Disulfiram/copper selectively eradicates AML leukemia stem cells in vitro and in vivo by simultaneous induction of ROS-JNK and inhibition of NF-κB and Nrf2
出版年份 2017 全文链接
标题
Disulfiram/copper selectively eradicates AML leukemia stem cells in vitro and in vivo by simultaneous induction of ROS-JNK and inhibition of NF-κB and Nrf2
作者
关键词
-
出版物
Cell Death & Disease
Volume 8, Issue 5, Pages e2797
出版商
Springer Nature
发表日期
2017-05-18
DOI
10.1038/cddis.2017.176
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- The Nrf2-ARE signaling pathway: An update on its regulation and possible role in cancer prevention and treatment
- (2017) Violetta Krajka-Kuźniak et al. Pharmacological Reports
- The Role of JNK Signalling in Responses to Oxidative DNA Damage
- (2016) Zeeshan Shaukat et al. CURRENT DRUG TARGETS
- Targeting reactive oxygen species in development and progression of pancreatic cancer
- (2016) Nisha Durand et al. Expert Review of Anticancer Therapy
- NFKB1: a suppressor of inflammation, ageing and cancer
- (2016) Tyrell Cartwright et al. FEBS Journal
- Signaling via the NFκB system
- (2016) Simon Mitchell et al. Wiley Interdisciplinary Reviews-Systems Biology and Medicine
- A New Strategy to Target Acute Myeloid Leukemia Stem and Progenitor Cells Using Chidamide, a Histone Deacetylase Inhibitor
- (2015) Yin Li et al. CURRENT CANCER DRUG TARGETS
- The cytotoxic mechanisms of disulfiram and copper(ii) in cancer cells
- (2015) Patricia Erebi Tawari et al. Toxicology Research
- Disulfiram targeting lymphoid malignant cell lines via ROS-JNK activation as well as Nrf2 and NF-kB pathway inhibition
- (2014) Jie Zha et al. Journal of Translational Medicine
- Free Radicals in Cross Talk Between Autophagy and Apoptosis
- (2013) Vitaliy O. Kaminskyy et al. ANTIOXIDANTS & REDOX SIGNALING
- Low-dose triptolide in combination with idarubicin induces apoptosis in AML leukemic stem-like KG1a cell line by modulation of the intrinsic and extrinsic factors
- (2013) Y Liu et al. Cell Death & Disease
- Disulfiram, an old drug with new potential therapeutic uses for human hematological malignancies
- (2012) Concetta Conticello et al. INTERNATIONAL JOURNAL OF CANCER
- Molecular mechanisms for the regulation of Nrf2-mediated cell proliferation in non-small-cell lung cancers
- (2012) T Yamadori et al. ONCOGENE
- The cytoprotective role of the Keap1–Nrf2 pathway
- (2011) Liam Baird et al. ARCHIVES OF TOXICOLOGY
- Disulfiram/copper complex activated JNK/c-jun pathway and sensitized cytotoxicity of doxorubicin in doxorubicin resistant leukemia HL60 cells
- (2011) Bing Xu et al. BLOOD CELLS MOLECULES AND DISEASES
- Disulfiram modulated ROS–MAPK and NFκB pathways and targeted breast cancer cells with cancer stem cell-like properties
- (2011) N C Yip et al. BRITISH JOURNAL OF CANCER
- Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution
- (2011) Keiko Taguchi et al. GENES TO CELLS
- The critical role of JNK in the ER-mitochondrial crosstalk during apoptotic cell death
- (2011) Gaurav Verma et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Disulfiram Treatment Facilitates Phosphoinositide 3-Kinase Inhibition in Human Breast Cancer Cells In vitro and In vivo
- (2010) H. Zhang et al. CANCER RESEARCH
- TIM-3 Is a Promising Target to Selectively Kill Acute Myeloid Leukemia Stem Cells
- (2010) Yoshikane Kikushige et al. Cell Stem Cell
- Reactive oxygen species in cancer
- (2010) Geou-Yarh Liou et al. FREE RADICAL RESEARCH
- Disulfiram induces copper-dependent stimulation of reactive oxygen species and activation of the extrinsic apoptotic pathway in melanoma
- (2010) Brian W. Morrison et al. MELANOMA RESEARCH
- Disulfiram is a DNA demethylating agent and inhibits prostate cancer cell growth
- (2010) Jianqing Lin et al. PROSTATE
- Disulfiram/copper complex inhibiting NFκB activity and potentiating cytotoxic effect of gemcitabine on colon and breast cancer cell lines
- (2009) Xiaoxia Guo et al. CANCER LETTERS
- Surfactin induces apoptosis in human breast cancer MCF-7 cells through a ROS/JNK-mediated mitochondrial/caspase pathway
- (2009) Xiao-hong Cao et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Elevated copper and oxidative stress in cancer cells as a target for cancer treatment
- (2008) Anshul Gupte et al. CANCER TREATMENT REVIEWS
- The value of proteasome inhibition in cancer
- (2008) Boris Cvek et al. DRUG DISCOVERY TODAY
- JNK signaling in apoptosis
- (2008) D N Dhanasekaran et al. ONCOGENE
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationPublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More