Blockade of reactive oxygen species and Akt activation is critical for anti-inflammation and growth inhibition of metformin in phosphatase and tensin homolog-deficient RAW264.7 cells

Role of the Phosphatase PTEN in Early Vascular Remodeling

(2013) Daniel G. Sedding et al.   PLoS One

Metformin inhibits inflammatory response via AMPK–PTEN pathway in vascular smooth muscle cells

(2012) Sun Ae Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

(2012) Paul D. Ray et al.   CELLULAR SIGNALLING

AMPK activators inhibit the proliferation of human melanomas bearing the activated MAPK pathway

(2012) Carlotta Petti et al.   MELANOMA RESEARCH

Upsides and Downsides of Reactive Oxygen Species for Cancer: The Roles of Reactive Oxygen Species in Tumorigenesis, Prevention, and Therapy

(2011) Subash C. Gupta et al.   ANTIOXIDANTS & REDOX SIGNALING

Metformin induces apoptosis of lung cancer cells through activating JNK/p38 MAPK pathway and GADD153

(2011) N. WU et al.   NEOPLASMA

AICAR induces cyclooxygenase-2 expression through AMP-activated protein kinase-transforming growth factor-β-activated kinase 1-p38 mitogen-activated protein kinase signaling pathway

(2010) Mei-Ying Chang et al.   BIOCHEMICAL PHARMACOLOGY

Prognostic significance of AMP-activated protein kinase expression and modifying effect of MAPK3/1 in colorectal cancer

(2010) Y Baba et al.   BRITISH JOURNAL OF CANCER

Genetic variation in a metabolic signaling pathway and colon and rectal cancer risk: mTOR , PTEN , STK11 , RPKAA1 , PRKAG2 , TSC1 , TSC2 , PI3K and Akt1

(2010) Martha L. Slattery et al.   CARCINOGENESIS

Metformin: A Therapeutic Opportunity in Breast Cancer

(2010) A. M. Gonzalez-Angulo et al.   CLINICAL CANCER RESEARCH

Cancer and Inflammation: Implications for Pharmacology and Therapeutics

(2010) F Balkwill et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

AMP-activated Protein Kinase Antagonizes Pro-apoptotic Extracellular Signal-regulated Kinase Activation by Inducing Dual-specificity Protein Phosphatases in Response to Glucose Deprivation in HCT116 Carcinoma

(2010) Min-Jung Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alkylation of the Tumor Suppressor PTEN Activates Akt and β-Catenin Signaling: A Mechanism Linking Inflammation and Oxidative Stress with Cancer

(2010) Tracy M. Covey et al.   PLoS One

Methionine sulfoxide reductase A down-regulation in human breast cancer cells results in a more aggressive phenotype

(2010) A. De Luca et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Convergence of Hormones, Inflammation, and Energy-Related Factors: A Novel Pathway of Cancer Etiology

(2009) M. L. Slattery et al.   Cancer Prevention Research

Activation and Signaling by the AMP-Activated Protein Kinase in Endothelial Cells

(2009) Beate Fisslthaler et al.   CIRCULATION RESEARCH

Sex difference in the liver of hepatocyte-specific Pten-deficient mice: A model of nonalcoholic steatohepatitis

(2009) Yumiko Anezaki et al.   HEPATOLOGY RESEARCH

Role of the Tumor Suppressor PTEN in Antioxidant Responsive Element-mediated Transcription and Associated Histone Modifications

(2009) Kensuke Sakamoto et al.   MOLECULAR BIOLOGY OF THE CELL

Redox Regulation of Cell Survival

(2008) Dunyaporn Trachootham et al.   ANTIOXIDANTS & REDOX SIGNALING

Important role of the LKB1–AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice

(2008) Xu Huang et al.   BIOCHEMICAL JOURNAL

High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinase

(2008) Masayuki Adachi et al.   HEPATOLOGY

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE