Epigenetic alterations in rheumatoid arthritis fibroblast-like synoviocytes

DNA Methylation in Cancer and Aging

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Identification of citrullinated peptides in the synovial fluid of patients with rheumatoid arthritis using LC-MALDI-TOF/TOF

(2016) Fei Wang et al.   CLINICAL RHEUMATOLOGY

Uncovering the Role of the Methylome in Dementia and Neurodegeneration

(2016) Hans-Ulrich Klein et al.   TRENDS IN MOLECULAR MEDICINE

Joint-specific DNA methylation and transcriptome signatures in rheumatoid arthritis identify distinct pathogenic processes

(2016) Rizi Ai et al.   Nature Communications

LBH Gene Transcription Regulation by the Interplay of an Enhancer Risk Allele and DNA Methylation in Rheumatoid Arthritis

(2016) Deepa Hammaker et al.   Arthritis & Rheumatology

Associations of Smoking and Age With Inflammatory Joint Signs Among Unaffected First-Degree Relatives of Rheumatoid Arthritis Patients: Results From Studies of the Etiology of Rheumatoid Arthritis

(2016) Jeffrey A. Sparks et al.   Arthritis & Rheumatology

A novel NF-κB/YY1/microRNA-10a regulatory circuit in fibroblast-like synoviocytes regulates inflammation in rheumatoid arthritis

(2016) Nan Mu et al.   Scientific Reports

An overview of microRNAs

(2015) Scott M. Hammond   ADVANCED DRUG DELIVERY REVIEWS

MicroRNA-124 inhibits the progression of adjuvant-induced arthritis in rats

(2015) Yuji Nakamachi et al.   ANNALS OF THE RHEUMATIC DISEASES

Epigenomics of autoimmune diseases

(2015) Bhawna Gupta et al.   IMMUNOLOGY AND CELL BIOLOGY

MicroRNA-663 activates the canonical Wnt signaling through the adenomatous polyposis coli suppression

(2015) Cheng-gui Miao et al.   IMMUNOLOGY LETTERS

Targeting bromodomain-containing protein 4 (BRD4) benefits rheumatoid arthritis

(2015) Qing-gang Zhang et al.   IMMUNOLOGY LETTERS

Suberoylanilide Hydroxamic Acid, an Inhibitor of Histone Deacetylase, Induces Apoptosis in Rheumatoid Arthritis Fibroblast-Like Synoviocytes

(2015) Hui Chen et al.   INFLAMMATION

10-Hydroxy-2-decenoic acid inhibiting the proliferation of fibroblast-like synoviocytes by PI3K–AKT pathway

(2015) Jianguang Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

MicroRNA regulation of lymphocyte tolerance and autoimmunity

(2015) Laura J. Simpson et al.   JOURNAL OF CLINICAL INVESTIGATION

Function and information content of DNA methylation

(2015) Dirk Schübeler   NATURE

The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment

(2015) Xuan Zhang et al.   NATURE MEDICINE

Deregulation and therapeutic potential of microRNAs in arthritic diseases

(2015) Rita Vicente et al.   Nature Reviews Rheumatology

Integrative Omics Analysis of Rheumatoid Arthritis Identifies Non-Obvious Therapeutic Targets

(2015) John W. Whitaker et al.   PLoS One

DNA methylation profiling of synovial fluid FLS in rheumatoid arthritis reveals changes common with tissue-derived FLS

(2015) John R Glossop et al.   Epigenomics

DNA Methylome Signature in Synoviocytes From Patients With Early Rheumatoid Arthritis Compared to Synoviocytes From Patients With Longstanding Rheumatoid Arthritis

(2015) Rizi Ai et al.   Arthritis & Rheumatology

The Rheumatoid Arthritis Risk GeneLBHRegulates Growth in Fibroblast-like Synoviocytes

(2015) Anna-Karin H. Ekwall et al.   Arthritis & Rheumatology

Towards an understanding of the role of DNA methylation in rheumatoid arthritis: therapeutic and diagnostic implications

(2015) Adam Cribbs et al.   Therapeutic Advances in Musculoskeletal Disease

Inflammatory cytokines epigenetically regulate rheumatoid arthritis fibroblast-like synoviocyte activation by suppressing HDAC5 expression

(2014) Chiara Angiolilli et al.   ANNALS OF THE RHEUMATIC DISEASES

The bromodomain protein inhibitor I-BET151 suppresses expression of inflammatory genes and matrix degrading enzymes in rheumatoid arthritis synovial fibroblasts

(2014) Kerstin Klein et al.   ANNALS OF THE RHEUMATIC DISEASES

Cigarette smoking reduces DNA methylation levels at multiple genomic loci but the effect is partially reversible upon cessation

(2014) Loukia G Tsaprouni et al.   Epigenetics

A novel histone deacetylase 6-selective inhibitor suppresses synovial inflammation and joint destruction in a collagen antibody-induced arthritis mouse model

(2014) Jaejoon Lee et al.   International Journal of Rheumatic Diseases

Epigenome Analysis Reveals TBX5 as a Novel Transcription Factor Involved in the Activation of Rheumatoid Arthritis Synovial Fibroblasts

(2014) Emmanuel Karouzakis et al.   JOURNAL OF IMMUNOLOGY

Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders

(2014) Katrina J. Falkenberg et al.   NATURE REVIEWS DRUG DISCOVERY

Targeting bromodomains: epigenetic readers of lysine acetylation

(2014) Panagis Filippakopoulos et al.   NATURE REVIEWS DRUG DISCOVERY

Histone core modifications regulating nucleosome structure and dynamics

(2014) Peter Tessarz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inhibition of osteoclastogenesis and inflammatory bone resorption by targeting BET proteins and epigenetic regulation

(2014) Kyung-Hyun Park-Min et al.   Nature Communications

Prolonged Tumor Necrosis Factor α Primes Fibroblast-like Synoviocytes in a Gene-Specific Manner by Altering Chromatin

(2014) Christopher Sohn et al.   Arthritis & Rheumatology

DNA Methyltransferases: A Novel Target for Prevention and Therapy

(2014) Dharmalingam Subramaniam et al.   Frontiers in Oncology

MicroRNAs in Cancer

(2013) Gianpiero Di Leva et al.   Annual Review of Pathology-Mechanisms of Disease

Protein Tyrosine Phosphatase Expression Profile of Rheumatoid Arthritis Fibroblast-like Synoviocytes: A Novel Role of SH2 Domain-Containing Phosphatase 2 as a Modulator of Invasion and Survival

(2013) Stephanie M. Stanford et al.   ARTHRITIS AND RHEUMATISM

Tumor Necrosis Factor α Induces Sustained Signaling and a Prolonged and Unremitting Inflammatory Response in Rheumatoid Arthritis Synovial Fibroblasts

(2013) Angela Lee et al.   ARTHRITIS AND RHEUMATISM

Therapeutic Effects of NK-HDAC-1, a Novel Histone Deacetylase Inhibitor, on Collagen-Induced Arthritis Through the Induction of Apoptosis of Fibroblast-Like Synoviocytes

(2013) Minghui Li et al.   INFLAMMATION

Identification of novel markers in rheumatoid arthritis through integrated analysis of DNA methylation and microRNA expression

(2013) Lorenzo de la Rica et al.   JOURNAL OF AUTOIMMUNITY

Regulation of DNA Methylation in Rheumatoid Arthritis Synoviocytes

(2013) K. Nakano et al.   JOURNAL OF IMMUNOLOGY

Genetics of rheumatoid arthritis contributes to biology and drug discovery

(2013) Yukinori Okada et al.   NATURE

On the Origin of Rheumatoid Arthritis: The Impact of Environment and Genes—A Population Based Twin Study

(2013) Anders J. Svendsen et al.   PLoS One

An imprinted rheumatoid arthritis methylome signature reflects pathogenic phenotype

(2013) John W Whitaker et al.   Genome Medicine

Epigenetics in Rheumatoid Arthritis: A Primer for Rheumatologists

(2013) Nunzio Bottini et al.   Current Rheumatology Reports

Identification of microRNA-221/222 and microRNA-323-3p association with rheumatoid arthritis via predictions using the human tumour necrosis factor transgenic mouse model

(2012) Ioannis Pandis et al.   ANNALS OF THE RHEUMATIC DISEASES

DNA methylome signature in rheumatoid arthritis

(2012) Kazuhisa Nakano et al.   ANNALS OF THE RHEUMATIC DISEASES

MiR-20a regulates ASK1 expression and TLR4-dependent cytokine release in rheumatoid fibroblast-like synoviocytes

(2012) Lucas Philippe et al.   ANNALS OF THE RHEUMATIC DISEASES

Tumor Necrosis Factor α-Induced MicroRNA-18a Activates Rheumatoid Arthritis Synovial Fibroblasts Through a Feedback Loop in NF-κB Signaling

(2012) Michelle Trenkmann et al.   ARTHRITIS AND RHEUMATISM

The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α

(2012) Shu Zhu et al.   NATURE MEDICINE

Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors

(2012) Nunzio Bottini et al.   Nature Reviews Rheumatology

A miR-19 regulon that controls NF-κB signaling

(2012) Michael P. Gantier et al.   NUCLEIC ACIDS RESEARCH

Histone deacetylase inhibitors suppress rheumatoid arthritis fibroblast-like synoviocyte and macrophage IL-6 production by accelerating mRNA decay

(2011) Aleksander M Grabiec et al.   ANNALS OF THE RHEUMATIC DISEASES

miR-124a as a key regulator of proliferation and MCP-1 secretion in synoviocytes from patients with rheumatoid arthritis

(2011) S. Kawano et al.   ANNALS OF THE RHEUMATIC DISEASES

Safety and efficacy of an oral histone deacetylase inhibitor in systemic-onset juvenile idiopathic arthritis

(2011) Jelena Vojinovic et al.   ARTHRITIS AND RHEUMATISM

Down-regulation of microRNA-34a* in rheumatoid arthritis synovial fibroblasts promotes apoptosis resistance

(2011) Fabienne Niederer et al.   ARTHRITIS AND RHEUMATISM

Increased recycling of polyamines is associated with global DNA hypomethylation in rheumatoid arthritis synovial fibroblasts

(2011) Emmanuel Karouzakis et al.   ARTHRITIS AND RHEUMATISM

DNA methylation regulates the expression of CXCL12 in rheumatoid arthritis synovial fibroblasts

(2011) E Karouzakis et al.   GENES AND IMMUNITY

TLR2 Expression Is Regulated by MicroRNA miR-19 in Rheumatoid Fibroblast-like Synoviocytes

(2011) L. Philippe et al.   JOURNAL OF IMMUNOLOGY

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(2011) Leo Joosten et al.   MOLECULAR MEDICINE

miR-346 Controls Release of TNF-α Protein and Stability of Its mRNA in Rheumatoid Arthritis via Tristetraprolin Stabilization

(2011) Noha Semaan et al.   PLoS One

MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis

(2011) M. Kurowska-Stolarska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered expression of microRNA-203 in rheumatoid arthritis synovial fibroblasts and its role in fibroblast activation

(2010) Joanna Stanczyk et al.   ARTHRITIS AND RHEUMATISM

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

(2010) Eli A Stahl et al.   NATURE GENETICS

Histone deacetylase inhibitors MS-275 and SAHA induced growth arrest and suppressed lipopolysaccharide-stimulated NF- B p65 nuclear accumulation in human rheumatoid arthritis synovial fibroblastic E11 cells

(2010) Q.-Y. Choo et al.   RHEUMATOLOGY

Increased activity and expression of histone deacetylase 1 in relation to tumor necrosis factor-alpha in synovial tissue of rheumatoid arthritis

(2010) Tomoko Kawabata et al.   ARTHRITIS RESEARCH & THERAPY

MicroRNA-124a is a key regulator of proliferation and monocyte chemoattractant protein 1 secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis

(2009) Yuji Nakamachi et al.   ARTHRITIS AND RHEUMATISM

DNA hypomethylation in rheumatoid arthritis synovial fibroblasts

(2009) Emmanuel Karouzakis et al.   ARTHRITIS AND RHEUMATISM

Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis

(2009) Beatrix Bartok et al.   IMMUNOLOGICAL REVIEWS

Bruton's Tyrosine Kinase Is Involved in miR-346-Related Regulation of IL-18 Release by Lipopolysaccharide-Activated Rheumatoid Fibroblast-Like Synoviocytes

(2009) G. Alsaleh et al.   JOURNAL OF IMMUNOLOGY

Expression and Function of Histone Deacetylases in Rheumatoid Arthritis Synovial Fibroblasts

(2009) M. HORIUCHI et al.   JOURNAL OF RHEUMATOLOGY

Synovial fibroblasts spread rheumatoid arthritis to unaffected joints

(2009) Stephanie Lefèvre et al.   NATURE MEDICINE

Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis

(2008) Joanna Stanczyk et al.   ARTHRITIS AND RHEUMATISM