From structure to redox: The diverse functional roles of disulfides and implications in disease

Human CD4 Metastability Is a Function of the Allosteric Disulfide Bond in Domain 2

(2016) Gavin R. Owen et al.   BIOCHEMISTRY

Regulation of DJ-1 by Glutaredoxin 1 in Vivo: Implications for Parkinson’s Disease

(2016) William M. Johnson et al.   BIOCHEMISTRY

Thioredoxin (Trx1) regulates CD4 membrane domain localization and is required for efficient CD4-dependent HIV-1 entry

(2016) Naazneen Moolla et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

A clickable glutathione approach for identification of protein glutathionylation in response to glucose metabolism

(2016) Kusal T. G. Samarasinghe et al.   Molecular BioSystems

Copper and Zinc Ions Specifically Promote Nonamyloid Aggregation of the Highly Stable Human γ-D Crystallin

(2015) Liliana Quintanar et al.   ACS Chemical Biology

S-Glutathionylation Enhances Human Cystathionine β-Synthase Activity Under Oxidative Stress Conditions

(2015) Wei-Ning Niu et al.   ANTIOXIDANTS & REDOX SIGNALING

Autophagy and oxidative stress in cardiovascular diseases

(2015) Yu Mei et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Diagnostic approach to von Willebrand disease

(2015) C. Ng et al.   BLOOD

A Novel Serpin Regulatory Mechanism

(2015) Matthew S. J. Mangan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Protein-disulfide Isomerase ERp57 Regulates the Steady-state Levels of the Prion Protein

(2015) Mauricio Torres et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Caged Electrophilic Probe for Global Analysis of Cysteine Reactivity in Living Cells

(2015) Masahiro Abo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET

Mapping native disulfide bonds at a proteome scale

(2015) Shan Lu et al.   NATURE METHODS

Chemical-proteomic strategies to investigate cysteine posttranslational modifications

(2014) Shalise M. Couvertier et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Identification of Allosteric Disulfides from Prestress Analysis

(2014) Beifei Zhou et al.   BIOPHYSICAL JOURNAL

Control of blood proteins by functional disulfide bonds

(2014) Diego Butera et al.   BLOOD

The protein disulfide isomerases PDIA4 and PDIA6 mediate resistance to cisplatin-induced cell death in lung adenocarcinoma

(2014) G Tufo et al.   CELL DEATH AND DIFFERENTIATION

Glutaredoxin deficiency exacerbates neurodegeneration in C. elegans models of Parkinson's disease

(2014) William M. Johnson et al.   HUMAN MOLECULAR GENETICS

Disulfide Reduction in CD4 Domain 1 or 2 Is Essential for Interaction with HIV Glycoprotein 120 (gp120), which Impairs Thioredoxin-driven CD4 Dimerization

(2014) Nichole Cerutti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Determinants in Prion Protein Folding and Stability

(2014) Federico Benetti et al.   JOURNAL OF MOLECULAR BIOLOGY

Metabolic Synthesis of Clickable Glutathione for Chemoselective Detection of Glutathionylation

(2014) Kusal T. G. Samarasinghe et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Putative Herpes Simplex Virus 1 Chaperone Protein UL32 Modulates Disulfide Bond Formation during Infection

(2014) Brandon S. Albright et al.   JOURNAL OF VIROLOGY

Cys34-Cysteinylated Human Serum Albumin Is a Sensitive Plasma Marker in Oxidative Stress-Related Chronic Diseases

(2014) Kohei Nagumo et al.   PLoS One

Post-Translational Modification by Cysteine Protects Cu/Zn-Superoxide Dismutase from Oxidative Damage

(2013) Jared R. Auclair et al.   BIOCHEMISTRY

Protein glutathionylation in health and disease

(2013) Pietro Ghezzi   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Proteome-wide Quantification and Characterization of Oxidation-Sensitive Cysteines in Pathogenic Bacteria

(2013) Xin Deng et al.   Cell Host & Microbe

An Isotopically Tagged Azobenzene-Based Cleavable Linker for Quantitative Proteomics

(2013) Yu Qian et al.   CHEMBIOCHEM

Protein disulfide isomerase: a promising target for cancer therapy

(2013) Shili Xu et al.   DRUG DISCOVERY TODAY

Oxidant Sensing by Reversible Disulfide Bond Formation

(2013) Claudia M. Cremers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A chemoproteomic platform to quantitatively map targets of lipid-derived electrophiles

(2013) Chu Wang et al.   NATURE METHODS

Oral Treatment Targeting the Unfolded Protein Response Prevents Neurodegeneration and Clinical Disease in Prion-Infected Mice

(2013) J. A. Moreno et al.   Science Translational Medicine

Diverse Functional Roles of Reactive Cysteines

(2012) Nicholas J. Pace et al.   ACS Chemical Biology

The Thioredoxin System as a Therapeutic Target in Human Health and Disease

(2012) Dler Faieeq Darweesh Mahmood et al.   ANTIOXIDANTS & REDOX SIGNALING

Post-Translational Control of Protein Function by Disulfide Bond Cleavage

(2012) Kristina M. Cook et al.   ANTIOXIDANTS & REDOX SIGNALING

Glutaredoxins in Thiol/Disulfide Exchange

(2012) Christopher Horst Lillig et al.   ANTIOXIDANTS & REDOX SIGNALING

Disulfide Bond Formation in the Cytoplasm

(2012) Mirva J. Saaranen et al.   ANTIOXIDANTS & REDOX SIGNALING

S-Glutathionylation signaling in cell biology: Progress and prospects

(2012) Anna Pastore et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Oxidative stress, neurodegeneration, and the balance of protein degradation and protein synthesis

(2012) Kalavathi Dasuri et al.   FREE RADICAL BIOLOGY AND MEDICINE

Murine tissue factor coagulant activity is critically dependent on the presence of an intact allosteric disulfide

(2012) L. G. van den Hengel et al.   HAEMATOLOGICA

Unique Disulfide Bonds in Epidermal Growth Factor (EGF) Domains of β3 Affect Structure and Function of αIIbβ3 and αvβ3 Integrins in Different Manner

(2012) Ronit Mor-Cohen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of cross-linked peptides from complex samples

(2012) Bing Yang et al.   NATURE METHODS

The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies

(2012) B Luo et al.   ONCOGENE

The disulfide isomerase ERp57 mediates platelet aggregation, hemostasis, and thrombosis

(2011) Y. Wu et al.   BLOOD

Lateral self-association of VWF involves the Cys2431-Cys2453 disulfide/dithiol in the C2 domain

(2011) T. Ganderton et al.   BLOOD

Vertebrate-specific glutaredoxin is essential for brain development

(2011) L. Brautigam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells

(2011) Christian Münch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HSV Infection Induces Production of ROS, which Potentiate Signaling from Pattern Recognition Receptors: Role for S-glutathionylation of TRAF3 and 6

(2011) Regina Gonzalez-Dosal et al.   PLoS Pathogens

Control of Mature Protein Function by Allosteric Disulfide Bonds

(2010) Iman Azimi et al.   ANTIOXIDANTS & REDOX SIGNALING

How Proteins Form Disulfide Bonds

(2010) Matthieu Depuydt et al.   ANTIOXIDANTS & REDOX SIGNALING

Cysteine sulfenic Acid as an Intermediate in Disulfide Bond Formation and Nonenzymatic Protein Folding

(2010) Douglas S. Rehder et al.   BIOCHEMISTRY

Naturally occurring free thiols within  2-glycoprotein I in vivo: nitrosylation, redox modification by endothelial cells, and regulation of oxidative stress-induced cell injury

(2010) Y. Ioannou et al.   BLOOD

The importance of vicinal cysteines, C1669 and C1670, for von Willebrand factor A2 domain function

(2010) B. M. Luken et al.   BLOOD

Disulfide bonds in ER protein folding and homeostasis

(2010) Matthias J Feige et al.   CURRENT OPINION IN CELL BIOLOGY

A structural overview of the PDI family of proteins

(2010) Guennadi Kozlov et al.   FEBS Journal

Accumulation of oxidized proteins in Herpesvirus infected cells

(2010) Shomita S. Mathew et al.   FREE RADICAL BIOLOGY AND MEDICINE

Disulfide Bond That Constrains the HIV-1 gp120 V3 Domain Is Cleaved by Thioredoxin

(2010) Iman Azimi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Both Thioredoxin 2 and Glutaredoxin 2 Contribute to the Reduction of the Mitochondrial 2-Cys Peroxiredoxin Prx3

(2010) Eva-Maria Hanschmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reduced Monomeric CD4 Is the Preferred Receptor for HIV

(2010) Lisa J. Matthias et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disulfide Bond Acquisition through Eukaryotic Protein Evolution

(2010) Jason W. H. Wong et al.   MOLECULAR BIOLOGY AND EVOLUTION

Mitochondrial Disulfide Bond Formation Is Driven by Intersubunit Electron Transfer in Erv1 and Proofread by Glutathione

(2010) Melanie Bien et al.   MOLECULAR CELL

Quantitative reactivity profiling predicts functional cysteines in proteomes

(2010) Eranthie Weerapana et al.   NATURE

Superoxide Dismutase 1 and tgSOD1G93A Mouse Spinal Cord Seed Fibrils, Suggesting a Propagative Cell Death Mechanism in Amyotrophic Lateral Sclerosis

(2010) Ruth Chia et al.   PLoS One

Prion hypothesis: the end of the controversy?

(2010) Claudio Soto   TRENDS IN BIOCHEMICAL SCIENCES

Protein Disulfide Isomerase: A Critical Evaluation of Its Function in Disulfide Bond Formation

(2009) Feras Hatahet et al.   ANTIOXIDANTS & REDOX SIGNALING

DJ-1 Loss by Glutaredoxin but Not Glutathione Depletion Triggers Daxx Translocation and Cell Death

(2009) Uzma Saeed et al.   ANTIOXIDANTS & REDOX SIGNALING

Disulfides as Redox Switches: From Molecular Mechanisms to Functional Significance

(2009) Merridee A. Wouters et al.   ANTIOXIDANTS & REDOX SIGNALING

Oxidative modifications of glyceraldehyde-3-phosphate dehydrogenase play a key role in its multiple cellular functions

(2009) Na Rae Hwang et al.   BIOCHEMICAL JOURNAL

Disulphide Bond Formation in the Intermembrane Space of Mitochondria

(2009) M. Deponte et al.   JOURNAL OF BIOCHEMISTRY

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

MIA40 is an oxidoreductase that catalyzes oxidative protein folding in mitochondria

(2009) Lucia Banci et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Conformational changes in redox pairs of protein structures

(2009) Samuel W. Fan et al.   PROTEIN SCIENCE

Molecular Mechanisms and Clinical Implications of Reversible Protein S-Glutathionylation

(2008) John J. Mieyal et al.   ANTIOXIDANTS & REDOX SIGNALING

Identification, Expression Pattern, and Characterization of Mouse Glutaredoxin 2 Isoforms

(2008) Christoph Hudemann et al.   ANTIOXIDANTS & REDOX SIGNALING

Kinetic and Thermodynamic Aspects of Cellular Thiol–Disulfide Redox Regulation

(2008) Kristine Steen Jensen et al.   ANTIOXIDANTS & REDOX SIGNALING

Two Novel Monothiol Glutaredoxins fromSaccharomyces cerevisiaeProvide Further Insight into Iron-Sulfur Cluster Binding, Oligomerization, and Enzymatic Activity of Glutaredoxins†

(2008) Nikola Mesecke et al.   BIOCHEMISTRY

Redox compartmentalization in eukaryotic cells

(2008) Young-Mi Go et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Glutaredoxin systems

(2008) Christopher Horst Lillig et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Thioredoxins and glutaredoxins as facilitators of protein folding

(2008) Carsten Berndt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Predicting disulfide bond connectivity in proteins by correlated mutations analysis

(2008) R. Rubinstein et al.   BIOINFORMATICS

Bleach Activates a Redox-Regulated Chaperone by Oxidative Protein Unfolding

(2008) J. Winter et al.   CELL

Induction of apoptosis by cigarette smoke via ROS-dependent endoplasmic reticulum stress and CCAAT/enhancer-binding protein-homologous protein (CHOP)

(2008) Yasuhiro Tagawa et al.   FREE RADICAL BIOLOGY AND MEDICINE

Human glutaredoxin-1 catalyzes the reduction of HIV-1 gp120 and CD4 disulfides and its inhibition reduces HIV-1 replication

(2008) Joeri Auwerx et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Redox Environment in the Mitochondrial Intermembrane Space Is Maintained Separately from the Cytosol and Matrix

(2008) Jingjing Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cysteinylation and homocysteinylation of plasma protein thiols during ageing of healthy human beings

(2008) R. Rossi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

Quantifying changes in the thiol redox proteome upon oxidative stress in vivo

(2008) L. I. Leichert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nonequilibrium thermodynamics of thiol/disulfide redox systems: A perspective on redox systems biology

(2007) Melissa Kemp et al.   FREE RADICAL BIOLOGY AND MEDICINE