More insights into the pharmacological effects of artemisinin

Anti-inflammatory activity of Vismia guianensis (Aubl.) Pers. extracts and antifungal activity against Sporothrix schenckii

(2017) A.H. Oliveira et al.   JOURNAL OF ETHNOPHARMACOLOGY

Artemisinin as an anticancer drug: Recent advances in target profiling and mechanisms of action

(2017) Yin Kwan Wong et al.   MEDICINAL RESEARCH REVIEWS

Inulin-type fructan and infusion of Artemisia vulgaris protect the liver against carbon tetrachloride-induced liver injury

(2017) Marília Locatelli Corrêa-Ferreira et al.   PHYTOMEDICINE

Hepatotoxicity by combination treatment of temozolomide, artesunate and Chinese herbs in a glioblastoma multiforme patient: case report review of the literature

(2016) Thomas Efferth et al.   ARCHIVES OF TOXICOLOGY

Synthesis of a series of novel dihydroartemisinin monomers and dimers containing chalcone as a linker and their anticancer activity

(2016) Rashmi Gaur et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and cytotoxicity of novel artemisinin derivatives containing sulfur atoms

(2016) Cang-Cang Xu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Flavonoids and Sesquiterpene Lactones from Artemisia absinthium and Tanacetum parthenium against Schistosoma mansoni Worms

(2016) Luísa Maria Silveira de Almeida et al.   Evidence-based Complementary and Alternative Medicine

Antischistosomal activity of artemisinin derivatives in vivo and in patients

(2016) Mohamed E.M. Saeed et al.   PHARMACOLOGICAL RESEARCH

Artesunate attenuated progression of atherosclerosis lesion formation alone or combined with rosuvastatin through inhibition of pro-inflammatory cytokines and pro-inflammatory chemokines

(2016) Weiwei Jiang et al.   PHYTOMEDICINE

Fatal Liver and Bone Marrow Toxicity by Combination Treatment of Dichloroacetate and Artesunate in a Glioblastoma Multiforme Patient: Case Report and Review of the Literature

(2016) Martin Uhl et al.   Frontiers in Oncology

Genetic engineering of artemisinin biosynthesis: prospects to improve its production

(2015) Malik Zainul Abdin et al.   ACTA PHYSIOLOGIAE PLANTARUM

Highly potent artemisinin-derived dimers and trimers: Synthesis and evaluation of their antimalarial, antileukemia and antiviral activities

(2015) Christoph Reiter et al.   BIOORGANIC & MEDICINAL CHEMISTRY

New efficient artemisinin derived agents against human leukemia cells, human cytomegalovirus and Plasmodium falciparum: 2nd generation 1,2,4-trioxane-ferrocene hybrids

(2015) Christoph Reiter et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Activity of Artemisia annua and artemisinin derivatives, in prostate carcinoma

(2015) Friedrich-Wilhelm Michaelsen et al.   PHYTOMEDICINE

Nobel Prize for artemisinin brings phytotherapy into the spotlight

(2015) Thomas Efferth et al.   PHYTOMEDICINE

Dried whole-plantArtemisia annuaslows evolution of malaria drug resistance and overcomes resistance to artemisinin

(2015) Mostafa A. Elfawal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The discovery of artemisinin and the Nobel Prize in Physiology or Medicine

(2015) Xin-Zhuan Su et al.   Science China-Life Sciences

Sesquiterpene Lactones fromArtemisiaGenus: Biological Activities and Methods of Analysis

(2015) Bianca Ivanescu et al.   Journal of Analytical Methods in Chemistry

Anti-inflammatory, Antioxidant and Antimicrobial Effects of Artemisinin Extracts fromArtemisia annuaL.

(2015) Wan-Su Kim et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Comparative Phytochemical Analysis of Essential Oils from Different Biological Parts of Artemisia herba alba and Their Cytotoxic Effect on Cancer Cells

(2015) Mounir Tilaoui et al.   PLoS One

Comparative Cytotoxicity of Artemisinin and Cisplatin and Their Interactions with Chlorogenic Acids in MCF7 Breast Cancer Cells

(2014) John O. Suberu et al.   ChemMedChem

Design, Synthesis, and Biological Evaluation of Artemisinin-Indoloquinoline Hybrids as Potent Antiproliferative Agents

(2014) Li Wang et al.   MOLECULES

Anthelmintic activity of Artemisia annua L. extracts in vitro and the effect of an aqueous extract and artemisinin in sheep naturally infected with gastrointestinal nematodes

(2014) Aida C. Cala et al.   PARASITOLOGY RESEARCH

Antimicrobial Activity of Artemisinin and Precursor Derived fromIn VitroPlantlets ofArtemisia annuaL.

(2014) Suganthi Appalasamy et al.   Biomed Research International

Natural products: A continuing source of novel drug leads

(2013) Gordon M. Cragg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Holotransferrin enhances selective anticancer activity of artemisinin against human hepatocellular carcinoma cells

(2013) Xiao-rong Deng et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

Artesunate exerts specific cytotoxicity in retinoblastoma cells via CD71

(2013) FEI ZHAO et al.   ONCOLOGY REPORTS

Artesunate induces G0/G1 cell cycle arrest and iron-mediated mitochondrial apoptosis in A431 human epidermoid carcinoma cells

(2012) Zhongyong Jiang et al.   ANTI-CANCER DRUGS

Antihistomonal effects of artemisinin andArtemisia annuaextractsin vitrocould not be confirmed byin vivoexperiments in turkeys and chickens

(2012) I. C. N. Thøfner et al.   AVIAN PATHOLOGY

Artesunate induces apoptosis via a Bak-mediated caspase-independent intrinsic pathway in human lung adenocarcinoma cells

(2012) Chenjuan Zhou et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Dihydroartemisinin induces autophagy and inhibits the growth of iron-loaded human myeloid leukemia K562 cells via ROS toxicity

(2012) Zeng Wang et al.   FEBS Open Bio

Antiproliferative effects of artemisinin on human breast cancer cells requires the downregulated expression of the E2F1 transcription factor and loss of E2F1-target cell cycle genes

(2011) Antony S. Tin et al.   ANTI-CANCER DRUGS

Dihydroartemisinin inhibits angiogenesis in pancreatic cancer by targeting the NF-κB pathway

(2011) Shuang-Jia Wang et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

2011: the immune hallmarks of cancer

(2011) Federica Cavallo et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

The redox antimalarial dihydroartemisinin targets human metastatic melanoma cells but not primary melanocytes with induction of NOXA-dependent apoptosis

(2011) Christopher M. Cabello et al.   INVESTIGATIONAL NEW DRUGS

Down-regulation of BMI-1 cooperates with artemisinin on growth inhibition of nasopharyngeal carcinoma cells

(2011) Jing Wu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine

(2011) Youyou Tu   NATURE MEDICINE

Development of Resistance towards Artesunate in MDA-MB-231 Human Breast Cancer Cells

(2011) Beatrice Bachmeier et al.   PLoS One

Chemical composition and antiproliferative activity of essential oil from aerial parts of a medicinal herb Artemisia herba-alba

(2011) Mounir Tilaoui et al.   Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy

Effect of artemisinin derivatives on apoptosis and cell cycle in prostate cancer cells

(2010) Colm Morrissey et al.   ANTI-CANCER DRUGS

Dihydroartemisinin accelerates c-MYC oncoprotein degradation and induces apoptosis in c-MYC-overexpressing tumor cells

(2010) Jin-Jian Lu et al.   BIOCHEMICAL PHARMACOLOGY

Suppression of PMA-induced tumor cell invasion by dihydroartemisinin via inhibition of PKCα/Raf/MAPKs and NF-κB/AP-1-dependent mechanisms

(2010) Yong Pil Hwang et al.   BIOCHEMICAL PHARMACOLOGY

In vitro study of the anti-cancer effects of artemisone alone or in combination with other chemotherapeutic agents

(2010) Andrew M. Gravett et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Heme synthesis increases artemisinin-induced radical formation and cytotoxicity that can be suppressed by superoxide scavengers

(2010) Shiming Zhang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Toxicity of the antimalarial artemisinin and its dervatives

(2010) Thomas Efferth et al.   CRITICAL REVIEWS IN TOXICOLOGY

Chemosensitization of Prostate Cancer by Modulating Bcl-2 Family Proteins

(2010) David Karnak et al.   CURRENT DRUG TARGETS

A comparison of low-dose cyclophosphamide treatment with artemisinin treatment in reducing the number of regulatory T cells in murine breast cancer model

(2010) Ladan Langroudi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Efficacy of artemisinin in experimental visceral leishmaniasis

(2010) Rupashree Sen et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

First evidence that the antimalarial drug artesunate inhibits invasion and in vivo metastasis in lung cancer by targeting essential extracellular proteases

(2010) Suhail Ahmed Kabeer Rasheed et al.   INTERNATIONAL JOURNAL OF CANCER

The antimalarial agent artesunate possesses anticancer properties that can be enhanced by combination strategies

(2010) Wai M. Liu et al.   INTERNATIONAL JOURNAL OF CANCER

The anti-malarial artemisinin inhibits pro-inflammatory cytokines via the NF-κB canonical signaling pathway in PMA-induced THP-1 monocytes

(2010) Wang   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

The anti-cancer activity of dihydroartemisinin is associated with induction of iron-dependent endoplasmic reticulum stress in colorectal carcinoma HCT116 cells

(2010) Jin-Jian Lu et al.   INVESTIGATIONAL NEW DRUGS

Artesunate Activates Mitochondrial Apoptosis in Breast Cancer Cells via Iron-catalyzed Lysosomal Reactive Oxygen Species Production

(2010) Anne Hamacher-Brady et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacogenomic Identification of c-Myc/Max-Regulated Genes Associated with Cytotoxicity of Artesunate towards Human Colon, Ovarian and Lung Cancer Cell Lines

(2010) Serkan Sertel et al.   MOLECULES

The Molecular Mechanism of Action of Artemisinin—The Debate Continues

(2010) Paul M. O’Neill et al.   MOLECULES

SM905, an artemisinin derivative, inhibited NO and pro-inflammatory cytokine production by suppressing MAPK and NF-κB pathways in RAW 264.7 macrophages

(2009) Jun-xia Wang et al.   ACTA PHARMACOLOGICA SINICA

Gene expression profiling identifies novel key players involved in the cytotoxic effect of Artesunate on pancreatic cancer cells

(2009) Mahmoud Youns et al.   BIOCHEMICAL PHARMACOLOGY

Anti-cancer effects of artesunate in a panel of chemoresistant neuroblastoma cell lines

(2009) Martin Michaelis et al.   BIOCHEMICAL PHARMACOLOGY

Antiprotozoal, anticancer and antimicrobial activities of dihydroartemisinin acetal dimers and monomers

(2009) Desmond Slade et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Artesunate induces oncosis-like cell death in vitro and has antitumor activity against pancreatic cancer xenografts in vivo

(2009) Ji-Hui Du et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

The Role of Downstream Signaling Pathways of the Epidermal Growth Factor Receptor for Artesunates Activity in Cancer Cells

(2009) V. Konkimalla et al.   CURRENT CANCER DRUG TARGETS

Anticancer activities of artemisinin and its bioactive derivatives

(2009) Gary L. Firestone et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Artemisinin dimer anticancer activity correlates with heme-catalyzed reactive oxygen species generation and endoplasmic reticulum stress induction

(2009) Luke H. Stockwin et al.   INTERNATIONAL JOURNAL OF CANCER

The anti-malaria agent artesunate inhibits expression of vascular endothelial growth factor and hypoxia-inducible factor-1α in human rheumatoid arthritis fibroblast-like synoviocyte

(2009) Ya He et al.   RHEUMATOLOGY INTERNATIONAL

Experimental Therapy of Hepatoma with Artemisinin and Its Derivatives: In vitro and In vivo Activity, Chemosensitization, and Mechanisms of Action

(2008) J. Hou et al.   CLINICAL CANCER RESEARCH

The Antiviral Activities of Artemisinin and Artesunate

(2008) Thomas Efferth et al.   CLINICAL INFECTIOUS DISEASES

Artemisinin reduces human melanoma cell migration by down-regulating αVβ3 integrin and reducing metalloproteinase 2 production

(2008) Elisabetta Buommino et al.   INVESTIGATIONAL NEW DRUGS

Artemisinin Blocks Prostate Cancer Growth and Cell Cycle Progression by Disrupting Sp1 Interactions with the Cyclin-dependent Kinase-4 (CDK4) Promoter and Inhibiting CDK4 Gene Expression

(2008) Jamin A. Willoughby et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dihydroartemisinin induces apoptosis and sensitizes human ovarian cancer cells to carboplatin therapy

(2008) Tao Chen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Chemical Stability of the Peroxide Bond Enables Diversified Synthesis of Potent Tetraoxane Antimalarials(1)

(2008) Igor Opsenica et al.   JOURNAL OF MEDICINAL CHEMISTRY

Flavonoids and Related Compounds in Parasitic Disease Control

(2008) D. Kerboeuf et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Artemisinin Inhibits Tumor Lymphangiogenesis by Suppression of Vascular Endothelial Growth Factor C

(2008) Jun Wang et al.   PHARMACOLOGY

Qinghaosu (Artemisinin): The Price of Success

(2008) N. J. White   SCIENCE

Toxicity of artemisinin [Artemisia annua L.] in two different periods of pregnancy in Wistar rats

(2007) Ana C. Boareto et al.   REPRODUCTIVE TOXICOLOGY