Article
Biochemistry & Molecular Biology
Yao Xiao, TingYu M. Liu, Ian J. MacRae
Summary: Argonaute (AGO) proteins use microRNAs (miRNAs) and small interfering RNAs (siRNAs) to regulate gene expression. The functional distinction between AGOs in plants and animals depends on a minor structural difference in the PIWI domain. Swapping a 9-amino acid loop in the PIWI domain can alter the targeting properties and silencing efficiency of AGO proteins.
Article
Biochemistry & Molecular Biology
Vivek Nilesh Shah, Julia Neumeier, Miguel Quevillon Huberdeau, Daniela M. Zeitler, Astrid Bruckmann, Gunter Meister, Martin J. Simard
Summary: The conserved serine/threonine kinases CK1A1 and CK2 regulate a phosphorylation cluster on the miRNA-specific AGO protein ALG-1, which is essential for miRISC-target RNA binding and silencing in Caenorhabditis elegans and humans.
Review
Cell Biology
Pierre-Marc Frederick, Martin J. Simard
Summary: miRNAs play a key role in gene expression regulation by forming the miRNA induced silencing complex (miRISC) with Argonaute protein to target specific mRNAs. The regulation of miRISC functions in animals involves post-translational modifications, 3' UTR environment, and interactions with other proteins. Subcellular localization and vesicular trafficking also play important roles in modulating miRISC function.
WILEY INTERDISCIPLINARY REVIEWS-RNA
(2022)
Article
Cardiac & Cardiovascular Systems
Milessa Silva Afonso, Monika Sharma, Martin Schlegel, Coen van Solingen, Graeme J. Koelwyn, Lianne C. Shanley, Lauren Beckett, Daniel Peled, Karishma Rahman, Chiara Giannarelli, Huilin Li, Emily J. Brown, Alireza Khodadadi-Jamayran, Edward A. Fisher, Kathryn J. Moore
Summary: Inhibition of miR-33 shifts the balance of proatherosclerotic and antiatherosclerotic immune cell subsets in atherosclerotic plaques, reducing plaque burden and inflammation. This treatment also affects the expression of specific target genes in different macrophage subsets, ultimately leading to a decrease in aortic CD8+ T cells and CD4+ T-helper 1 cells, and an increase in regulatory T cells within plaques. These findings shed light on the immune mechanisms underlying the atheroprotective effects of anti-miR-33.
CIRCULATION RESEARCH
(2021)
Article
Biochemical Research Methods
Li Guo, Yongsheng Li, Kara M. Cirillo, Robert A. Marick, Zhe Su, Xing Yin, Xu Hua, Gordon B. Mills, Nidhi Sahni, S. Stephen Yi
Summary: miRNA is not a single sequence, but a series of multiple variants with sequence and expression heterogeneity. Variations in isomiRs generated from the same miRNA locus often exhibit remarkable variation in their sequence, expression, and function, leading to potential novel target discovery and expansion of interaction capabilities between small RNAs and mRNAs, rewiring regulatory networks and increasing signaling circuit complexity. The widespread expansion of isomiR and mRNA interaction networks suggests global gene regulation network perturbations by alternative small RNA variants or isoforms, playing a far more complex and plastic role in gene regulation than previously anticipated.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Chemistry, Analytical
Shuai Wang, Liyan Zhang, Ailing Kan, Xiaowen Xu, Nan Zhang, Wei Jiang
Summary: In this study, a MnO2 nanosheet-mediated target-binding-induced fluorescence resonance energy transfer (FRET) strategy was developed for detection and imaging of multiplexed miRNAs in living cells. The strategy successfully enabled simultaneous imaging of miRNA-373 and miRNA-96 in MDA-MB-231 and L02 cells, revealing higher expression levels of target miRNAs in MDA-MB-231 cells compared to L02 cells. This approach provides an alternative method for simultaneous accurate detection and imaging of multiplexed miRNAs with potential biomedical applications.
Article
Chemistry, Analytical
Anisa Kaur, Roaa Mahmoud, Anoja Megalathan, Sydney Pettit, Soma Dhakal
Summary: The multiplexed detection of disease biomarkers is an important aspect of improving diagnostic testing quality, reducing analysis costs, and speeding up treatment processes. Although there have been efforts to develop more sensitive and rapid multiplexed screening methods, such as microarrays and electrochemical sensors, their intricate designs and semi-quantitative capabilities limit their effectiveness. On the other hand, fluorescence resonance energy transfer (FRET)-based single-molecule counting shows promise for sensitive and quantitative detection of biomarkers. However, current FRET-based multiplexed sensing methods require multiple excitation sources and/or FRET pairs, which complicates labeling and data analysis. This study presents a nanotweezer (NT)-based sensing strategy that uses a single FRET pair to detect multiple targets, offering a simple and promising approach for sensitive detection of nucleic acid biomarkers.
Article
Biochemistry & Molecular Biology
Dheeraj Chitara, Richa Anand, B. S. Sanjeev
Summary: RNA interference (RNAi) plays a role in genetic interference and is identified as an antiviral response mechanism in humans. The study on the interfaces between Ago, miRNA and Target RNA in the presence of molecular crowders through molecular dynamics simulations reveals that crowding changes dynamics, stabilizes the complex and aids in binding free energy. Conserved features and amino acid residues with crowding resilient interactions with RNA are identified in all three systems.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Plant Sciences
Xinyi Hu, Kristian Persson Hoden, Zhen Liao, Anna Asman, Christina Dixelius
Summary: Phytophthora spp. cause damage to plants by using effector proteins and small RNAs. The study found that the sRNA encoded by P. infestans can affect potato mRNA, expanding our understanding of the strategies used by this species to facilitate infection.
Review
Cell Biology
Shintaro Komatsu, Hiroki Kitai, Hiroshi I. Suzuki
Summary: MicroRNAs (miRNAs) act as versatile regulators of gene expression at the post-transcriptional level. Recent studies have uncovered the mechanisms involved in miRNA biogenesis, including the processing of both canonical and non-canonical miRNAs. Additionally, the complex interactions between miRNAs and their targets have been explored, revealing target-mediated miRNA degradation and cooperative regulation by multiple miRNAs. These findings highlight the coordinated regulation of miRNA biogenesis and miRNA-target interaction in miRNA biology.
Article
Biochemistry & Molecular Biology
Andras Makkos, Bence Agg, Zoltan V. Varga, Zoltan Giricz, Mariann Gyongyosi, Dominika Lukovic, Rainer Schulz, Monika Bartekova, Aniko Gorbe, Peter Ferdinandy
Summary: This study aimed to identify key molecular targets of ProtectomiRs and confirm their association with cardioprotection. The results demonstrated that Rictor is the central molecular target of ProtectomiRs and may be a potential novel drug target for acute cardioprotection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Pavan Kumar Kakumani
Summary: The interplay between miRNA-AGO and multiple RBPs determines the fate of target mRNA and plays a crucial role in cancer initiation and progression.
TRANSLATIONAL ONCOLOGY
(2022)
Article
Health Care Sciences & Services
Aleksander Turk, Tanja Kunej, Borut Peterlin
Summary: Alzheimer's Disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia, making early diagnosis challenging. Research on miRNAs as biomarkers for AD diagnostics has potential. An analysis using tools such as Cytoscape, STRING, and mirPath revealed potential disease modules for further biomarker development from experimentally validated AD-associated MTIs obtained from miRTarBase.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Plant Sciences
Gigi Y. Wong, Anthony A. Millar
Summary: In plants, the relationships between microRNAs (miRNAs) and their target genes are complex, with predictions indicating numerous and diverse targets based on complementarity. However, there is also a hypothesis suggesting that miRNA specificity is constrained and limited to a few targets with compatible expression. To explore these opposing views, a bioinformatic pipeline was used to identify highly conserved miRNA targets across species. The results supported the constrained hypothesis, showing that the majority of miRNA targets belong to conserved target gene families, with a minority of secondary families or non-conserved targets.
PLANT AND CELL PHYSIOLOGY
(2023)
Article
Biochemical Research Methods
Mengqi Luo, Shangfu Li, Yuxuan Pang, Lantian Yao, Renfei Ma, Hsi-Yuan Huang, Hsien-Da Huang, Tzong-Yi Lee
Summary: This study constructed a deep learning-based model to efficiently extract miRNA-target interaction knowledge from large-scale published biomedical literature. The model performed outstandingly and outperformed other machine learning methods. This research is of great significance for advancing miRNA analysis and regulation studies.
BRIEFINGS IN BIOINFORMATICS
(2023)
Article
Biochemistry & Molecular Biology
Suzan Ruijtenberg, Stijn Sonneveld, Tao Ju Cui, Ive Logister, Dion de Steenwinkel, Yao Xiao, Ian J. MacRae, Chirlmin Joo, Marvin E. Tanenbaum
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Carolien Bastiaanssen, Chirlmin Joo
Summary: Tetrahymena uniquely deals with transposable elements by having separate somatic and germline genomes in a single cell. During sexual reproduction, a small RNA directed system compares the two genomes to identify and process transposable elements. The chromatin context in Tetrahymena allows for potential advantages in genome editing and gene therapy compared to the CRISPR-Cas9 system.
Article
Biochemistry & Molecular Biology
Hamza Balci, Viktorija Globyte, Chirlmin Joo
Summary: The structural characteristics of the complex formed by CRISPR-Cas9 and target DNA are influenced by the stability of GQ and the position of PQS, leading to variations in conformational states and dynamics. The presence of PQS in the target or nontarget strand results in different structural heterogeneity within the target dsDNA and the R-loop, impacting Cas9 activity.
ACS CHEMICAL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Mike Filius, Sung Hyun Kim, Ivo Severins, Chirlmin Joo
Summary: The research team introduced a new method that allows for determining multiple distances between FRET pairs in a single object by resolving the FRET efficiency of multiple fluorophore pairs through transient binding of short DNA strands. This FRET X technology is expected to be a tool for high-resolution analysis of biomolecules and nanostructures.
Review
Biology
Eitan Lerner, Anders Barth, Jelle Hendrix, Benjamin Ambrose, Victoria Birkedal, Scott C. Blanchard, Richard Boerner, Hoi Sung Chung, Thorben Cordes, Timothy D. Craggs, Ashok A. Deniz, Jiajia Diao, Jingyi Fei, Ruben L. Gonzalez, Irina Gopich, Taekjip Ha, Christian A. Hanke, Gilad Haran, Nikos S. Hatzakis, Sungchul Hohng, Seok-Cheol Hong, Thorsten Hugel, Antonino Ingargiola, Chirlmin Joo, Achillefs N. Kapanidis, Harold D. Kim, Ted Laurence, Nam Ki Lee, Tae-Hee Lee, Edward A. Lemke, Emmanuel Margeat, Jens Michaelis, Xavier Michalet, Sua Myong, Daniel Nettels, Thomas-Otavio Peulen, Evelyn Ploetz, Yair Razvag, Nicole C. Robb, Benjamin Schuler, Hamid Soleimaninejad, Chun Tang, Reza Vafabakhsh, Don C. Lamb, Claus A. M. Seidel, Shimon Weiss
Summary: Single-molecule FRET (smFRET) has become a mainstream technique for studying biomolecular structural dynamics, with significant progress being made in sample preparation, measurement procedures, data analysis, algorithms, and documentation. Efforts have been made to streamline experiments and analyze results for obtaining quantitative information. Open science practices are strongly encouraged for further progress in this field.
Article
Biophysics
Carlos Victor de Lannoy, Mike Filius, Sung Hyun Kim, Chirlmin Joo, Dick de Ridder
Summary: FRET is a useful phenomenon in biomolecular investigations for nanoscale measurements, and a semisupervised approach with the web tool FRETboard has been proposed to fit models more intuitively. This approach accurately reproduces ground truth FRET statistics in simulated scenarios and retrieves parameters in vitro data in a fraction of the time required for manual classification. Additionally, FRETboard is designed to easily adapt to future developments in FRET measurement and analysis by being extendable to other models.
BIOPHYSICAL JOURNAL
(2021)
Article
Biochemical Research Methods
Javier Antonio Alfaro, Peggy Bohlander, Mingjie Dai, Mike Filius, Cecil J. Howard, Xander F. van Kooten, Shilo Ohayon, Adam Pomorski, Sonja Schmid, Aleksei Aksimentiev, Eric V. Anslyn, Georges Bedran, Chan Cao, Mauro Chinappi, Etienne Coyaud, Cees Dekker, Gunnar Dittmar, Nicholas Drachman, Rienk Eelkema, David Goodlett, Sebastien Hentz, Umesh Kalathiya, Neil L. Kelleher, Ryan T. Kelly, Zvi Kelman, Sung Hyun Kim, Bernhard Kuster, David Rodriguez-Larrea, Stuart Lindsay, Giovanni Maglia, Edward M. Marcotte, John P. Marino, Christophe Masselon, Michael Mayer, Patroklos Samaras, Kumar Sarthak, Lusia Sepiashvili, Derek Stein, Meni Wanunu, Mathias Wilhelm, Peng Yin, Amit Meller, Chirlmin Joo
Summary: Single-cell profiling methods have greatly impacted the understanding of cellular heterogeneity, although proteome profiling at the single-cell level is still in the early stages. The development of new technologies, such as single-molecule protein sequencing and innovations in mass spectrometry, will eventually enable broad sequence coverage in single-cell proteomics, leading to new biological discoveries and opportunities for ultra-sensitive disease diagnostics.
Correction
Biochemistry & Molecular Biology
Suzan Ruijtenberg, Stijn Sonneveld, Tao Ju Cui, Ive Logister, Dion de Steenwinkel, Yao Xiao, Ian J. MacRae, Chirlmin Joo, Marvin E. Tanenbaum
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2021)
Article
Optics
Jelmer Cnossen, Tao Ju Cui, Chirlmin Joo, Carlas Smith
Summary: The study introduces a new algorithm for drift estimation in localization microscopy, showing a 5x improvement in precision over the widely used RCC algorithm. The algorithm operates directly on fluorophore localizations and is tested on simulated and experimental datasets in 2D and 3D.
Review
Biochemistry & Molecular Biology
Raman van Wee, Mike Filius, Chirlmin Joo
Summary: Single-molecule localization microscopy (SMLM) is a powerful tool for examining biological systems with unprecedented resolution. DNA-based point accumulation for imaging in nanoscale topography (DNA-PAINT) has faced challenges such as low throughput, long acquisition time, and difficulty integrating with live-cell imaging, but recent advances are addressing these issues and expanding its applications. The current state of DNA-PAINT is reviewed in light of these advancements, with consideration for further developments needed to achieve live-cell imaging.
TRENDS IN BIOCHEMICAL SCIENCES
(2021)
Editorial Material
Multidisciplinary Sciences
Chirlmin Joo, Amit Meller
Article
Multidisciplinary Sciences
Carlos Victor de Lannoy, Mike Filius, Raman van Wee, Chirlmin Joo, Dick de Ridder
Summary: The study introduces a method called FRET X fingerprinting for single-molecule protein identification, which aims to create fingerprints for proteins. Through simulations and experimental validation, the effectiveness of the method was demonstrated, successfully identifying complex mixtures including multiple proteins, providing a new analysis tool for targeted proteomics.
Article
Engineering, Electrical & Electronic
Miri Seo, Eunseo Yang, Dong Hoon Shin, Yugyeong Je, Chirlmin Joo, Kookjin Lee, Sang Wook Lee
Summary: In this study, we successfully reduced noise interference and improved the accuracy of mass detection in suspended graphene-based nanomechanical resonators using machine learning techniques.
ACS APPLIED ELECTRONIC MATERIALS
(2022)
Article
Computer Science, Artificial Intelligence
Luuk Loeff, Jacob W. J. Kerssemakers, Chirlmin Joo, Cees Dekker
Summary: Single-molecule techniques allow visualization of molecular dynamics with high resolution. AutoStepfinder is a fast, automated, bias-free step detection method that can be used for a wide variety of experimental traces, providing a robust and user-friendly analysis procedure.
Article
Biochemistry & Molecular Biology
Benjamin Davis, Keri Backus, Georg Winter, Roberto Chica, Dan Li, Sang Yup Lee, Chuan He, Amy Weeks, Christopher Overall, Shinya Hagihara, Ben Thuronyi, Siddhesh Kamat, Ling-Ling Chen, Ramon Hurtado Guerrero, Shao Yao, Lara K. Mahal, Christopher Voigt, Christina Woo, Erick Strauss, Kazuya Kikuchi, Timothy Dore, Sheena Radford, Xiang David Li, Won Do Heo, Giulio Superti-Furga, Tara Deans, Vsevolod Belousov, Megan Matthews, Colin Jackson, Shiva Malek, Herbert Waldmann, Anna Rising, Michael Jewett, Dimitrios Stamou, Emily Parker, Mario Murakami, Karen Polizzi, Itaru Hamachi, Tobias Erb, Chirlmin Joo, Motonari Uesugi, Rab Prinjha, Gidi Rechavi, Roberto Solano, Brenda Schulman, Yael David, Rob Oslund
Summary: In the last five years, the most exciting research achievements or technological innovations in chemical biology have garnered attention from many chemical biologists.
NATURE CHEMICAL BIOLOGY
(2021)
Review
Cell Biology
Alyssa Kearly, Andrew D. L. Nelson, Aleksandra Skirycz, Monika Chodasiewicz
Summary: Stress Granules (SGs) and Processing-bodies (P-bodies) are important biomolecular condensates that play crucial roles in maintaining mRNA balance and regulating stress responses. They are composed of proteins and RNAs involved in translation, protein folding, and energy metabolism.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
P. Lemonnier, T. Lawson
Summary: Stomatal conductance plays a crucial role in determining CO2 uptake and water loss in plants, affecting overall water status and productivity. However, the signals coordinating mesophyll demands for CO2, the role of chloroplasts in stomatal function, and other GC metabolic processes in stomatal function remain poorly understood.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Matteo Gionfriddo, Timothy Rhodes, Spencer M. Whitney
Summary: Rubisco is a key enzyme that facilitates the entry of CO2 into the biosphere, but its catalytic properties are slow and error-prone. More effective Rubisco variants have been discovered in certain algae, offering the potential to significantly improve crop productivity. However, incompatibilities in protein folding have hindered the transplantation of these variants into plants. Directed evolution is now being explored to enhance Rubisco catalysis.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Vittoria Clapero, Stephanie Arrivault, Mark Stitt
Summary: The Calvin-Benson cycle has undergone massive selection and co-evolution with carbon-concentrating mechanisms due to changing environmental factors. Metabolite profiling reveals species-specific variations in the operation of the cycle, indicating the influence of different modes of photosynthesis. Connectivity analysis identifies constraints and driving factors for cross-species diversity in the cycle.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Sukhbir Kaur, David D. Roberts
Summary: Thrombospondin-1 modulates cell behavior by interacting with components of the extracellular matrix and cell surface receptors. Its release and expression are influenced by injuries and various diseases, while its sustained presence in the extracellular space is regulated by receptor-mediated clearance. Thrombospondin-1 plays important roles in immune responses.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Richard P. Tucker, Josephine C. Adams
Summary: Thrombospondins (TSPs) play diverse roles in animals and have been found to belong to a superfamily that includes different subgroups such as mega-TSPs, sushi-TSPs, and poriferan-TSPs. Invertebrates encode a greater diversity of TSP superfamily members than vertebrates.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
James Petrik, Sylvia Lauks, Bianca Garlisi, Jack Lawler
Summary: Many cancers start with a small nest of transformed cells that can remain dormant. Thrombospondin-1 (TSP-1) initially promotes dormancy by suppressing angiogenesis, but over time, factors promoting angiogenesis become dominant and recruit various cells to form a complex tumor microenvironment. TSPs play a role in the proliferation, migration, and invasion of cells in the tumor microenvironment, as well as influencing the immune characteristics and phenotype of tumor-associated macrophages.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Hana Fakim, Christine Vande Velde
Summary: There has been increasing attention to the role of phase-separated biomolecular condensates, specifically stress granules, in neurodegenerative diseases like ALS. ALS-associated mutations in genes involved in stress granule assembly have been found, and stress granule proteins have been detected in pathological inclusions in ALS patient neurons. However, protein components of stress granules are also present in other physiological biomolecular condensates, which have not been adequately discussed in relation to ALS. This review explores the functions of TDP-43 and FUS in physiological condensates occurring in the nucleus and neurites beyond stress granules, and discusses the impact of ALS-linked mutations on their ability to phase separate and perform their functions in stress-independent biomolecular condensates.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Alexander Lin, Yogambha Ramaswamy, Ashish Misra
Summary: Smooth muscle cells, endothelial cells, and macrophages in blood vessels display remarkable heterogeneity, and their developmental origins may influence their plasticity. Unbiased single cell whole transcriptome analysis techniques are revolutionizing the understanding of cellular diversity and plasticity, providing insights for therapeutic research.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Elton P. Hudson
Summary: The Calvin Benson cycle plays a crucial role in the ecological and biotechnological aspects of bacteria. Recent studies have shed light on the regulation of this cycle in bacteria, with post-transcriptional and post-translational regulation being important in phototrophic bacteria, and transcriptional regulation being prominent in chemolithoautotrophic bacteria. Understanding the regulation of the Calvin Benson cycle has implications for enhancing CO2 fixation and improving the synthesis of desired products. Non-canonical cycles may offer potential benefits for industrial applications.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Xin-Guang Zhu, Haim Treves, Honglong Zhao
Summary: This paper discusses the major regulatory mechanisms over the Calvin Benson Cycle (CBC) that maintain homeostasis of metabolite levels. These mechanisms include redox regulation of enzymes, metabolite regulations (especially allosteric regulations), and balanced activities of enzymes. These regulatory mechanisms are crucial for maintaining high flux and photosynthetic efficiency in CBC.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Hunter C. Herriage, Yi-Ting Huang, Brian R. Calvi
Summary: Apoptosis prevents the inappropriate acquisition of extra copies of the genome, known as polyploidy, but the polyploid state can suppress apoptosis. The mechanisms linking apoptosis and polyploid cell cycles are still largely unknown, and studying the regulation of apoptosis in development and cancer could lead to more effective therapies.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Daniel Campbell, Steven Zuryn
Summary: Mitochondrial dynamics play a crucial role in regulating cellular and organismal homeostasis, impacting various aspects of an organism's healthspan. By studying the nematode Caenorhabditis elegans, a comprehensive understanding of the impact of mitochondrial dynamics on homeostasis over a lifetime can be obtained.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Diba Borgmann, Henning Fenselau
Summary: Maintaining blood glucose at an appropriate physiological level requires coordination of multiple organs and tissues, with the vagus nerve playing a key role in central control. Recent studies have revealed the cellular identity, neuroanatomical organization, and functional contributions of vagal neurons in the regulation of systemic glucose metabolism. These findings provide new insights into the precise roles of vagal neurons in coordinating glucose levels and offer potential avenues for treating glucose metabolism disorders.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Tatiana C. Coverdell, Stephen B. G. Abbott, John N. Campbell
Summary: In this article, we review how genetic technology and single-cell genomics are revealing the organizational principles of the efferent vagus in unprecedented detail.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
