Negative Epistasis and Evolvability in TEM-1 β-Lactamase—The Thin Line between an Enzyme's Conformational Freedom and Disorder

Published 2015 View Full Article

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Title
Negative Epistasis and Evolvability in TEM-1 β-Lactamase—The Thin Line between an Enzyme's Conformational Freedom and Disorder
Authors
Keywords
protein evolution, protein disorder, protein folds, conformational diversity, interactions network
Journal
JOURNAL OF MOLECULAR BIOLOGY
Volume 427, Issue 14, Pages 2396-2409
Publisher
Elsevier BV
Online
2015-05-23
DOI
10.1016/j.jmb.2015.05.011

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