Polyketide synthase and non-ribosomal peptide synthetase thioesterase selectivity: logic gate or a victim of fate?

Insights into the Biosynthesis of 12-Membered Resorcylic Acid Lactones from Heterologous Production in Saccharomyces cerevisiae

(2014) Yuquan Xu et al.   ACS Chemical Biology

Fungal Polyketide Synthase Product Chain-Length Control by Partnering Thiohydrolase

(2014) Angelica O. Zabala et al.   ACS Chemical Biology

Comparative Analysis of the Substrate Specificity of trans- versus cis-Acyltransferases of Assembly Line Polyketide Synthases

(2014) Briana J. Dunn et al.   BIOCHEMISTRY

An Evolutionary Model Encompassing Substrate Specificity and Reactivity of Type I Polyketide Synthase Thioesterases

(2014) Taylor P. A. Hari et al.   CHEMBIOCHEM

Biosynthesis of Crocacin Involves an Unusual Hydrolytic Release Domain Showing Similarity to Condensation Domains

(2014) Stefan Müller et al.   CHEMISTRY & BIOLOGY

Epimerization and substrate gating by a TE domain in β-lactam antibiotic biosynthesis

(2014) Nicole M Gaudelli et al.   Nature Chemical Biology

Resorcylic Acid Lactone Biosynthesis Relies on a Stereotolerant Macrocyclizing Thioesterase

(2014) Graham W. Heberlig et al.   ORGANIC LETTERS

Diversity-oriented combinatorial biosynthesis of benzenediol lactone scaffolds by subunit shuffling of fungal polyketide synthases

(2014) Y. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of the Biosynthetic Genes for 10,11-Dehydrocurvularin, a Heat Shock Response-Modulating Anticancer Fungal Polyketide from Aspergillus terreus

(2013) Yuquan Xu et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Bioinformatics tools for genome mining of polyketide and non-ribosomal peptides

(2013) Christopher N. Boddy   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Thioesterase Domains of Fungal Nonreducing Polyketide Synthases Act as Decision Gates during Combinatorial Biosynthesis

(2013) Yuquan Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

antiSMASH 2.0—a versatile platform for genome mining of secondary metabolite producers

(2013) Kai Blin et al.   NUCLEIC ACIDS RESEARCH

Pfam: the protein families database

(2013) Robert D. Finn et al.   NUCLEIC ACIDS RESEARCH

Catalytic Efficiency of Enzymes: A Theoretical Analysis

(2012) Sharon Hammes-Schiffer   BIOCHEMISTRY

Characterization of a Fungal Thioesterase Having Claisen Cyclase and Deacetylase Activities in Melanin Biosynthesis

(2012) Anna L. Vagstad et al.   CHEMISTRY & BIOLOGY

Polyketide Proofreading by an Acyltransferase-like Enzyme

(2012) Katja Jensen et al.   CHEMISTRY & BIOLOGY

Structural analysis of protein–protein interactions in type I polyketide synthases

(2012) Wei Xu et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Ribosome-independent biosynthesis of biologically active peptides: Application of synthetic biology to generate structural diversity

(2012) Tobias W. Giessen et al.   FEBS LETTERS

The structures of type I polyketide synthases

(2012) Adrian T. Keatinge-Clay   NATURAL PRODUCT REPORTS

A fungal ketoreductase domain that displays substrate-dependent stereospecificity

(2012) Hui Zhou et al.   Nature Chemical Biology

ClusterMine360: a database of microbial PKS/NRPS biosynthesis

(2012) Kyle R. Conway et al.   NUCLEIC ACIDS RESEARCH

6-Deoxyerythronolide B Synthase Thioesterase-Catalyzed Macrocyclization Is Highly Stereoselective

(2012) Atahualpa Pinto et al.   ORGANIC LETTERS

Employing a polyketide synthase module and thioesterase in the semipreparative biocatalysis of diverse triketide pyrones

(2012) Amanda J. Hughes et al.   MedChemComm

Genome-wide analysis of the role of GlnR in Streptomyces venezuelae provides new insights into global nitrogen regulation in actinomycetes

(2011) Steven T Pullan et al.   BMC GENOMICS

Different Active-Site Loop Orientation in Serine Hydrolases versus Acyltransferases

(2011) Yun Jiang et al.   CHEMBIOCHEM

Structural Basis for Phosphopantetheinyl Carrier Domain Interactions in the Terminal Module of Nonribosomal Peptide Synthetases

(2011) Ye Liu et al.   CHEMISTRY & BIOLOGY

Terminal Alkene Formation by the Thioesterase of Curacin A Biosynthesis

(2011) Jennifer J. Gehret et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and Function of the RedJ Protein, a Thioesterase from the Prodiginine Biosynthetic Pathway inStreptomyces coelicolor

(2011) Jonathan R. Whicher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemoenzymatic Synthesis of Cryptophycin Anticancer Agents by an Ester Bond-Forming Non-ribosomal Peptide Synthetase Module

(2011) Yousong Ding et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

NRPSpredictor2—a web server for predicting NRPS adenylation domain specificity

(2011) Marc Röttig et al.   NUCLEIC ACIDS RESEARCH

Biochemical and Structural Characterization of the Tautomycetin Thioesterase: Analysis of a Stereoselective Polyketide Hydrolase

(2010) Jamie B. Scaglione et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Insights into Protein-Protein and Enzyme-Substrate Interactions in Modular Polyketide Synthases

(2010) Lucky Tran et al.   CHEMISTRY & BIOLOGY

Structural Basis for the Activity and Substrate Specificity of Fluoroacetyl-CoA Thioesterase FlK

(2010) Marcio V. B. Dias et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insights into Radicicol Biosynthesis via Heterologous Synthesis of Intermediates and Analogs

(2010) Hui Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NetTurnP – Neural Network Prediction of Beta-turns by Use of Evolutionary Information and Predicted Protein Sequence Features

(2010) Bent Petersen et al.   PLoS One

Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesis

(2010) T. P. Korman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thioesterases: A new perspective based on their primary and tertiary structures

(2010) David C. Cantu et al.   PROTEIN SCIENCE

Thermodynamic and Structural Effects of Macrocyclic Constraints in Protein−Ligand Interactions

(2010) John E. DeLorbe et al.   ACS Medicinal Chemistry Letters

A Thioesterase from an Iterative Fungal Polyketide Synthase Shows Macrocyclization and Cross Coupling Activity and May Play a Role in Controlling Iterative Cycling through Product Offloading

(2009) Meng Wang et al.   BIOCHEMISTRY

Polyketide synthase thioesterases catalyze rapid hydrolysis of peptidyl thioesters

(2009) Meng Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Hsp90 Inhibition with Resorcylic Acid Lactones (RALs)

(2009) Nicolas Winssinger et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Structural insights into nonribosomal peptide enzymatic assembly lines

(2009) Alexander Koglin et al.   NATURAL PRODUCT REPORTS

PKS and NRPS release mechanisms

(2009) Liangcheng Du et al.   NATURAL PRODUCT REPORTS

NMR spectroscopy brings invisible protein states into focus

(2009) Andrew J Baldwin et al.   Nature Chemical Biology

Protein structure prediction on the Web: a case study using the Phyre server

(2009) Lawrence A Kelley et al.   Nature Protocols

Towards Prediction of Metabolic Products of Polyketide Synthases: An In Silico Analysis

(2009) Gitanjali Yadav et al.   PLoS Computational Biology

Examining the Role of Hydrogen Bonding Interactions in the Substrate Specificity for the Loading Step of Polyketide Synthase Thioesterase Domains†

(2008) Meng Wang et al.   BIOCHEMISTRY

In silico analysis of methyltransferase domains involved in biosynthesis of secondary metabolites

(2008) Mohd Ansari et al.   BMC BIOINFORMATICS

Covalent Linkage Mediates Communication between ACP and TE Domains in Modular Polyketide Synthases

(2008) Lucky Tran et al.   CHEMBIOCHEM

A Polylinker Approach to Reductive Loop Swaps in Modular Polyketide Synthases

(2008) Laurenz Kellenberger et al.   CHEMBIOCHEM

Engineered Synthesis of 7-Oxo- and 15-Deoxy-15-Oxo-Amphotericins: Insights into Structure-Activity Relationships in Polyene Antibiotics

(2008) Patrick Power et al.   CHEMISTRY & BIOLOGY

Apralactone A and a New Stereochemical Class of Curvularins from the Marine FungusCurvulariasp.

(2008) Hendrik Greve et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Isolation and Structure Determination of Two Microcystins and Sequence Comparison of the McyABC Adenylation Domains inPlanktothrixSpecies

(2008) Guntram Christiansen et al.   JOURNAL OF NATURAL PRODUCTS

The unusual macrocycle forming thioesterase of mycolactone

(2008) Jordan L. Meier et al.   Molecular BioSystems

Dynamic thiolation–thioesterase structure of a non-ribosomal peptide synthetase

(2008) Dominique P. Frueh et al.   NATURE

Structural basis for the selectivity of the external thioesterase of the surfactin synthetase

(2008) Alexander Koglin et al.   NATURE

Phylogeny.fr: robust phylogenetic analysis for the non-specialist

(2008) A. Dereeper et al.   NUCLEIC ACIDS RESEARCH

Crystal Structure of the Termination Module of a Nonribosomal Peptide Synthetase

(2008) A. Tanovic et al.   SCIENCE