Embracing polygenicity: a review of methods and tools for psychiatric genetics research

Gene-based analysis of regulatory variants identifies 4 putative novel asthma risk genes related to nucleotide synthesis and signaling

(2017) Manuel A.R. Ferreira et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Contrasting the Genetic Architecture of 30 Complex Traits from Summary Association Data

(2016) Huwenbo Shi et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Transethnic Genetic-Correlation Estimates from Summary Statistics

(2016) Brielin C. Brown et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Disease and Polygenic Architecture: Avoid Trio Design and Appropriately Account for Unscreened Control Subjects for Common Disease

(2016) Wouter J. Peyrot et al.   AMERICAN JOURNAL OF HUMAN GENETICS

LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis

(2016) Jie Zheng et al.   BIOINFORMATICS

Association Between Cannabis and Psychosis: Epidemiologic Evidence

(2016) Suzanne H. Gage et al.   BIOLOGICAL PSYCHIATRY

Genetic resilience to amyloid related cognitive decline

(2016) Timothy J. Hohman et al.   Brain Imaging and Behavior

Schizophrenia risk from complex variation of complement component 4

(2016) Aswin Sekar et al.   NATURE

Genetic variants associated with subjective well-being, depressive symptoms and neuroticism identified through genome-wide analyses

(2016) Aysu Okbay et al.   NATURE GENETICS

A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases

(2016) Buhm Han et al.   NATURE GENETICS

Detection and interpretation of shared genetic influences on 42 human traits

(2016) Joseph K Pickrell et al.   NATURE GENETICS

Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets

(2016) Zhihong Zhu et al.   NATURE GENETICS

Integrative approaches for large-scale transcriptome-wide association studies

(2016) Alexander Gusev et al.   NATURE GENETICS

Rare variants are common in schizophrenia

(2016) Jacob Gratten   NATURE NEUROSCIENCE

Assessing causality in associations between cannabis use and schizophrenia risk: a two-sample Mendelian randomization study

(2016) S. H. Gage et al.   PSYCHOLOGICAL MEDICINE

Investigating causality in the association between 25(OH)D and schizophrenia

(2016) Amy E. Taylor et al.   Scientific Reports

The Schizophrenia Polygenic Risk Score

(2016) Kenneth S. Kendler   JAMA Psychiatry

Phenotypic Manifestation of Genetic Risk for Schizophrenia During Adolescence in the General Population

(2016) Hannah J. Jones et al.   JAMA Psychiatry

A significant causal association between C-reactive protein levels and schizophrenia

(2016) Masatoshi Inoshita et al.   Scientific Reports

Body mass index and psychiatric disorders: a Mendelian randomization study

(2016) Fernando Pires Hartwig et al.   Scientific Reports

Joint Analysis of Psychiatric Disorders Increases Accuracy of Risk Prediction for Schizophrenia, Bipolar Disorder, and Major Depressive Disorder

(2015) Robert Maier et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

(2015) Bjarni J. Vilhjálmsson et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mendelian Randomization: New Applications in the Coming Age of Hypothesis-Free Causality

(2015) David M. Evans et al.   Annual Review of Genomics and Human Genetics

Genome-wide genetic homogeneity between sexes and populations for human height and body mass index

(2015) Jian Yang et al.   HUMAN MOLECULAR GENETICS

Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index

(2015) Jian Yang et al.   NATURE GENETICS

Partitioning heritability by functional annotation using genome-wide association summary statistics

(2015) Hilary K Finucane et al.   NATURE GENETICS

An atlas of genetic correlations across human diseases and traits

(2015) Brendan Bulik-Sullivan et al.   NATURE GENETICS

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

Efficient Bayesian mixed-model analysis increases association power in large cohorts

(2015) Po-Ru Loh et al.   NATURE GENETICS

A gene-based association method for mapping traits using reference transcriptome data

(2015) Eric R Gamazon et al.   NATURE GENETICS

Polygenic risk scores for schizophrenia and bipolar disorder predict creativity

(2015) Robert A Power et al.   NATURE NEUROSCIENCE

FTO Obesity Variant Circuitry and Adipocyte Browning in Humans

(2015) Melina Claussnitzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Polygenic interactions with environmental adversity in the aetiology of major depressive disorder

(2015) N. Mullins et al.   PSYCHOLOGICAL MEDICINE

Biological interpretation of genome-wide association studies using predicted gene functions

(2015) Tune H. Pers et al.   Nature Communications

Second-generation PLINK: rising to the challenge of larger and richer datasets

(2015) Christopher C Chang et al.   GigaScience

PRSice: Polygenic Risk Score software

(2014) Jack Euesden et al.   BIOINFORMATICS

Effect of polygenic risk scores on depression in childhood trauma

(2014) Wouter J. Peyrot et al.   BRITISH JOURNAL OF PSYCHIATRY

Research Review: Polygenic methods and their application to psychiatric traits

(2014) Naomi R. Wray et al.   JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY

Genetic predisposition to schizophrenia associated with increased use of cannabis

(2014) R A Power et al.   MOLECULAR PSYCHIATRY

Biological insights from 108 schizophrenia-associated genetic loci

(2014)   NATURE

Advantages and pitfalls in the application of mixed-model association methods

(2014) Jian Yang et al.   NATURE GENETICS

Efficient multivariate linear mixed model algorithms for genome-wide association studies

(2014) Xiang Zhou et al.   NATURE METHODS

The Genetics of Major Depression

(2014) Jonathan Flint et al.   NEURON

Additive Genetic Variation in Schizophrenia Risk Is Shared by Populations of African and European Descent

(2013) Teresa R. de Candia et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Estimation and Partition of Heritability in Human Populations Using Whole-Genome Analysis Methods

(2013) Anna A.E. Vinkhuyzen et al.   Annual Review of Genetics

USING MENDELIAN RANDOMISATION TO INFER CAUSALITY IN DEPRESSION AND ANXIETY RESEARCH

(2013) Suzanne H. Gage et al.   DEPRESSION AND ANXIETY

Mendelian Randomization Analysis With Multiple Genetic Variants Using Summarized Data

(2013) Stephen Burgess et al.   GENETIC EPIDEMIOLOGY

Calculating statistical power in Mendelian randomization studies

(2013) Marie-Jo A Brion et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

(2013) S Hong Lee et al.   NATURE GENETICS

Pleiotropy in complex traits: challenges and strategies

(2013) Nadia Solovieff et al.   NATURE REVIEWS GENETICS

Improved Heritability Estimation from Genome-wide SNPs

(2012) Doug Speed et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Five Years of GWAS Discovery

(2012) Peter M. Visscher et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Estimation of pleiotropy between complex diseases using single-nucleotide polymorphism-derived genomic relationships and restricted maximum likelihood

(2012) S.H. Lee et al.   BIOINFORMATICS

Impact of diagnostic misclassification on estimation of genetic correlations using genome-wide genotypes

(2012) Naomi R Wray et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Performance and Robustness of Penalized and Unpenalized Methods for Genetic Prediction of Complex Human Disease

(2012) Gad Abraham et al.   GENETIC EPIDEMIOLOGY

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

(2012) Benjamin F Voight et al.   LANCET

Why has it taken so long for biological psychiatry to develop clinical tests and what to do about it?

(2012) S Kapur et al.   MOLECULAR PSYCHIATRY

Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs

(2012) S Hong Lee et al.   NATURE GENETICS

Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis

(2012) Eli A Stahl et al.   NATURE GENETICS

Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits

(2012) Jian Yang et al.   NATURE GENETICS

The causal role of smoking in anxiety and depression: a Mendelian randomization analysis of the HUNT study

(2012) J. H. Bjørngaard et al.   PSYCHOLOGICAL MEDICINE

Estimating Missing Heritability for Disease from Genome-wide Association Studies

(2011) Sang Hong Lee et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genomic inflation factors under polygenic inheritance

(2011) Jian Yang et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Transethnic meta-analysis of genomewide association studies

(2011) Andrew P. Morris   GENETIC EPIDEMIOLOGY

GCTA: A Tool for Genome-wide Complex Trait Analysis

(2010) Jian Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Association Between Cannabis Use and Psychosis-Related Outcomes Using Sibling Pair Analysis in a Cohort of Young Adults

(2010) John McGrath et al.   ARCHIVES OF GENERAL PSYCHIATRY

Common SNPs explain a large proportion of the heritability for human height

(2010) Jian Yang et al.   NATURE GENETICS

Analysing biological pathways in genome-wide association studies

(2010) Kai Wang et al.   NATURE REVIEWS GENETICS

Increased accuracy of artificial selection by using the realized relationship matrix

(2009) B. J. HAYES et al.   Genetics Research

Genomic privacy and limits of individual detection in a pool

(2009) Sriram Sankararaman et al.   NATURE GENETICS

The misdiagnosis of bipolar disorder as a psychotic disorder: Some of its causes and their influence on therapy

(2008) Friederike Meyer et al.   JOURNAL OF AFFECTIVE DISORDERS