Network Regulation of microRNA Biogenesis and Target Interaction

Secondary structure RNA elements control the cleavage activity of DICER

(2022) Trung Duc Nguyen et al.   Nature Communications

Critical contribution of 3′ non-seed base pairing to the in vivo function of the evolutionarily conserved let-7a microRNA

(2022) Ye Duan et al.   Cell Reports

Structure of the Dicer-2–R2D2 heterodimer bound to a small RNA duplex

(2022) Sonomi Yamaguchi et al.   NATURE

Structural insights into dsRNA processing by Drosophila Dicer-2–Loqs-PD

(2022) Shichen Su et al.   NATURE

MicroRNA turnover: a tale of tailing, trimming, and targets

(2022) Jaeil Han et al.   TRENDS IN BIOCHEMICAL SCIENCES

The developmentally timed decay of an essential microRNA family is seed-sequence dependent

(2022) Bridget F. Donnelly et al.   Cell Reports

Structural and functional basis of mammalian microRNA biogenesis by Dicer

(2022) David Zapletal et al.   MOLECULAR CELL

Endogenous transcripts direct microRNA degradation in Drosophila, and this targeted degradation is required for proper embryonic development

(2022) Elena R. Kingston et al.   MOLECULAR CELL

Structural basis of microRNA biogenesis by Dicer-1 and its partner protein Loqs-PB

(2022) Karina Jouravleva et al.   MOLECULAR CELL

Systematic characterization of seed overlap microRNA cotargeting associated with lupus pathogenesis

(2022) Hiroki Kitai et al.   BMC BIOLOGY

Global miRNA dosage control of embryonic germ layer specification

(2021) Yingzi Cui et al.   NATURE

Systemic CLIP-seq analysis and game theory approach to model microRNA mode of binding

(2021) Fabrizio Serra et al.   NUCLEIC ACIDS RESEARCH

A quantitative map of human primary microRNA processing sites

(2021) Kijun Kim et al.   MOLECULAR CELL

Cis regulation within a cluster of viral microRNAs

(2021) Monika Vilimova et al.   NUCLEIC ACIDS RESEARCH

The regulatory impact of RNA-binding proteins on microRNA targeting

(2021) Sukjun Kim et al.   Nature Communications

Characterizing microRNA-mediated modulation of gene expression noise and its effect on synthetic gene circuits

(2021) Lei Wei et al.   Cell Reports

Widespread microRNA degradation elements in target mRNAs can assist the encoded proteins

(2021) Lu Li et al.   GENES & DEVELOPMENT

MapToCleave: High-throughput profiling of microRNA biogenesis in living cells

(2021) Wenjing Kang et al.   Cell Reports

MicroRNA function can be reversed by altering target gene expression levels

(2021) Alexander A. Svoronos et al.   iScience

Imprinted Maternally Expressed microRNAs Antagonize Paternally Driven Gene Programs in Neurons

(2020) Amanda J. Whipple et al.   MOLECULAR CELL

MicroRNAs Cause Accelerated Decay of Short-Tailed Target mRNAs

(2020) Timothy J. Eisen et al.   MOLECULAR CELL

The internal loops in the lower stem of primary microRNA transcripts facilitate single cleavage of human Microprocessor

(2020) Thuy Linh Nguyen et al.   NUCLEIC ACIDS RESEARCH

Cryo-EM Structures of Human Drosha and DGCR8 in Complex with Primary MicroRNA

(2020) Alexander C. Partin et al.   MOLECULAR CELL

Structural Basis for pri-miRNA Recognition by Drosha

(2020) Wenxing Jin et al.   MOLECULAR CELL

MicroRNA Clustering Assists Processing of Suboptimal MicroRNA Hairpins through the Action of the ERH Protein

(2020) Wenwen Fang et al.   MOLECULAR CELL

Genomic Clustering Facilitates Nuclear Processing of Suboptimal Pri-miRNA Loci

(2020) Renfu Shang et al.   MOLECULAR CELL

Ago2-Dependent Processing Allows miR-451 to Evade the Global MicroRNA Turnover Elicited during Erythropoiesis

(2020) Dmitry A. Kretov et al.   MOLECULAR CELL

Base-pair conformational switch modulates miR-34a targeting of Sirt1 mRNA

(2020) Lorenzo Baronti et al.   NATURE

High-Resolution In Vivo Identification of miRNA Targets by Halo-Enhanced Ago2 Pull-Down

(2020) Xiaoyi Li et al.   MOLECULAR CELL

SAFB2 Enables the Processing of Suboptimal Stem-Loop Structures in Clustered Primary miRNA Transcripts

(2020) Katharina Hutter et al.   MOLECULAR CELL

mRNA structural dynamics shape Argonaute-target interactions

(2020) Suzan Ruijtenberg et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The biochemical basis for the cooperative action of microRNAs

(2020) Daniel Briskin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Robust partitioning of microRNA targets from downstream regulatory changes

(2020) Ravi K Patel et al.   NUCLEIC ACIDS RESEARCH

ERH facilitates microRNA maturation through the interaction with the N-terminus of DGCR8

(2020) S Chul Kwon et al.   NUCLEIC ACIDS RESEARCH

Translation is required for miRNA‐dependent decay of endogenous transcripts

(2020) Adriano Biasini et al.   EMBO JOURNAL

Functional Atlas of Primary miRNA Maturation by the Microprocessor

(2020) Greggory M. Rice et al.   MOLECULAR CELL

Validation of human microRNA target pathways enables evaluation of target prediction tools

(2020) Fabian Kern et al.   NUCLEIC ACIDS RESEARCH

Identification of microRNA clusters cooperatively acting on epithelial to mesenchymal transition in triple negative breast cancer

(2019) Laura Cantini et al.   NUCLEIC ACIDS RESEARCH

Gain-of-function mutation of microRNA-140 in human skeletal dysplasia

(2019) Giedre Grigelioniene et al.   NATURE MEDICINE

Structural Basis for Target-Directed MicroRNA Degradation

(2019) Jessica Sheu-Gruttadauria et al.   MOLECULAR CELL

Time-Resolved Small RNA Sequencing Unravels the Molecular Principles of MicroRNA Homeostasis

(2019) Brian Reichholf et al.   MOLECULAR CELL

High-Throughput Analysis Reveals Rules for Target RNA Binding and Cleavage by AGO2

(2019) Winston R. Becker et al.   MOLECULAR CELL

3′ Uridylation Confers miRNAs with Non-canonical Target Repertoires

(2019) Acong Yang et al.   MOLECULAR CELL

Oncogenic Biogenesis of pri-miR-17∼92 Reveals Hierarchy and Competition among Polycistronic MicroRNAs

(2019) Ariel O. Donayo et al.   MOLECULAR CELL

Sequestration of microRNA-mediated target repression by the Ago2-associated RNA binding protein FAM120A

(2019) Tim J Kelly et al.   RNA

Global analyses of the dynamics of mammalian microRNA metabolism

(2019) Elena Kingston et al.   GENOME RESEARCH

Cotargeting among microRNAs in the brain

(2019) Jennifer M. Cherone et al.   GENOME RESEARCH

Temporal Control of the TGF-β Signaling Network by Mouse ESC MicroRNA Targets of Different Affinities

(2019) Timothy J. Kelly et al.   Cell Reports

Systems and Synthetic microRNA Biology: From Biogenesis to Disease Pathogenesis

(2019) Hironori Matsuyama et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The biochemical basis of microRNA targeting efficacy

(2019) Sean E. McGeary et al.   SCIENCE

A Network of Noncoding Regulatory RNAs Acts in the Mammalian Brain

(2018) Benjamin Kleaveland et al.   CELL

Cryo-EM Structure of Human Dicer and Its Complexes with a Pre-miRNA Substrate

(2018) Zhongmin Liu et al.   CELL

Metazoan MicroRNAs

(2018) David P. Bartel   CELL

Systematic Discovery of RNA Binding Proteins that Regulate MicroRNA Levels

(2018) Julia K. Nussbacher et al.   MOLECULAR CELL

Deconvolution of seed and RNA-binding protein crosstalk in RNAi-based functional genomics

(2018) Hiroshi I. Suzuki et al.   NATURE GENETICS

MicroRNA degradation by a conserved target RNA regulates animal behavior

(2018) Angelo Bitetti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MicroRNA degradation by a conserved target RNA regulates animal behavior

(2018) Angelo Bitetti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Regulation of microRNA function in animals

(2018) Luca F. R. Gebert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A novel class of microRNA-recognition elements that function only within open reading frames

(2018) Kai Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Endogenous transcripts control miRNA levels and activity in mammalian cells by target-directed miRNA degradation

(2018) Francesco Ghini et al.   Nature Communications

Molecular Basis for the Single-Nucleotide Precision of Primary microRNA Processing

(2018) S. Chul Kwon et al.   MOLECULAR CELL

A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis

(2017) Thomas Treiber et al.   MOLECULAR CELL

Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function

(2017) Monika Piwecka et al.   SCIENCE

microRNAs in the Same Clusters Evolve to Coordinately Regulate Functionally Related Genes

(2016) Yirong Wang et al.   MOLECULAR BIOLOGY AND EVOLUTION

Re-evaluation of the roles ofDROSHA,Exportin 5, andDICERin microRNA biogenesis

(2016) Young-Kook Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Anatomy of the Human Microprocessor

(2015) Tuan Anh Nguyen et al.   CELL

A Biogenesis Step Upstream of Microprocessor Controls miR-17∼92 Expression

(2015) Peng Du et al.   CELL

Human Argonaute 2 Has Diverse Reaction Pathways on Target RNAs

(2015) Myung Hyun Jo et al.   MOLECULAR CELL

The Menu of Features that Define Primary MicroRNAs and Enable De Novo Design of MicroRNA Genes

(2015) Wenwen Fang et al.   MOLECULAR CELL

Small-RNA asymmetry is directly driven by mammalian Argonautes

(2015) Hiroshi I Suzuki et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A heterotrimer model of the complete Microprocessor complex revealed by single-molecule subunit counting

(2015) Kristina M. Herbert et al.   RNA

MicroRNA control of protein expression noise

(2015) J. M. Schmiedel et al.   SCIENCE

Small-RNA asymmetry is directly driven by mammalian Argonautes

(2015) Hiroshi I Suzuki et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Predicting effective microRNA target sites in mammalian mRNAs

(2015) Vikram Agarwal et al.   eLife

Structural basis for microRNA targeting

(2014) N. T. Schirle et al.   SCIENCE

Structure of precursor microRNA’s terminal loop regulates human Dicer’s dicing activity by switching DExH/D domain

(2014) Zhongmin Liu et al.   Protein & Cell

Beyond Secondary Structure: Primary-Sequence Determinants License Pri-miRNA Hairpins for Processing

(2013) Vincent C. Auyeung et al.   CELL

Highly Complementary Target RNAs Promote Release of Guide RNAs from Human Argonaute2

(2013) Nabanita De et al.   MOLECULAR CELL

The Loop Position of shRNAs and Pre-miRNAs Is Critical for the Accuracy of Dicer Processing In Vivo

(2012) Shuo Gu et al.   CELL

Mono-Uridylation of Pre-MicroRNA as a Key Step in the Biogenesis of Group II let-7 MicroRNAs

(2012) Inha Heo et al.   CELL

Ribosome Profiling Shows That miR-430 Reduces Translation Before Causing mRNA Decay in Zebrafish

(2012) A. A. Bazzini et al.   SCIENCE

Dicer recognizes the 5′ end of RNA for efficient and accurate processing

(2011) Jong-Eun Park et al.   NATURE

Recognition of the pre-miRNA structure by Drosophila Dicer-1

(2011) Akihisa Tsutsumi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A MicroRNA Targeting Dicer for Metastasis Control

(2010) Graziano Martello et al.   CELL

Structural basis for 5′-nucleotide base-specific recognition of guide RNA by human AGO2

(2010) Filipp Frank et al.   NATURE

Mammalian microRNAs predominantly act to decrease target mRNA levels

(2010) Huili Guo et al.   NATURE

The terminal loop region controls microRNA processing by Drosha and Dicer

(2010) X. Zhang et al.   NUCLEIC ACIDS RESEARCH

Down-Regulation of a Host MicroRNA by a Herpesvirus saimiri Noncoding RNA

(2010) D. Cazalla et al.   SCIENCE

Target RNA-Directed Trimming and Tailing of Small Silencing RNAs

(2010) S. L. Ameres et al.   SCIENCE

Posttranscriptional Crossregulation between Drosha and DGCR8

(2009) Jinju Han et al.   CELL

The impact of microRNAs on protein output

(2008) Daehyun Baek et al.   NATURE