Modeling Bone Marrow Toxicity Using Kinase Structural Motifs and the Inhibition Profiles of Small Molecular Kinase Inhibitors

The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: Results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP-690,550 versus placebo

(2009) Joel M. Kremer et al.   ARTHRITIS AND RHEUMATISM

Molecular Cloning, Expression, and Chromosomal Mapping of the Porcine CDC-2-Like Kinase 1 (CLK1) Gene

(2009) Shui Hua Xie et al.   BIOCHEMICAL GENETICS

Analysis of Cell Type-specific Expression of CK1ε in Various Tissues of Young Adult BALB/c Mice and in Mammary Tumors of SV40 T-Ag-transgenic Mice

(2009) Anja C. Utz et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

MAPK signaling pathways in the regulation of hematopoiesis

(2009) Christian R. Geest et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The Nek6 and Nek7 Protein Kinases Are Required for Robust Mitotic Spindle Formation and Cytokinesis

(2009) L. O'Regan et al.   MOLECULAR AND CELLULAR BIOLOGY

LOK is a major ERM kinase in resting lymphocytes and regulates cytoskeletal rearrangement through ERM phosphorylation

(2009) N. V. Belkina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro to in vivo concordance of a high throughput assay of bone marrow toxicity across a diverse set of drug candidates

(2009) Andrew J. Olaharski et al.   TOXICOLOGY LETTERS

Identification of a Kinase Profile that Predicts Chromosome Damage Induced by Small Molecule Kinase Inhibitors

(2009) Andrew J. Olaharski et al.   PLoS Computational Biology

Regulation of FLT3 and its ligand in normal hematopoietic progenitor cells

(2008) Katja C. Weisel et al.   ANNALS OF HEMATOLOGY

Pim Kinases Promote Cell Cycle Progression by Phosphorylating and Down-regulating p27Kip1 at the Transcriptional and Posttranscriptional Levels

(2008) D. Morishita et al.   CANCER RESEARCH

A KIT juxtamembrane PY567 -directed pathway provides nonredundant signals for erythroid progenitor cell development and stress erythropoiesis

(2008) Valter Agosti et al.   EXPERIMENTAL HEMATOLOGY

PDGF Receptor β Is a Potent Regulator of Mesenchymal Stromal Cell Function

(2008) Ayano Tokunaga et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The PKC inhibitor AEB071 may be a therapeutic option for psoriasis

(2008) Hans Skvara et al.   JOURNAL OF CLINICAL INVESTIGATION

Efficacy and safety of dasatinib in imatinib-resistant or -intolerant patients with chronic myeloid leukemia in blast phase

(2008) J Cortes et al.   LEUKEMIA

Inhibition of p38α MAPK disrupts the pathological loop of proinflammatory factor production in the myelodysplastic syndrome bone marrow microenvironment

(2008) Tony Navas et al.   LEUKEMIA & LYMPHOMA