The redox antimalarial dihydroartemisinin targets human metastatic melanoma cells but not primary melanocytes with induction of NOXA-dependent apoptosis

Systematic Review of Medical Treatment in Melanoma: Current Status and Future Prospects

(2011) C. Garbe et al.   ONCOLOGIST

Gambogic acid triggers DNA damage signaling that induces p53/p21Waf1/CIP1 activation through the ATR-Chk1 pathway

(2010) Jing-Jing Rong et al.   CANCER LETTERS

DCPIP (2,6-dichlorophenolindophenol) as a genotype-directed redox chemotherapeutic targeting NQO1*2 breast carcinoma

(2010) Christopher M. Cabello et al.   FREE RADICAL RESEARCH

The Role of Heme and the Mitochondrion in the Chemical and Molecular Mechanisms of Mammalian Cell Death Induced by the Artemisinin Antimalarials

(2010) Amy E. Mercer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dihydroartemisinin Induces Apoptosis by a Bak-Dependent Intrinsic Pathway

(2010) R. Handrick et al.   MOLECULAR CANCER THERAPEUTICS

Proteomic Identification of Cathepsin B and Nucleophosmin as Novel UVA-Targets in Human Skin Fibroblasts

(2010) Sarah D. Lamore et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Effect of artesunate on immune cells in ret-transgenic mouse melanoma model

(2009) Marcel Ramacher et al.   ANTI-CANCER DRUGS

Dihydroartemisinin inhibits growth of pancreatic cancer cells in vitro and in vivo

(2009) Hua Chen et al.   ANTI-CANCER DRUGS

Redox-Directed Cancer Therapeutics: Molecular Mechanisms and Opportunities

(2009) Georg T. Wondrak   ANTIOXIDANTS & REDOX SIGNALING

Antimelanoma activity of the redox dye DCPIP (2,6-dichlorophenolindophenol) is antagonized by NQO1

(2009) Christopher M. Cabello et al.   BIOCHEMICAL PHARMACOLOGY

The topical antimicrobial zinc pyrithione is a heat shock response inducer that causes DNA damage and PARP-dependent energy crisis in human skin cells

(2009) Sarah D. Lamore et al.   CELL STRESS & CHAPERONES

Artemisinin dimer anticancer activity correlates with heme-catalyzed reactive oxygen species generation and endoplasmic reticulum stress induction

(2009) Luke H. Stockwin et al.   INTERNATIONAL JOURNAL OF CANCER

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Cancer cell iron metabolism and the development of potent iron chelators as anti-tumour agents

(2008) D.R. Richardson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Artesunate Derived from Traditional Chinese Medicine Induces DNA Damage and Repair

(2008) P. C.H. Li et al.   CANCER RESEARCH

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

(2008) Wan Seok Yang et al.   CHEMISTRY & BIOLOGY

Reactive oxygen species: an Achilles’ heel of melanoma?

(2008) John P Fruehauf et al.   Expert Review of Anticancer Therapy

Artemisinin reduces human melanoma cell migration by down-regulating αVβ3 integrin and reducing metalloproteinase 2 production

(2008) Elisabetta Buommino et al.   INVESTIGATIONAL NEW DRUGS

 -H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin

(2008) A. Kinner et al.   NUCLEIC ACIDS RESEARCH

Melanosomal Damage in Normal Human Melanocytes Induced by UVB and Metal Uptake—A Basis for the Pro-oxidant State of Melanoma

(2008) Shirley Gidanian et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

The reactive oxygen-driven tumor: relevance to melanoma

(2008) Levi Fried et al.   Pigment Cell & Melanoma Research