The properdin pathway: an “alternative activation pathway” or a “critical amplification loop” for C3 and C5 activation?

Analysis of Factor D Isoforms in Malpuech–Michels–Mingarelli–Carnevale Patients Highlights the Role of MASP-3 as a Maturase in the Alternative Pathway of Complement

(2017) Rasmus Pihl et al.   JOURNAL OF IMMUNOLOGY

Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses

(2017) Xiaoguang Xue et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Properdin binding to complement activating surfaces depends on initial C3b deposition

(2017) Morten Harboe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses

(2017) Xiaoguang Xue et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Small-molecule factor D inhibitors selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome

(2016) Xuan Yuan et al.   HAEMATOLOGICA

Regulation of the mouse adipose Factor D biosynthesis by the endocrine hypothalamic–pituitary–adrenal axis

(2016) Xiaobo Wu et al.   IMMUNOBIOLOGY

The complement factor H-related proteins

(2016) Nicholas Medjeral-Thomas et al.   IMMUNOLOGICAL REVIEWS

Small-molecule factor D inhibitors targeting the alternative complement pathway

(2016) Jürgen Maibaum et al.   Nature Chemical Biology

Hybrid mass spectrometry approaches in glycoprotein analysis and their usage in scoring biosimilarity

(2016) Yang Yang et al.   Nature Communications

Small-molecule factor D inhibitors selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome

(2016) Xuan Yuan et al.   HAEMATOLOGICA

MASP-3 is the exclusive pro-factor D activator in resting blood: the lectin and the alternative complement pathways are fundamentally linked

(2016) József Dobó et al.   Scientific Reports

Molecular insights into the surface-specific arrangement of complement C5 convertase enzymes

(2015) Evelien T. M. Berends et al.   BMC BIOLOGY

Is the Complement Activation Product C3a a Proinflammatory Molecule? Re-evaluating the Evidence and the Myth

(2015) Liam G. Coulthard et al.   JOURNAL OF IMMUNOLOGY

Factor H-related proteins determine complement-activating surfaces

(2015) Mihály Józsi et al.   TRENDS IN IMMUNOLOGY

Properdin Binds to Late Apoptotic and Necrotic Cells Independently of C3b and Regulates Alternative Pathway Complement Activation

(2014) W. Xu et al.   JOURNAL OF IMMUNOLOGY

Identification of Factor H–like Protein 1 as the Predominant Complement Regulator in Bruch’s Membrane: Implications for Age-Related Macular Degeneration

(2014) Simon J. Clark et al.   JOURNAL OF IMMUNOLOGY

A Novel Atypical Hemolytic Uremic Syndrome-Associated Hybrid CFHR1/CFH Gene Encoding a Fusion Protein That Antagonizes Factor H-Dependent Complement Regulation

(2014) E. Valoti et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Complement Nomenclature 2014

(2014) Claudia Kemper et al.   MOLECULAR IMMUNOLOGY

C3 dysregulation due to factor H deficiency is mannan-binding lectin-associated serine proteases (MASP)-1 and MASP-3 independentin vivo

(2013) M. M. Ruseva et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Human Factor H-Related Protein 2 (CFHR2) Regulates Complement Activation

(2013) Hannes U. Eberhardt et al.   PLoS One

Dimerization of complement factor H-related proteins modulates complement activation in vivo

(2013) E. Goicoechea de Jorge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The tick-over theory revisited: Is C3 a contact-activated protein?

(2012) Bo Nilsson et al.   IMMUNOBIOLOGY

Mannan-Binding Lectin-Associated Serine Protease (MASP)-1 Is Crucial for Lectin Pathway Activation in Human Serum, whereas neither MASP-1 nor MASP-3 Is Required for Alternative Pathway Function

(2012) S. E. Degn et al.   JOURNAL OF IMMUNOLOGY

The Role of Properdin in Zymosan- and Escherichia coli-Induced Complement Activation

(2012) M. Harboe et al.   JOURNAL OF IMMUNOLOGY

Mechanisms of mannose-binding lectin-associated serine proteases-1/3 activation of the alternative pathway of complement

(2011) Nirmal K. Banda et al.   MOLECULAR IMMUNOLOGY

Common polymorphisms in C3, factor B, and factor H collaborate to determine systemic complement activity and disease risk

(2011) M. Heurich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual interaction of factor H with C3d and glycosaminoglycans in host-nonhost discrimination by complement

(2011) T. Kajander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Use of time-resolved FRET to validate crystal structure of complement regulatory complex between C3b and factor H (N terminus)

(2011) Isabell C. Pechtl et al.   PROTEIN SCIENCE

Linkage Specificity and Role of Properdin in Activation of the Alternative Complement Pathway by Fungal Glycans

(2011) S. Agarwal et al.   mBio

Native Properdin Binds toChlamydia pneumoniaeand Promotes Complement Activation

(2010) Claudio Cortes et al.   INFECTION AND IMMUNITY

Properdin: Emerging Roles of a Pattern-Recognition Molecule

(2009) Claudia Kemper et al.   Annual Review of Immunology

Factor H-related protein 1 (CFHR-1) inhibits complement C5 convertase activity and terminal complex formation

(2009) S. Heinen et al.   BLOOD

Essential role of Mannose-binding lectin-associated serine protease-1 in activation of the complement factor D

(2009) Minoru Takahashi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The spectrum of complement alternative pathway-mediated diseases

(2008) V. Michael Holers   IMMUNOLOGICAL REVIEWS

Activator-specific requirement of properdin in the initiation and amplification of the alternative pathway complement

(2007) Y. Kimura et al.   BLOOD

The tick-over theory revisited: Formation and regulation of the soluble alternative complement C3 convertase (C3(H2O)Bb)

(2007) Fredrik Bexborn et al.   MOLECULAR IMMUNOLOGY