Building and re-building the heart by cardiomyocyte proliferation

Complete cardiac regeneration in a mouse model of myocardial infarction

(2016) Bernhard Johannes Haubner et al.   Aging-US

Cardiomyocyte Cell-Cycle Activity during Preadolescence

(2015) Mark H. Soonpaa et al.   CELL

Cardiomyocytes Replicate and their Numbers Increase in Young Hearts

(2015) Nawazish Naqvi et al.   CELL

No Evidence for Cardiomyocyte Number Expansion in Preadolescent Mice

(2015) Kanar Alkass et al.   CELL

Dynamics of Cell Generation and Turnover in the Human Heart

(2015) Olaf Bergmann et al.   CELL

Fetal Mammalian Heart Generates a Robust Compensatory Response to Cell LossCLINICAL PERSPECTIVE

(2015) Anthony C. Sturzu et al.   CIRCULATION

The Hippo Pathway in Heart Development, Regeneration, and Diseases

(2015) Q. Zhou et al.   CIRCULATION RESEARCH

Direct Cardiac Reprogramming: Progress and Challenges in Basic Biology and Clinical Applications

(2015) T. Sadahiro et al.   CIRCULATION RESEARCH

Tissue-Specific Cell Cycle Indicator Reveals Unexpected Findings for Cardiac Myocyte ProliferationNovelty and Significance

(2015) Maretoshi Hirai et al.   CIRCULATION RESEARCH

Molecular Regulation of Cardiomyocyte Differentiation

(2015) S. L. Paige et al.   CIRCULATION RESEARCH

Nerves Regulate Cardiomyocyte Proliferation and Heart Regeneration

(2015) Ahmed I. Mahmoud et al.   DEVELOPMENTAL CELL

HIF1α Represses Cell Stress Pathways to Allow Proliferation of Hypoxic Fetal Cardiomyocytes

(2015) Nuno Guimarães-Camboa et al.   DEVELOPMENTAL CELL

Redox regulation of cardiomyocyte cell cycling via an ERK1/2 and c-Myc-dependent activation of cyclin D2 transcription

(2015) Thomas V.A. Murray et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Harnessing the microRNA pathway for cardiac regeneration

(2015) Mauro Giacca et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Hypoxia fate mapping identifies cycling cardiomyocytes in the adult heart

(2015) Wataru Kimura et al.   NATURE

Epicardial regeneration is guided by cardiac outflow tract and Hedgehog signalling

(2015) Jinhu Wang et al.   NATURE

Epicardial FSTL1 reconstitution regenerates the adult mammalian heart

(2015) Ke Wei et al.   NATURE

ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation

(2015) Gabriele D’Uva et al.   NATURE CELL BIOLOGY

Myocardial NF-κB activation is essential for zebrafish heart regeneration

(2015) Ravi Karra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A microRNA-Hippo pathway that promotes cardiomyocyte proliferation and cardiac regeneration in mice

(2015) Ying Tian et al.   Science Translational Medicine

Neuregulin stimulation of cardiomyocyte regeneration in mice and human myocardium reveals a therapeutic window

(2015) Brian D. Polizzotti et al.   Science Translational Medicine

Telomerase Is Essential for Zebrafish Heart Regeneration

(2015) Dorota Bednarek et al.   Cell Reports

Nrg1 is an injury-induced cardiomyocyte mitogen for the endogenous heart regeneration program in zebrafish

(2015) Matthew Gemberling et al.   eLife

The Oxygen-Rich Postnatal Environment Induces Cardiomyocyte Cell-Cycle Arrest through DNA Damage Response

(2014) Bao N. Puente et al.   CELL

A Proliferative Burst during Preadolescence Establishes the Final Cardiomyocyte Number

(2014) Nawazish Naqvi et al.   CELL

Hydrogen peroxide primes heart regeneration with a derepression mechanism

(2014) Peidong Han et al.   CELL RESEARCH

Cardiac-Specific YAP Activation Improves Cardiac Function and Survival in an Experimental Murine MI Model

(2014) Zhiqiang Lin et al.   CIRCULATION RESEARCH

High-resolution imaging of cardiomyocyte behavior reveals two distinct steps in ventricular trabeculation

(2014) D. W. Staudt et al.   DEVELOPMENT

Differential reparative phenotypes between zebrafish and medaka after cardiac injury

(2014) Kohei Ito et al.   DEVELOPMENTAL DYNAMICS

Macrophages are required for neonatal heart regeneration

(2014) Arin B. Aurora et al.   JOURNAL OF CLINICAL INVESTIGATION

c-kit+ cells minimally contribute cardiomyocytes to the heart

(2014) Jop H. van Berlo et al.   NATURE

An emerging consensus on cardiac regeneration

(2014) Jop H van Berlo et al.   NATURE MEDICINE

Cell therapy for cardiac repair—lessons from clinical trials

(2014) Atta Behfar et al.   Nature Reviews Cardiology

c-kit+ Cardiac Stem Cells Alleviate Post-Myocardial Infarction Left Ventricular Dysfunction Despite Poor Engraftment and Negligible Retention in the Recipient Heart

(2014) Kyung U. Hong et al.   PLoS One

Recombinant Neuregulin 1 Does Not Activate Cardiomyocyte DNA Synthesis in Normal or Infarcted Adult Mice

(2014) Sean Reuter et al.   PLoS One

Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart

(2014) Kory J. Lavine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Existing cardiomyocytes generate cardiomyocytes at a low rate after birth in mice

(2014) S. R. Ali et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The epicardium signals the way towards heart regeneration

(2014) Megan Masters et al.   Stem Cell Research

Telomerase expression confers cardioprotection in the adult mouse heart after acute myocardial infarction

(2014) Christian Bär et al.   Nature Communications

Heart Fields and Cardiac Morphogenesis

(2014) R. G. Kelly et al.   Cold Spring Harbor Perspectives in Medicine

Adult c-kitpos Cardiac Stem Cells Are Necessary and Sufficient for Functional Cardiac Regeneration and Repair

(2013) Georgina M. Ellison et al.   CELL

An Injury-Responsive Gata4 Program Shapes the Zebrafish Cardiac Ventricle

(2013) Vikas Gupta et al.   CURRENT BIOLOGY

Hippo signaling impedes adult heart regeneration

(2013) T. Heallen et al.   DEVELOPMENT

Fkbp1a controls ventricular myocardium trabeculation and compaction by regulating endocardial Notch1 activity

(2013) H. Chen et al.   DEVELOPMENT

In vivo cardiac reprogramming contributes to zebrafish heart regeneration

(2013) Ruilin Zhang et al.   NATURE

Meis1 regulates postnatal cardiomyocyte cell cycle arrest

(2013) Ahmed I. Mahmoud et al.   NATURE

Igf Signaling is Required for Cardiomyocyte Proliferation during Zebrafish Heart Development and Regeneration

(2013) Ying Huang et al.   PLoS One

Translational profiling of cardiomyocytes identifies an early Jak1/Stat3 injury response required for zebrafish heart regeneration

(2013) Y. Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hippo pathway effector Yap promotes cardiac regeneration

(2013) Mei Xin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cardiomyocyte proliferation contributes to heart growth in young humans

(2013) Mariya Mollova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia Induces Myocardial Regeneration in Zebrafish

(2012) Chris Jopling et al.   CIRCULATION

Inefficient Reprogramming of Fibroblasts into Cardiomyocytes Using Gata4, Mef2c, and Tbx5

(2012) Jenny X. Chen et al.   CIRCULATION RESEARCH

Pan-epicardial lineage tracing reveals that epicardium derived cells give rise to myofibroblasts and perivascular cells during zebrafish heart regeneration

(2012) Juan Manuel González-Rosa et al.   DEVELOPMENTAL BIOLOGY

ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012

(2012) et al.   EUROPEAN JOURNAL OF HEART FAILURE

An Update on Cardioprotection

(2012) Paul Z. Gerczuk et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Heart repair by reprogramming non-myocytes with cardiac transcription factors

(2012) Kunhua Song et al.   NATURE

Clonally dominant cardiomyocytes direct heart morphogenesis

(2012) Vikas Gupta et al.   NATURE

In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes

(2012) Li Qian et al.   NATURE

Functional screening identifies miRNAs inducing cardiac regeneration

(2012) Ana Eulalio et al.   NATURE

Mammalian heart renewal by pre-existing cardiomyocytes

(2012) Samuel E. Senyo et al.   NATURE

YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy

(2012) A. von Gise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family

(2012) E. R. Porrello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Giant Danio (D. Aequipinnatus) as A Model of Cardiac Remodeling and Regeneration

(2011) Pascal J. Lafontant et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

The zebrafish heart regenerates after cryoinjury-induced myocardial infarction

(2011) Fabian Chablais et al.   BMC DEVELOPMENTAL BIOLOGY

Formation of the Building Plan of the Human Heart

(2011) Aleksander Sizarov et al.   CIRCULATION

The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletion

(2011) Jinhu Wang et al.   DEVELOPMENT

tcf21+ epicardial cells adopt non-myocardial fates during zebrafish heart development and regeneration

(2011) K. Kikuchi et al.   DEVELOPMENT

IGF signaling directs ventricular cardiomyocyte proliferation during embryonic heart development

(2011) P. Li et al.   DEVELOPMENT

Extensive scar formation and regression during heart regeneration after cryoinjury in zebrafish

(2011) J. M. Gonzalez-Rosa et al.   DEVELOPMENT

Recapitulation of developmental cardiogenesis governs the morphological and functional regeneration of adult newt hearts following injury

(2011) Nevin Witman et al.   DEVELOPMENTAL BIOLOGY

Retinoic Acid Production by Endocardium and Epicardium Is an Injury Response Essential for Zebrafish Heart Regeneration

(2011) Kazu Kikuchi et al.   DEVELOPMENTAL CELL

Rb and p130 control cell cycle gene silencing to maintain the postmitotic phenotype in cardiac myocytes

(2011) Patima Sdek et al.   JOURNAL OF CELL BIOLOGY

De novo cardiomyocytes from within the activated adult heart after injury

(2011) Nicola Smart et al.   NATURE

Heart regeneration

(2011) Michael A. Laflamme et al.   NATURE

Regeneration of Cryoinjury Induced Necrotic Heart Lesions in Zebrafish Is Associated with Epicardial Activation and Cardiomyocyte Proliferation

(2011) Kristin Schnabel et al.   PLoS One

Hippo Pathway Inhibits Wnt Signaling to Restrain Cardiomyocyte Proliferation and Heart Size

(2011) T. Heallen et al.   SCIENCE

Transient Regenerative Potential of the Neonatal Mouse Heart

(2011) E. R. Porrello et al.   SCIENCE

Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined Factors

(2010) Masaki Ieda et al.   CELL

A dual role for ErbB2 signaling in cardiac trabeculation

(2010) J. Liu et al.   DEVELOPMENT

Retinoic acid stimulates myocardial expansion by induction of hepatic erythropoietin which activates epicardial Igf2

(2010) T. Brade et al.   DEVELOPMENT

Primary contribution to zebrafish heart regeneration by gata4 + cardiomyocytes

(2010) Kazu Kikuchi et al.   NATURE

Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation

(2010) Chris Jopling et al.   NATURE

Advances in understanding tissue regenerative capacity and mechanisms in animals

(2010) Kenneth D. Poss   NATURE REVIEWS GENETICS

PDGF signaling is required for epicardial function and blood vessel formation in regenerating zebrafish hearts

(2010) J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuregulin1/ErbB4 Signaling Induces Cardiomyocyte Proliferation and Repair of Heart Injury

(2009) Kevin Bersell et al.   CELL

Distinct phases of cardiomyocyte differentiation regulate growth of the zebrafish heart

(2009) E. de Pater et al.   DEVELOPMENT

Evidence for Cardiomyocyte Renewal in Humans

(2009) Olaf Bergmann et al.   SCIENCE

Comparative Aspects of Animal Regeneration

(2008) Jeremy P. Brockes et al.   Annual Review of Cell and Developmental Biology

Paracrine Mechanisms in Adult Stem Cell Signaling and Therapy

(2008) Massimiliano Gnecchi et al.   CIRCULATION RESEARCH

A Caudal Proliferating Growth Center Contributes to Both Poles of the Forming Heart Tube

(2008) Gert van den Berg et al.   CIRCULATION RESEARCH

ndrg4 is required for normal myocyte proliferation during early cardiac development in zebrafish

(2008) Xianghu Qu et al.   DEVELOPMENTAL BIOLOGY

Compensatory Growth of Healthy Cardiac Cells in the Presence of Diseased Cells Restores Tissue Homeostasis during Heart Development

(2008) Jörg-Detlef Drenckhahn et al.   DEVELOPMENTAL CELL

TEAD mediates YAP-dependent gene induction and growth control

(2008) B. Zhao et al.   GENES & DEVELOPMENT