S. Medina-Martinez, Yi Feng, Ryan N. Ptashkin, Kelly L. Bolton, Noushin Farnoud, Yangyu Zhou, Minal A. Patel, Georgios Asimomitis, Cassidy C. Cobbs, Neeman Mohibullah, Kety H. Huberman, Maria E. Arcilla, Brian H. Kushner, Shakeel Modak, Andrew L. Kung, Ahmet Zehir, Ross L. Levine, Scott A. Armstrong, Nai Kong Cheung, Elli Papaemmanuil
Summary: This study aimed to explore the relationship between the development of t-MDS/AL and molecular abnormalities in pediatric patients with high-risk neuroblastoma. The study found that at least one disease-defining alteration was detected in all cases at t-MDS/AL diagnosis, with TP53 gene mutations and KMT2A gene rearrangements being the most common. Compared to the transient and control groups, t-MDS/AL patients had acquired mutations at an earlier stage before the onset of the disease. Additionally, the study revealed that only a small number of pediatric patients with solid tumors had clonal hematopoiesis involving myeloid genes.
CLINICAL CANCER RESEARCH
(2022)
Article
Neurosciences
Krishnakant Saboo, Chang Hu, Yogatheesan Varatharajah, Scott A. Przybelski, Robert Reid, Christopher G. Schwarz, Jonathan Graff-Radford, David S. Knopman, Mary M. Machulda, Michelle M. Mielke, Ronald C. Petersen, Paul M. Arnold, Gregory A. Worrell, David T. Jones, Clifford R. Jack, Ravishankar K. Iyer, Prashanthi Vemuri
Summary: Using deep learning models and interpretation techniques, we identified brain structures that were most predictive of cognitive trajectories and indicative of cognitive resilience or vulnerability. Medial temporal lobe, fornix, and corpus callosum were the most predictive structures.
Article
Oncology
Quan Zhou, Yuxi Ou, Xiyu Dai, Xinan Chen, Siqi Wu, Wensun Chen, Mengbo Hu, Chen Yang, Limin Zhang, Haowen Jiang
Summary: The clinical significance and immune correlation of CD103(+) cells in prostate cancer (PCa) have not been explored. This study found that high CD103(+) cell infiltration was associated with reduced biochemical recurrence (BCR)-free survival in PCa. Adjuvant hormone therapy (HT) prolonged the BCR-free survival in high-risk node-negative cases with abundant CD103(+) cells.
BRITISH JOURNAL OF CANCER
(2023)
Article
Neurosciences
Kuan Tian, Andi Wang, Junbao Wang, Wei Li, Wenchen Shen, Yamu Li, Zhiyuan Luo, Ying Liu, Yan Zhou
Summary: This study used a bioinformatics pipeline to investigate the dynamic expression and potential cis-regulatory effects of mouse lncRNAs in the development of the cerebral cortex. A novel sense lncRNA, SenZfp536, was identified to regulate the proliferation of cortical neural progenitor cells by cis-regulating Zfp536. These findings enhance our understanding of how lncRNAs modulate the propagation of cortical NPCs through cis-regulatory mechanisms.
NEUROSCIENCE BULLETIN
(2021)
Article
Biology
Ilhame Diboun, Sachin Wani, Stuart H. Ralston, Omar M. E. Albagha
Summary: The study aimed to characterize changes in DNA methylation profiles in the blood of Paget's disease of bone (PDB) patients, identifying significant differences in DNA methylation at certain loci associated with functions related to osteoclast differentiation, mechanical loading, immune function, and viral infection. A multivariate classifier based on the data was able to discriminate PDB cases and controls with high sensitivity, specificity, and accuracy, indicating that epigenetic factors play a role in the pathogenesis of PDB and may serve as diagnostic markers for predicting the disease.
Article
Obstetrics & Gynecology
Philip Xie, Olena M. Kocur, Stephanie Cheung, Lily Ng, David F. Albertini, Zev Rosenwaks, Gianpiero D. Palermo
Summary: The sperm centrosome, an important organelle in fertilization and embryonic development, plays a crucial role in mitotic spindle formation, chromosome segregation, and syngamy. Abnormalities of the sperm centrosome can lead to abnormal embryonic development, pregnancy loss, and chromosomal instability. Understanding the molecular composition, regulation, and function of the sperm centrosome is vital for elucidating the mechanisms of successful fertilization and embryonic development, as well as addressing infertility and developmental disorders associated with centrosomal defects.
FERTILITY AND STERILITY
(2023)
Article
Oncology
Yaqun Zhang, Lingfan Xu, Yan Chang, YanJing Li, William Butler, Er Jin, Aifen Wang, Yulei Tao, Xufeng Chen, Chaozhao Liang, Jiaoti Huang
PROSTATE CANCER AND PROSTATIC DISEASES
(2020)
Article
Medical Laboratory Technology
Jing Hu, Bo Han, Jiaoti Huang
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2020)
Article
Urology & Nephrology
Steve R. Zhou, Edward Chang, Aalhad Patankar, Jiaoti Huang, Leonard S. Marks, Shyam Natarajan
JOURNAL OF UROLOGY
(2020)
Editorial Material
Medical Laboratory Technology
Jiaoti Huang, Lanjing Zhang
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2020)
Article
Multidisciplinary Sciences
Liang Wang, Bryan A. Smith, Nikolas G. Balanis, Brandon L. Tsai, Kim Nguyen, Michael W. Cheng, Matthew B. Obusan, Favour N. Esedebe, Saahil J. Patel, Hanwei Zhang, Peter M. Clark, Anthony E. Sisk, Jonathan W. Said, Jiaoti Huang, Thomas G. Graeber, Owen N. Witte, Arnold I. Chin, Jung Wook Park
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Oncology
Rahul Aggarwal, Gustavo Rubio Romero, Verena Friedl, Alana Weinstein, Adam Foye, Huang Jiaoti, Felix Feng, Joshua M. Stuart, Eric J. Small
Summary: This study aimed to prospectively characterize the molecular features and clinical outcomes of Low PSA Secretors. The findings revealed that Low PSA Secretors demonstrated higher t-SCNC and RB1 loss, as well as lower AR transcriptional signature scores compared to normal secretors. Additionally, genomic loss of RB1 and/or TP53 was more common in Low PSA Secretors.
PROSTATE CANCER AND PROSTATIC DISEASES
(2021)
Review
Medical Laboratory Technology
Jonathan Epstein, Mahul B. Amin, Samson W. Fine, Ferran Algaba, Manju Aron, Dilek E. Baydar, Antonio Lopez Beltran, Fadi Brimo, John C. Cheville, Maurizio Colecchia, Eva Comperat, Isabela Werneck da Cunha, Warick Delprado, Angelo M. DeMarzo, Giovanna A. Giannico, Jennifer B. Gordetsky, Charles C. Guo, Donna E. Hansel, Michelle S. Hirsch, Jiaoti Huang, Peter A. Humphrey, Rafael E. Jimenez, Francesca Khani, Qingnuan Kong, Oleksandr N. Kryvenko, L. Priya Kunju, Priti Lal, Mathieu Latour, Tamara Lotan, Fiona Maclean, Cristina Magi-Galluzzi, Rohit Mehra, Santosh Menon, Hiroshi Miyamoto, Rodolfo Montironi, George J. Netto, Jane K. Nguyen, Adeboye O. Osunkoya, Anil Parwani, Brian D. Robinson, Mark A. Rubin, Rajal B. Shah, Jeffrey S. So, Hiroyuki Takahashi, Fabio Tavora, Maria S. Tretiakova, Lawrence True, Sara E. Wobker, Ximing J. Yang, Ming Zhou, Debra L. Zynger, Kiril Trpkov
Summary: Controversies and uncertainty persist in prostate cancer grading. Recommendations include reporting percentage Gleason pattern 4 (%GP4) in needle biopsies, updating tertiary grade patterns, and providing global scores in MRI-targeted biopsies.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2021)
Article
Oncology
William Hankey, Benjamin Sunkel, Fuwen Yuan, Haiyan He, Jennifer M. Thomas-Ahner, Zhong Chen, Steven K. Clinton, Jiaoti Huang, Qianben Wang
TRANSLATIONAL ONCOLOGY
(2020)
Article
Cell Biology
Bushu Dong, Alex M. Jaeger, Philip F. Hughes, David R. Loiselle, J. Spencer Hauck, Yao Fu, Timothy A. Haystead, Jiaoti Huang, Dennis J. Thiele
SCIENCE TRANSLATIONAL MEDICINE
(2020)
Article
Immunology
Dev Bhatt, Boxi Kang, Deepali Sawant, Liangtao Zheng, Kristy Perez, Zhiyu Huang, Laura Sekirov, Dan Wolak, Julie Y. Huang, Xian Liu, Jason DeVoss, Paolo S. Manzanillo, Nathan Pierce, Zemin Zhang, Antony Symons, Wenjun Ouyang
Summary: Single-cell RNA sequencing was utilized to analyze T cell subsets and activation states, revealing differences and similarities between human and mouse tumors. The identification of specific T reg cell markers and therapeutic strategies, such as CCR8 depletion, showed potential benefits in tumor treatment and combination therapies with anti-PD-1 treatment in various tumor models.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Oncology
Landon C. Brown, Susan Halabi, Jason A. Somarelli, Michael Humeniuk, Yuan Wu, Taofik Oyekunle, Lauren Howard, Jiaoti Huang, Monika Anand, Catrin Davies, Prekshaben Patel, Janet Staats, Kent J. Weinhold, Michael R. Harrison, Tian Zhang, Daniel J. George, Andrew J. Armstrong
Summary: Immunotherapy with avelumab showed poor efficacy in men with progressive neuroendocrine or aggressive-variant metastatic prostate cancer, but potential mechanisms for immune activation were identified in an extraordinary responder.
PROSTATE CANCER AND PROSTATIC DISEASES
(2022)
Article
Cell Biology
Yu-Ching Wen, Wei-Yu Chen, Van Thi Ngoc Tram, Hsiu-Lien Yeh, Wei-Hao Chen, Kuo-Ching Jiang, Wassim Abou-Kheir, Jiaoti Huang, Michael Hsiao, Yen-Nien Liu
Summary: Neuroendocrine differentiation (NED) frequently occurs in androgen-deprivation therapy (ADT)-resistant prostate cancer (PCa) and is typically associated with metabolic pathway alterations, acquisition of lineage plasticity, and malignancy. This study identified the regulatory mechanism of NED-associated metabolic reprogramming and suggested that targeting pyruvate kinase L/R (PKLR) with FDA-approved compounds can reduce the aggressiveness and NED of ADT-resistant PCa.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Jennie C. Kim, Xian Liu, Karen Fitzgerald, Jason S. Eng, Jessica Orf, Sarah A. O'Brien, Brian Belmontes, Amy-Jo Casbon, Sergey Novitskiy, Kristin Tarbell, Jason DeVoss, Jackson G. Egen
Summary: STING pathway plays context-dependent roles in regulating anti-tumor immunity and response to immunotherapy. In poorly immunogenic tumor models, STING expression in non-tumor cells is crucial for productive anti-tumor immune responses. In immunogenic models, constitutive STING activation in tumor cells can partially bypass the requirement for STING-dependent activity from immune cells.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Cell Biology
Yu-Ching Wen, Van Thi Ngoc Tram, Wei-Hao Chen, Chien-Hsiu Li, Hsiu-Lien Yeh, Phan Vu Thuy Dung, Kuo-Ching Jiang, Han-Ru Li, Jiaoti Huang, Michael Hsiao, Wei-Yu Chen, Yen-Nien Liu
Summary: Current treatment options for prostate cancer focus on targeting androgen receptor (AR) signaling, but inhibiting AR may promote the development of neuroendocrine prostate cancer (NEPC). Understanding the regulatory mechanisms of AR is crucial for the clinical management of NEPC. This study revealed the tumor-suppressive role of AR and identified its downregulation of CHRM4 expression. CHRM4 overexpression drives neuroendocrine differentiation in prostate cancer cells and is associated with immunosuppressive cytokine responses in the tumor microenvironment (TME). Targeting CHRM4 and evaluating IFNA17 secretion as a prognostic biomarker could be potential therapeutic strategies for NEPC.
CELL DEATH & DISEASE
(2023)
Article
Multidisciplinary Sciences
Jake L. Owens, Elena Beketova, Sheng Liu, Samantha L. Tinsley, Andrew M. Asberry, Xuehong Deng, Jiaoti Huang, Chenglong Li, Jun Wan, Chang-Deng Hu
