☆ 4.7 Article

Production and identification of antioxidant and angiotensin-converting enzyme inhibition and dipeptidyl peptidase IV inhibitory peptides from bighead carp (Hypophthalmichthys nobilis) muscle hydrolysate

JOURNAL OF FUNCTIONAL FOODS (2017)

Journal

JOURNAL OF FUNCTIONAL FOODS

Volume 35, Issue -, Pages 224-235

Publisher

ELSEVIER

DOI: 10.1016/j.jff.2017.05.032

Keywords

Bighead carp; Bioactive peptides; Antioxidant; Dipeptidyl peptidase IV inhibition; Angiotensin converting enzyme inhibition; In silico prediction

Categories

Food Science & Technology Nutrition & Dietetics

Funding

Earmarked Fund for China Agriculture Research System [CARS-46]
National Science and Technology Ministry of China [2017YFD0400200]
Chinese Universities Scientific Fund [15056148]
Tianjin Project of Transformation and Extension of Agricultural Science and Technology Achievements [201404020]

Ask authors/readers for more resources

Protocol

Community support

Reagent

Community support

Abstract

We investigated bioactive peptides obtained from muscle protein hydrolysate of bighead carp by evaluating in vitro dipeptidyl peptidase IV (DPP-IV) and angiotensin-converting enzyme (ACE) inhibitory capacities and antioxidant activity. Peptide sequences were identified from pepsin hydrolysates. Met-Lys-Ala-Val-Cys-Phe-Ser-Leu was one of the most effective sequences with 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity (EC50 = 4.58 +/- 0.15 mu M) and relatively high ACE inhibitory capacity (IC50 = 3.68 +/- 0.13 mu M). Tyr-Asn-Leu-Lys-Glu-Arg-Tyr-Ala-Ala-Trp (IC50 = 1.35 +/- 0.23 mu M) and Tyr-Asn-Arg-Leu-Pro-Glu-Leu (IC50 = 3.42 +/- 0.39 mu M) exhibited the most potent ACE inhibitory activity. Ile-Ala-Asp-His-Phe-Leu showed the highest DPP-IV inhibitory activity with an IC50 value of 610.1 +/- 82.6 mu M. All selected peptides were non-toxic, and most were non-allergenic according to in silico predictions. These results indicate the promising potential of bighead carp muscle hydrolysates as functional additives in foods and pharmaceuticals. (C) 2017 Elsevier Ltd. All rights reserved.

Authors

I am an author on this paper

Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7

Not enough ratings

Secondary Ratings

Novelty

-

Significance

-

Scientific rigor

-

Rate this paper

Recommended

Article Peripheral Vascular Disease

DPP4 (Dipeptidyl Peptidase-4) Inhibition Increases Catecholamines Without Increasing Blood Pressure During Sustained ACE (Angiotensin-Converting Enzyme) Inhibitor Treatment

Jessica R. Wilson, Erica M. Garner, Mona Mashayekhi, Scott A. Hubers, Claudia E. Ramirez Bustamante, Scott Jafarian Kerman, Hui Nian, Cyndya A. Shibao, Nancy J. Brown

Summary: DPP4 inhibition may increase catecholamine levels, but does not increase blood pressure. Increased catecholamines during concurrent use of ACE and DPP4 inhibitors may contribute to cardiovascular complications in patients predisposed to heart failure.

HYPERTENSION (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Gel-Forming of Self-Assembling Peptides Functionalized with Food Bioactive Motifs Modulate DPP-IV and ACE Inhibitory Activity in Human Intestinal Caco-2 Cells

Raffaele Pugliese, Martina Bartolomei, Carlotta Bollati, Giovanna Boschin, Anna Arnoldi, Carmen Lammi

Summary: Food bioactive peptides are widely used in food products and functional biomaterials, but their practical applications are limited due to their instability and low bioavailability. In this study, the self-assembling peptide RADA16 was functionalized with two synthetic analogues of food bioactive peptides to improve their nanostructures and biological features. The co-assembly of the functionalized food bioactive peptides with RADA16 was found to enhance their bioactivity and potential for the prevention of metabolic syndrome.

BIOMEDICINES (2022)

Add to Collection

Article Agriculture, Multidisciplinary

Identification of in vitro angiotensin-converting enzyme and dipeptidyl peptidase IV inhibitory peptides from draft beer by virtual screening and molecular docking

Tian Wenhui, Hu Shumin, Zhuang Yongliang, Sun Liping, Yin Hua

Summary: This study established a rapid screening method for bioactive peptides from Tsingtao draft beer, identified two ACE and DPP-IV inhibitory peptides, and analyzed their mechanism of action.

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE (2022)

Add to Collection

Article Agriculture, Multidisciplinary

Bioactive peptides identified from enzymatic hydrolysates of sturgeon skin

Meng Gui, Liang Gao, Lei Rao, Pinglan Li, Ying Zhang, Jia-Wei Han, Jun Li

Summary: The study demonstrated that sturgeon skin protein extract hydrolyzed by flavourzyme generated bioactive peptides with antioxidant, DPP-IV inhibitory, and ACE inhibitory activities. Peptides such as P1, P6, P11, and P12 showed strong bioactive properties and potential for use in the health food industry. The molecular docking analysis revealed the mechanisms of action for the bioactive peptides in inhibiting DPP-IV and ACE activities.

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE (2022)

Add to Collection

Article Food Science & Technology

Bioactivity of collagen peptides derived from commercial animals: In silico investigation

Yakun Hou, Bimal Chitrakar, Kemin Mao, Ke Wang, Xin Gu, Jie Gao, Qing Zhang, Alaa El-Din Ahmed Bekhit, Yaxin Sang

Summary: Collagen peptides (CP) obtained from different sources show diverse bioactivities, with higher bioactivity potential in CP from chicken and mammals compared to fish. The most common bioactivities of CP are the inhibition of ACE and DPP-IV enzymes.

LWT-FOOD SCIENCE AND TECHNOLOGY (2023)

Add to Collection

Article Biology

In silico proteolysis and analysis of bioactive peptides from sequences of fatty acid desaturase 3 (FAD3) of flaxseed protein

Sapna Langyan, Fatima Nazish Khan, Pranjal Yadava, Alaa Alhazmi, Samy F. Mahmoud, Dalia Saleh, Ali Tan Kee Zuan, Ashok Kumar

Summary: Flaxseed, rich in ALA, fibres and lignans, has potential health benefits in reducing various diseases. Through bioinformatics analysis, FAD3 protein in flaxseed was found to have potential for cardiovascular disease prevention and blood sugar regulation, making it a valuable source for functional peptide synthesis.

SAUDI JOURNAL OF BIOLOGICAL SCIENCES (2021)

Add to Collection

Article Food Science & Technology

An in silico approach to unveil peptides from Acheta domesticus with potential bioactivity against hypertension, diabetes, cardiac and pulmonary fibrosis

Carla S. S. Teixeira, Caterina Villa, Sergio F. Sousa, Joana Costa, Isabel M. P. L. V. O. Ferreira, Isabel Mafra

Summary: This study simulated the gastrointestinal digestion of six A. domesticus proteins and identified new peptides with potential anti-hypertensive and/or anti-diabetic properties. Molecular docking was used to evaluate the binding interactions between the peptides and two drug targets. Five peptides showed potential to inhibit both DPP-4 and sACE, suggesting multifunctional bioactive properties. Two peptides showed potential selective inhibition of the N-domain of sACE, indicating anti-cardiac and pulmonary fibrosis bioactivities. This is the first study to identify peptides from the simulated GI digestion of A. domesticus with potential activities against hypertension, diabetes, cardiac, and pulmonary fibrosis.

FOOD RESEARCH INTERNATIONAL (2023)

Add to Collection

Article Plant Sciences

Antioxidant Properties and Prediction of Bioactive Peptides Produced from Flixweed (sophia, Descurainis sophia L.) and Camelina (Camelina sativa (L.) Crantz) Seed Meal: Integrated In Vitro and In Silico Studies

Na Thi Ty Ngo, Tharindu R. L. Senadheera, Fereidoon Shahidi

Summary: This study investigated the protein hydrolysates from sophia and camelina and found that they exhibited high antioxidant activity and released potential DPP IV and ACE inhibitory peptides. The integrated analysis using in vitro and in silico methods suggested that these hydrolysates could be promising candidates for functional foods, nutraceuticals, and natural therapeutics.

PLANTS-BASEL (2023)

Add to Collection

Article Biochemistry & Molecular Biology

Protease Inhibitors Purified from the Canola Meal Extracts of Two Genetically Diverse Genotypes Exhibit Antidiabetic and Antihypertension Properties

Saira Hussain, Ata ur Rehman, David J. Luckett, Syed Muhammad Saqlan Naqvi, Christopher L. Blanchard

Summary: The research focused on purifying protease inhibitors (PIs) from canola meal of genetically diverse Brassica napus genotypes BLN-3347 and Rivette. The purified PIs exhibited diverse functionalities, inhibiting DPP-IV and ACE with differing effectiveness. These PIs have potential applications in human therapy and in breeding for canola disease resistance.

MOLECULES (2021)

Add to Collection

Article Nutrition & Dietetics

Rainbow Trout (Oncorhynchus mykiss) as Source of Multifunctional Peptides with Antioxidant, ACE and DPP-IV Inhibitory Activities

Martina Bartolomei, Janna Cropotova, Carlotta Bollati, Kristine Kvangarsnes, Lorenza d'Adduzio, Jianqiang Li, Giovanna Boschin, Carmen Lammi

Summary: The study aimed to investigate the biological activities of low molecular weight peptides isolated from rainbow trout obtained by enzymatic hydrolysis. The fish protein hydrolysate (FPH) showed antioxidant, ACE inhibitory, and DPP-IV inhibitory activities. In vitro antioxidant activity was evaluated using various assays, while cell-free ACE and DPP-IV inhibitory activity assays were also conducted. The results suggest that peptides derived from Oncorhynchus mykiss may have potential applications as health-promoting ingredients.

NUTRIENTS (2023)

Add to Collection

Article Chemistry, Physical

Exploring the Potential of Black Soldier Fly Larval Proteins as Bioactive Peptide Sources through in Silico Gastrointestinal Proteolysis: A Cheminformatic Investigation

Fai-Chu Wong, You-Han Lee, Joe-Hui Ong, Fazilah Abd Manan, Mohamad Zulkeflee Sabri, Tsun-Thai Chai

Summary: This computational study investigated the potential of black soldier fly larvae (BSFL) proteins to release health-promoting peptides after human gastrointestinal (GI) digestion. The results showed that the digestion of BSFL proteins can generate peptides with high GI absorption and non-toxicity, some of which have antioxidant, anti-angiotensin-converting enzyme, and anti-dipeptidyl peptidase IV activities. The findings suggest that BSFL proteins may have potential health benefits when consumed as a functional food ingredient.

CATALYSTS (2023)

Add to Collection

Article Biochemistry & Molecular Biology

In silico strategies for probing novel DPP-IV inhibitors as anti-diabetic agents

Shweta Sharma, Shubham Srivastav, Garima Singh, Smrita Singh, Ruchi Malik, Mohammad Mumtaz Alam, Mohammad Shaqiquzamman, Shakir Ali, Mymoona Akhter

Summary: This study presents the identification of novel DPP-IV inhibitors using a combination of validated computational methods. Among the compounds analyzed, KB-10 showed promising DPP-IV inhibition both in vitro and in vivo. The research demonstrates the potential of these techniques for efficient screening of compounds with unknown affinity for DPP-IV, which could serve as candidates for therapeutic development.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2021)

Add to Collection

Article Food Science & Technology

Identification of Polyphenols in Sea Fennel (Crithmum maritimum) and Seaside Arrowgrass (Triglochin maritima) Extracts with Antioxidant, ACE-I, DPP-IV and PEP-Inhibitory Capacity

Marta Maria Calvo, Maria Elvira Lopez-Caballero, Oscar Martinez-Alvarez

Summary: Sea fennel and seaside arrowgrass are abundant halophytes with high phenol content and antioxidant capacity. Their polyphenol extracts showed potential antihypertensive, hypoglycaemic, and nootropic activity. The extracts contained effective ACE inhibitors, DPP-IV inhibitors, and PEP inhibitors, making them valuable bioactive ingredients.

FOODS (2023)

Add to Collection

Article Biochemistry & Molecular Biology

In silico identification of novel ACE and DPP-IV inhibitory peptides derived from buffalo milk proteins and evaluation of their inhibitory mechanisms

Yuxiang Gu, Xing Li, Xiaofen Qi, Ying Ma, Eric Chun Yong Chan

Summary: The capacity of buffalo milk proteins to release bioactive peptides was evaluated, and novel bioactive peptides were identified. The sequential similarity between buffalo milk proteins and their cow counterparts was analyzed. In silico proteolysis was used to simulate the release of theoretical peptides from buffalo milk proteins. The potential of selected proteins to release specific bioactive peptides was evaluated, and two ACE inhibitory peptides and four DPP-IV inhibitory peptides were identified.

AMINO ACIDS (2023)

Add to Collection

Article Biochemistry & Molecular Biology

Evaluating Khaya senegalensis for Dipeptidyl Peptidase-IV Inhibition Using in Vitro Analysis and Molecular Dynamic Simulation of Identified Bioactive Compounds

Victoria Ojonogecha Idoko, Mohammed Aliyu Sulaiman, Rahma Muhammad Adamu, Aliyu Dantani Abdullahi, Nasir Tajuddeen, Aminu Mohammed, Hajiya Mairo Inuwa, Mohammed Auwal Ibrahim

Summary: The DPP-IV inhibitory activity of Khaya senegalensis extracts was evaluated, and the hexane extract showed the best inhibitory activity. The major bioactive compounds in the extract were identified as 3-amino-3-hydroxyimino-N-phenylpropanamide (1) and 11-(2-cyclopenten-1-yl)undecanoic acid (2).

CHEMISTRY & BIODIVERSITY (2023)

Add to Collection

Article Biotechnology & Applied Microbiology

Application of Illumina-MiSeq high throughput sequencing and culture-dependent techniques for the identification of microbiota of silver carp (Hypophthalmichthys molitrix) treated by tea polyphenols

Shiliang Jia, Zhan Huang, Yutian Lei, Longteng Zhang, Yan Li, Yongkang Luo

FOOD MICROBIOLOGY (2018)

Add to Collection

Article Chemistry, Applied

Effect of glazing and rosemary (Rosmarinus officinalis) extract on preservation of mud shrimp (Solenocera melantho) during frozen storage

Jing Shi, Yutian Lei, Huixing Shen, Hui Hong, Xunpei Yu, Beiwei Zhu, Yongkang Luo

FOOD CHEMISTRY (2019)

Add to Collection

Article Food Science & Technology

Characterization of the microbial composition and quality of lightly salted grass carp (Ctenopharyngodon idellus) fillets with vacuum or modified atmosphere packaging

Jingbin Zhang, Yan Li, Xiaochang Liu, Yutian Lei, Joe M. Regenstein, Yongkang Luo

INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY (2019)

Add to Collection

Article Thermodynamics

Degradation of adenosine triphosphate, water loss and textural changes in frozen common carp (Cyprinus carpio) fillets during storage at different temperatures

Dapeng Li, Na Qin, Longteng Zhang, Qian Li, Witoon Prinyawiwatkul, Yongkang Luo

INTERNATIONAL JOURNAL OF REFRIGERATION-REVUE INTERNATIONALE DU FROID (2019)

Add to Collection

Article Food Science & Technology

Assessment of structural, textural, and gelation properties of myofibrillar protein of silver carp (Hypophthalmichthys molitrix) modified by stunning and oxidative stress

Longteng Zhang, Ping Gui, Yuqi Zhang, Jun Lin, Qian Li, Hui Hong, Yongkang Luo

LWT-FOOD SCIENCE AND TECHNOLOGY (2019)

Add to Collection

Article Chemistry, Applied

Antioxidant and cryoprotective effects of hydrolysate from gill protein of bighead carp (Hypophthalmichthys nobilis) in preventing denaturation of frozen surimi

Jun Lin, Hui Hong, Longteng Zhang, Chi Zhang, Yongkang Luo

FOOD CHEMISTRY (2019)

Add to Collection

Article Food Science & Technology

Inhibitory effects and membrane damage caused to fish spoilage bacteria by cinnamon bark (Cinnamomum tamala) oil

Zhan Huang, Shiliang Jia, Longteng Zhang, Xiaochang Liu, Yongkang Luo

LWT-FOOD SCIENCE AND TECHNOLOGY (2019)

Add to Collection

Article Biotechnology & Applied Microbiology

Effects of pomegranate peel extract on quality and microbiota composition of bighead carp (Aristichthys nobilis) fillets during chilled storage

Shuai Zhuang, Yan Li, Shiliang Jia, Hui Hong, Yiming Liu, Yongkang Luo

FOOD MICROBIOLOGY (2019)

Add to Collection

Article Chemistry, Applied

Stunning stress-induced textural softening in silver carp (Hypophthalmichthys molitrix) fillets and underlying mechanisms

Longteng Zhang, Yuqi Zhang, Shiliang Jia, Yan Li, Qian Li, Kaifeng Li, Hui Hong, Yongkang Luo

FOOD CHEMISTRY (2019)

Add to Collection

Article Biotechnology & Applied Microbiology

Biochemical changes induced by dominant bacteria in chill-stored silver carp (Hypophthalmichthys molitrix) and GC-IMS identification of volatile organic compounds

Shiliang Jia, Yan Li, Shuai Zhuang, Xiaohui Sun, Longteng Zhang, Jing Shi, Hui Hong, Yongkang Luo

FOOD MICROBIOLOGY (2019)

Add to Collection

Article Chemistry, Applied

Prevention of protein oxidation and enhancement of gel properties of silver carp (Hypophthalmichthys molitrix) surimi by addition of protein hydrolysates derived from surimi processing by-products

Longteng Zhang, Qian Li, Hui Hong, Yongkang Luo

FOOD CHEMISTRY (2020)

Add to Collection

Article Biotechnology & Applied Microbiology

Effect of grape seed extract on quality and microbiota community of container -cultured snakehead ( Channa argus ) fillets during chilled storage

Yan Li, Shuai Zhuang, Yueyue Liu, Longteng Zhang, Xiaochang Liu, Hao Cheng, Jun Liu, Rui Shu, Yongkang Luo

FOOD MICROBIOLOGY (2020)

Add to Collection

Article Biotechnology & Applied Microbiology

Assessment of bacterial contributions to the biochemical changes of chill-stored blunt snout bream ( Megalobrama amblycephala ) fillets: Protein degradation and volatile organic compounds accumulation

Yan Li, Shiliang Jia, Hui Hong, Longteng Zhang, Shuai Zhuang, Xiaohui Sun, Xiaochang Liu, Yongkang Luo

FOOD MICROBIOLOGY (2020)

Add to Collection

Article Biotechnology & Applied Microbiology

TMT-based proteomic analysis of the fish-borne spoiler Pseudomonas psychrophila subjected to chitosan oligosaccharides in fish juice system

Shiliang Jia, Hui Hong, Qingfeng Yang, Xiaochang Liu, Shuai Zhuang, Yan Li, Jun Liu, Yongkang Luo

FOOD MICROBIOLOGY (2020)

Add to Collection

Article Chemistry, Applied

Biochemical changes and amino acid deamination & decarboxylation activities of spoilage microbiota in chill-stored grass carp (Ctenopharyngodon idella) fillets

Shuai Zhuang, Xiaochang Liu, Yan Li, Longteng Zhang, Hui Hong, Jun Liu, Yongkang Luo

Summary: The study revealed the deamination and decarboxylation activities of spoilage microbiota in chill-stored grass carp fillets. It was found that different taste amino acids were affected differently by microbial deamination activities. Additionally, putrescine in fish fillets was mainly produced through microbial decarboxylation activity of ornithine, and spoilage microbiota showed active glucose utilization during the late period of storage.

FOOD CHEMISTRY (2021)

Add to Collection

No Data Available

© Peeref 2019-2024. All rights reserved.