Th17 cells in autoimmune diseases

The role of T helper 17 cell subsets in Sjögren's syndrome: similarities and differences between mouse model and humans

(2014) Xiang Lin et al.   ANNALS OF THE RHEUMATIC DISEASES

Emerging Potential of Therapeutic Targeting of Ubiquitin-Specific Proteases in the Treatment of Cancer

(2014) A. Pal et al.   CANCER RESEARCH

Clinical parameter and Th17 related to lymphocytes infiltrating degree of labial salivary gland in primary Sjögren’s syndrome

(2014) Yunyun Fei et al.   CLINICAL RHEUMATOLOGY

Small-Molecule RORγt Antagonists Inhibit T Helper 17 Cell Transcriptional Network by Divergent Mechanisms

(2014) Sheng Xiao et al.   IMMUNITY

CD4−CD8− T-cells in primary Sjögren's syndrome: Association with the extent of glandular involvement

(2014) Alessia Alunno et al.   JOURNAL OF AUTOIMMUNITY

The E3 Deubiquitinase USP17 Is a Positive Regulator of Retinoic Acid-related Orphan Nuclear Receptor γt (RORγt) in Th17 Cells

(2014) Lei Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of IL-18 and Th17 Cells in Salivary Glands of Patients with Sjogren's Syndrome, and Amplification of IL-17-Mediated Secretion of Inflammatory Cytokines from Salivary Gland Cells by IL-18

(2014) A. Sakai et al.   JOURNAL OF IMMUNOLOGY

Expanded Double Negative T Cells in Patients with Systemic Lupus Erythematosus Produce IL-17 and Infiltrate the Kidneys

(2014) J. C. Crispin et al.   JOURNAL OF IMMUNOLOGY

IL-2 Protects Lupus-Prone Mice from Multiple End-Organ Damage by Limiting CD4−CD8−IL-17–Producing T Cells

(2014) Masayuki Mizui et al.   JOURNAL OF IMMUNOLOGY

IL-17 Promotes Murine Lupus

(2014) Gil Amarilyo et al.   JOURNAL OF IMMUNOLOGY

The Role of Endogenous IFN-  in the Regulation of Th17 Responses in Patients with Relapsing-Remitting Multiple Sclerosis

(2014) Y. Tao et al.   JOURNAL OF IMMUNOLOGY

Mechanistic Target of Rapamycin Complex 1 Expands Th17 and IL-4+ CD4-CD8- Double-Negative T Cells and Contracts Regulatory T Cells in Systemic Lupus Erythematosus

(2014) H. Kato et al.   JOURNAL OF IMMUNOLOGY

The immunomodulator AS101 suppresses production of inflammatory cytokines and ameliorates the pathogenesis of experimental autoimmune encephalomyelitis

(2014) Li Xie et al.   JOURNAL OF NEUROIMMUNOLOGY

Increased Th17 Cell Frequency and Poor Clinical Outcome in Rheumatoid Arthritis Are Associated With a Genetic Variant in theIL4RGene, rs1805010

(2014) Jan Leipe et al.   Arthritis & Rheumatology

IL-17/Th17 mediated synovial inflammation is IL-22 independent

(2013) Jan Piet van Hamburg et al.   ANNALS OF THE RHEUMATIC DISEASES

Innate and adaptive immunity in inflammatory bowel disease

(2013) Alessandra Geremia et al.   AUTOIMMUNITY REVIEWS

Th17 Cells in Immunity and Autoimmunity

(2013) Simone Kennedy Bedoya et al.   Clinical & Developmental Immunology

Interleukin 17 contributes to the chronicity of inflammatory diseases such as rheumatoid arthritis

(2013) Giulia Benedetti et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Reduction of CD68+ Macrophages and Decreased IL-17 Expression in Intestinal Mucosa of Patients with Inflammatory Bowel Disease Strongly Correlate With Endoscopic Response and Mucosal Healing following Infliximab Therapy

(2013) Flavio Caprioli et al.   INFLAMMATORY BOWEL DISEASES

Th17 Cytokines in Inflammatory Bowel Diseases: Discerning the Good from the Bad

(2013) Edoardo Troncone et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Th22, but not Th17 Might be a Good Index to Predict the Tissue Involvement of Systemic Lupus Erythematosus

(2013) Xu-yan Yang et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells

(2013) Markus Kleinewietfeld et al.   NATURE

Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis

(2013) Noriko Komatsu et al.   NATURE MEDICINE

Systemic Inflammation in Progressive Multiple Sclerosis Involves Follicular T-Helper, Th17- and Activated B-Cells and Correlates with Progression

(2013) Jeppe Romme Christensen et al.   PLoS One

Clinical associations of serum interleukin-17 in systemic lupus erythematosus

(2013) Fabien B Vincent et al.   ARTHRITIS RESEARCH & THERAPY

Th17 Cells

(2012) Mohan S. Maddur et al.   AMERICAN JOURNAL OF PATHOLOGY

IL-17-producing CD4−CD8−T cells are expanded in the peripheral blood, infiltrate salivary glands and are resistant to corticosteroids in patients with primary Sjögren's syndrome

(2012) Alessia Alunno et al.   ANNALS OF THE RHEUMATIC DISEASES

Effect of IL-17A blockade with secukinumab in autoimmune diseases

(2012) Dhavalkumar D Patel et al.   ANNALS OF THE RHEUMATIC DISEASES

Effective treatment of rat adjuvant-induced arthritis by celastrol

(2012) R. Cascão et al.   AUTOIMMUNITY REVIEWS

TWEAK promotes the production of Interleukin-17 in rheumatoid arthritis

(2012) Jin-Sil Park et al.   CYTOKINE

Small molecule inhibitors of RORγt: Targeting Th17 cells and other applications

(2012) Jun R. Huh et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial

(2012) Wolfgang Hueber et al.   GUT

The CD27 and CD70 Costimulatory Pathway Inhibits Effector Function of T Helper 17 Cells and Attenuates Associated Autoimmunity

(2012) Jonathan M. Coquet et al.   IMMUNITY

The T cell in Sjogren's syndrome: Force majeure, not spectateur

(2012) Namrata Singh et al.   JOURNAL OF AUTOIMMUNITY

The potential role of Th17 cells and Th17-related cytokines in the pathogenesis of lupus nephritis

(2012) D-Y Chen et al.   LUPUS

Negative regulation of IL-17-mediated signaling and inflammation by the ubiquitin-specific protease USP25

(2012) Bo Zhong et al.   NATURE IMMUNOLOGY

Induction and molecular signature of pathogenic TH17 cells

(2012) Youjin Lee et al.   NATURE IMMUNOLOGY

Increased Frequencies of Th22 Cells as well as Th17 Cells in the Peripheral Blood of Patients with Ankylosing Spondylitis and Rheumatoid Arthritis

(2012) Lei Zhang et al.   PLoS One

Elevated Levels of T Helper 17 Cells Are Associated with Disease Activity in Patients with Rheumatoid Arthritis

(2012) Jimyung Kim et al.   Annals of Laboratory Medicine

Potential involvement of IL-22 and IL-22-producing cells in the inflamed salivary glands of patients with Sjögren's syndrome

(2011) Francesco Ciccia et al.   ANNALS OF THE RHEUMATIC DISEASES

Disturbed Th1, Th2, Th17 and Treg balance in patients with systemic lupus erythematosus

(2011) Sebastian Dolff et al.   CLINICAL IMMUNOLOGY

Serum and synovial fluid levels of interleukin-17 in correlation with disease activity in patients with RA

(2011) Siham Ali Metawi et al.   CLINICAL RHEUMATOLOGY

New IBD genetics: common pathways with other diseases

(2011) C. W. Lees et al.   GUT

Interleukin-23 and T helper 17-type responses in intestinal inflammation: from cytokines to T-cell plasticity

(2011) Peter J. Morrison et al.   IMMUNOLOGY

The complexity of Sjögren's syndrome: Novel aspects on pathogenesis

(2011) Roland Jonsson et al.   IMMUNOLOGY LETTERS

New Pathogenic Paradigms in Inflammatory Bowel Disease

(2011) Antonio Di Sabatino et al.   INFLAMMATORY BOWEL DISEASES

Ursolic Acid Suppresses Interleukin-17 (IL-17) Production by Selectively Antagonizing the Function of RORγt Protein

(2011) Tao Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Th17 Cells Induce Colitis and Promote Th1 Cell Responses through IL-17 Induction of Innate IL-12 and IL-23 Production

(2011) T. Feng et al.   JOURNAL OF IMMUNOLOGY

Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity

(2011) Jun R. Huh et al.   NATURE

Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand

(2011) Laura A. Solt et al.   NATURE

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

(2011) Laura Codarri et al.   NATURE IMMUNOLOGY

The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF

(2011) Mohamed El-Behi et al.   NATURE IMMUNOLOGY

Elevated Th17 cells are accompanied by FoxP3+ Treg cells decrease in patients with lupus nephritis

(2011) Qian Xing et al.   RHEUMATOLOGY INTERNATIONAL

Pathogenic effect of interleukin-17A in induction of Sjögren's syndrome-like disease using adenovirus-mediated gene transfer

(2011) Cuong Q Nguyen et al.   ARTHRITIS RESEARCH & THERAPY

Disturbance of cytokine networks in Sjögren's syndrome

(2011) Pierre Youinou et al.   ARTHRITIS RESEARCH & THERAPY

Mast cells are the main interleukin 17-positive cells in anticitrullinated protein antibody-positive and -negative rheumatoid arthritis and osteoarthritis synovium

(2011) Jolien Suurmond et al.   ARTHRITIS RESEARCH & THERAPY

Inflammatory Bowel Disease

(2010) Arthur Kaser et al.   Annual Review of Immunology

Th17 cells, but not Th1 cells, from patients with early rheumatoid arthritis are potent inducers of matrix metalloproteinases and proinflammatory cytokines upon synovial fibroblast interaction, including autocrine interleukin-17A production

(2010) J. P. van Hamburg et al.   ARTHRITIS AND RHEUMATISM

LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I randomized, double-blind, placebo-controlled, proof-of-concept study

(2010) M. C. Genovese et al.   ARTHRITIS AND RHEUMATISM

Anti-IL-17A therapy protects against bone erosion in experimental models of rheumatoid arthritis

(2010) Cheng-Chi Chao et al.   AUTOIMMUNITY

EAE mediated by a non-IFN-γ/non-IL-17 pathway

(2010) Mark A. Kroenke et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-23/IL-17 axis in IBD

(2010) Massimiliano Sarra et al.   INFLAMMATORY BOWEL DISEASES

Th17 cells can provide B cell help in autoantibody induced arthritis

(2010) Cynthia L. Hickman-Brecks et al.   JOURNAL OF AUTOIMMUNITY

Pathogenetic mechanisms in the initiation and perpetuation of Sjögren's syndrome

(2010) Michael Voulgarelis et al.   Nature Reviews Rheumatology

Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environment

(2010) K. Nistala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of AIN457, a Fully Human Antibody to Interleukin-17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis

(2010) W. Hueber et al.   Science Translational Medicine

Rheumatoid synovial fluid interleukin-17-producing CD4 T cells have abundant tumor necrosis factor-alpha co-expression, but little interleukin-22 and interleukin-23R expression

(2010) Leigh D Church et al.   ARTHRITIS RESEARCH & THERAPY

Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus

(2010) Kamini Shah et al.   ARTHRITIS RESEARCH & THERAPY

Systemic and Local Interleukin-17 and Linked Cytokines Associated with Sjögren’s Syndrome Immunopathogenesis

(2009) Gikas E. Katsifis et al.   AMERICAN JOURNAL OF PATHOLOGY

Decreased plasma IL22 levels, but not increased IL17 and IL23 levels, correlate with disease activity in patients with systemic lupus erythematosus

(2009) F Cheng et al.   ANNALS OF THE RHEUMATIC DISEASES

Frequency and phenotype of peripheral blood Th17 cells in ankylosing spondylitis and rheumatoid arthritis

(2009) Hui Shen et al.   ARTHRITIS AND RHEUMATISM

Th17 and natural Treg cell population dynamics in systemic lupus erythematosus

(2009) Ji Yang et al.   ARTHRITIS AND RHEUMATISM

Th1, Th17, and Th9 Effector Cells Induce Experimental Autoimmune Encephalomyelitis with Different Pathological Phenotypes

(2009) A. Jager et al.   JOURNAL OF IMMUNOLOGY

Increased serum interleukin 17 in patients with systemic lupus erythematosus

(2009) Xue-Fei Zhao et al.   MOLECULAR BIOLOGY REPORTS

C-C chemokine receptor 6–regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE

(2009) Andrea Reboldi et al.   NATURE IMMUNOLOGY

A protective function for interleukin 17A in T cell–mediated intestinal inflammation

(2009) William O'Connor Jr et al.   NATURE IMMUNOLOGY

CD4 T-cell differentiation and inflammatory bowel disease

(2009) Lauren A. Zenewicz et al.   TRENDS IN MOLECULAR MEDICINE

Salivary gland tissue expression of interleukin-23 and interleukin-17 in Sjögren's syndrome: Findings in humans and mice

(2008) Cuong Q. Nguyen et al.   ARTHRITIS AND RHEUMATISM

Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: Implications for Th17-mediated inflammation in auto-immunity

(2008) Chun Kwok Wong et al.   CLINICAL IMMUNOLOGY

IL‐21 and IL‐21R are not required for development of Th17 cells and autoimmunityin vivo

(2008) Ivo Sonderegger et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A Randomized Trial of Ustekinumab, a Human Interleukin-12/23 Monoclonal Antibody, in Patients With Moderate-to-Severe Crohn's Disease

(2008) William J. Sandborn et al.   GASTROENTEROLOGY

The Biological Functions of T Helper 17 Cell Effector Cytokines in Inflammation

(2008) Wenjun Ouyang et al.   IMMUNITY

T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ

(2008) Xuexian O. Yang et al.   IMMUNITY

Foxp3 Inhibits RORγt-mediatedIL-17AmRNA Transcription through Direct Interaction with RORγt

(2008) Kenji Ichiyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of inflammatory responses by IL-17F

(2008) Xuexian O. Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor

(2008) Francisco J. Quintana et al.   NATURE

Induction and effector functions of TH17 cells

(2008) Estelle Bettelli et al.   NATURE

A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responses

(2008) Elisabetta Volpe et al.   NATURE IMMUNOLOGY

The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt

(2008) Nicolas Manel et al.   NATURE IMMUNOLOGY

Role of the novel Th17 cytokine IL-17F in inflammatory bowel disease (IBD): Upregulated colonic IL-17F expression in active Crohnʼs disease and analysis of the IL17F p.His161Arg polymorphism in IBD

(2007) Julia Seiderer et al.   INFLAMMATORY BOWEL DISEASES