Halogenation of glycopeptide antibiotics occurs at the amino acid level during non-ribosomal peptide synthesis

Specific Enzymatic Halogenation-From the Discovery of Halogenated Enzymes to Their Applications In Vitro and In Vivo

(2016) Veit Weichold et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A stepwise dechlorination/cross-coupling strategy to diversify the vancomycin ‘in-chloride’

(2016) Tyler J. Wadzinski et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Understanding the crucial interactions between Cytochrome P450s and non-ribosomal peptide synthetases during glycopeptide antibiotic biosynthesis

(2016) Madeleine Peschke et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Regulation of the P450 Oxygenation Cascade Involved in Glycopeptide Antibiotic Biosynthesis

(2016) Madeleine Peschke et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

More than just recruitment: the X-domain influences catalysis of the first phenolic coupling reaction in A47934 biosynthesis by Cytochrome P450 StaH

(2016) Veronika Ulrich et al.   Molecular BioSystems

Polyketide synthase and non-ribosomal peptide synthetase thioesterase selectivity: logic gate or a victim of fate?

(2016) Mark E. Horsman et al.   NATURAL PRODUCT REPORTS

How To Make a Glycopeptide: A Synthetic Biology Approach To Expand Antibiotic Chemical Diversity

(2016) Grace Yim et al.   ACS Infectious Diseases

A Peptidyl-Transesterifying Type I Thioesterase in Salinamide Biosynthesis

(2015) Lauren Ray et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Sequential In Vitro Cyclization by Cytochrome P450 Enzymes of Glycopeptide Antibiotic Precursors Bearing the X-Domain from Nonribosomal Peptide Biosynthesis

(2015) Clara Brieke et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Investigation of halogenation during the biosynthesis of ramoplanin in Actinoplanes sp. ATCC33076

(2015) Jun-Sheng Chen et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Structural aspects of phenylglycines, their biosynthesis and occurrence in peptide natural products

(2015) Rashed S. Al Toma et al.   NATURAL PRODUCT REPORTS

X-domain of peptide synthetases recruits oxygenases crucial for glycopeptide biosynthesis

(2015) Kristina Haslinger et al.   NATURE

Rapid access to glycopeptide antibiotic precursor peptides coupled with cytochrome P450-mediated catalysis: towards a biomimetic synthesis of glycopeptide antibiotics

(2015) Clara Brieke et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Extending the biocatalytic scope of regiocomplementary flavin-dependent halogenase enzymes

(2015) Sarah A. Shepherd et al.   Chemical Science

The Structure of a Transient Complex of a Nonribosomal Peptide Synthetase and a Cytochrome P450 Monooxygenase

(2014) Kristina Haslinger et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Epimerization and substrate gating by a TE domain in β-lactam antibiotic biosynthesis

(2014) Nicole M Gaudelli et al.   Nature Chemical Biology

Bis-chlorination of a hexapeptide–PCP conjugate by the halogenase involved in vancomycin biosynthesis

(2014) Patrick C. Schmartz et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Cytochrome P450sky Interacts Directly with the Nonribosomal Peptide Synthetase to Generate Three Amino Acid Precursors in Skyllamycin Biosynthesis

(2013) Stefanie Uhlmann et al.   ACS Chemical Biology

Investigation into the functional impact of the vancomycin C-ring aryl chloride

(2013) Joseph R. Pinchman et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Glycopeptide antibiotic biosynthesis

(2013) Grace Yim et al.   JOURNAL OF ANTIBIOTICS

Probing the Role of the Vancomycin E-Ring Aryl Chloride: Selective Divergent Synthesis and Evaluation of Alternatively Substituted E-Ring Analogues

(2013) Joseph R. Pinchman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identifying producers of antibacterial compounds by screening for antibiotic resistance

(2013) Maulik N Thaker et al.   NATURE BIOTECHNOLOGY

Substituent Effects on the Phenol Coupling Reaction Catalyzed by the Vancomycin Biosynthetic P450 Enzyme OxyB

(2012) Patrick C. Schmartz et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Explorations of catalytic domains in non-ribosomal peptide synthetase enzymology

(2012) Gene H. Hur et al.   NATURAL PRODUCT REPORTS

Glycopeptide biosynthesis in the context of basic cellular functions

(2010) Evi Stegmann et al.   CURRENT OPINION IN MICROBIOLOGY

Discovery of a Novel Series of Semisynthetic Vancomycin Derivatives Effective against Vancomycin-Resistant Bacteria

(2010) Yuki Nakama et al.   JOURNAL OF MEDICINAL CHEMISTRY

Enduracidin Analogues with Altered Halogenation Patterns Produced by Genetically Engineered Strains ofStreptomyces fungicidicus

(2010) Xihou Yin et al.   JOURNAL OF NATURAL PRODUCTS

Conformational Dynamics in the Acyl-CoA Synthetases, Adenylation Domains of Non-ribosomal Peptide Synthetases, and Firefly Luciferase

(2009) Andrew M. Gulick   ACS Chemical Biology

Catalytic Turnover-Based Phage Selection for Engineering the Substrate Specificity of Sfp Phosphopantetheinyl Transferase

(2009) Murat Sunbul et al.   JOURNAL OF MOLECULAR BIOLOGY

Nonribosomal Peptide Synthetases Involved in the Production of Medically Relevant Natural Products

(2008) Elizabeth A. Felnagle et al.   MOLECULAR PHARMACEUTICS

Screening of fusion partners for high yield expression and purification of bioactive viscotoxins

(2008) Julius Bogomolovas et al.   PROTEIN EXPRESSION AND PURIFICATION