Roles of the Polycomb group proteins in stem cells and cancer

Polycomb-Dependent Regulatory Contacts between Distant Hox Loci in Drosophila

(2011) Frédéric Bantignies et al.   CELL

PCL2 modulates gene regulatory networks controlling self-renewal and commitment in embryonic stem cells

(2011) Emily Walker et al.   CELL CYCLE

Chromatin states in pluripotent, differentiated, and reprogrammed cells

(2011) Cynthia L Fisher et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Polycomblike 2 facilitates the recruitment of PRC2 Polycomb group complexes to the inactive X chromosome and to target loci in embryonic stem cells

(2011) M. Casanova et al.   DEVELOPMENT

The Polycomb complex PRC2 and its mark in life

(2011) Raphaël Margueron et al.   NATURE

Conditional Activation of Bmi1 Expression Regulates Self-renewal, Apoptosis, and Differentiation of Neural Stem/Progenitor Cells In Vitro and In Vivo

(2011) Gokhan Yadirgi et al.   STEM CELLS

Polycomb Group Proteins Set the Stage for Early Lineage Commitment

(2010) Lauren E. Surface et al.   Cell Stem Cell

Bmi-1 Is a Crucial Regulator of Prostate Stem Cell Self-Renewal and Malignant Transformation

(2010) Rita U. Lukacs et al.   Cell Stem Cell

Poised Lineage Specification in Multipotential Hematopoietic Stem and Progenitor Cells by the Polycomb Protein Bmi1

(2010) Hideyuki Oguro et al.   Cell Stem Cell

Polycomb-like 2 Associates with PRC2 and Regulates Transcriptional Networks during Mouse Embryonic Stem Cell Self-Renewal and Differentiation

(2010) Emily Walker et al.   Cell Stem Cell

ESCs Require PRC2 to Direct the Successful Reprogramming of Differentiated Cells toward Pluripotency

(2010) Carlos F. Pereira et al.   Cell Stem Cell

Ring1B and Suv39h1 delineate distinct chromatin states at bivalent genes during early mouse lineage commitment

(2010) O. Alder et al.   DEVELOPMENT

Polycomb complexes act redundantly to repress genomic repeats and genes

(2010) M. Leeb et al.   GENES & DEVELOPMENT

Epigenetic signatures and temporal expression of lineage-specific genes in hESCs during differentiation to hepatocytes in vitro

(2010) Hyemin Kim et al.   HUMAN MOLECULAR GENETICS

Recognition and Specificity Determinants of the Human Cbx Chromodomains

(2010) Lilia Kaustov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ring1B Compacts Chromatin Structure and Represses Gene Expression Independent of Histone Ubiquitination

(2010) Ragnhild Eskeland et al.   MOLECULAR CELL

Chromatin signature of embryonic pluripotency is established during genome activation

(2010) Nadine L. Vastenhouw et al.   NATURE

Transcriptional activation of polycomb-repressed genes by ZRF1

(2010) Holger Richly et al.   NATURE

JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells

(2010) Diego Pasini et al.   NATURE

Tbx3 improves the germ-line competency of induced pluripotent stem cells

(2010) Jianyong Han et al.   NATURE

Epigenetic modifications and human disease

(2010) Anna Portela et al.   NATURE BIOTECHNOLOGY

Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators

(2010) David Landeira et al.   NATURE CELL BIOLOGY

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

(2010) Louis Vermeulen et al.   NATURE CELL BIOLOGY

Targeting cancer stem cells by inhibiting Wnt, Notch and Hedgehog pathways

(2010) Naoko Takebe et al.   Nature Reviews Clinical Oncology

Polycomb group protein-mediated repression of transcription

(2010) Lluís Morey et al.   TRENDS IN BIOCHEMICAL SCIENCES

EZH2 Is Essential for Glioblastoma Cancer Stem Cell Maintenance

(2009) M.-L. Suva et al.   CANCER RESEARCH

Polycomb protein EZH2 regulates E2F1-dependent apoptosis through epigenetically modulating Bim expression

(2009) Z L Wu et al.   CELL DEATH AND DIFFERENTIATION

Chromatin Signatures in Multipotent Human Hematopoietic Stem Cells Indicate the Fate of Bivalent Genes during Differentiation

(2009) Kairong Cui et al.   Cell Stem Cell

Modifications of RNA polymerase II are pivotal in regulating gene expression states

(2009) Emily Brookes et al.   EMBO REPORTS

The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformation

(2009) H. Boukarabila et al.   GENES & DEVELOPMENT

Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia

(2009) Chen Zhao et al.   NATURE

EZH2 is a mediator of EWS/FLI1 driven tumor growth and metastasis blocking endothelial and neuro-ectodermal differentiation

(2009) G. H. S. Richter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic Landscaping During hESC Differentiation to Neural Cells

(2009) Anna Golebiewska et al.   STEM CELLS

Maintenance of Undifferentiated State and Self-Renewal of Embryonic Neural Stem Cells by Polycomb Protein Ring1B

(2009) Mónica Román-Trufero et al.   STEM CELLS

Association between Bmi1 and clinicopathological status of esophageal squamous cell carcinoma

(2009) Xiao-Ting He et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Targeting of the Bmi-1 Oncogene/Stem Cell Renewal Factor by MicroRNA-128 Inhibits Glioma Proliferation and Self-Renewal

(2008) J. Godlewski et al.   CANCER RESEARCH

The overexpression of polycomb group proteins Bmi1 and EZH2 is associated with the progression and aggressive biological behavior of hepatocellular carcinoma

(2008) Motoko Sasaki et al.   LABORATORY INVESTIGATION

SWI/SNF Mediates Polycomb Eviction and Epigenetic Reprogramming of the INK4b-ARF-INK4a Locus

(2008) S. K. Kia et al.   MOLECULAR AND CELLULAR BIOLOGY

Lineage-Specific Polycomb Targets and De Novo DNA Methylation Define Restriction and Potential of Neuronal Progenitors

(2008) Fabio Mohn et al.   MOLECULAR CELL

High expression of EZH2 is associated with tumor proliferation and prognosis in human oral squamous cell carcinomas

(2008) Kazunori Kidani et al.   ORAL ONCOLOGY

Bmi1 is critical for lung tumorigenesis and bronchioalveolar stem cell expansion

(2008) J. S. Dovey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polycomb Repressive Complex 2 Is Dispensable for Maintenance of Embryonic Stem Cell Pluripotency

(2008) Stormy J. Chamberlain et al.   STEM CELLS

Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains

(2008) Manching Ku et al.   PLoS Genetics