Post-Translational Control of Protein Function by Disulfide Bond Cleavage

Regulation of Ca2+/calmodulin-dependent protein kinase phosphatase (CaMKP) by oxidation/reduction at Cys-359

(2012) Hiromi Baba et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Mechanical Force Can Fine-Tune Redox Potentials of Disulfide Bonds

(2012) Ilona B. Baldus et al.   BIOPHYSICAL JOURNAL

Recent advances involving the renin–angiotensin system

(2012) Steven D. Crowley et al.   EXPERIMENTAL CELL RESEARCH

Thioredoxin-1 and protein disulfide isomerase catalyze the reduction of similar disulfides in HIV gp120

(2012) Kathrin Reiser et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Factor XI is a substrate for oxidoreductases: Enhanced activation of reduced FXI and its role in antiphospholipid syndrome thrombosis

(2012) Bill Giannakopoulos et al.   JOURNAL OF AUTOIMMUNITY

Unique Disulfide Bonds in Epidermal Growth Factor (EGF) Domains of β3 Affect Structure and Function of αIIbβ3 and αvβ3 Integrins in Different Manner

(2012) Ronit Mor-Cohen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Preparation of human vascular endothelial growth factor-D for structural and preclinical therapeutic studies

(2012) Natalia Davydova et al.   PROTEIN EXPRESSION AND PURIFICATION

Interleukin-2 signalling is modulated by a labile disulfide bond in the CD132 chain of its receptor

(2012) C. Metcalfe et al.   Open Biology

Protein Folding and Modification in the Mammalian Endoplasmic Reticulum

(2011) Ineke Braakman et al.   Annual Review of Biochemistry

Novel assays of thrombogenic pathogenicity in the antiphospholipid syndrome based on the detection of molecular oxidative modification of the major autoantigen β2-glycoprotein I

(2011) Yiannis Ioannou et al.   ARTHRITIS AND RHEUMATISM

Lateral self-association of VWF involves the Cys2431-Cys2453 disulfide/dithiol in the C2 domain

(2011) T. Ganderton et al.   BLOOD

A redox switch in C-reactive protein modulates activation of endothelial cells

(2011) Ming-Yu Wang et al.   FASEB JOURNAL

Crystal Structure of Reduced and of Oxidized Peroxiredoxin IV Enzyme Reveals a Stable Oxidized Decamer and a Non-disulfide-bonded Intermediate in the Catalytic Cycle

(2011) Zhenbo Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stabilization of HIV-1 Envelope in the CD4-bound Conformation through Specific Cross-linking of a CD4 Mimetic

(2011) Grégoire Martin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of Extracellular Transglutaminase 2 by Thioredoxin

(2011) Xi Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N-acetylcysteine reduces the size and activity of von Willebrand factor in human plasma and mice

(2011) Junmei Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Structural basis of ligand specificity in the human pentraxins, C-reactive protein and serum amyloid P component

(2011) Halina Mikolajek et al.   JOURNAL OF MOLECULAR RECOGNITION

Vicinal thiols are required for activation of the αIIbβ3 platelet integrin

(2011) N. MANICKAM et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Coronary artery calcification score and carotid intima-media thickness in patients with hemophilia

(2011) M. ZWIERS et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin 1

(2011) Bjoern O. Schroeder et al.   NATURE

Transglutaminase 2: Biology, Relevance to Neurodegenerative Diseases and Therapeutic Implications

(2011) Hilary Grosso et al.   PHARMACOLOGY & THERAPEUTICS

Structural basis and evolution of redox regulation in plant adenosine-5'-phosphosulfate kinase

(2011) G. E. Ravilious et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Labile disulfide bonds are common at the leucocyte cell surface

(2011) C. Metcalfe et al.   Open Biology

The transient receptor potential family of ion channels

(2011) Bernd Nilius et al.   GENOME BIOLOGY

Botulinum Neurotoxin: A Marvel of Protein Design

(2010) Mauricio Montal   Annual Review of Biochemistry

Novel Synthetic, Salt-Resistant Analogs of Human Beta-Defensins 1 and 3 Endowed with Enhanced Antimicrobial Activity

(2010) O. Scudiero et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Control of Mature Protein Function by Allosteric Disulfide Bonds

(2010) Iman Azimi et al.   ANTIOXIDANTS & REDOX SIGNALING

How Proteins Form Disulfide Bonds

(2010) Matthieu Depuydt et al.   ANTIOXIDANTS & REDOX SIGNALING

Thiol-Based Redox Switches and Gene Regulation

(2010) Haike Antelmann et al.   ANTIOXIDANTS & REDOX SIGNALING

Structural determinants of vascular endothelial growth factor-D receptor binding and specificity

(2010) V.-M. Leppanen et al.   BLOOD

Specific N-linked glycosylation sites modulate synthesis and secretion of von Willebrand factor

(2010) T. A. J. McKinnon et al.   BLOOD

Beta 2 glycoprotein I is a substrate of thiol oxidoreductases

(2010) F. H. Passam et al.   BLOOD

Naturally occurring free thiols within  2-glycoprotein I in vivo: nitrosylation, redox modification by endothelial cells, and regulation of oxidative stress-induced cell injury

(2010) Y. Ioannou et al.   BLOOD

The importance of vicinal cysteines, C1669 and C1670, for von Willebrand factor A2 domain function

(2010) B. M. Luken et al.   BLOOD

Characterization of Phosphoglycerate Kinase-1 Expression of Stromal Cells Derived from Tumor Microenvironment in Prostate Cancer Progression

(2010) J. Wang et al.   CANCER RESEARCH

Crystal structure of human transglutaminase 2 in complex with adenosine triphosphate

(2010) Byeong-Gu Han et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Disulfide Bond That Constrains the HIV-1 gp120 V3 Domain Is Cleaved by Thioredoxin

(2010) Iman Azimi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stabilization of HIV-1 gp120-CD4 Receptor Complex through Targeted Interchain Disulfide Exchange

(2010) Nichole Cerutti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Redox Regulation of Transglutaminase 2 Activity

(2010) Jorunn Stamnaes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reduced Monomeric CD4 Is the Preferred Receptor for HIV

(2010) Lisa J. Matthias et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of the Disulfide Bond Arrangement of the HIV-1 Envelope Protein CON-S gp140 ΔCFI Shows Variability in the V1 and V2 Regions

(2010) Eden P. Go et al.   JOURNAL OF PROTEOME RESEARCH

Disulfide bond reduction of von Willebrand factor by ADAMTS-13

(2010) H.-C. YEH et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Redox control of β2-glycoprotein I-von Willebrand factor interaction by thioredoxin-1

(2010) F. H. PASSAM et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Disulfide Bond Acquisition through Eukaryotic Protein Evolution

(2010) Jason W. H. Wong et al.   MOLECULAR BIOLOGY AND EVOLUTION

A redox switch in angiotensinogen modulates angiotensin release

(2010) Aiwu Zhou et al.   NATURE

Control of sulfur partitioning between primary and secondary metabolism

(2010) Sarah G. Mugford et al.   PLANT JOURNAL

IntegrinαIIbβ3exists in an activated state in subjects with elevated plasma homocysteine levels

(2010) Sarah A. McGarrigle et al.   PLATELETS

Structural determinants of growth factor binding and specificity by VEGF receptor 2

(2010) V.-M. Leppanen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidation state of the XRCC1 N-terminal domain regulates DNA polymerase   binding affinity

(2010) M. J. Cuneo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemical physiology of oxidative stress-activated TRPM2 and TRPC5 channels

(2010) Shinichiro Yamamoto et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Monomeric C-Reactive Protein Generation on Activated Platelets: The Missing Link Between Inflammation and Atherothrombotic Risk

(2010) Steffen U. Eisenhardt et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Regulation of interleukin-4 signaling by extracellular reduction of intramolecular disulfides

(2009) Sophie Curbo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dissociation of Pentameric to Monomeric C-Reactive Protein on Activated Platelets Localizes Inflammation to Atherosclerotic Plaques

(2009) Steffen U. Eisenhardt et al.   CIRCULATION RESEARCH

VEGFs and receptors involved in angiogenesis versus lymphangiogenesis

(2009) Marja Lohela et al.   CURRENT OPINION IN CELL BIOLOGY

Monomeric C-reactive protein activates endothelial cells via interaction with lipid raft microdomains

(2009) Shang-Rong Ji et al.   FASEB JOURNAL

Novel Vascular Endothelial Growth Factor D Variants with Increased Biological Activity

(2009) Pyry I. Toivanen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of the complete integrin αVβ3 ectodomain plus an α/β transmembrane fragment

(2009) Jian-Ping Xiong et al.   JOURNAL OF CELL BIOLOGY

von Willebrand factor assembly and secretion

(2009) J. E. SADLER   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

REDOX Reaction at ASK1-Cys250 Is Essential for Activation of JNK and Induction of Apoptosis

(2009) Philippe J. Nadeau et al.   MOLECULAR BIOLOGY OF THE CELL

The Structure of a Receptor with Two Associating Transmembrane Domains on the Cell Surface: Integrin αIIbβ3

(2009) Jieqing Zhu et al.   MOLECULAR CELL

Structural specializations of A2, a force-sensing domain in the ultralarge vascular protein von Willebrand factor

(2009) Q. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational changes in redox pairs of protein structures

(2009) Samuel W. Fan et al.   PROTEIN SCIENCE

Basal and inducible expression of the thiol-sensitive ART2.1 ecto-ADP-ribosyltransferase in myeloid and lymphoid leukocytes

(2009) Shiyuan Hong et al.   Purinergic Signalling

C-Reactive Protein Isoforms Differ in Their Effects on Thrombus Growth

(2008) Blanca Molins et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Relaxation of ultralarge VWF bundles in a microfluidic–AFM hybrid reactor

(2008) D.M. Steppich et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Thioredoxins and glutaredoxins as facilitators of protein folding

(2008) Carsten Berndt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

How we diagnose the antiphospholipid syndrome

(2008) B. Giannakopoulos et al.   BLOOD

Thiols in the IIb3 integrin are necessary for platelet aggregation

(2008) Nagaraj Manickam et al.   BRITISH JOURNAL OF HAEMATOLOGY

Molecular and Structural Basis of Cytokine Receptor Pleiotropy in the Interleukin-4/13 System

(2008) Sherry L. LaPorte et al.   CELL

Interaction and functional association of protein disulfide isomerase with αVβ3 integrin on endothelial cells

(2008) Maria Swiatkowska et al.   FEBS Journal

Human glutaredoxin-1 catalyzes the reduction of HIV-1 gp120 and CD4 disulfides and its inhibition reduces HIV-1 replication

(2008) Joeri Auwerx et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Specific Cysteines in β3 Are Involved in Disulfide Bond Exchange-dependent and -independent Activation of αIIbβ3

(2008) Ronit Mor-Cohen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DsbL and DsbI Form a Specific Dithiol Oxidase System for Periplasmic Arylsulfate Sulfotransferase in Uropathogenic Escherichia coli

(2008) John P.A. Grimshaw et al.   JOURNAL OF MOLECULAR BIOLOGY

Covalent regulation of ULVWF string formation and elongation on endothelial cells under flow conditions

(2008) Y. LI et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Structure of a Complete Integrin Ectodomain in a Physiologic Resting State and Activation and Deactivation by Applied Forces

(2008) Jianghai Zhu et al.   MOLECULAR CELL

TRPC channel activation by extracellular thioredoxin

(2008) Shang-Zhong Xu et al.   NATURE

Extracellular Transglutaminase 2 Is Catalytically Inactive, but Is Transiently Activated upon Tissue Injury

(2008) Matthew Siegel et al.   PLoS One

A structural and biochemical basis for PAPS-independent sulfuryl transfer by aryl sulfotransferase from uropathogenic Escherichia coli

(2008) G. Malojcic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA