Inhibition of osteoclastogenesis and inflammatory bone resorption by targeting BET proteins and epigenetic regulation

Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer

(2014) Irfan A. Asangani et al.   NATURE

Selective inhibition of BET bromodomain epigenetic signalling interferes with the bone-associated tumour vicious cycle

(2014) François Lamoureux et al.   Nature Communications

Metabolic regulation of osteoclast differentiation and function

(2013) Yoriko Indo et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Female Mice Lacking Estrogen Receptor-Alpha in Osteoblasts Have Compromised Bone Mass and Strength

(2013) Katherine M Melville et al.   JOURNAL OF BONE AND MINERAL RESEARCH

From ApoA1 upregulation to BET family bromodomain inhibition: Discovery of I-BET151

(2012) Olivier Mirguet et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification of a novel series of BET family bromodomain inhibitors: Binding mode and profile of I-BET151 (GSK1210151A)

(2012) Jonathan Seal et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The collection of NFATc1-dependent transcripts in the osteoclast includes numerous genes non-essential to physiologic bone resorption

(2012) Julia F. Charles et al.   BONE

Cancer Epigenetics: From Mechanism to Therapy

(2012) Mark A. Dawson et al.   CELL

Negative regulation of osteoclast precursor differentiation by CD11b andβ2 integrin-B-cell lymphoma 6 signaling

(2012) Kyung-Hyun Park-Min et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Epigenetic protein families: a new frontier for drug discovery

(2012) Cheryl H. Arrowsmith et al.   NATURE REVIEWS DRUG DISCOVERY

Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors

(2012) H. S. Bandukwala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Place your BETs: the therapeutic potential of bromodomains

(2012) R.K. Prinjha et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Feedback inhibition of osteoclastogenesis during inflammation by IL-10, M-CSF receptor shedding, and induction of IRF8

(2011) Lionel B. Ivashkiv et al.   Annals of the New York Academy of Sciences

Epigenetic regulation of osteoclast differentiation

(2011) Tetsuro Yasui et al.   Annals of the New York Academy of Sciences

Pathogenesis of NUT Midline Carcinoma

(2011) Christopher A. French   Annual Review of Pathology-Mechanisms of Disease

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

(2011) Jake E. Delmore et al.   CELL

Epigenetic regulation of osteoclast differentiation: Possible involvement of Jmjd3 in the histone demethylation of Nfatc1

(2011) Tetsuro Yasui et al.   JOURNAL OF BONE AND MINERAL RESEARCH

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

(2011) Johannes Zuber et al.   NATURE

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

(2011) Mark A. Dawson et al.   NATURE

The Pathogenesis of Rheumatoid Arthritis

(2011) Iain B. McInnes et al.   NEW ENGLAND JOURNAL OF MEDICINE

TNF activates calcium-nuclear factor of activated T cells (NFAT)c1 signaling pathways in human macrophages

(2011) A. Yarilina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Negative regulation of osteoclastogenesis and bone resorption by cytokines and transcriptional repressors

(2011) Baohong Zhao et al.   ARTHRITIS RESEARCH & THERAPY

Loss of Osteoclasts Contributes to Development of Osteosarcoma Pulmonary Metastases

(2010) L. Endo-Munoz et al.   CANCER RESEARCH

Effects of combination treatment with alendronate and vitamin K2 on bone mineral density and strength in ovariectomized mice

(2010) Hiroshi Sasaki et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Bone histomorphometry: Standardization of nomenclature, symbols, and units: Report of the asbmr histomorphometry nomenclature committee

(2010) A. Michael Parfitt et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Guidelines for assessment of bone microstructure in rodents using micro-computed tomography

(2010) Mary L Bouxsein et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The Blimp1–Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis

(2010) Yoshiteru Miyauchi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Suppression of inflammation by a synthetic histone mimic

(2010) Edwige Nicodeme et al.   NATURE

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

Chromatin structure and the inheritance of epigenetic information

(2010) Raphaël Margueron et al.   NATURE REVIEWS GENETICS

Blimp1-mediated repression of negative regulators is required for osteoclast differentiation

(2010) K. Nishikawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ca2+-NFATc1 signaling is an essential axis of osteoclast differentiation

(2009) Takako Negishi-Koga et al.   IMMUNOLOGICAL REVIEWS

Bisphosphonates: Mechanism of Action and Role in Clinical Practice

(2009) Matthew T. Drake et al.   MAYO CLINIC PROCEEDINGS

The Osteoclast: Friend or Foe?

(2008) Deborah V. Novack et al.   Annual Review of Pathology-Mechanisms of Disease

Osteoimmunology: Interactions of the Bone and Immune System

(2008) Joseph Lorenzo et al.   ENDOCRINE REVIEWS

NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism

(2008) Antonios O. Aliprantis et al.   JOURNAL OF CLINICAL INVESTIGATION