Article
Anatomy & Morphology
Xinyan Huang, Songzhao Zhang, Wenxi Wang
Summary: This study found that artemisinin has inhibitory effects on cutaneous squamous cell carcinoma, possibly through inhibition of the PI3K/AKT pathway.
Article
Oncology
Peng Wang, Chun Wang, Chunying Liu
Summary: Dioscin inhibits skin cancer cell proliferation by adjusting ATM/p53-mediated cell apoptosis, migration, and DNA damage.
Article
Chemistry, Physical
Nurhidayah Ab Rahim, Mohd Hafiz Mail, Musthahimah Muhamad, Sarah Sapuan, Rabiatul Basria S. M. N. Mydin, Azman Seeni
Summary: In this study, A. angustiloba-AgNPs were synthesized using the aqueous extract of A. angustiloba leaves, and their antiproliferative mechanisms were investigated. The nanoparticles showed inhibitory effects on the growth of A431 cells, inducing both apoptosis and cell cycle arrest. These findings suggest that the biosynthesized A. angustiloba-AgNPs have potential applications in cancer treatment.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Biochemistry & Molecular Biology
Jing-Yan Gao, Chih-Shiang Chang, Jin-Cherng Lien, Ting-Wei Chen, Jing-Lan Hu, Jing-Ru Weng
Summary: Trytanthrin, a natural compound found in Ban-Lan-Gen, has anti-inflammatory and anti-viral properties. Two derivatives, A1 and A6, showed higher cytotoxicity in HCC cells and targeted multiple aspects of cancer cell growth, making them potential candidates for clinical applications.
Article
Biochemistry & Molecular Biology
Chuang Zhang, Yuanyuan Tian, Ao Yang, Weihua Tan, Xiaoqing Liu, Wenchao Yang
Summary: This study revealed the anti-tumor effect of propolis on human cutaneous squamous cell carcinoma (CSCC) A431 cells and investigated its potential mechanism. The results showed that propolis ethanol extract inhibited A431 cell proliferation by regulating multiple signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Meng Qu, Guoxin Zhang, Han Qu, Alexander Vu, Raymond Wu, Hidekazu Tsukamoto, Zhenyu Jia, Wendong Huang, Heinz-Josef Lenz, Jeremy N. Rich, Steve A. Kay
Summary: Hepatocellular carcinoma (HCC) is a global health challenge with increasing incidence worldwide. The circadian clock has been shown to play a key role in hepatocarcinogenesis, but the cellular and molecular mechanisms underlying the HCC-clock crosstalk are unknown. In this study, we found that HCC cells rely on the circadian clock transcription factors BMAL1 and CLOCK for cell growth, and down-regulation of these factors induces apoptosis and cell cycle arrest. Mechanistically, inhibiting BMAL1/CLOCK dysregulates cell cycle regulators Wee1 and p21, leading to tumor cell death. Our findings provide insights into the cellular impact of clock proteins in HCC oncogenesis and suggest a potential therapeutic approach based on modulation of the circadian clock.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Yaxin Sun, Beibei Sha, Wenjing Huang, Miaomiao Li, Shan Zhao, Yuan Zhang, Jie Yan, Zheng Li, Jingwen Tang, Peiyan Duan, Jianxiang Shi, Pei Li, Tao Hu, Ping Chen
Summary: This study demonstrates the cytotoxic effect of ML323 on esophageal squamous cell carcinoma (ESCC) cells and elucidates its underlying mechanisms. ML323 inhibits the growth of ESCC cells by blocking the cell cycle, inducing DNA damage, and triggering apoptosis through the p53-Noxa pathway. Additionally, ML323 stimulates autophagy in cells, and co-treatment with autophagy inhibitors enhances its cytotoxicity.
Article
Plant Sciences
Subrata Das, Ashikur Rahaman, Rajat Nath, Anupam Das Talukdar, Deepa Nath, Shamee Bhattacharjee, Deba Prasad Mandal, Manabendra Dutta Choudhury, Dipika Das, Gitishree Das, Jayanta Kumar Patra
Summary: The aquatic plant Ottelia alismoides has been used in traditional medicine for treating various diseases. This study aimed to evaluate the apoptotic potential of its acetone extract and identify the compounds responsible for this effect.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Cell Biology
Qiong Liu, Lingying Chen, Wenjun Yin, Yuehua Nie, Penghui Zeng, Xin Yang
Summary: The study demonstrated that ginkgetin has an anti-tumor effect on human hepatocellular carcinoma cell lines by inducing apoptosis through affecting the balance between cell proliferation and apoptosis.
Article
Chemistry, Medicinal
Chao-Jie Wang, Xinxin Guo, Rui-Qin Zhai, Changning Sun, Guokai Xiao, Jin Chen, Mei-Yan Wei, Chang-Lun Shao, Yuchao Gu
Summary: The study successfully synthesized a derivative with cytotoxic activity in HCC patients by synthesizing the 2-benzoylquinazolin-4(3H)-one skeleton and demonstrated its potential as a chemotherapy agent.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biology
Weiwei Kuang, Wenlong Hu, Hong Ren, Yinhong Shao, Bingqian Liu
Summary: The study found that the phytoestrogen coumestrol has significant toxicity against human skin cancer cells, inducing cell cytotoxicity through apoptosis stimulation. Coumestrol also inhibits cell migration and invasion in skin cancer cells while blocking the m-TOR/PI3K/AKT signaling pathway.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Izabela Buniowska, Norbert Wronski, Malgorzata Insinska-Rak, Marek Sikorski, Agnieszka Wolnicka-Glubisz
Summary: This study compared the effects of 3MeTARF and riboflavin on A431 cancer cells under irradiation. The results showed that 3MeTARF more effectively activated MAPK and induced cell death in skin cancer cells, suggesting its therapeutic potential in photodynamic oxidation processes.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Phuriwat Laomethakorn, Malatee Tayeh, Siritron Samosorn, Chantra Tananyuthawongse, Ramida Watanapokasin
Summary: This study found that 13-butoxyberberine bromide effectively inhibited migration, invasion, and adhesion of skin cancer A431 cells. In addition, it down-regulated MMP-2 and MMP-9 expression and up-regulated TIMP-1 and TIMP-2 expression. These findings suggest that 13-butoxyberberine bromide has the potential to be developed as an anticancer agent.
Article
Oncology
Javad Saffari-Chaleshtori, Esfandiar Heidarian, Sayed M. Shafiee
Summary: Bilirubin affects melanoma and non-melanoma skin cancer cells mainly through apoptosis and genotoxicity, with lesser effects on normal human dermal fibroblast cells.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Jin-yi Liu, Wei-qi Fu, Xiang-jin Zheng, Wan Li, Li-wen Ren, Jin-hua Wang, Cui Yang, Guan-hua Du
Summary: Avasimibe demonstrated potent anticancer effects on human glioblastoma cells by inhibiting proliferation, inducing apoptosis, and regulating multiple signaling pathways. The drug showed promising potential as a chemotherapy treatment for glioblastoma.
ACTA PHARMACOLOGICA SINICA
(2021)