Valosin-containing protein (VCP)–Adaptor Interactions are Exceptionally Dynamic and Subject to Differential Modulation by a VCP Inhibitor

Valosin-containing Protein (VCP)/p97 Segregase Mediates Proteolytic Processing of Cockayne Syndrome Group B (CSB) in Damaged Chromatin

(2016) Jinshan He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis

(2015) Daniel J. Anderson et al.   CANCER CELL

CCR 20th Anniversary Commentary: In the Beginning, There Was PS-341

(2015) B. A. Teicher et al.   CLINICAL CANCER RESEARCH

Control of p97 function by cofactor binding

(2015) Alexander Buchberger et al.   FEBS LETTERS

Discovery of a First-in-Class, Potent, Selective, and Orally Bioavailable Inhibitor of the p97 AAA ATPase (CB-5083)

(2015) Han-Jie Zhou et al.   JOURNAL OF MEDICINAL CHEMISTRY

Systematic proteomics of the VCP–UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis

(2015) Malavika Raman et al.   NATURE CELL BIOLOGY

Short- and long-term effects of chromosome mis-segregation and aneuploidy

(2015) Stefano Santaguida et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Altered cofactor regulation with disease-associated p97/VCP mutations

(2015) Xiaoyi Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy

(2014) Raymond J Deshaies   BMC BIOLOGY

The p97-Ufd1-Npl4 ATPase complex ensures robustness of the G2/M checkpoint by facilitating CDC25A degradation

(2014) Anne Riemer et al.   CELL CYCLE

The VCP/p97 system at a glance: connecting cellular function to disease pathogenesis

(2014) H. Meyer et al.   JOURNAL OF CELL SCIENCE

Specific Inhibition of p97/VCP ATPase and Kinetic Analysis Demonstrate Interaction between D1 and D2 ATPase Domains

(2014) Tsui-Fen Chou et al.   JOURNAL OF MOLECULAR BIOLOGY

Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells

(2014) S Sane et al.   Cell Death & Disease

Eukaryotic Stress Granules Are Cleared by Autophagy and Cdc48/VCP Function

(2013) J. Ross Buchan et al.   CELL

Structure-Activity Relationship Study Reveals ML240 and ML241 as Potent and Selective Inhibitors of p97 ATPase

(2013) Tsui-Fen Chou et al.   ChemMedChem

Characterization of Native Protein Complexes and Protein Isoform Variation Using Size-fractionation-based Quantitative Proteomics

(2013) Kathryn J. Kirkwood et al.   MOLECULAR & CELLULAR PROTEOMICS

Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death

(2013) Paola Magnaghi et al.   Nature Chemical Biology

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Protein rescue from aggregates by powerful molecular chaperone machines

(2013) Shannon M. Doyle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

VCP Phosphorylation-Dependent Interaction Partners Prevent Apoptosis in Helicobacter pylori-Infected Gastric Epithelial Cells

(2013) Cheng-Chou Yu et al.   PLoS One

Cdc48-associated complex bound to 60S particles is required for the clearance of aberrant translation products

(2013) Q. Defenouillere et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A proteolytic pathway that controls glucose uptake in fat and muscle

(2013) Jonathan P. Belman et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome

(2013) Rati Verma et al.   eLife

Mitochondrial quality control by the ubiquitin–proteasome system: Figure 1

(2012) Eric B. Taylor et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

A Ribosome-Bound Quality Control Complex Triggers Degradation of Nascent Peptides and Signals Translation Stress

(2012) Onn Brandman et al.   CELL

The p97/VCP ATPase is critical in muscle atrophy and the accelerated degradation of muscle proteins

(2012) Rosanna Piccirillo et al.   EMBO JOURNAL

The Role of the N-Domain in the ATPase Activity of the Mammalian AAA ATPase p97/VCP

(2012) Hajime Niwa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Proteomics Identifications (PRIDE) database and associated tools: status in 2013

(2012) Juan Antonio Vizcaíno et al.   NUCLEIC ACIDS RESEARCH

ATP Binding to p97/VCP D1 Domain Regulates Selective Recruitment of Adaptors to Its Proximal N-Domain

(2012) Wei Sheng Chia et al.   PLoS One

Development of p97 AAA ATPase inhibitors

(2011) Tsui-Fen Chou et al.   Autophagy

The Ubiquitin Regulatory X (UBX) Domain-containing Protein TUG Regulates the p97 ATPase and Resides at the Endoplasmic Reticulum-Golgi Intermediate Compartment

(2011) Charisse M. Orme et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cdc48/p97 Mediates UV-Dependent Turnover of RNA Pol II

(2011) Rati Verma et al.   MOLECULAR CELL

Endolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutations

(2011) Danilo Ritz et al.   NATURE CELL BIOLOGY

Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways

(2011) T.-F. Chou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hierarchical Binding of Cofactors to the AAA ATPase p97

(2011) Petra Hänzelmann et al.   STRUCTURE

VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD

(2010) Emilie Tresse et al.   Autophagy

Chaperone-mediated autophagy in protein quality control

(2010) Esperanza Arias et al.   CURRENT OPINION IN CELL BIOLOGY

Liver Cytochrome P450 3A Endoplasmic Reticulum-associated Degradation

(2010) Poulomi Acharya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction

(2009) Ji Luo et al.   CELL

p97/valosin-containing protein (VCP) is highly modulated by phosphorylation and acetylation

(2009) Chiho Mori-Konya et al.   GENES TO CELLS

Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease

(2009) Jeong-Sun Ju et al.   JOURNAL OF CELL BIOLOGY

UBXD4, a UBX-Containing Protein, Regulates the Cell Surface Number and Stability of  3-Containing Nicotinic Acetylcholine Receptors

(2009) K. Rezvani et al.   JOURNAL OF NEUROSCIENCE

UBXD7 Binds Multiple Ubiquitin Ligases and Implicates p97 in HIF1α Turnover

(2008) Gabriela Alexandru et al.   CELL

UBX domain proteins: major regulators of the AAA ATPase Cdc48/p97

(2008) C. Schuberth et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Impaired Protein Aggregate Handling and Clearance Underlie the Pathogenesis of p97/VCP-associated Disease

(2008) Jeong-Sun Ju et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heat shock and oxygen radicals stimulate ubiquitin-dependent degradation mainly of newly synthesized proteins

(2008) Balasubrahmanyam Medicherla et al.   JOURNAL OF CELL BIOLOGY

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE