Deconvoluting Kinase Inhibitor Induced Cardiotoxicity

Phase I, open-label, dose-escalation study of AZD7762 in combination with irinotecan (irino) in patients (pts) with advanced solid tumors.

(2017) A. L. Ho et al.   JOURNAL OF CLINICAL ONCOLOGY

The Use of Ratiometric Fluorescence Measurements of the Voltage Sensitive Dye Di-4-ANEPPS to Examine Action Potential Characteristics and Drug Effects on Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

(2016) M. P. Hortigon-Vinagre et al.   TOXICOLOGICAL SCIENCES

Cardio-Oncology

(2015) Andrew M. Bellinger et al.   CIRCULATION

Etiology of angiogenesis inhibition-related hypertension

(2015) Stephanie Lankhorst et al.   CURRENT OPINION IN PHARMACOLOGY

FDA-approved small-molecule kinase inhibitors

(2015) Peng Wu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Human Stem Cell-Derived Cardiomyocytes in Cellular Impedance Assays: Bringing Cardiotoxicity Screening to the Front Line

(2014) Matthew F. Peters et al.   Cardiovascular Toxicology

An Impedance-Based Cellular Assay Using Human iPSC-Derived Cardiomyocytes to Quantify Modulators of Cardiac Contractility

(2014) Clay W. Scott et al.   TOXICOLOGICAL SCIENCES

RegPhos 2.0: an updated resource to explore protein kinase–substrate phosphorylation networks in mammals

(2014) Kai-Yao Huang et al.   Database-The Journal of Biological Databases and Curation

Cancer Genetics and the Cardiotoxicity of the Therapeutics

(2013) Hind Lal et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cellular Impedance Assays for Predictive Preclinical Drug Screening of Kinase Inhibitor Cardiovascular Toxicity

(2013) Sarah D. Lamore et al.   TOXICOLOGICAL SCIENCES

Refining the Human iPSC-Cardiomyocyte Arrhythmic Risk Assessment Model

(2013) Liang Guo et al.   TOXICOLOGICAL SCIENCES

Regulation of voltage-gated potassium channels by PI(4,5)P2

(2012) Martin Kruse et al.   JOURNAL OF GENERAL PHYSIOLOGY

Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity

(2011) Theonie Anastassiadis et al.   NATURE BIOTECHNOLOGY

Comprehensive analysis of kinase inhibitor selectivity

(2011) Mindy I Davis et al.   NATURE BIOTECHNOLOGY

Cardiotoxicity of kinase inhibitors: the prediction and translation of preclinical models to clinical outcomes

(2011) Thomas Force et al.   NATURE REVIEWS DRUG DISCOVERY

Determination of the Human Cardiomyocyte mRNA and miRNA Differentiation Network by Fine-Scale Profiling

(2011) Joshua E. Babiarz et al.   STEM CELLS AND DEVELOPMENT

Extended-Connectivity Fingerprints

(2010) David Rogers et al.   Journal of Chemical Information and Modeling

Modeling Bone Marrow Toxicity Using Kinase Structural Motifs and the Inhibition Profiles of Small Molecular Kinase Inhibitors

(2010) Andrew J. Olaharski et al.   TOXICOLOGICAL SCIENCES

Cardiotoxicity induced by tyrosine kinase inhibitors

(2009) George S. Orphanos et al.   ACTA ONCOLOGICA

PIP2-Binding Site in Kir Channels: Definition by Multiscale Biomolecular Simulations

(2009) Phillip J. Stansfeld et al.   BIOCHEMISTRY

Identification of a Kinase Profile that Predicts Chromosome Damage Induced by Small Molecule Kinase Inhibitors

(2009) Andrew J. Olaharski et al.   PLoS Computational Biology

Phosphorylation of cardiac troponin I by mammalian sterile 20-like kinase 1

(2008) Bei You et al.   BIOCHEMICAL JOURNAL

Mechanisms of Cardiac Dysfunction Associated With Tyrosine Kinase Inhibitor Cancer Therapeutics

(2008) Ming Hui Chen et al.   CIRCULATION