Overcoming an optimization plateau in the directed evolution of highly efficient nerve agent bioscavengers
Published 2017 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Overcoming an optimization plateau in the directed evolution of highly efficient nerve agent bioscavengers
Authors
Keywords
-
Journal
PROTEIN ENGINEERING DESIGN & SELECTION
Volume 30, Issue 4, Pages 333-345
Publisher
Oxford University Press (OUP)
Online
2017-01-30
DOI
10.1093/protein/gzx003
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Current and emerging strategies for organophosphate decontamination: special focus on hyperstable enzymes
- (2016) Pauline Jacquet et al. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
- Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability
- (2016) Adi Goldenzweig et al. MOLECULAR CELL
- Efficient laboratory evolution of computationally designed enzymes with low starting activities using fluorescence-activated droplet sorting
- (2016) Richard Obexer et al. PROTEIN ENGINEERING DESIGN & SELECTION
- Single treatment of VX poisoned guinea pigs with the phosphotriesterase mutant C23AL: Intraosseous versus intravenous injection
- (2016) Timo Wille et al. TOXICOLOGY LETTERS
- Catalytic bioscavengers in nerve agent poisoning: A promising approach?
- (2016) Franz Worek et al. TOXICOLOGY LETTERS
- The Moderately Efficient Enzyme: Futile Encounters and Enzyme Floppiness
- (2015) Arren Bar-Even et al. BIOCHEMISTRY
- Variants of Phosphotriesterase for the Enhanced Detoxification of the Chemical Warfare Agent VR
- (2015) Andrew N. Bigley et al. BIOCHEMISTRY
- Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently
- (2015) Andrew Currin et al. CHEMICAL SOCIETY REVIEWS
- Protein stability: computation, sequence statistics, and new experimental methods
- (2015) Thomas J Magliery CURRENT OPINION IN STRUCTURAL BIOLOGY
- Negative Epistasis and Evolvability in TEM-1 β-Lactamase—The Thin Line between an Enzyme's Conformational Freedom and Disorder
- (2015) Eynat Dellus-Gur et al. JOURNAL OF MOLECULAR BIOLOGY
- FireProt: Energy- and Evolution-Based Computational Design of Thermostable Multiple-Point Mutants
- (2015) David Bednar et al. PLoS Computational Biology
- Efficacy of the rePON1 mutant IIG1 to prevent cyclosarin toxicity in vivo and to detoxify structurally different nerve agents in vitro
- (2014) Franz Worek et al. ARCHIVES OF TOXICOLOGY
- Post-exposure treatment of VX poisoned guinea pigs with the engineered phosphotriesterase mutant C23: A proof-of-concept study
- (2014) Franz Worek et al. TOXICOLOGY LETTERS
- Engineering V-Type Nerve Agents Detoxifying Enzymes Using Computationally Focused Libraries
- (2013) Izhack Cherny et al. ACS Chemical Biology
- Computational design gains momentum in enzyme catalysis engineering
- (2013) Hein J. Wijma et al. FEBS Journal
- Enzymatic Neutralization of the Chemical Warfare Agent VX: Evolution of Phosphotriesterase for Phosphorothiolate Hydrolysis
- (2013) Andrew N. Bigley et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Patterns of Epistasis between Beneficial Mutations in an Antibiotic Resistance Gene
- (2013) Martijn F. Schenk et al. MOLECULAR BIOLOGY AND EVOLUTION
- Evolved Stereoselective Hydrolases for Broad-Spectrum G-Type Nerve Agent Detoxification
- (2012) Moshe Goldsmith et al. CHEMISTRY & BIOLOGY
- Stabilizing Proteins from Sequence Statistics: The Interplay of Conservation and Correlation in Triosephosphate Isomerase Stability
- (2012) Brandon J. Sullivan et al. JOURNAL OF MOLECULAR BIOLOGY
- Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing
- (2012) Timothy A Whitehead et al. NATURE BIOTECHNOLOGY
- Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis
- (2012) Sagar D Khare et al. Nature Chemical Biology
- Evolutionary transitions to new DNA methyltransferases through target site expansion and shrinkage
- (2012) Liat Rockah-Shmuel et al. NUCLEIC ACIDS RESEARCH
- Robust design and optimization of retroaldol enzymes
- (2012) Eric A. Althoff et al. PROTEIN SCIENCE
- Diminishing returns and tradeoffs constrain the laboratory optimization of an enzyme
- (2012) Nobuhiko Tokuriki et al. Nature Communications
- The Moderately Efficient Enzyme: Evolutionary and Physicochemical Trends Shaping Enzyme Parameters
- (2011) Arren Bar-Even et al. BIOCHEMISTRY
- Directed evolution of hydrolases for prevention of G-type nerve agent intoxication
- (2011) Rinkoo D Gupta et al. Nature Chemical Biology
- RosettaScripts: A Scripting Language Interface to the Rosetta Macromolecular Modeling Suite
- (2011) Sarel J. Fleishman et al. PLoS One
- Diminishing Returns Epistasis Among Beneficial Mutations Decelerates Adaptation
- (2011) H.-H. Chou et al. SCIENCE
- Epistasis between Beneficial Mutations and the Phenotype-to-Fitness Map for a ssDNA Virus
- (2011) Darin R. Rokyta et al. PLoS Genetics
- Initial Mutations Direct Alternative Pathways of Protein Evolution
- (2011) Merijn L. M. Salverda et al. PLoS Genetics
- Enzyme Promiscuity: A Mechanistic and Evolutionary Perspective
- (2010) Olga Khersonsky and Dan S. Tawfik Annual Review of Biochemistry
- Diminishing Returns From Beneficial Mutations and Pervasive Epistasis Shape the Fitness Landscape for Rifampicin Resistance in Pseudomonas aeruginosa
- (2010) R. C. MacLean et al. GENETICS
- Role of conformational sampling in computing mutation-induced changes in protein structure and stability
- (2010) Elizabeth H. Kellogg et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- Ultrahigh-Throughput FACS-Based Screening for Directed Enzyme Evolution
- (2009) Guangyu Yang et al. CHEMBIOCHEM
- Stability effects of mutations and protein evolvability
- (2009) Nobuhiko Tokuriki et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- RosettaLigand Docking with Full Ligand and Receptor Flexibility
- (2008) Ian W. Davis et al. JOURNAL OF MOLECULAR BIOLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationPublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More