Cellular reprogramming technology for dissecting cancer epigenome in vivo

Gene Resistance to Transcriptional Reprogramming following Nuclear Transfer Is Directly Mediated by Multiple Chromatin-Repressive Pathways

(2017) Jerome Jullien et al.   MOLECULAR CELL

Bioactive Nutrients and Nutrigenomics in Age-Related Diseases

(2017) Tania Rescigno et al.   MOLECULES

Cellular context-dependent consequences ofApcmutations on gene regulation and cellular behavior

(2017) Kyoichi Hashimoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ever-Changing Landscapes: Transcriptional Enhancers in Development and Evolution

(2016) Hannah K. Long et al.   CELL

Editing DNA Methylation in the Mammalian Genome

(2016) X. Shawn Liu et al.   CELL

Pioneer transcription factors, chromatin dynamics, and cell fate control

(2016) Kenneth S Zaret et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Cell fate control by pioneer transcription factors

(2016) Makiko Iwafuchi-Doi et al.   DEVELOPMENT

Chromatin Control of Developmental Dynamics and Plasticity

(2016) Matteo Perino et al.   DEVELOPMENTAL CELL

Tumour hypoxia causes DNA hypermethylation by reducing TET activity

(2016) Bernard Thienpont et al.   NATURE

Targeted DNA demethylation in vivo using dCas9–peptide repeat and scFv–TET1 catalytic domain fusions

(2016) Sumiyo Morita et al.   NATURE BIOTECHNOLOGY

DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells

(2016) Xiaotian Zhang et al.   NATURE GENETICS

Targeting EZH2 in cancer

(2016) Kimberly H Kim et al.   NATURE MEDICINE

Epigenetic modulators, modifiers and mediators in cancer aetiology and progression

(2016) Andrew P. Feinberg et al.   NATURE REVIEWS GENETICS

Re-patterning of H3K27me3, H3K4me3 and DNA methylation during fibroblast conversion into induced cardiomyocytes

(2016) Ziqing Liu et al.   Stem Cell Research

Tet3-Mediated DNA Demethylation Contributes to the Direct Conversion of Fibroblast to Functional Neuron

(2016) Juan Zhang et al.   Cell Reports

Epigenetic impact of infection on carcinogenesis: mechanisms and applications

(2016) Naoko Hattori et al.   Genome Medicine

Small Molecules Modulate Chromatin Accessibility to Promote NEUROG2-Mediated Fibroblast-to-Neuron Reprogramming

(2016) Derek K. Smith et al.   Stem Cell Reports

Ezh2 loss in hematopoietic stem cells predisposes mice to develop heterogeneous malignancies in an Ezh1-dependent manner

(2015) M. Mochizuki-Kashio et al.   BLOOD

Modulation of EZH2 Expression by MEK-ERK or PI3K-AKT Signaling in Lung Cancer Is Dictated by Different KRAS Oncogene Mutations

(2015) E. Riquelme et al.   CANCER RESEARCH

Generation of a Mouse Model of Atypical Teratoid/Rhabdoid Tumor of the Central Nervous System through Combined Deletion of Snf5 and p53

(2015) Jessica M.Y. Ng et al.   CANCER RESEARCH

Induced pluripotent stem cell technology for dissecting the cancer epigenome

(2015) Katsunori Semi et al.   CANCER SCIENCE

Reducing DNA methylation suppresses colon carcinogenesis by inducing tumor cell differentiation

(2015) Yuichiro Hatano et al.   CARCINOGENESIS

Association of gastric cancer risk factors with DNA methylation levels in gastric mucosa of healthy Japanese: a cross-sectional study

(2015) Taichi Shimazu et al.   CARCINOGENESIS

Pioneer Transcription Factors Target Partial DNA Motifs on Nucleosomes to Initiate Reprogramming

(2015) Abdenour Soufi et al.   CELL

Trithorax and Polycomb group-dependent regulation: a tale of opposing activities

(2015) S. J. Geisler et al.   DEVELOPMENT

Chromatin remodeling and bivalent histone modifications in embryonic stem cells

(2015) A. Harikumar et al.   EMBO REPORTS

Fusobacterium nucleatumin colorectal carcinoma tissue and patient prognosis

(2015) Kosuke Mima et al.   GUT

Promoter Hypermethylation of Tumour Suppressor Genes as Potential Biomarkers in Colorectal Cancer

(2015) Jennifer Ng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Germline and Pluripotent Stem Cells

(2015) Wolf Reik et al.   Cold Spring Harbor Perspectives in Biology

Epigenetic epidemiology of cancer

(2014) Timothy M. Barrow et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Biological significance of the CpG island methylator phenotype

(2014) Hiromu Suzuki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Epigenetic regulation leading to induced pluripotency drives cancer development in vivo

(2014) Kotaro Ohnishi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Fusobacterium in Colonic Flora and Molecular Features of Colorectal Carcinoma

(2014) T. Tahara et al.   CANCER RESEARCH

Premature Termination of Reprogramming In Vivo Leads to Cancer Development through Altered Epigenetic Regulation

(2014) Kotaro Ohnishi et al.   CELL

Embryonic Development following Somatic Cell Nuclear Transfer Impeded by Persisting Histone Methylation

(2014) Shogo Matoba et al.   CELL

The Developmental Potential of iPSCs Is Greatly Influenced by Reprogramming Factor Selection

(2014) Yosef Buganim et al.   Cell Stem Cell

SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma

(2014) Soufiane Boumahdi et al.   NATURE

Discovery and saturation analysis of cancer genes across 21 tumour types

(2014) Michael S. Lawrence et al.   NATURE

Exploration of liver cancer genomes

(2014) Tatsuhiro Shibata et al.   Nature Reviews Gastroenterology & Hepatology

Concise Review: Dedifferentiation Meets Cancer Development: Proof of Concept for Epigenetic Cancer

(2014) Yosuke Yamada et al.   Stem Cells Translational Medicine

A Prospective Study of Duration of Smoking Cessation and Colorectal Cancer Risk by Epigenetics-related Tumor Classification

(2013) Reiko Nishihara et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Human Embryonic Stem Cells Derived by Somatic Cell Nuclear Transfer

(2013) Masahito Tachibana et al.   CELL

FGF Signaling Inhibition in ESCs Drives Rapid Genome-wide Demethylation to the Epigenetic Ground State of Pluripotency

(2013) Gabriella Ficz et al.   Cell Stem Cell

Whole-Genome Bisulfite Sequencing of Two Distinct Interconvertible DNA Methylomes of Mouse Embryonic Stem Cells

(2013) Ehsan Habibi et al.   Cell Stem Cell

Hepatitis Virus Infection Affects DNA Methylation in Mice With Humanized Livers

(2013) Yasuyuki Okamoto et al.   GASTROENTEROLOGY

A double take on bivalent promoters

(2013) P. Voigt et al.   GENES & DEVELOPMENT

Widespread resetting of DNA methylation in glioblastoma-initiating cells suppresses malignant cellular behavior in a lineage-dependent manner

(2013) S. H. Stricker et al.   GENES & DEVELOPMENT

Reprogramming of MLL-AF9 leukemia cells into pluripotent stem cells

(2013) Y Liu et al.   LEUKEMIA

EZH2 in normal and malignant hematopoiesis

(2013) K Lund et al.   LEUKEMIA

Molecular pathological epidemiology of epigenetics: emerging integrative science to analyze environment, host and disease

(2013) Shuji Ogino et al.   MODERN PATHOLOGY

Reprogramming in vivo produces teratomas and iPS cells with totipotency features

(2013) María Abad et al.   NATURE

Chromatin dynamics during cellular reprogramming

(2013) Effie Apostolou et al.   NATURE

Chromatin modifiers and remodellers: regulators of cellular differentiation

(2013) Taiping Chen et al.   NATURE REVIEWS GENETICS

Emerging patterns of somatic mutations in cancer

(2013) Ian R. Watson et al.   NATURE REVIEWS GENETICS

DNA methylation: roles in mammalian development

(2013) Zachary D. Smith et al.   NATURE REVIEWS GENETICS

Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer

(2013) Christoph Plass et al.   NATURE REVIEWS GENETICS

An iPSC Line from Human Pancreatic Ductal Adenocarcinoma Undergoes Early to Invasive Stages of Pancreatic Cancer Progression

(2013) Jungsun Kim et al.   Cell Reports

PU.1 target genes undergo Tet2-coupled demethylation and DNMT3b-mediated methylation in monocyte-to-osteoclast differentiation

(2013) Lorenzo de la Rica et al.   GENOME BIOLOGY

Integrated analysis of genetic and epigenetic alterations reveals CpG island methylator phenotype associated with distinct clinical characters of lung adenocarcinoma

(2012) Keiko Shinjo et al.   CARCINOGENESIS

Single-Cell Expression Analyses during Cellular Reprogramming Reveal an Early Stochastic and a Late Hierarchic Phase

(2012) Yosef Buganim et al.   CELL

Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties

(2012) Sarah Schwitalla et al.   CELL

Inflammation-Associated Cancer Development in Digestive Organs: Mechanisms and Roles for Genetic and Epigenetic Modulation

(2012) Tsutomu Chiba et al.   GASTROENTEROLOGY

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

(2012) Jeremy Schwartzentruber et al.   NATURE

Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas

(2012) Gang Wu et al.   NATURE GENETICS

Maintaining differentiated cellular identity

(2012) Johan Holmberg et al.   NATURE REVIEWS GENETICS

Dedifferentiation of Neurons and Astrocytes by Oncogenes Can Induce Gliomas in Mice

(2012) D. Friedmann-Morvinski et al.   SCIENCE

Reprogramming mammalian somatic cells

(2012) N. Rodriguez-Osorio et al.   THERIOGENOLOGY

Pioneer transcription factors: establishing competence for gene expression

(2011) K. S. Zaret et al.   GENES & DEVELOPMENT

Dnmt3a is essential for hematopoietic stem cell differentiation

(2011) Grant A Challen et al.   NATURE GENETICS

Trithorax group proteins: switching genes on and keeping them active

(2011) Bernd Schuettengruber et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Roles of the Polycomb group proteins in stem cells and cancer

(2011) H Richly et al.   Cell Death & Disease

Inflammatory Processes Triggered by Helicobacter pylori Infection Cause Aberrant DNA Methylation in Gastric Epithelial Cells

(2010) T. Niwa et al.   CANCER RESEARCH

Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined Factors

(2010) Masaki Ieda et al.   CELL

Wilms Tumor Chromatin Profiles Highlight Stem Cell Properties and a Renal Developmental Network

(2010) Aviva Presser Aiden et al.   Cell Stem Cell

Oxidative stress, inflammation, and cancer: How are they linked?

(2010) Simone Reuter et al.   FREE RADICAL BIOLOGY AND MEDICINE

Direct conversion of fibroblasts to functional neurons by defined factors

(2010) Thomas Vierbuchen et al.   NATURE

Epigenetic modifications and human disease

(2010) Anna Portela et al.   NATURE BIOTECHNOLOGY

Active DNA demethylation: many roads lead to Rome

(2010) Susan C. Wu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNMT3AMutations in Acute Myeloid Leukemia

(2010) Timothy J. Ley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Frequent Mutations of Chromatin Remodeling Gene ARID1A in Ovarian Clear Cell Carcinoma

(2010) Siân Jones et al.   SCIENCE

Recruitment of Polycomb group complexes and their role in the dynamic regulation of cell fate choice

(2009) B. Schuettengruber et al.   DEVELOPMENT

The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence

(2009) K. Agger et al.   GENES & DEVELOPMENT

Suppression of induced pluripotent stem cell generation by the p53–p21 pathway

(2009) Hyenjong Hong et al.   NATURE

Immortalization eliminates a roadblock during cellular reprogramming into iPS cells

(2009) Jochen Utikal et al.   NATURE

A reprogrammable mouse strain from gene-targeted embryonic stem cells

(2009) Matthias Stadtfeld et al.   NATURE METHODS

Mutation inTET2in Myeloid Cancers

(2009) François Delhommeau et al.   NEW ENGLAND JOURNAL OF MEDICINE

Quantitative Analysis of DNA Methylation Profiles in Lung Cancer Identifies Aberrant DNA Methylation of Specific Genes and Its Association with Gender and Cancer Risk Factors

(2008) T. Vaissiere et al.   CANCER RESEARCH

In vivo reprogramming of adult pancreatic exocrine cells to β-cells

(2008) Qiao Zhou et al.   NATURE

Crypt stem cells as the cells-of-origin of intestinal cancer

(2008) Nick Barker et al.   NATURE

An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors

(2008) Ittai Ben-Porath et al.   NATURE GENETICS