Review
Biochemistry & Molecular Biology
Maria Jose Sanchez-Quintero, Cristina Rodriguez-Diaz, Francisco J. Rodriguez-Gonzalez, Alejandra Fernandez-Castaner, Eduardo Garcia-Fuentes, Carlos Lopez-Gomez
Summary: Mitochondria play a crucial role in maintaining cellular functions and are involved in various cellular processes. Dysfunction of mitochondria has been linked to complex disorders, including inflammatory bowel diseases (IBD). The impact of mitochondrial dysfunction on IBD, including its role in intestinal mucosa, immune cell populations, mucosal repair, microbiota-brain-gut axes, and the development of colitis-associated colorectal cancer, is discussed in this review.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Medicinal
Alexander V. Blagov, Varvara A. Orekhova, Vasily N. Sukhorukov, Alexandra A. Melnichenko, Alexander N. Orekhov
Summary: This review discusses the role of oxidative stress in the development and progression of inflammatory bowel diseases (IBDs) and proposes several effective natural and artificial antioxidants as potential therapeutic options. The study also highlights the potential use of other antioxidants that have not yet been tested in the treatment of IBD.
Article
Biochemistry & Molecular Biology
Anna Krystyna Zielinska, Maciej Salaga, Pawel Siwinski, Marcin Wlodarczyk, Adam Dziki, Jakub Fichna
Summary: The study found that IBD patients had significantly decreased SOD activity, GSH and GSSG levels, and GPX activity was significantly diminished only in CD patients. CAT and COX-1 activity was increased, while COX-2 was significantly decreased in IBD patients. TBARS were significantly higher in CD patients compared to the control group. There was no correlation between pain scores, inflammatory status, disease activity, disease duration, or dietary habits and OS markers.
Review
Chemistry, Medicinal
Jose Israel Rodrigues Jr, Joice Kelly Gomes de Vasconcelos, Lylian Ellen Militao dos Santos Xavier, Amanda da Silva Gomes, Juliana Celia de Farias Santos, Samara Bomfim Gomes Campos, Amylly Sanuelly da Paz Martins, Marilia Oliveira Fonseca Goulart, Fabiana Andrea Moura
Summary: The objective of this study was to assess the effectiveness of treatment for inflammatory bowel diseases in modulating oxidative stress biomarkers and cytokine levels. A systematic review and meta-analysis were conducted, and it was found that antioxidant capacity and lipid peroxidation levels were not significantly modulated, while superoxide dismutase levels showed significant modulation. However, there is still limited research on oxidative stress biomarkers and cytokines in the context of alternative therapies for IBD treatment. The results highlight the potential of antioxidant supplementation in IBD management and emphasize the need for further investigations into its effects on oxidative stress biomarkers and cytokines.
Review
Biochemistry & Molecular Biology
Sara Jarmakiewicz-Czaja, Katarzyna Ferenc, Rafal Filip
Summary: Inflammatory bowel disease (IBD) is a chronic disease characterized by periods of exacerbation and remission. The exact cause of IBD is still not fully understood, but genetic, immunological, microbiological, and environmental factors are known to play a role. Oxidative stress, caused by an imbalance between reactive oxygen species (ROS) and antioxidants, is a component that can increase the risk of IBD occurrence and progression. The body's antioxidant defense, both endogenous and exogenous, can influence the prevention of IBD and reduce the risk of exacerbation by neutralizing and removing ROS, as well as influencing the inflammatory state.
Review
Endocrinology & Metabolism
Dipak Kumar Sahoo, Romy M. Heilmann, Biswaranjan Paital, Ashish Patel, Virendra Kumar Yadav, David Wong, Albert E. Jergens
Summary: Inflammatory bowel disease (IBD) is a chronic gastrointestinal disorder characterized by intestinal inflammation. The causes of IBD are multifactorial, involving mucosal immunity, environmental factors, and host genetics. Understanding the cellular and molecular mechanisms mediated by reactive oxygen species (ROS) is crucial for the development of future therapies for IBD, which are driven by oxidative stress. This review discusses various natural antioxidant compounds and phytochemicals that target cellular signaling pathways to reduce intestinal inflammation in IBD.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Luiz C. Di Stasi
Summary: Inflammatory bowel disease is a chronic inflammatory disease without definitive pharmacological treatment. The unclear etiology limits the development of new drugs, leading to high rates of refractory patients. Natural products, such as coumarins, show potential as alternative therapies in IBD.
Review
Biochemistry & Molecular Biology
Vishal Khatri, Ramaswamy Kalyanasundaram
Summary: This review focuses on the association between IBD and gut inflammasome, as well as recent advances in research and therapeutic strategies for IBD, discussing inflammasomes and their components, outcomes from experimental animals and human studies, inflammasome inhibitors, and developments in inflammasome-targeted therapies for IBD.
Review
Biochemistry & Molecular Biology
HyunTaek Jung, Jae Seok Kim, Keum Hwa Lee, Kalthoum Tizaoui, Salvatore Terrazzino, Sarah Cargnin, Lee Smith, Ai Koyanagi, Louis Jacob, Han Li, Sung Hwi Hong, Dong Keon Yon, Seung Won Lee, Min Seo Kim, Paul Wasuwanich, Wikrom Karnsakul, Jae Il Shin, Andreas Kronbichler
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract that mainly affects young people. Recent studies have shown that microRNAs (miRNAs) play an important role in the pathogenesis, diagnosis, and treatment of IBD.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Uma Mahadevan, Millie D. Long, Sunanda Kane, Abhik Roy, Marla C. Dubinsky, Bruce E. Sands, Russell D. Cohen, Christina D. Chambers, William J. Sandborn
Summary: The study found that exposure to biologic, thiopurine, or combination therapy during pregnancy did not increase adverse maternal or fetal outcomes, and these treatments can be continued throughout pregnancy for women with IBD to maintain disease control.
Article
Medicine, General & Internal
Silvia Salvatori, Francesco Baldassarre, Michelangela Mossa, Giovanni Monteleone
Summary: Long COVID is common in patients with inflammatory bowel diseases (IBD), with fatigue being the most frequent symptom. It does not influence the frequency of IBD relapses, but is more prevalent in female patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Gastroenterology & Hepatology
Thomas M. Goodsall, Tran M. Nguyen, Claire E. Parker, Christopher Ma, Jane M. Andrews, Vipul Jairath, Robert Bryant
Summary: The study systematically identified ultrasound scoring indices for assessing inflammatory bowel disease activity, with common components including bowel wall thickness, colour Doppler imaging, and bowel wall stratification. The correlation between ultrasound indices and reference standards, as well as sensitivity, specificity, accuracy, and other properties, varied within certain ranges. However, reliability and responsiveness data were limited, and most studies were rated with unclear or high risk of bias.
JOURNAL OF CROHNS & COLITIS
(2021)
Review
Medicine, General & Internal
Katarzyna Akutko, Andrzej Stawarski
Summary: Inflammatory bowel diseases (IBD) are chronic inflammatory diseases of the digestive tract with periods of remission and relapses. The etiopathogenesis is not fully understood, leading to only symptomatic treatment. There is a constant need to search for new high safety profile therapies for IBD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biotechnology & Applied Microbiology
Guihua Chen, Jun Shen
Summary: Inflammatory bowel disease (IBD) is a global disease with high morbidity and medical costs. Early diagnosis and intervention are crucial for controlling its progression.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Editorial Material
Gastroenterology & Hepatology
Catherine Le Berre, Laurent Peyrin-Biroulet
Summary: The SPIRIT consensus group has agreed that the ultimate therapeutic goal in both CD and UC is to prevent disease impact on patients' lives, including health-related quality of life, disability, and fecal incontinence, as well as prevent complications in the short and long term, such as bowel damage, surgeries, disease extension, extraintestinal manifestations, and dysplasia or cancer. These recommendations will need to be validated in clinical studies before being implemented in disease-modification trials.
Article
Medicine, General & Internal
Moureq R. Alotaibi, Amal J. Fatani, Ahmed T. Almnaizel, Mohammed M. Ahmed, Hatem M. Abuohashish, Salim S. Al-Rejaie
MEDICAL PRINCIPLES AND PRACTICE
(2019)
Article
Dentistry, Oral Surgery & Medicine
Hatem Abuohashish, Haytham Al-Mahalawy, Osama Zakaria, Hesham Marei, Adel Abdelhady, Mohammed AlKindi, Badr Al-Jandan
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2019)
Article
Integrative & Complementary Medicine
Ahmed Z. Alanazi, Faleh Alqahtani, Ramzi A. A. Mothana, Mohamed Mohany, Hatem M. Abuohashish, Mohammed M. Ahmed, Salim S. Al-Rejaie
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2020)
Article
Biotechnology & Applied Microbiology
Marwa Madi, Hatem M. Abuohashish, Dina Attia, Norah AlQahtani, Nabras Alrayes, Verica Pavlic, Subraya G. Bhat
Summary: The study found that the risk of alveolar bone loss in periodontitis patients increases with diabetes in the presence of other comorbidities, regardless of smoking habits or gender.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Dentistry, Oral Surgery & Medicine
Omar Omar, Hatem M. Abuohashish, Taleb Alkhamis, Faisal Al-Qarni
Summary: The study evaluated the effect of habitual caffeine intake on stability, bone regeneration, and bone markers at the bone-implant interface. The results showed a positive promoting effect on long-term osseointegration with increased stability and bone formation, remodeling, and vascularization genes expression.
JOURNAL OF PERIODONTAL RESEARCH
(2021)
Article
Nutrition & Dietetics
Hatem M. Abuohashish, Abdullah F. AlAsmari, Mohamed Mohany, Mohammed M. Ahmed, Salim S. Al-Rejaie
Summary: This study finds that morin can protect against altered bone histomorphometry in diabetic rats by modulating the insulin/IGF-1 pathway, restoring bone density and histomorphology, and alleviating systemic oxidative stress.
Review
Dentistry, Oral Surgery & Medicine
Hala M. Elkamash, Hatem M. Abuohashish
Summary: This review examined the impact of OCD symptoms on dental procedures based on published clinical studies. Most of the included studies had low risk of bias in quality assessment. The article summarized various symptoms of OCD patients and suggested modifying dental procedures and protocols for successful appointments.
INTERNATIONAL JOURNAL OF DENTISTRY
(2021)
Article
Clinical Neurology
Reham Alfaraj, Zainab Alabdulsalam, Zahrah Alfaraj, Hawraa Alsunni, Hussain Alhawaj, Omar Omar, Hatem Abuohashish
Summary: This study investigates the influence of habitual caffeine intake on lidocaine action and reveals that chronic caffeine consumption can potentiate the local anesthetic effect of lidocaine. The study results also suggest that this enhancement may be related to the upregulation of voltage-gated sodium channels in the dorsal root ganglia by caffeine.
PAIN RESEARCH & MANAGEMENT
(2022)
Article
Biotechnology & Applied Microbiology
Hatem M. Abuohashish, Eman H. Zaghloul, Amany S. El Sharkawy, Eman M. Abbas, Mohammed M. Ahmed, Salim S. Al-Rejaie
Summary: This study found that marine-derived potential probiotic Enterococcus faecium EA9 has a protective role against pulmonary inflammation and oxidative stress in a sepsis model, reducing lung injury and pulmonary edema, improving inflammation and lipid peroxidation levels, and regulating antioxidant enzyme activities; marine-derived Enterococcus faecium EA9 may be considered as a prospective therapeutic tool for managing pulmonary dysfunction associated with sepsis.
BIOMED RESEARCH INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Moataz Elgezawi, Rasha Haridy, Khalid Almas, Moamen A. Abdalla, Omar Omar, Hatem Abuohashish, Abeer Elembaby, Uta Christine Woelfle, Yasir Siddiqui, Dalia Kaisarly
Summary: This review article discusses the roles of Matrix metalloproteinases (MMPs) in dental and periodontal tissues, as well as their potential as biomarkers for diagnosis and treatment. The article provides insights into the involvement of MMPs in development, remodeling, degradation, and turnover of dental and periodontal tissues, and their signals in the pathogenesis and wound healing. The review identified 119 published papers, two textbooks, and two doctoral theses as the basis for the discussion. MMPs are seen as significant proteases with potential diagnostic and prognostic value. Understanding their role in dental and periodontal lesions and dentine-pulp wound healing is crucial for future diagnostic and therapeutic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Doaa M. AlEraky, Ahmed M. Rahoma, Hatem M. Abuohashish, Abdullh AlQasser, Abbas AlHamali, Hussain M. AlHussain, Hussain M. AlShoalah, Zakrya AlSaghah, Abdulrahman Khattar, Shimaa Rifaat
Summary: The long-term success of root canal treatment relies on preventing bacterial leakage. This study compared the leakage of Enterococcus faecalis in single-rooted mandibular premolars using different obturation techniques and sealers. The results showed comparable sealing efficiency against Enterococcus faecalis between bio-ceramic sealers with single-cone obturation and a resin-based sealer with lateral condensation technique. MTA Fillapex demonstrated better sealing ability than CeraSeal bio-ceramic sealer.
APPLIED SCIENCES-BASEL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Hatem Abuohashish, Suliman Shahin, Abdulaziz Alamri, Zainah Salloot, Hussain Alhawaj, Omar Omar
Summary: The activation of the Ang(1-7)/Mas receptor axis inhibits tooth movement and regulates alveolar bone remodeling in response to mechanical force, with potential effects on osteoclastogenesis and osteoblast activity.
PROGRESS IN ORTHODONTICS
(2023)
Article
Biotechnology & Applied Microbiology
Hatem M. Abuohashish, Amany S. El Sharkawy
Summary: This study successfully isolated a characteristic blue pyocyanin compound from a marine pseudomonas strain and characterized its antimicrobial activity. The marine-isolated P. otitidis represents a promising new source of marine-derived pyocyanin, which has antimicrobial efficacy mainly against Gram-positive pathogens.
CURRENT RESEARCH IN BIOTECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
M. M. Mahmoud, H. M. Abuohashish, D. A. Khairy, A. S. Bugshan, A. M. Khan, M. M. Moothedath
Summary: COVID-19-induced dysgeusia is likely caused by peripheral neurotropism and direct toxicity to taste buds or olfactory epithelium. Other contributing factors may include defects in saliva, pro-inflammatory cytokines, angiotensin II accumulation, systemic diseases, hypozincemia, and excessive use of chemicals.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Meeting Abstract
Biochemistry & Molecular Biology
Hatem Mustafa Abuohashish